Quinone oxidoreductase

A quinone oxidoreductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08257]

EC 1.6.5.5;
NADPH:quinone reductase;
Zeta-crystallin

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ARS-1620	Homo sapiens (human)	IC50	8.4400	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
memoquin	Homo sapiens (human)	Km	12.7000	1	1

This protein enables 5 target(s):

Target	Category	Definition
mRNA 3'-UTR binding	molecular function	Binding to a 3' untranslated region of an mRNA molecule. [GOC:mah]
NADPH:quinone reductase activity	molecular function	Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. [EC:1.6.5.5]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
NADPH binding	molecular function	Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 3 target(s):

Target	Category	Definition
visual perception	biological process	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai]
xenobiotic catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
protein homotetramerization	biological process	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators]