Pathways > Drug ADME
Page last updated: 2024-10-06

Drug ADME

Proteins (62)

ProteinSynonymsTaxonomy
Basigin5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Hepatoma-associated antigen; HAb18G; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSFHomo sapiens (human)
Solute carrier family 22 member 1 Organic cation transporter 1; hOCT1Homo sapiens (human)
Multidrug resistance-associated protein 5ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11Homo sapiens (human)
CholinesteraseEC 3.1.1.8; Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; PseudocholinesteraseHomo sapiens (human)
ATP-dependent translocase ABCB1ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; 7.6.2.2; P-glycoprotein 1; Phospholipid transporter ABCB1; 7.6.2.1Homo sapiens (human)
Cytochrome P450 3A4EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; CytochromeHomo sapiens (human)
UDP-glucuronosyltransferase 1-6UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; EC 2.4.1.17; Phenol-metabolizing UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1-F; UGT-1F; UGT1F; UDP-glucuronosyltransferase 1A6Homo sapiens (human)
Corticosteroid 11-beta-dehydrogenase isozyme 1EC 1.1.1.146; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; Short chain dehydrogenase/reductase family 26C member 1Homo sapiens (human)
Aldo-keto reductase family 1 member C1EC 1.1.1.-; EC 1.1.1.112; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.357; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; EC 1.3.1.20; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 1.1.1.149; Chlordecone reductase homolog HAKRC; Dihydrodiol dehydrogenase 1; DD1; Homo sapiens (human)
Broad substrate specificity ATP-binding cassette transporter ABCG2EC 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporterHomo sapiens (human)
Sulfotransferase 1A3 ST1A3; EC 2.8.2.1; Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; HAST3; M-PST; Monoamine-sulfating phenol sulfotransferase; Placental estrogen sulfotransferase; Sulfotransferase 1A3/1A4; Sulfotransferase, monoamine-preferHomo sapiens (human)
GMP synthase [glutamine-hydrolyzing] EC 6.3.5.2; GMP synthetase; Glutamine amidotransferaseHomo sapiens (human)
Multidrug resistance-associated protein 4ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-BHomo sapiens (human)
Hypoxanthine-guanine phosphoribosyltransferaseHGPRT; HGPRTase; EC 2.4.2.8Homo sapiens (human)
AlbuminHomo sapiens (human)
Cytochrome P450 2E1EC 1.14.14.1; 4-nitrophenol 2-hydroxylase; 1.14.13.n7; CYPIIE1; Cytochrome P450-JHomo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 2IMP dehydrogenase 2; IMPD 2; IMPDH 2; EC 1.1.1.205; IMPDH-IIHomo sapiens (human)
Xanthine dehydrogenase/oxidaseHomo sapiens (human)
Corticosteroid 11-beta-dehydrogenase isozyme 2EC 1.1.1.-; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type II; 11-HSD type II; 11-beta-HSD type II; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; 11-beta-HSD; Short chain dehydrogenase/reHomo sapiens (human)
Equilibrative nucleoside transporter 1Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1Homo sapiens (human)
Cytosolic purine 5'-nucleotidaseEC 3.1.3.5; Cytosolic 5'-nucleotidase IIHomo sapiens (human)
Serum paraoxonase/lactonase 3EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1Homo sapiens (human)
Guanylate kinaseEC 2.7.4.8; GMP kinase; Guanylate kinase 1Homo sapiens (human)
Sulfotransferase 1C4ST1C4; EC 2.8.2.-; Sulfotransferase 1C2; SULT1C#2Homo sapiens (human)
Nucleoside diphosphate kinase ANDK A; NDP kinase A; EC 2.7.4.6; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; NM23-H1; Tumor metastatic process-associated proteinHomo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 1 IMP dehydrogenase 1; IMPD 1; IMPDH 1; EC 1.1.1.205; IMPDH-IHomo sapiens (human)
Nucleoside diphosphate kinase BNDK B; NDP kinase B; EC 2.7.4.6; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; 2.7.13.3; nm23-H2Homo sapiens (human)
Serum paraoxonase/arylesterase 1PON 1; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1Homo sapiens (human)
Sulfotransferase 1E1ST1E1; EC 2.8.2.4; EST-1; Estrogen sulfotransferase; Sulfotransferase, estrogen-preferringHomo sapiens (human)
Monocarboxylate transporter 1MCT 1; Solute carrier family 16 member 1Homo sapiens (human)
Adenosine kinaseAK; EC 2.7.1.20; Adenosine 5'-phosphotransferaseHomo sapiens (human)
Ras-related C3 botulinum toxin substrate 1EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1Homo sapiens (human)
Glutathione S-transferase A2EC 2.5.1.18; GST HA subunit 2; GST class-alpha member 2; GST-gamma; GSTA2-2; GTH2Homo sapiens (human)
Glutathione S-transferase Mu 1EC 2.5.1.18; GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4Homo sapiens (human)
Cocaine esteraseEC 3.1.1.84; Carboxylesterase 2; CE-2; hCE-2; 3.1.1.1; Methylumbelliferyl-acetate deacetylase 2; 3.1.1.56Homo sapiens (human)
Purine nucleoside phosphorylasePNP; EC 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylaseHomo sapiens (human)
Adenosine deaminaseEC 3.5.4.4; Adenosine aminohydrolaseHomo sapiens (human)
Glutathione S-transferase A1EC 2.5.1.18; 13-hydroperoxyoctadecadienoate peroxidase; 1.11.1.-; Androst-5-ene-3,17-dione isomerase; 5.3.3.-; GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1Homo sapiens (human)
Glutathione S-transferase PEC 2.5.1.18; GST class-pi; GSTP1-1Homo sapiens (human)
UDP-glucuronosyltransferase 1A3UGT1A3; EC 2.4.1.17; UDP-glucuronosyltransferase 1-3; UDPGT 1-3; UGT1*3; UGT1-03; UGT1.3; UDP-glucuronosyltransferase 1-C; UGT-1C; UGT1C; UDP-glucuronosyltransferase 1A isoform 3Homo sapiens (human)
Solute carrier organic anion transporter family member 1A2OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3Homo sapiens (human)
Adenosine deaminase-like proteinEC 3.5.4.-; Adenosine deaminase-like protein isoform 1; N6-mAMP deaminase; HsMAPDA; N6-methyl-AMP aminohydrolaseHomo sapiens (human)
Solute carrier family 22 member 8Organic anion transporter 3; hOAT3Homo sapiens (human)
Solute carrier family 22 member 7Novel liver transporter; Organic anion transporter 2; hOAT2Homo sapiens (human)
Alcohol dehydrogenase 1AEC 1.1.1.1; Alcohol dehydrogenase subunit alphaHomo sapiens (human)
Glutathione hydrolase 1 proenzymeEC 3.4.19.13; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; GGT 1; 2.3.2.2; Leukotriene-C4 hydrolase; 3.4.19.14Homo sapiens (human)
Thiopurine S-methyltransferaseEC 2.1.1.67; Thiopurine methyltransferaseHomo sapiens (human)
Corticosteroid-binding globulinCBG; Serpin A6; TranscortinHomo sapiens (human)
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]PEPCK-C; EC 4.1.1.32; Serine-protein kinase PCK1; 2.7.11.-Homo sapiens (human)
Inosine triphosphate pyrophosphatase ITPase; Inosine triphosphatase; EC 3.6.1.9; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; NTPase; Putative oncogene protein hlc14-06-pHomo sapiens (human)
Nucleotide triphosphate diphosphatase NUDT15EC 3.6.1.9; MutT homolog 2; MTH2; Nucleoside diphosphate-linked moiety X motif 15; Nudix motif 15; Nucleoside diphosphate-linked to another moiety X hydrolase 15; Nudix hydrolase 15Homo sapiens (human)
Glutathione S-transferase theta-1EC 2.5.1.18; GST class-theta-1; Glutathione transferase T1-1Homo sapiens (human)
Sulfotransferase 1A1ST1A1; EC 2.8.2.1; Aryl sulfotransferase 1; HAST1/HAST2; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; P-PST 1; ST1A3; Thermostable phenol sulfotransferase; Ts-PSTHomo sapiens (human)
Sulfotransferase 2A1ST2A1; EC 2.8.2.2; Bile salt sulfotransferase; 2.8.2.14; Dehydroepiandrosterone sulfotransferase; DHEA-ST; DHEA-ST8; Hydroxysteroid Sulfotransferase; HST; ST2; SULT2A3Homo sapiens (human)
Sulfotransferase 1A4 ST1A4; EC 2.8.2.1; Aryl sulfotransferase 1A3/1A4; Sulfotransferase 1A3/1A4Homo sapiens (human)
Cytosolic non-specific dipeptidaseEC 3.4.13.18; CNDP dipeptidase 2; Carnosine dipeptidase II; Epididymis secretory protein Li 13; Glutamate carboxypeptidase-like protein 1; Peptidase AHomo sapiens (human)
Aminoacylase-1ACY-1; EC 3.5.1.14; N-acyl-L-amino-acid amidohydrolaseHomo sapiens (human)
Putative glutathione hydrolase 3 proenzymeEC 3.4.19.13; Gamma-glutamyltransferase 3; Putative gamma-glutamyltranspeptidase 3; GGT 3; 2.3.2.2Homo sapiens (human)
Glutathione hydrolase 5 proenzymeEC 3.4.19.13; Gamma-glutamyl transpeptidase-related enzyme; GGT-rel; Gamma-glutamyltransferase 5; GGT 5; 2.3.2.2; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase; 3.4.19.14Homo sapiens (human)
Glutathione hydrolase 6EC 3.4.19.13; Gamma-glutamyltransferase 6; GGT 6; 2.3.2.2; Gamma-glutamyltranspeptidase 6Homo sapiens (human)
Equilibrative nucleoside transporter 3hENT3; Solute carrier family 29 member 3Homo sapiens (human)
Glutathione hydrolase 7EC 3.4.19.13; Gamma-glutamyltransferase 7; GGT 7; 2.3.2.2; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7Homo sapiens (human)

Compounds (65)

CompoundDescription
hydronium ion
Orthophosphate
acetaminophenAnalgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
NADH
Ammonium
aspirinThe prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
chlorineAn element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
isoniazidAntibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydroquinoline-3-carboxylatestructure in first source
abacavira carbocyclic nucleoside with potent selective anti-HIV activity
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
ciprofloxacin hydrochloride anhydrous
mercaptopurineAn antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
acetaminophen sulfate esterRN given refers to parent cpd; structure given in first source
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
molybdenum cofactoralso see records for molybdopterin cytosine dinucleotide and molybdopterin guanine dinucleotide
Inosine MonophosphateInosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
carbovir triphosphatemetabolite of abacavir
2,3-dihydroxybenzoate
2,5-dihydroxybenzoic acidRN given refers to parent cpd; a oxidative product of saligenin
salicylatesThe salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
NSC 614846
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
inosineA purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
carbovir triphosphatemetabolite of abacavir
carbovir triphosphatemetabolite of abacavir
ribavirin 5'-diphosphate
ribavirin 5'-diphosphate
ribavirin 5'-triphosphatestructure given in first source
6-thioguanosine 5'-triphosphate
6-thioguanylic acid
oxociprofloxacinstructure given in first source; ciprofloxacin metabolite
bay-s 9435
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
6-thiouric acidstructure
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
6-methylthiopurine
CysteineA thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
1,2,4-triazole-3-carboxamide
cyclopropylamineRN given refers to parent cpd
polyglutamineRN given for (D)-isomer
hydroxyl radicalThe univalent radical OH. Hydroxyl radical is a potent oxidizing agent.
gentisuric acidstructure
adenosine 3'-phosphate-5'-phosphate
ribose 1-phosphate, (alpha-D)-isomer
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
3-(glutathion-s-yl)acetaminophenbiliary metabolite of acetaminophen; RN given refers to parent cpd
6-methylthiopurine ribonucleoside-5'-phosphatecauses cyotoxicity
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