Compounds > lastar a
Page last updated: 2024-11-06

lastar a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

lastar A: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID75471
CHEMBL ID117625
SCHEMBL ID38638
MeSH IDM0082494

Synonyms (51)

Synonym
2,2,6,6-tetramethyl-piperidin-4-ol
2,2,6,6-tetramethyl-4-piperidinol
4-piperidinol, 2,2,6,6-tetramethyl-
2403-88-5
2,6,6-tetramethyl-4-hydroxypiperidine
nsc-16575
4-hydroxy-2,6,6-tetramethylpiperidine
lastar a
nsc16575
2,6,6-tetramethyl-4-piperidinol
4-piperidinol,2,6,6-tetramethyl-
2,2,6,6-tetramethyl-4-piperidinol, 98%
2,2,6,6-tetramethylpiperidin-4-ol
nsc 16575
2,2,6,6-tetramethyl-4-hydroxypiperidine
einecs 219-291-2
inchi=1/c9h19no/c1-8(2)5-7(11)6-9(3,4)10-8/h7,10-11h,5-6h2,1-4h
CHEMBL117625
T0910
4-hydroxy-2,2,6,6-tetramethylpiperidine
AKOS000119836
NCGC00248548-01
2,2,6,6-tetramethyl- 4-piperidinol
dtxsid3029655 ,
tox21_200165
NCGC00257719-01
cas-2403-88-5
dtxcid609655
ec 219-291-2
unii-is23q8egz6
is23q8egz6 ,
FT-0609127
AE-562/40209651
AM84816
4-hydroxyl-2,2,6,6-tetramethyl piperidine
SCHEMBL38638
PS-5856
4-hydroxy-2,2,6,6-tetramethyl piperidine
2,2,6,6-tetramethylpiperidine-4-ol
2,2,6,6-tetramethyl-4-hydroxy-piperidine
2,2,6,6-tetramethy-4-piperidinol
2, 2, 6, 6-tetramethyl-4-hydroxypiperidine
2,2,6,6-tetramethyl-4-hydroxypiperdine
2,2,6,6-tetramethyl-piperidin-4ol
W-109134
mfcd00005983
CS-0059143
EN300-19570
Q27280873
SB41078
Z104474268
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency55.53710.000714.592883.7951AID1259368
AR proteinHomo sapiens (human)Potency78.44820.000221.22318,912.5098AID1259243
pregnane X nuclear receptorHomo sapiens (human)Potency55.53710.005428.02631,258.9301AID1346982
heat shock protein beta-1Homo sapiens (human)Potency22.31200.042027.378961.6448AID743210
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID216890Mean surviving fraction of V79 cells following a 1-h exposure to H2O2.1998Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18
Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage.
AID216900Mean surviving fraction of V79 cells following a 12-Gy dose of radiation.1998Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18
Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's2 (33.33)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
5,5-dimethyl-1-pyrroline-1-oxide
5,5-dimethyl-1-pyrroline-1-oxide: do not confuse with DMPO (4',5'-dihydroxy-7-methoxy-4-phenyl-5,2'-oxidocoumarin). 5,5-dimethyl-1-pyrroline N-oxide : A member of the class of 1-pyrroline nitrones (1-pyrroline N-oxides) resulting from the formal N-oxidation of 5,5-dimethyl-1-pyrroline. Used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation.		1.99101-pyrroline nitronesneuroprotective agent;
spin trapping reagent
tempol-h
TEMPOL-H: hydroxylamine (protonated, reduced) form of TEMPOL; a N-hydroxyl form of LASTAR A; TEMPOL is paramagnetic radical used in NMR as SPIN LABELS whereas TEMPOL-H is not. 4-hydroxy-TEMPO : A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.		1.9910
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		2.1310chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		1.9910C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
tempidon
2,2,6,6-tetramethyl-4-piperidinone: structure in first source		1.9910piperidones
buthionine sulfoximine
Buthionine Sulfoximine: A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7). 2-amino-4-(S-butylsulfonimidoyl)butanoic acid : A non-proteinogenic alpha-amino acid that is homocysteine in which the thiol group carries an oxo, imino and butyl groups.. S-butyl-DL-homocysteine (S,R)-sulfoximine : A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.		210diastereoisomeric mixture;
homocysteines;
non-proteinogenic alpha-amino acid;
sulfoximide		EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor;
ferroptosis inducer
proxyl nitroxide
proxyl nitroxide: structure		1.9910aminoxyls;
pyrrolidines		radical scavenger
1-hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine
[no description available]		1.9910
3-hydroxymethyl-2,2,5,5-tetramethylpyrroline-n-oxyl
3-hydroxymethyl-2,2,5,5-tetramethylpyrroline-N-oxyl: a blood–brain barrier-permeative, redox-senstitive probe in electron paramagnetic resonance imaging		1.9910
tempol
[no description available]		1.9910aminoxyls;
hydroxypiperidine		anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
catalyst;
hepatoprotective agent;
nephroprotective agent;
neuroprotective agent;
radical scavenger
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.		210oxygen hydride;
oxygen radical;
reactive oxygen species
a 2545
A 2545: structure in first source		1.9910
sodium arsenite
sodium arsenite : An inoganic sodium salt with formula with formula NaAsO2.		210arsenic molecular entity;
inorganic sodium salt		antibacterial agent;
antifungal agent;
antineoplastic agent;
carcinogenic agent;
herbicide;
insecticide;
rodenticide
2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid
2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid: structure given in first source		1.9910aminoxyls;
pyrrolidinecarboxylic acid
triacetoneamine-n-oxyl
Triacetoneamine-N-Oxyl: Cyclic N-oxide radical functioning as a spin label and radiation-sensitizing agent.. 4-oxo-TEMPO : A member of the class of aminoxyls that is TEMPO carrying an oxo group at position 4.		1.9910aminoxyls;
piperidones		radical scavenger
3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyl-n-oxyl
3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyl-N-oxyl: structure given in first source		1.9910aminoxyls;
pyrrolidinecarboxamide
3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl
[no description available]		1.9910
tempo
TEMPO: structure. TEMPO : A member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and methyl groups at positions 2, 2, 6, and 6, respectively.		2.3820aminoxyls;
piperidines		catalyst;
ferroptosis inhibitor;
radical scavenger
piperidines
Piperidines: A family of hexahydropyridines.		3.0850
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.		1.9910nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
ConditionIndicatedRelationship StrengthStudiesTrials
Liver Dysfunction
[description not available]		02.1310
Acute Disease
Disease having a short and relatively severe course.		02.1310
Liver Diseases
Pathological processes of the LIVER.		02.1310
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9910