| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
cadaverine
[no description available] | 1.99 | 1 | 0 | alkane-alpha,omega-diamine | Daphnia magna metabolite;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite |
sym-homospermidine
sym-homospermidine: analog of spermidine isolated from sandal leaves (Santalum album L.); structure. sym-homospermidine : A polyazaalkane comprising undecane with three aza groups placed at the 1-, 6- and 11-positions. | 2.01 | 1 | 0 | polyazaalkane;
triamine | |
trimethylenediamine
trimethylenediamine: RN given refers to parent cpd; structure. trimethylenediamine : An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3. | 1.99 | 1 | 0 | alkane-alpha,omega-diamine | human metabolite;
mouse metabolite;
reagent |
imidazole
imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1. | 2.02 | 1 | 0 | imidazole | |
putrescine
[no description available] | 2.91 | 4 | 0 | alkane-alpha,omega-diamine | antioxidant;
fundamental metabolite |
spermidine
[no description available] | 8.6 | 9 | 0 | polyazaalkane;
triamine | autophagy inducer;
fundamental metabolite;
geroprotector |
spermine
[no description available] | 4.26 | 18 | 0 | polyazaalkane;
tetramine | antioxidant;
fundamental metabolite;
immunosuppressive agent |
eflornithine
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.. eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. | 1.99 | 1 | 0 | alpha-amino acid;
fluoroamino acid | trypanocidal drug |
n(1),n(11)-diethylnorspermine
N(1),N(11)-diethylnorspermine: structure given in first source | 1.99 | 1 | 0 | | |
n(1), n(12)-diethylspermine
N(1), N(12)-diethylspermine: structure in first source. N(1),N(12)-diethylspermine : A substituted spermine that is spermine in which a hydrogen attached to each of the primary amino groups has been replaced by an ethyl group. | 1.99 | 1 | 0 | polyazaalkane;
secondary amino compound;
substituted spermine;
tetramine | antineoplastic agent |
dipropylenetriame
N-(3-aminopropyl)-1,3-propanediamine: structure in first source | 3.09 | 5 | 0 | polyazaalkane | algal metabolite;
plant metabolite |
uridine
[no description available] | 2.03 | 1 | 0 | uridines | drug metabolite;
fundamental metabolite;
human metabolite |
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus. | 1.99 | 1 | 0 | antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol | anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor |
acrylonitrile
[no description available] | 2.41 | 1 | 0 | aliphatic nitrile;
volatile organic compound | antifungal agent;
carcinogenic agent;
fungal metabolite;
mutagen;
polar aprotic solvent |
succinamide
[no description available] | 2.41 | 1 | 0 | | |
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile. | 2.1 | 1 | 0 | glycopeptide | antibacterial drug;
antimicrobial agent;
bacterial metabolite |
octamethylenediamine
octamethylenediamine: RN given refers to parent cpd. 1,8-diaminooctane : An alkane-alpha,omega-diamine in which the two amino groups are separated by eight methylene groups. | 2.01 | 1 | 0 | alkane-alpha,omega-diamine | |
n(1),n(14)-bis(ethyl)homospermine
N(1),N(14)-bis(ethyl)homospermine: structure given in first source; depletes polyamines and inhibits the growth of tumor cells in tissue culture | 1.99 | 1 | 0 | | |
n-(3-aminopropyl)cadaverine
aminopropylcadaverine : A polyazaalkane that is the 1,4,11-triaza derivative of undecane. | 2.01 | 1 | 0 | polyazaalkane;
triamine | Escherichia coli metabolite |
1-methylspermidine
1-methylspermidine: RN & structure given in first source; RN given refers to parent cpd | 1.99 | 1 | 0 | | |
thermospermine
thermospermine: polyamine extracted from an extreme thermopile, Thermus thermophilus; structure. thermospermine : Propane-1,3-diamine in which a hydrogen attached to one nitrogen is substituted by a 3-aminoprop-1-yl group, and a hydrogen attached to the other nitrogen is substituted by a 4-aminobut-1-yl group. A polyamine natural product, its name arises from its similarity to spermine and the fact that it was first isolated from the extreme thermophile, Thermus thermophilus. | 2.73 | 3 | 0 | polyazaalkane;
tetramine | |
arabinose
[no description available] | 2.25 | 1 | 0 | L-arabinose | Escherichia coli metabolite;
mouse metabolite |
mdl 72527
MDL 72527: RN given refers to di-HCl; RN for parent cpd not available 6/85; polyamine oxidase inhibitor | 1.99 | 1 | 0 | | |
casein kinase ii
Casein Kinase II: A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. Casein kinase II has been shown to phosphorylate a large number of substrates, many of which are proteins involved in the regulation of gene expression. | 1.99 | 1 | 0 | | |
anticodon
Anticodon: The sequential set of three nucleotides in TRANSFER RNA that interacts with its complement in MESSENGER RNA, the CODON, during translation in the ribosome. | 2.02 | 1 | 0 | | |
piperidines
Piperidines: A family of hexahydropyridines. | 1.99 | 1 | 0 | | |
colistin
Colistin: Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.. colistin : A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa. | 2.25 | 1 | 0 | | |
daptomycin
[no description available] | 2.1 | 1 | 0 | | |