| Protein | Synonyms | Taxonomy |
|---|
| Basigin | 5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Hepatoma-associated antigen; HAb18G; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF | Homo sapiens (human) |
| Solute carrier family 22 member 1 | Organic cation transporter 1; hOCT1 | Homo sapiens (human) |
| Multidrug resistance-associated protein 5 | ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11 | Homo sapiens (human) |
| Cholinesterase | EC 3.1.1.8; Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase | Homo sapiens (human) |
| ATP-dependent translocase ABCB1 | ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; 7.6.2.2; P-glycoprotein 1; Phospholipid transporter ABCB1; 7.6.2.1 | Homo sapiens (human) |
| Cytochrome P450 3A4 | EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; Cytochrome | Homo sapiens (human) |
| UDP-glucuronosyltransferase 1-6 | UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; EC 2.4.1.17; Phenol-metabolizing UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1-F; UGT-1F; UGT1F; UDP-glucuronosyltransferase 1A6 | Homo sapiens (human) |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | EC 1.1.1.146; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; Short chain dehydrogenase/reductase family 26C member 1 | Homo sapiens (human) |
| Aldo-keto reductase family 1 member C1 | EC 1.1.1.-; EC 1.1.1.112; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.357; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; EC 1.3.1.20; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 1.1.1.149; Chlordecone reductase homolog HAKRC; Dihydrodiol dehydrogenase 1; DD1; | Homo sapiens (human) |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | EC 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter | Homo sapiens (human) |
| Sulfotransferase 1A3 | ST1A3; EC 2.8.2.1; Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; HAST3; M-PST; Monoamine-sulfating phenol sulfotransferase; Placental estrogen sulfotransferase; Sulfotransferase 1A3/1A4; Sulfotransferase, monoamine-prefer | Homo sapiens (human) |
| GMP synthase [glutamine-hydrolyzing] | EC 6.3.5.2; GMP synthetase; Glutamine amidotransferase | Homo sapiens (human) |
| Multidrug resistance-associated protein 4 | ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B | Homo sapiens (human) |
| Hypoxanthine-guanine phosphoribosyltransferase | HGPRT; HGPRTase; EC 2.4.2.8 | Homo sapiens (human) |
| Albumin | | Homo sapiens (human) |
| Cytochrome P450 2E1 | EC 1.14.14.1; 4-nitrophenol 2-hydroxylase; 1.14.13.n7; CYPIIE1; Cytochrome P450-J | Homo sapiens (human) |
| Inosine-5'-monophosphate dehydrogenase 2 | IMP dehydrogenase 2; IMPD 2; IMPDH 2; EC 1.1.1.205; IMPDH-II | Homo sapiens (human) |
| Xanthine dehydrogenase/oxidase | | Homo sapiens (human) |
| Corticosteroid 11-beta-dehydrogenase isozyme 2 | EC 1.1.1.-; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type II; 11-HSD type II; 11-beta-HSD type II; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; 11-beta-HSD; Short chain dehydrogenase/re | Homo sapiens (human) |
| Equilibrative nucleoside transporter 1 | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1 | Homo sapiens (human) |
| Cytosolic purine 5'-nucleotidase | EC 3.1.3.5; Cytosolic 5'-nucleotidase II | Homo sapiens (human) |
| Serum paraoxonase/lactonase 3 | EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1 | Homo sapiens (human) |
| Guanylate kinase | EC 2.7.4.8; GMP kinase; Guanylate kinase 1 | Homo sapiens (human) |
| Sulfotransferase 1C4 | ST1C4; EC 2.8.2.-; Sulfotransferase 1C2; SULT1C#2 | Homo sapiens (human) |
| Nucleoside diphosphate kinase A | NDK A; NDP kinase A; EC 2.7.4.6; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; NM23-H1; Tumor metastatic process-associated protein | Homo sapiens (human) |
| Inosine-5'-monophosphate dehydrogenase 1 | IMP dehydrogenase 1; IMPD 1; IMPDH 1; EC 1.1.1.205; IMPDH-I | Homo sapiens (human) |
| Nucleoside diphosphate kinase B | NDK B; NDP kinase B; EC 2.7.4.6; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; 2.7.13.3; nm23-H2 | Homo sapiens (human) |
| Serum paraoxonase/arylesterase 1 | PON 1; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1 | Homo sapiens (human) |
| Sulfotransferase 1E1 | ST1E1; EC 2.8.2.4; EST-1; Estrogen sulfotransferase; Sulfotransferase, estrogen-preferring | Homo sapiens (human) |
| Monocarboxylate transporter 1 | MCT 1; Solute carrier family 16 member 1 | Homo sapiens (human) |
| Adenosine kinase | AK; EC 2.7.1.20; Adenosine 5'-phosphotransferase | Homo sapiens (human) |
| Ras-related C3 botulinum toxin substrate 1 | EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1 | Homo sapiens (human) |
| Glutathione S-transferase A2 | EC 2.5.1.18; GST HA subunit 2; GST class-alpha member 2; GST-gamma; GSTA2-2; GTH2 | Homo sapiens (human) |
| Glutathione S-transferase Mu 1 | EC 2.5.1.18; GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4 | Homo sapiens (human) |
| Cocaine esterase | EC 3.1.1.84; Carboxylesterase 2; CE-2; hCE-2; 3.1.1.1; Methylumbelliferyl-acetate deacetylase 2; 3.1.1.56 | Homo sapiens (human) |
| Purine nucleoside phosphorylase | PNP; EC 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylase | Homo sapiens (human) |
| Adenosine deaminase | EC 3.5.4.4; Adenosine aminohydrolase | Homo sapiens (human) |
| Glutathione S-transferase A1 | EC 2.5.1.18; 13-hydroperoxyoctadecadienoate peroxidase; 1.11.1.-; Androst-5-ene-3,17-dione isomerase; 5.3.3.-; GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1 | Homo sapiens (human) |
| Glutathione S-transferase P | EC 2.5.1.18; GST class-pi; GSTP1-1 | Homo sapiens (human) |
| UDP-glucuronosyltransferase 1A3 | UGT1A3; EC 2.4.1.17; UDP-glucuronosyltransferase 1-3; UDPGT 1-3; UGT1*3; UGT1-03; UGT1.3; UDP-glucuronosyltransferase 1-C; UGT-1C; UGT1C; UDP-glucuronosyltransferase 1A isoform 3 | Homo sapiens (human) |
| Solute carrier organic anion transporter family member 1A2 | OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3 | Homo sapiens (human) |
| Adenosine deaminase-like protein | EC 3.5.4.-; Adenosine deaminase-like protein isoform 1; N6-mAMP deaminase; HsMAPDA; N6-methyl-AMP aminohydrolase | Homo sapiens (human) |
| Solute carrier family 22 member 8 | Organic anion transporter 3; hOAT3 | Homo sapiens (human) |
| Solute carrier family 22 member 7 | Novel liver transporter; Organic anion transporter 2; hOAT2 | Homo sapiens (human) |
| Alcohol dehydrogenase 1A | EC 1.1.1.1; Alcohol dehydrogenase subunit alpha | Homo sapiens (human) |
| Glutathione hydrolase 1 proenzyme | EC 3.4.19.13; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; GGT 1; 2.3.2.2; Leukotriene-C4 hydrolase; 3.4.19.14 | Homo sapiens (human) |
| Thiopurine S-methyltransferase | EC 2.1.1.67; Thiopurine methyltransferase | Homo sapiens (human) |
| Corticosteroid-binding globulin | CBG; Serpin A6; Transcortin | Homo sapiens (human) |
| Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | PEPCK-C; EC 4.1.1.32; Serine-protein kinase PCK1; 2.7.11.- | Homo sapiens (human) |
| Inosine triphosphate pyrophosphatase | ITPase; Inosine triphosphatase; EC 3.6.1.9; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; NTPase; Putative oncogene protein hlc14-06-p | Homo sapiens (human) |
| Nucleotide triphosphate diphosphatase NUDT15 | EC 3.6.1.9; MutT homolog 2; MTH2; Nucleoside diphosphate-linked moiety X motif 15; Nudix motif 15; Nucleoside diphosphate-linked to another moiety X hydrolase 15; Nudix hydrolase 15 | Homo sapiens (human) |
| Glutathione S-transferase theta-1 | EC 2.5.1.18; GST class-theta-1; Glutathione transferase T1-1 | Homo sapiens (human) |
| Sulfotransferase 1A1 | ST1A1; EC 2.8.2.1; Aryl sulfotransferase 1; HAST1/HAST2; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; P-PST 1; ST1A3; Thermostable phenol sulfotransferase; Ts-PST | Homo sapiens (human) |
| Sulfotransferase 2A1 | ST2A1; EC 2.8.2.2; Bile salt sulfotransferase; 2.8.2.14; Dehydroepiandrosterone sulfotransferase; DHEA-ST; DHEA-ST8; Hydroxysteroid Sulfotransferase; HST; ST2; SULT2A3 | Homo sapiens (human) |
| Sulfotransferase 1A4 | ST1A4; EC 2.8.2.1; Aryl sulfotransferase 1A3/1A4; Sulfotransferase 1A3/1A4 | Homo sapiens (human) |
| Cytosolic non-specific dipeptidase | EC 3.4.13.18; CNDP dipeptidase 2; Carnosine dipeptidase II; Epididymis secretory protein Li 13; Glutamate carboxypeptidase-like protein 1; Peptidase A | Homo sapiens (human) |
| Aminoacylase-1 | ACY-1; EC 3.5.1.14; N-acyl-L-amino-acid amidohydrolase | Homo sapiens (human) |
| Putative glutathione hydrolase 3 proenzyme | EC 3.4.19.13; Gamma-glutamyltransferase 3; Putative gamma-glutamyltranspeptidase 3; GGT 3; 2.3.2.2 | Homo sapiens (human) |
| Glutathione hydrolase 5 proenzyme | EC 3.4.19.13; Gamma-glutamyl transpeptidase-related enzyme; GGT-rel; Gamma-glutamyltransferase 5; GGT 5; 2.3.2.2; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase; 3.4.19.14 | Homo sapiens (human) |
| Glutathione hydrolase 6 | EC 3.4.19.13; Gamma-glutamyltransferase 6; GGT 6; 2.3.2.2; Gamma-glutamyltranspeptidase 6 | Homo sapiens (human) |
| Equilibrative nucleoside transporter 3 | hENT3; Solute carrier family 29 member 3 | Homo sapiens (human) |
| Glutathione hydrolase 7 | EC 3.4.19.13; Gamma-glutamyltransferase 7; GGT 7; 2.3.2.2; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7 | Homo sapiens (human) |
| Compound | Description |
|---|
| hydronium ion | |
| Orthophosphate | |
| acetaminophen | Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. |
| uridine diphosphate | A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety. |
| NADH | |
| Ammonium | |
| aspirin | The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| Manganese | A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035) |
| chlorine | An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family. |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| Orthophosphate | |
| isoniazid | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. |
| 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydroquinoline-3-carboxylate | structure in first source |
| abacavir | a carbocyclic nucleoside with potent selective anti-HIV activity |
| uridine diphosphate | A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety. |
| adenosine | A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. |
| ciprofloxacin hydrochloride anhydrous | |
| mercaptopurine | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| acetaminophen sulfate ester | RN given refers to parent cpd; structure given in first source |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Sodium | A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| molybdenum cofactor | also see records for molybdopterin cytosine dinucleotide and molybdopterin guanine dinucleotide |
| Inosine Monophosphate | Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. |
| carbovir triphosphate | metabolite of abacavir |
| 2,3-dihydroxybenzoate | |
| 2,5-dihydroxybenzoic acid | RN given refers to parent cpd; a oxidative product of saligenin |
| salicylates | The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis. |
| NSC 614846 | |
| Guanosine Diphosphate | A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. |
| inosine | A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed) |
| carbovir triphosphate | metabolite of abacavir |
| carbovir triphosphate | metabolite of abacavir |
| ribavirin 5'-diphosphate | |
| ribavirin 5'-diphosphate | |
| ribavirin 5'-triphosphate | structure given in first source |
| 6-thioguanosine 5'-triphosphate | |
| 6-thioguanylic acid | |
| oxociprofloxacin | structure given in first source; ciprofloxacin metabolite |
| bay-s 9435 | |
| adenosine monophosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| 6-thiouric acid | structure |
| glutamate | |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| 6-methylthiopurine | |
| Cysteine | A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. |
| 1,2,4-triazole-3-carboxamide | |
| cyclopropylamine | RN given refers to parent cpd |
| polyglutamine | RN given for (D)-isomer |
| hydroxyl radical | The univalent radical OH. Hydroxyl radical is a potent oxidizing agent. |
| gentisuric acid | structure |
| adenosine 3'-phosphate-5'-phosphate | |
| ribose 1-phosphate, (alpha-D)-isomer | |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Coenzyme A | |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |
| 3-(glutathion-s-yl)acetaminophen | biliary metabolite of acetaminophen; RN given refers to parent cpd |
| 6-methylthiopurine ribonucleoside-5'-phosphate | causes cyotoxicity |