Page last updated: 2024-12-07

jietacin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

jietacin A: isolated from a streptomycete; MF C18-H34-N2-O2; azoxy cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID131028
CHEMBL ID4446187
MeSH IDM0151070

Synonyms (8)

Synonym
109766-61-2
8-pentadecanone, 1-(ethenyl-onn-azoxy)-14-methyl-
1-(ethenyl-onn-azoxy)-14-methyl-8-pentadecanone
brn 5538455
jietacine a
jietacin a
ethenyl-(14-methyl-8-oxopentadecyl)imino-oxidoazanium
CHEMBL4446187
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1568279Antiproliferative activity against human ATN1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay2019European journal of medicinal chemistry, Sep-15, Volume: 178Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.
AID1568280Antiproliferative activity against human K562 cells assessed as reduction in cell viability at 10 ug/ml measured after 24 hrs by MTT assay relative to control2019European journal of medicinal chemistry, Sep-15, Volume: 178Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.
AID1568277Inhibition of NF-kappaB localization in nucleus of human L540 cells at 10 ug/ml measured after 5 to 24 hrs by DAPI staining immunofluorescence microscopy2019European journal of medicinal chemistry, Sep-15, Volume: 178Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.
AID1568284Inhibition of TNF alpha stimulated NF-kappaB in human FL cells transfected with kappaB luciferase at 5 to 10 ug/ml incubated for 4 hrs followed by TNF alpha stimulation measured after 3 hrs by dual luciferase reporter gene assay2019European journal of medicinal chemistry, Sep-15, Volume: 178Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.42 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.42)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]