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oxaline

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Description

oxaline: a fungal alkaloid from the culture broth of Penicillium oxalicum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

oxaline : An indole alkaloid with a heterotetracyclic skeleton isolated from Penicillium oxalicum and has been shown to exhibit cytotoxic activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID70698220
CHEMBL ID4443890
MeSH IDM0472832

Synonyms (7)

Synonym
oxaline
55623-37-5
',2':1,2]pyrido[2,3-b]indole-2,5(3h)-dione
(3e,7ar,12as)-3-[(1h-imidazol-4-yl)methylidene]-6,12-dimethoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1h,5h-imidazo[1
(3e,7ar,12as)-3-[(1h-imidazol-4-yl)methylidene]-6,12-dimethoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1h,5h-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3h)-dione
Q63399742
CHEMBL4443890
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1635218Antibacterial activity against Mycobacterium tuberculosis H37Rv by broth microdilution method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Metabolites from the Fungal Endophyte Aspergillus austroafricanus in Axenic Culture and in Fungal-Bacterial Mixed Cultures.
AID1568277Inhibition of NF-kappaB localization in nucleus of human L540 cells at 10 ug/ml measured after 5 to 24 hrs by DAPI staining immunofluorescence microscopy2019European journal of medicinal chemistry, Sep-15, Volume: 178Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's6 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]