cyflumetofen: acaricide; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
cyflumetofen : A racemate comprising equimolar amounts of (R)- and (S)-cyflumetofen. A proacaricide (via ester hydrolysis and subsequent decarboxylation), it is used to control phytophagous mites at all development stages in a variety of fruit crops. It acts as an inhibitor of complex II of mitochondrial electron transport chain. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
2-methoxyethyl 2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate : A nitrile that is acetonitrile in which the methyl hydrogens have been replaced by o-trifluoromethylbenzoyl, p-tert-butylphenyl, and (2-methoxyethoxy)carbonyl groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 11496052 |
| CHEMBL ID | 2268728 |
| CHEBI ID | 136837 |
| CHEBI ID | 81798 |
| SCHEMBL ID | 27174 |
| MeSH ID | M0573696 |
| Synonym |
|---|
| 2-methoxyethyl 2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate |
| CHEBI:136837 |
| FT-0655283 |
| cyflumetofen |
| C18517 |
| 400882-07-7 |
| A824911 |
| 2-methoxyethyl 2-cyano-2-[4-(2-methyl-2-propanyl)phenyl]-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate |
| 2-methoxyethyl-(rs)-2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(alpha,alpha,alpha-trifluoro-o-tolyl)propionate |
| cyflumetofen [iso] |
| 2-methoxyethyl (rs)-2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(alpha,alpha,alpha-trifluoro-o-tolyl)propionate |
| unii-qjw6n27119 |
| qjw6n27119 , |
| AKOS015852468 |
| SCHEMBL27174 |
| CHEMBL2268728 |
| chebi:81798 |
| cyflometofen |
| DTXSID8058089 |
| cyflumetofen [mi] |
| benzenepropanoic acid, .alpha.-cyano-.alpha.-(4-(1,1-dimethylethyl)phenyl)-.beta.-oxo-2-(trifluoromethyl)-, 2-methoxyethyl ester |
| 2-methoxyethyl (rs)-2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(.alpha.,.alpha.,.alpha.-trifluoro-o-tolyl)propionate |
| cyflumetofen, pestanal(r), analytical standard |
| Q3008637 |
| F21308 |
| EN300-19737091 |
| awszrjqnbmezoi-uhfffaoysa-n |
| AS-82676 |
| benzenepropanoic acid, .alpha.-cyano-.alpha.-[4-(1,1-dimethylethyl)phenyl]-.beta.-oxo-2-(trifluoromethyl)-, 2-methoxyethyl ester |
| Z3234818630 |
Cyflumetofen is a novel acaricide developed by Otsuka AgriTechno Co., Ltd. It inhibits the mitochondrial electron transport chain at complex II (succinate dehydrogenase, SDH) This represents the most recently developed mode of action for mite control worldwide.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Replacing carbon with silicon in pharmaceuticals and pesticides has shown to result in positive effects on efficacy and selectivity, physicochemical properties, and bioavailability and also to eliminate or improve human or environmental safety properties as well as to provide novelty and new intellectual property in many cases." | ( Silicon-Containing Complex II Acaricides─Design, Synthesis, and Pharmacological Optimization. Cheng, J; Li, Z; Maienfisch, P; Quan, X; Wang, X; Zhou, C, 2022) | 0.72 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The half-lives of (−)-cyflumetofen and (+)-cyflumetofen obtained under 5-fold applied dosage equal to 22." | ( Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple. Fan, B; Francis, F; Guo, J; Huang, Y; Jin, N; Kong, Z; Li, M; Liu, J; Liu, Y; Lu, J; Sun, Y; Wang, F, 2018) | 1.05 |
| Class | Description |
|---|---|
| nitrile | A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it. |
| beta-ketoester | A ketoester where the ketone and ester functionalities are separated by a single carbon atom. |
| (trifluoromethyl)benzenes | An organofluorine compound that is (trifluoromethyl)benzene and derivatives arising from substitution of one or more of the phenyl hydrogens. |
| 2-methoxyethyl ester | A carboxylic ester resulting from the formal condensation between a carboxylic acid and the hydroxy group of 2-methoxyethanol. In contrast to many other water-solubilising esters, the 2-methoxyethyl esters of many amino acids are crystalline, allowing them to be easily purified. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 21 (50.00) | 24.3611 |
| 2020's | 21 (50.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (32.65) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (4.76%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 40 (95.24%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||