thermospermine: polyamine extracted from an extreme thermopile, Thermus thermophilus; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
thermospermine : Propane-1,3-diamine in which a hydrogen attached to one nitrogen is substituted by a 3-aminoprop-1-yl group, and a hydrogen attached to the other nitrogen is substituted by a 4-aminobut-1-yl group. A polyamine natural product, its name arises from its similarity to spermine and the fact that it was first isolated from the extreme thermophile, Thermus thermophilus. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 194365 |
| CHEMBL ID | 151993 |
| CHEBI ID | 59564 |
| SCHEMBL ID | 333029 |
| MeSH ID | M0075566 |
| Synonym |
|---|
| n-(3-amino-propyl)-n-(5-aminopropyl)-1,4-diaminobutane |
| thermospermine |
| CHEMBL151993 |
| 70862-11-2 |
| CHEBI:59564 , |
| n-{3-[(3-aminopropyl)amino]propyl}butane-1,4-diamine |
| n1-(3-(3-aminopropylamino)propyl)butane-1,4-diamine |
| 1,12-diamino-4,8-diazadodecane |
| n'-[3-(3-aminopropylamino)propyl]butane-1,4-diamine |
| C19669 |
| 1,4-butanediamine, n-(3-((3-aminopropyl)amino)propyl)- |
| SCHEMBL333029 |
| DTXSID00221096 |
| AKOS028111177 |
| 1,4-butanediamine, n-[3-[(3-aminopropyl)amino]propyl]- |
| thermospermine; pa(334) |
| Q3984484 |
| {3-[(4-aminobutyl)amino]propyl}(3-aminopropyl)amine |
| n1-(3-((3-aminopropyl)amino)propyl)butane-1,4-diamine |
| (4-aminobutyl)({3-[(3-aminopropyl)amino]propyl})amine |
| BS-24492 |
| EX-A6687 |
Thermospermine (Tspm) is a polyamine found to play a crucial role in xylem development in Arabidopsis thaliana. It is an isomer of spermine and assumed to be synthesized by an analogous mechanism.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Thermospermine (Tspm) is a polyamine found to play a crucial role in xylem development in Arabidopsis thaliana. " | ( Quantification of Xylem-Specific Thermospermine-Dependent Translation of SACL Transcripts with Dual Luciferase Reporter System. Blázquez, MA; Ferrando, A; Solé-Gil, A; Úrbez, C, 2024) | 3.17 |
| "Thermospermine is a structural isomer of spermine and is required for stem elongation in Arabidopsis thaliana. " | ( Norspermine substitutes for thermospermine in the control of stem elongation in Arabidopsis thaliana. Igarashi, K; Kakehi, J; Kuwashiro, Y; Motose, H; Takahashi, T, 2010) | 2.1 |
| "Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants. " | ( Thermospermine is not a minor polyamine in the plant kingdom. Kakehi, J; Takahashi, T; Takano, A, 2012) | 3.26 |
| "Thermospermine is an isomer of spermine and assumed to be synthesized by an analogous mechanism." | ( Putative spermine synthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine. Knott, JM; Römer, P; Sumper, M, 2007) | 1.28 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Thermospermine plays a critical role in negatively regulating xylem development in angiosperms. " | ( Suppression of the dwarf phenotype of an Arabidopsis mutant defective in thermospermine biosynthesis by a synonymous codon change in the SAC51 uORF. Fukushima, H; Koyama, D; Nishii, Y; Takahashi, T, 2023) | 2.58 |
| Class | Description |
|---|---|
| polyazaalkane | Any azaalkane in which two or more carbons in the chain are replaced by nitrogen. |
| tetramine | Any polyamine that contains four amino groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (8.33) | 18.7374 |
| 1990's | 2 (4.17) | 18.2507 |
| 2000's | 2 (4.17) | 29.6817 |
| 2010's | 33 (68.75) | 24.3611 |
| 2020's | 7 (14.58) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (24.71) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 7 (14.58%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 41 (85.42%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||