meleagrin profile

meleagrin: low molecular weight protein found in turkey (Meleagris gallopavo) ovomucoid preparation; amino acid sequence given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

meleagrine : An indole alkaloid with a heterotetracyclic skeleton isolated from Penicillium oxalicum. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	23728435
CHEMBL ID	4746496
MeSH ID	M0168470

Synonym
MEGXM0_000075
ACON1_001969
MEGXM0_000097
ACON0_001257
ACON1_001373
ACON0_001256
meleagrin
71751-77-4
unii-5780k492k3
5780k492k3 ,
1h,5h-imidazo(1',2':1,2)pyrido(2,3-b)indole-2,5(3h)-dione, 7a-(1,1-dimethyl-2-propenyl)-7a,12-dihydro-6-hydroxy-3-(1h-imidazol-4-ylmethylene)-12-methoxy-, (7ar-(3e,7ar,12as))-
meleagrine
meleagrin, (-)-
6-o-demethyloxaline
1h,5h-imidazo(1',2':1,2)pyrido(2,3-b)indole-2,5(3h)-dione, 7a-(1,1-dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1h-imidazol-5-ylmethylene)-12-methoxy-, (3e,7ar,12as)-
(3e,7ar,12as)-7a-(1,1-dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1h-imidazol-5-ylmethylene)-12-methoxy-1h,5h-imidazo(1',2':1,2)pyrido(2,3-b)indole-2,5(3h)-dione
AKOS027307612
DTXSID80891812
bdbm50558000
chembl4746496 ,
BCP14992
Q63409166
(7ar,12as,e)-3-((1h-imidazol-5-yl)methylene)-6-hydroxy-12-methoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1h,5h-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3h)-dione
CS-0100053
HY-N6797
(1s,9r,14e)-11-hydroxy-14-(1h-imidazol-5-ylmethylidene)-2-methoxy-9-(2-methylbut-3-en-2-yl)-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7,10-tetraene-12,15-dione
BM162737

Excerpt	Reference	Relevance
"Meleagrin B is a terpene-alkaloid hybrid natural product that contains both the conidiogenone and meleagrin scaffold. "	( An Enzyme-Mediated Aza-Michael Addition Is Involved in the Biosynthesis of an Imidazoyl Hybrid Product of Conidiogenone B. Chein, RJ; Chen, YJ; Hewage, RT; Huang, RJ; Lai, SJ; Li, D; Lien, YC; Lin, HC; Weng, SH; Wu, SH, 2021)	2.06
"Meleagrin is a potential nontoxic antifoulant that is isolated from the fungus Penicillium sp.; however, its mechanistic effect mode of action on larval settlement remains unknown."	( iTRAQ-based proteomic profiling of the barnacle Balanus amphitrite in response to the antifouling compound meleagrin. Han, Z; He, F; He, LS; Matsumura, K; Qi, SH; Qian, PY; Qiu, JW; Sun, J; Xu, Y; Zhang, Y, 2013)	1.32

Excerpt	Reference	Relevance
"Meleagrin treatment potently suppressed the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model, promoting this unique natural product from hit to a lead rank."	( The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. Ebrahim, HY; El Sayed, KA; Elsayed, HE; Haggag, EG; Houssen, WE; Mady, MS; Mohyeldin, MM; Soliman, RF, 2016)	1.48

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50 (µMol)	3.1500	0.0004	0.3722	10.0000	AID1710748; AID1710749
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
endothelial cell morphogenesis	Hepatocyte growth factor receptor	Homo sapiens (human)
signal transduction	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of autophagy	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of microtubule polymerization	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of Rho protein signal transduction	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Hepatocyte growth factor receptor	Homo sapiens (human)
hepatocyte growth factor receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
branching morphogenesis of an epithelial tube	Hepatocyte growth factor receptor	Homo sapiens (human)
positive chemotaxis	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of stress fiber assembly	Hepatocyte growth factor receptor	Homo sapiens (human)
excitatory postsynaptic potential	Hepatocyte growth factor receptor	Homo sapiens (human)
establishment of skin barrier	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of thrombin-activated receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
semaphorin-plexin signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of hydrogen peroxide-mediated programmed cell death	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of guanyl-nucleotide exchange factor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Hepatocyte growth factor receptor	Homo sapiens (human)
liver development	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
phagocytosis	Hepatocyte growth factor receptor	Homo sapiens (human)
multicellular organism development	Hepatocyte growth factor receptor	Homo sapiens (human)
neuron differentiation	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	Hepatocyte growth factor receptor	Homo sapiens (human)
cell migration	Hepatocyte growth factor receptor	Homo sapiens (human)
pancreas development	Hepatocyte growth factor receptor	Homo sapiens (human)
nervous system development	Hepatocyte growth factor receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
protein tyrosine kinase activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protein binding	Hepatocyte growth factor receptor	Homo sapiens (human)
ATP binding	Hepatocyte growth factor receptor	Homo sapiens (human)
semaphorin receptor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protein phosphatase binding	Hepatocyte growth factor receptor	Homo sapiens (human)
identical protein binding	Hepatocyte growth factor receptor	Homo sapiens (human)
molecular function activator activity	Hepatocyte growth factor receptor	Homo sapiens (human)
hepatocyte growth factor receptor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Hepatocyte growth factor receptor	Homo sapiens (human)
plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
basal plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface	Hepatocyte growth factor receptor	Homo sapiens (human)
membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
postsynapse	Hepatocyte growth factor receptor	Homo sapiens (human)
basal plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
receptor complex	Hepatocyte growth factor receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (29)

Assay ID	Title	Year	Journal	Article
AID1710732	Antiproliferative activity against human BT-474 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710749	Inhibition of recombinant human His-tagged c-MET M1250T mutant expressed in baculovirus expression system assessed as reduction in c-MET phosphorylation using Tyr6 as substrate incubated for 1 hr by Z'-lyte assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710752	Antiinvasive activity against human MDA-MB-231 cells assessed as reduction in HGF-induced cell invasion incubated for 24 hrs by fluorescence based assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710738	Cytotoxicity against human MCF-10A cells assessed as cell viability at 10 uM incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710734	Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710740	Cytotoxicity against human MCF-10A cells assessed as cell viability at 30 uM incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710744	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability at 50 uM incubated for 24 hrs by LDH assay relative to control	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710757	Toxicity in athymic nude-Foxn1nu/Fox1+ mouse assessed as effect on body weight at 10 mg/kg, ip dosed 3 times per week for 3 weeks treatment started 14 days of post inoculation	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710758	Antiinvasive activity against human MDA-MB-231 cells assessed as reduction in HGF-mediate cell invasion at 4 uM incubated for 24 hrs by fluorescence based assay relative to control	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710736	Antiproliferative activity against human T47D cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710727	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710748	Inhibition of recombinant human His-tagged c-MET expressed in baculovirus expression system assessed as reduction in c-MET phosphorylation using Tyr6 as substrate incubated for 1 hr by Z'-lyte assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710731	Antiproliferative activity against human MCF7-DOX cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710746	Inhibition of recombinant human His-tagged c-MET expressed in baculovirus expression system assessed as reduction in c-MET phosphorylation at 10 uM using Tyr6 as substrate incubated for 1 hr by Z'-lyte assay relative to control	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710751	Antimigratory activity against human MDA-MB-231 cells assessed as inhibition of HGF-induced cell migration incubated for 24 hrs by Giemsa-staining based wound healing assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710759	Antiinvasive activity against human MDA-MB-231 cells assessed as reduction in HGF-mediate cell invasion at 8 uM incubated for 24 hrs by fluorescence based assay relative to control	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710750	Selectivity index, ratio of IC50 for recombinant human His-tagged c-MET expressed in baculovirus expression system to IC50 for recombinant human His-tagged c-MET M1250T mutant expressed in baculovirus expression system	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710743	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability at 25 uM incubated for 24 hrs by LDH assay relative to control	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710755	Antitumor activity against GFP-tagged human MDA-MB-231 cells xenografted in athymic nude-Foxn1nu/Fox1+ mouse assessed as the reduction in tumor volume at 10 mg/kg, ip dosed 3 times per week for 3 weeks treatment started 14 days of post inoculation	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710739	Cytotoxicity against human MCF-10A cells assessed as cell viability at 20 uM incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710726	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710754	Inhibition of c-MET in human MDA-MB-231 cells assessed as reduction in c-MET phosphorylation level at 15 to 30 uM incubated for 48 hrs by Western blot analysis	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710756	Antitumor activity against GFP-tagged human MDA-MB-231 cells xenografted in athymic nude-Foxn1nu/Fox1+ mouse assessed as the reduction in tumor growth at 10 mg/kg, ip dosed 3 times per week for 3 weeks treatment started 14 days of post inoculation	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710735	Antiproliferative activity against human MDA-MB-468 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710745	Inhibition of recombinant human His-tagged c-MET expressed in baculovirus expression system assessed as reduction in c-MET phosphorylation at 5 uM using Tyr6 as substrate incubated for 1 hr by Z'-lyte assay relative to control	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710737	Cytotoxicity against human MCF-10A cells assessed as cell viability at 5 uM incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710730	Antiproliferative activity against human MCF7 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710733	Antiproliferative activity against human SK-BR-3 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
AID1710753	Reduction of c-MET expression level in human MDA-MB-231 cells at 15 to 30 uM incubated for 48 hrs by Western blot analysis	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (8.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (8.33)	29.6817
2010's	8 (66.67)	24.3611
2020's	2 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (7.69%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (92.31%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
imidazole imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.	2.31	1	imidazole
4-butyrolactone 4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.	2.08	1	butan-4-olide	metabolite; neurotoxin
butenolide butenolide: inhibits experimental allergic encephalomyelitis in rats. butenolide : A gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.	2.08	1	butenolide
alpha-chymotrypsin Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.	1.97	1
roquefortine roquefortine: metabolite of Penicillium roqueforti; structure	4.27	5	pyrroloindole
((3z)-n-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1h-pyrrol-2-yl)methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide) [no description available]	2.13	1	sulfonamide
2,4,3',5'-tetrahydroxystilbene oleocanthal: newly pressed extra-virgin olive oil contains oleocanthal, acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen; structure in first source. oleocanthal : A carboxylic ester that is the 2-(p-hydroxyphenyl)ethyl ester of (3S)-4-formyl-3-(2-oxoethyl)hex-4-enoic acid. Oleocanthal is found in olive oil but it is not clear whether the natural product is a mixture of E/Z isomers or a single isomer as the two isomers readily interconvert in solution; most pharmacological studies will have been performed using a mixture.	2.13	1
roquefortine [no description available]	2.13	1	pyrroloindole
oxaline oxaline: a fungal alkaloid from the culture broth of Penicillium oxalicum; structure in first source. oxaline : An indole alkaloid with a heterotetracyclic skeleton isolated from Penicillium oxalicum and has been shown to exhibit cytotoxic activity.	7.47	2
neoxaline neoxaline: alkaloid isolated from fermentation broth of Aspergillus japonicus	3.56	2

Condition	Relationship Strength	Studies
Breast Cancer [description not available]	7.13	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.13	1
Experimental Mammary Neoplasms [description not available]	2.13	1
Invasiveness, Neoplasm [description not available]	2.13	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.13	1

meleagrin

Description

Cross-References

Synonyms (27)

Research Excerpts

Overview

Treatment

Protein Targets (1)

Inhibition Measurements

Biological Processes (27)

Molecular Functions (8)

Ceullar Components (7)

Bioassays (29)

Research

Studies (12)

Market Indicators

Research Demand Index: 22.16

Study Types

meleagrin

Description

Cross-References

Synonyms (27)

Research Excerpts

Overview

Treatment

Protein Targets (1)

Inhibition Measurements

Biological Processes (27)

Molecular Functions (8)

Ceullar Components (7)

Bioassays (29)

Research

Studies (12)

Market Indicators

Research Demand Index: 22.16

Study Types

Related Drugs (10)

Related Conditions (5)