Page last updated: 2024-11-06

tolclofos-methyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tolclofos-methyl: a fungicide used in the cultivation of cotton, sugar beets, and ornamental plants [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

tolclofos-methyl : An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for controlling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID91664
CHEMBL ID2141416
CHEBI ID81731
SCHEMBL ID30367
MeSH IDM0388323

Synonyms (54)

Synonym
BIDD:ER0164
AC-12691
phosphorothioic acid, o-(2,6-dichloro-4-methylphenyl) o,o-dimethyl ester
tolclofos-methyl
o-(2,6-dichloro-p-tolyl) o,o-dimethyl thiophosphate
o-(2,6-dichloro-4-methylphenyl) o,o-dimethyl phosphorothioate
brn 2136521
phosphorothioic acid, o-(2,6-dichloro-p-tolyl) o,o-dimethyl ester
toclofos-methyl
risolex
einecs 260-515-3
rizolex
tolclofos-methyl [bsi:iso]
s-3349 ,
o-(2,6-dichloro-p-tolyl) o,o-dimethyl ester of phosphorothioic acid
o-2,6-dichloro-p-tolyl o,o-dimethyl phosphorothioate
o,o-dimethyl o-(2,6-dichloro-4-methylphenyl)phosphorothioate
NCGC00164279-01
57018-04-9
C18407
dtxsid0034776 ,
tox21_301347
NCGC00255519-01
cas-57018-04-9
dtxcid8014776
hsdb 8440
unii-g42oql6f5b
g42oql6f5b ,
AKOS015961111
FT-0630695
SCHEMBL30367
chebi:81731 ,
CHEMBL2141416
tolcofos-methyl
tolclofos-methyl [iso]
tolclofos-methyl [mi]
grancer
basilex
o-(2,6-dichloro-4-methylphenyl)phosphorothioic acid o,o-dimethyl ester
tolclofos-me
HY-B2053
CS-5201
o-(2,6-dichloro-4-methylphenyl) o,o-dimethyl thiophosphate #
dimethyl o-(2,6-dichloro-4-methylphenyl) phosphorothioate
o,o-dimethyl o-(2,6-dichloro-4-methylphenyl) phosphorothioate
OBZIQQJJIKNWNO-UHFFFAOYSA-N
tolclophos-methyl
W-111130
tolclofos-methyl, pestanal(r), analytical standard
tolclofos-methyl 10 microg/ml in cyclohexane
o-2,6-dichloro-4-methylphenyl o,o-dimethyl phosphorothioate
Q1651656
(2,6-dichloro-4-methylphenoxy)-dimethoxy-sulfanylidene-lambda5-phosphane
phosphorothioic acid, o-(2,6-dichloro-4-methylphenyl) o,o-dimethylester

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Mortality, weight change, and oxidative damage of earthworms were determined to investigate the toxicological bioavailability of TM."( Combination of chemical and toxicological methods to assess bioavailability of Tolclofos-methyl by earthworms.
Lang, Z; Li, M; Wang, S; Xu, G; Yu, Y, 2019
)
0.74
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
antifungal agrochemicalAny substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
organic thiophosphate
dichlorobenzeneAny member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency56.38130.007215.758889.3584AID1224835
GLI family zinc finger 3Homo sapiens (human)Potency45.88420.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency32.89670.000221.22318,912.5098AID1259243; AID1259247; AID743036
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency22.42880.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency27.30600.000417.946075.1148AID1346795
pregnane X nuclear receptorHomo sapiens (human)Potency47.56560.005428.02631,258.9301AID1346982; AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency30.63790.000229.305416,493.5996AID743079
aryl hydrocarbon receptorHomo sapiens (human)Potency52.49160.000723.06741,258.9301AID651777; AID743085; AID743122
thyroid stimulating hormone receptorHomo sapiens (human)Potency37.94250.001628.015177.1139AID1224843; AID1259385; AID1259395
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.23 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index47.46 (26.88)
Search Engine Supply Index2.25 (0.95)

This Compound (35.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]