glutamate profile

L-glutamate(1-) : An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	5460299
CHEBI ID	29985
MeSH ID	M0028012

Synonym
l-glutamic acid, ion(1-)
(2s)-2-ammoniopentanedioate
l-glutamate(1-)
11070-68-1
l-glutamic acid monoanion
CHEBI:29985
hydrogen l-glutamate
1-amino-propane-1,3-dicarboxylic acid
glutaminic acid
2XXX
2PYY
2XXR
3FUZ
2XXW
3FF3
2ZNS
3FAS
3S9E
Q41875350
l-glutamate(1-) zwitterionic
l-glutamic acid, inner salt, ion(1-)

Role	Description
EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor	An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2).
human metabolite	Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Saccharomyces cerevisiae metabolite	Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
glutamate(1-)	An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group
polar amino acid zwitterion
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (743)

Pathway	Proteins	Compounds
Transport of small molecules	392	95
SLC-mediated transmembrane transport	135	67
Transport of inorganic cations/anions and amino acids/oligopeptides	54	27
Amino acid transport across the plasma membrane	34	13
Organic anion transporters	5	8
Developmental Biology	727	30
Axon guidance	313	13
EPH-Ephrin signaling	38	9
EPHB-mediated forward signaling	24	9
Metabolism	1496	1108
Carbohydrate metabolism	173	120
Glucose metabolism	76	42
Gluconeogenesis	30	31
Metabolism of lipids	500	463
Fatty acid metabolism	113	203
Arachidonic acid metabolism	36	82
Synthesis of Leukotrienes (LT) and Eoxins (EX)	13	29
Biosynthesis of specialized proresolving mediators (SPMs)	13	107
Biosynthesis of DHA-derived SPMs	11	56
Biosynthesis of DHA-derived sulfido conjugates	2	20
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	2	8
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)	1	16
Nucleotide metabolism	89	125
Nucleotide biosynthesis	12	46
Purine ribonucleoside monophosphate biosynthesis	9	36
Pyrimidine biosynthesis	3	21
Interconversion of nucleotide di- and triphosphates	22	30
Metabolism of vitamins and cofactors	146	155
Metabolism of water-soluble vitamins and cofactors	102	114
Nicotinate metabolism	22	43
Metabolism of folate and pterines	16	29
Amino acid and derivative metabolism	250	260
Amino acid synthesis and interconversion (transamination)	23	43
Serine biosynthesis	4	16
Branched-chain amino acid catabolism	20	31
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	44	85
Histidine catabolism	8	22
Lysine catabolism	10	31
Phenylalanine and tyrosine catabolism	11	31
Proline catabolism	3	11
Tryptophan catabolism	14	26
Urea cycle	8	22
Sulfur amino acid metabolism	27	63
Degradation of cysteine and homocysteine	15	38
Biological oxidations	150	276
Phase II - Conjugation of compounds	73	122
Glutathione conjugation	35	23
Glutathione synthesis and recycling	11	14
Aflatoxin activation and detoxification	18	21
Signaling Pathways	1269	117
Signaling by GPCR	249	55
GPCR ligand binding	193	39
Class C/3 (Metabotropic glutamate/pheromone receptors)	7	3
GPCR downstream signalling	172	52
G alpha (i) signalling events	87	41
G alpha (q) signalling events	79	28
Neuronal System	166	50
Transmission across Chemical Synapses	122	50
Neurotransmitter release cycle	31	33
Glutamate Neurotransmitter Release Cycle	15	8
GABA synthesis, release, reuptake and degradation	16	14
GABA synthesis	2	4
Degradation of GABA	2	10
Neurotransmitter uptake and metabolism In glial cells	2	6
Astrocytic Glutamate-Glutamine Uptake And Metabolism	2	6
Neurotransmitter receptors and postsynaptic signal transmission	78	20
Glutamate binding, activation of AMPA receptors and synaptic plasticity	17	6
Activation of AMPA receptors	2	3
Activation of NMDA receptors and postsynaptic events	40	13
Unblocking of NMDA receptors, glutamate binding and activation	1	5
Post NMDA receptor activation events	22	8
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	8	6
Ras activation upon Ca2+ influx through NMDA receptor	4	4
Activation of kainate receptors upon glutamate binding	5	4
Ionotropic activity of kainate receptors	5	4
Activation of Na-permeable kainate receptors	2	3
Activation of Ca-permeable Kainate Receptor	5	3
Presynaptic function of Kainate receptors	1	2
Protein-protein interactions at synapses	26	2
Synaptic adhesion-like molecules	7	2
Long-term potentiation	6	4
Negative regulation of NMDA receptor-mediated neuronal transmission	7	4
Metabolism of proteins	1058	144
Translation	267	33
tRNA Aminoacylation	42	26
Cytosolic tRNA aminoacylation	24	26
Mitochondrial tRNA aminoacylation	21	26
Post-translational protein modification	666	112
Asparagine N-linked glycosylation	164	78
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	50	68
Synthesis of substrates in N-glycan biosythesis	37	56
Synthesis of UDP-N-acetyl-glucosamine	6	17
Carboxyterminal post-translational modifications of tubulin	7	9
Disease	1278	231
Disorders of transmembrane transporters	102	43
SLC transporter disorders	45	37
Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)	1	2
Diseases of metabolism	69	121
Metabolic disorders of biological oxidation enzymes	6	47
Defective GCLC causes HAGGSD	1	3
Infectious disease	895	79
Gene expression (Transcription)	902	49
RNA Polymerase II Transcription	728	42
Generic Transcription Pathway	608	39
Transcriptional Regulation by TP53	219	31
TP53 Regulates Metabolic Genes	43	24
superpathway of L-asparagine biosynthesis	0	10
L-glutamine degradation I	0	4
4-hydroxybenzoate biosynthesis I (eukaryotes)	0	18
L-aspartate degradation I	0	4
L-proline biosynthesis I	0	13
4-aminobenzoate biosynthesis I	0	7
L-glutamate biosynthesis I	0	8
L-proline degradation I	0	9
L-proline biosynthesis I (from L-glutamate)	0	13
L-lysine biosynthesis I	0	24
L-proline biosynthesis III (from L-ornithine)	0	10
3-(4-hydroxyphenyl)pyruvate biosynthesis	0	4
L-tyrosine degradation I	0	13
5-aminoimidazole ribonucleotide biosynthesis II	0	16
superpathway of proto- and siroheme biosynthesis	16	38
L-aspartate degradation II	5	8
L-glutamate biosynthesis III	1	7
superpathway of phenylalanine, tyrosine and tryptophan biosynthesis	29	25
superpathway of aspartate and asparagine biosynthesis	4	12
ethylene biosynthesis II (microbes)	0	15
NAD salvage pathway II (PNC IV cycle)	0	12
UMP biosynthesis III	0	20
L-tyrosine biosynthesis I	0	9
UMP biosynthesis II	0	20
glutathione degradation	3	6
UMP biosynthesis I	3	19
superpathway of branched chain amino acid biosynthesis	0	30
glycolysis IV (plant cytosol)	13	47
C4 photosynthetic carbon assimilation cycle, NAD-ME type	3	21
L-isoleucine biosynthesis I (from threonine)	2	16
superpathway of L-citrulline metabolism	6	29
methiin metabolism	2	14
superpathway of Allium flavor precursors	0	28
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis	10	34
superpathway of plastoquinol biosynthesis	3	18
indole-3-acetate inactivation VIII	6	14
C4 photosynthetic carbon assimilation cycle, PEPCK type	1	19
L-proline biosynthesis III	1	15
UTP and CTP dephosphorylation I	1	13
L-arginine degradation VI (arginase 2 pathway)	1	12
superpathway of pyrimidine ribonucleotides de novo biosynthesis	6	22
L-tyrosine biosynthesis III	0	9
L-histidine biosynthesis	4	27
u03B3-glutamyl cycle	6	14
4-aminobenzoate biosynthesis	3	7
L-leucine biosynthesis	4	17
L-glutamate biosynthesis II	0	7
L-lysine biosynthesis VI	8	21
L-asparagine biosynthesis I	0	9
superpathway of purine nucleotides de novo biosynthesis I	12	32
glutathione biosynthesis	2	9
L-glutamate degradation IV	5	16
L-arginine biosynthesis I (via L-ornithine)	2	27
ammonia assimilation cycle I	2	13
L-alanine degradation III	3	4
L-serine biosynthesis I	3	11
(S)-reticuline biosynthesis I	0	30
L-lysine degradation I	0	19
L-arginine biosynthesis II (acetyl cycle)	2	26
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde	0	14
rosmarinic acid biosynthesis I	1	30
4-aminobutanoate degradation I	1	9
indole-3-acetate biosynthesis II	8	20
superpathway of isoleucine and valine biosynthesis	2	20
L-citrulline biosynthesis	6	21
folate polyglutamylation	5	9
L-valine biosynthesis	2	12
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle	28	56
L-asparagine biosynthesis III (tRNA-dependent)	1	11
propanethial S-oxide biosynthesis	3	16
guanosine ribonucleotides de novo biosynthesis	2	15
UTP and CTP dephosphorylation II	1	11
UDP-N-acetyl-D-glucosamine biosynthesis II	9	16
L-phenylalanine degradation III	1	12
superpathway of L-lysine, L-threonine and L-methionine biosynthesis II	11	33
L-leucine degradation I	7	20
L-phenylalanine biosynthesis II	10	14
L-isoleucine degradation I	3	16
L-valine degradation I	5	20
glutathione-mediated detoxification II	8	16
glutamate removal from folates	0	3
pyrimidine ribonucleotides interconversion	4	16
superpathay of heme b biosynthesis from glutamate	11	28
L-alanine degradation II (to D-lactate)	0	10
2'-deoxymugineic acid phytosiderophore biosynthesis	11	15
lysine degradation II	4	21
L-tyrosine biosynthesis II	6	10
5-aminoimidazole ribonucleotide biosynthesis I	4	16
L-glutamine biosynthesis I	2	7
superpathway of indole-3-acetate conjugate biosynthesis	8	28
superpathway of pyrimidine ribonucleosides salvage	7	20
glycine biosynthesis	4	10
lysine degradation III	2	22
ornithine-citrulline shuttle	2	12
alliin metabolism	1	20
L-aspartate biosynthesis	0	4
dimethylsulfoniopropanoate biosynthesis II (Spartina)	0	21
rosmarinic acid biosynthesis II	0	23
L-arginine degradation I (arginase pathway)	2	10
glutaminyl-tRNAgln biosynthesis via transamidation	1	10
u03B3-glutamyl cycle (plant pathway)	3	12
tetrapyrrole biosynthesis I (from glutamate)	5	19
L-proline degradation	0	9
photorespiration	8	23
superpathway of rosmarinic acid biosynthesis	1	40
UTP and CTP de novo biosynthesis	3	11
pyridoxal 5'-phosphate biosynthesis II	2	8
L-pipecolate biosynthesis	1	11
NAD de novo biosynthesis I (from aspartate)	5	22
NAD de novo biosynthesis II (from tryptophan)	0	24
superpathway of pyrimidine nucleobases salvage	5	14
folate polyglutamylation II	2	6
superpathway of tetrahydrofolate biosynthesis	10	29
L-Nu03B4-acetylornithine biosynthesis	5	20
L-tryptophan biosynthesis	13	17
tetrahydrofolate biosynthesis	3	13
superpathway of L-phenylalanine and L-tyrosine biosynthesis	12	13
superpathway of L-isoleucine biosynthesis I	4	26
pyridine nucleotide cycling (plants)	3	22
L-ornithine biosynthesis I	1	17
tetrahydrofolate biosynthesis II	12	32
indole glucosinolate activation (intact plant cell)	5	17
superpathway of L-threonine biosynthesis	2	17
4-hydroxyphenylpyruvate biosynthesis	1	6
L-proline biosynthesis IV	0	10
L-glutamate degradation I	2	7
Rubisco shunt	6	32
superpathway of anaerobic sucrose degradation	33	60
homoglutathione biosynthesis	2	9
L-alanine biosynthesis II	3	4
acridone alkaloid biosynthesis	4	17
L-glutamate biosynthesis IV	0	6
tetrahydrofolate biosynthesis I	0	13
Aspartate and asparagine metabolism	7	20
Glutamate and glutamine metabolism	11	27
Alanine metabolism	2	4
Phenylalanine and tyrosine metabolism	11	32
Tyrosine catabolism	5	15
Biomarkers for urea cycle disorders	12	22
Urea cycle and associated pathways	24	30
nitrate reduction II (assimilatory)	2	15
Inorganic Nitrogen Assimilation	4	14
ammonia assimilation cycle II	3	8
superpathway of ammonia assimilation (plants)	3	13
glucosinolate biosynthesis from dihomomethionine	6	27
Organic Nitrogen Assimilation	4	36
camalexin biosynthesis	3	18
L-ornithine biosynthesis II	2	15
felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis	0	8
glucosinolate biosynthesis from tryptophan	12	29
L-glutamine biosynthesis III	7	25
ophthalmate biosynthesis	0	10
glutamate-glutamine shuttle	2	8
glucosinolate biosynthesis from pentahomomethionine	4	18
glucosinolate biosynthesis from phenylalanine	6	27
glucosinolate biosynthesis from homomethionine	6	29
L-glutamate biosynthesis V	1	4
glucosinolate biosynthesis from trihomomethionine	4	22
glucosinolate biosynthesis from hexahomomethionine	4	19
glucosinolate biosynthesis from tetrahomomethionine	4	18
NAD salvage pathway V (PNC V cycle)	0	17
glucosinolate biosynthesis from tyrosine	0	21
N-hydroxy-L-pipecolate biosynthesis	0	13
Nervous system development	337	13
Leishmania infection	66	26
Leishmania parasite growth and survival	20	18
Anti-inflammatory response favouring Leishmania parasite infection	20	18
LTC4-CYSLTR mediated IL4 production	5	7
Sensory Perception	215	68
Sensory processing of sound	36	7
Sensory processing of sound by inner hair cells of the cochlea	30	6
Peptidoglycan cytoplasmic synthesis and recycling pathways	8	34
Serine metabolism	8	22
Sensory perception of taste	40	12
Sensory perception of sweet, bitter, and umami (glutamate) taste	36	10
Drug ADME	63	87
Azathioprine ADME	16	26
APAP ADME	17	30
GABA shunt II	0	11
superpathway of L-serine and glycine biosynthesis I	0	13
superpathway of heme b biosynthesis from glutamate	0	22
L-lysine degradation XI (mammalian)	0	16
L-glutamate degradation IX (via 4-aminobutanoate)	1	4
Metabolic pathways of fibroblasts	17	18
Parasitic Infection Pathways	66	26
10q22q23 copy number variation	0	14
5-aminoimidazole ribonucleotide biosynthesis	3	16
NAD de novo biosynthesis	12	33
proline degradation	1	13
glutamine biosynthesis	1	8
L-glutamine tRNA biosynthesis	2	9
glutamine degradation/glutamate biosynthesis	2	4
alanine biosynthesis/degradation	2	5
4-aminobutyrate degradation	2	20
(S)-reticuline biosynthesis	1	16
serine and glycine biosynthesis	6	13
4-hydroxybenzoate biosynthesis	1	19
leucine degradation	12	21
guanosine nucleotides de novo biosynthesis	15	18
purine nucleotides de novo biosynthesis	30	37
proline biosynthesis	3	12
valine degradation	13	20
isoleucine degradation	12	17
lysine degradation II (pipecolate pathway)	5	23
lysine degradation I (saccharopine pathway)	4	31
u03B2-alanine degradation	1	9
L-kynurenine degradation	13	52
superpathway of tryptophan utilization	42	92
4-hydroxyproline degradation	4	13
ornithine de novo biosynthesis	3	14
aspartate biosynthesis	2	4
malate-aspartate shuttle	3	8
asparagine biosynthesis	1	9
asparagine degradation	4	10
superpathway of methionine degradation	19	45
tyrosine degradation	5	17
UMP biosynthesis	3	20
glutamate dependent acid resistance	3	5
serine biosynthesis (phosphorylated route)	4	11
glutamate biosynthesis/degradation	2	6
histidine degradation	5	10
pyridine nucleotide cycling (plants)	0	22
CMP-legionaminate biosynthesis I	10	26
chitin biosynthesis	16	40
superpathway of 5-aminoimidazole ribonucleotide biosynthesis	6	36
5-aminoimidazole ribonucleotide biosynthesis I	12	38
superpathway of L-alanine biosynthesis	7	15
5-aminoimidazole ribonucleotide biosynthesis II	6	32
L-alanine biosynthesis II	4	5
L-alanine biosynthesis I	4	14
UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)	9	26
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)	17	38
UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)	2	22
ammonia assimilation cycle I	4	14
ammonia assimilation cycle III	4	33
ammonia assimilation cycle II	6	8
L-tyrosine biosynthesis II	6	11
L-glutamine biosynthesis I	7	25
superpathway of ammonia assimilation (plants)	2	14
L-tyrosine biosynthesis I	6	16
superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis	22	57
peptidoglycan biosynthesis V (u03B2-lactam resistance)	1	38
L-tyrosine biosynthesis III	1	9
peptidoglycan biosynthesis IV (Enterococcus faecium)	3	36
polymyxin resistance	4	20
L-glutamate degradation VII (to butanoate)	10	36
ethylene biosynthesis IV (engineered)	2	18
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle	24	59
nitrate reduction VI (assimilatory)	5	18
nitrate reduction II (assimilatory)	4	15
rosmarinic acid biosynthesis I	3	34
nitrate reduction V (assimilatory)	4	26
rosmarinic acid biosynthesis II	1	22
O-antigen building blocks biosynthesis (E. coli)	9	50
Rubisco shunt	8	32
superpathay of heme b biosynthesis from glutamate	20	47
methylaspartate cycle	10	35
enterobacterial common antigen biosynthesis	11	33
pyruvate fermentation to acetate and alanine	3	12
L-lysine biosynthesis V	14	24
L-lysine biosynthesis IV	3	23
L-lysine biosynthesis VI	8	23
L-lysine biosynthesis II	6	35
L-lysine biosynthesis I	16	63
camalexin biosynthesis	5	17
indole-3-acetate biosynthesis VI (bacteria)	2	19
indole-3-acetate biosynthesis II	6	21
2-acetamido-4-amino-2,4,6-trideoxy-u03B1-D-galactosyl-diphospho-ditrans,octacis-undecaprenol biosynthesis	3	10
L-tryptophan degradation IV (via indole-3-lactate)	1	8
L-tryptophan degradation VIII (to tryptophol)	12	13
L-glutamate degradation VIII (to propanoate)	0	20
L-glutamine degradation I	4	10
L-glutamine degradation II	4	18
partial TCA cycle (obligate autotrophs)	0	26
L-phenylalanine biosynthesis II	3	14
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)	12	33
superpathway of L-phenylalanine biosynthesis	16	65
L-phenylalanine biosynthesis I	6	28
UMP biosynthesis II	7	24
UMP biosynthesis III	10	23
superpathway of rosmarinic acid biosynthesis	2	43
UMP biosynthesis I	12	34
L-aspartate biosynthesis	2	8
dTDP-D-forosamine biosynthesis	6	24
superpathway of trimethylamine degradation	12	24
L-glutamate degradation II	2	23
isopropylamine degradation	8	16
superpathway of ornithine degradation	7	27
ectoine degradation	3	12
L-pipecolate biosynthesis	1	9
L-lysine degradation II (L-pipecolate pathway)	5	22
coenzyme M biosynthesis II	3	19
superpathway of L-lysine degradation	33	112
4-hydroxy-2(1H)-quinolone biosynthesis	5	15
L-lysine degradation IV	0	39
L-lysine degradation III	1	26
L-lysine degradation X	2	19
L-lysine degradation V	1	33
L-lysine degradation XI (mammalian)	5	31
L-tyrosine degradation I	10	23
L-lysine degradation VI	2	11
L-tyrosine degradation IV (to 4-methylphenol)	2	11
L-tyrosine degradation V (Stickland reaction)	3	14
mannojirimycin biosynthesis	4	13
(R)-cysteate degradation	2	10
homotaurine degradation	2	9
L-tyrosine degradation III	9	13
superpathway of sulfate assimilation and cysteine biosynthesis	12	41
superpathway of quinolone and alkylquinolone biosynthesis	7	24
L-tyrosine degradation II	0	14
L-glutamate and L-glutamine biosynthesis	14	42
dTDP-3-acetamido-u03B1-D-fucose biosynthesis	6	14
dTDP-3-acetamido-3,6-dideoxy-u03B1-D-glucose biosynthesis	3	15
dTDP-N-acetylthomosamine biosynthesis	6	18
L-asparagine degradation III (mammalian)	4	10
dTDP-L-megosamine biosynthesis	5	19
L-glutamate degradation IX (via 4-aminobutanoate)	2	34
dTDP-D-ravidosamine and dTDP-4-acetyl-D-ravidosamine biosynthesis	5	19
tRNA charging	26	54
glutaminyl-tRNAgln biosynthesis via transamidation	9	10
4-hydroxy-2-nonenal detoxification	2	12
atromentin biosynthesis	3	8
glutathione-mediated detoxification II	15	17
L-serine biosynthesis I	11	15
superpathway of purine nucleotides de novo biosynthesis I	36	49
superpathway of guanosine nucleotides de novo biosynthesis I	24	36
dTDP-N-acetylviosamine biosynthesis	2	16
L-alanine degradation II (to D-lactate)	0	17
dTDP-L-daunosamine biosynthesis	6	16
L-alanine degradation III	2	9
UTP and CTP de novo biosynthesis	13	21
dTDP-u03B2-L-4-epi-vancosamine biosynthesis	5	20
4-hydroxybenzoate biosynthesis I (eukaryotes)	4	14
dTDP-D-desosamine biosynthesis	14	22
L-alanine fermentation to propanoate and acetate	7	31
L-glutamate degradation V (via hydroxyglutarate)	7	26
dTDP-u03B1-D-mycaminose biosynthesis	4	15
superpathway of anaerobic energy metabolism (invertebrates)	16	60
pyoverdine I biosynthesis	7	23
anaerobic energy metabolism (invertebrates, cytosol)	3	29
acridone alkaloid biosynthesis	3	17
tetrahydrofolate biosynthesis	7	42
superpathway of tetrahydrofolate biosynthesis	19	65
4-aminobenzoate biosynthesis	7	11
glutamate removal from folates	0	4
folate polyglutamylation	4	20
superpathway of tetrahydrofolate biosynthesis and salvage	13	70
aniline degradation	5	16
peptidoglycan biosynthesis III (mycobacteria)	12	36
rhizobactin 1021 biosynthesis	6	22
norspermidine biosynthesis	7	25
peptidoglycan biosynthesis I (meso-diaminopimelate containing)	11	42
nicotine degradation I (pyridine pathway)	13	41
peptidoglycan biosynthesis II (staphylococci)	20	44
superpathway of polyamine biosynthesis III	7	28
L-leucine degradation II	0	10
L-leucine degradation III	8	12
ectoine biosynthesis	5	20
methanofuran biosynthesis	6	24
L-leucine degradation IV (Stickland reaction)	3	13
superpathway of arginine and polyamine biosynthesis	18	101
factor 430 biosynthesis	6	20
L-leucine degradation I	20	26
L-aspartate degradation II	5	13
L-aspartate degradation I	4	6
superpathway of pyrimidine ribonucleosides salvage	22	37
citrate lyase activation	4	12
factor 420 polyglutamylation	1	11
u03B3-glutamyl cycle	12	19
guanosine ribonucleotides de novo biosynthesis	15	35
GDP-L-colitose biosynthesis	0	12
2'-deoxymugineic acid phytosiderophore biosynthesis	12	14
L-phenylalanine degradation VI (Stickland reaction)	3	16
superpathway of neomycin biosynthesis	10	37
3-methylarginine biosynthesis	2	11
superpathway of purine nucleotide salvage	13	34
superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis	12	39
glucosinolate biosynthesis from tetrahomomethionine	10	27
superpathway of pyrimidine nucleobases salvage	11	26
L-phenylalanine degradation III	12	13
roseoflavin biosynthesis	1	19
glucosinolate biosynthesis from phenylalanine	6	29
glucosinolate biosynthesis from pentahomomethionine	11	27
glucosinolate biosynthesis from dihomomethionine	12	38
paromomycin biosynthesis	6	20
L-phenylalanine degradation IV (mammalian, via side chain)	6	39
GDP-D-perosamine biosynthesis	2	8
glucosinolate biosynthesis from tryptophan	5	32
4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis (yeast)	7	29
glucosinolate biosynthesis from hexahomomethionine	12	27
6-methylpretetramide biosynthesis	9	17
glucosinolate biosynthesis from trihomomethionine	11	29
glucosinolate biosynthesis from tyrosine	0	24
L-phenylalanine degradation II (anaerobic)	5	12
glucosinolate biosynthesis from homomethionine	9	35
kanamycin biosynthesis	10	42
staphyloferrin B biosynthesis	7	20
superpathway of L-methionine biosynthesis (transsulfuration)	9	59
muropeptide degradation	5	10
glutathione biosynthesis	6	17
validamycin biosynthesis	10	34
baumannoferrin biosynthesis	6	20
superpathway of candicidin biosynthesis	15	30
superpathway of L-methionine biosynthesis (by sulfhydrylation)	19	55
gentamicin biosynthesis	4	26
dapdiamides biosynthesis	8	31
L-histidine degradation II	5	22
L-histidine degradation I	4	14
L-histidine degradation III	2	13
L-valine biosynthesis	16	34
ribostamycin biosynthesis	8	16
L-histidine degradation IV	0	9
superpathway of tetracycline and oxytetracycline biosynthesis	15	30
gluconeogenesis I	28	62
phenazine-1-carboxylate biosynthesis	4	26
L-leucine biosynthesis	7	19
L-histidine biosynthesis	18	33
imidazole-lactate degradation	0	6
L-tryptophan biosynthesis	20	27
neomycin biosynthesis	4	20
UDP-N-acetyl-D-glucosamine biosynthesis II	23	33
UDP-N-acetyl-D-glucosamine biosynthesis I	7	35
4-aminobutanoate degradation III	6	10
4-aminobutanoate degradation V	3	18
4-aminobutanoate degradation II	3	18
superpathway of 4-aminobutanoate degradation	5	20
4-aminobutanoate degradation I	7	20
GABA shunt	6	23
L-arginine biosynthesis III (via N-acetyl-L-citrulline)	2	28
kanosamine biosynthesis II	3	10
L-arginine biosynthesis I (via L-ornithine)	11	53
L-cysteine biosynthesis IX (Trichomonas vaginalis)	5	14
dehydrophos biosynthesis	10	25
L-arginine biosynthesis IV (archaebacteria)	6	20
L-arginine biosynthesis II (acetyl cycle)	1	37
L-proline degradation	7	15
L-isoleucine degradation I	15	20
L-isoleucine degradation II	12	12
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I	19	94
superpathway of L-aspartate and L-asparagine biosynthesis	7	30
superpathway of L-serine and glycine biosynthesis I	9	20
superpathway of L-phenylalanine and L-tyrosine biosynthesis	5	16
superpathway of branched chain amino acid biosynthesis	11	43
superpathway of L-lysine, L-threonine and L-methionine biosynthesis II	8	35
superpathway of aromatic amino acid biosynthesis	21	84
L-asparagine biosynthesis III (tRNA-dependent)	4	10
Methanobacterium thermoautotrophicum biosynthetic metabolism	22	79
superpathway of L-asparagine biosynthesis	2	16
L-asparagine biosynthesis I	2	26
L-valine degradation I	17	27
L-valine degradation II	11	12
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)	14	44
superpathway of L-citrulline metabolism	18	52
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)	17	31
L-citrulline biosynthesis	7	36
methylamine degradation II	9	17
CMP-pseudaminate biosynthesis	5	23
propanethial S-oxide biosynthesis	2	21
nylon-6 oligomer degradation	1	15
CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis	3	19
CMP-diacetamido-8-epilegionaminic acid biosynthesis	7	19
glutathione-mediated detoxification I	10	18
u03B2-alanine degradation I	0	11
archaeosine biosynthesis I	2	5
L-glutamate biosynthesis III	3	10
L-glutamate biosynthesis IV	1	10
L-ornithine degradation II (Stickland reaction)	10	43
L-glutamate biosynthesis V	0	4
L-glutamate biosynthesis II	2	6
L-glutamate biosynthesis I	2	12
L-dopa degradation	1	17
methiin metabolism	2	16
glycolysis IV (plant cytosol)	7	47
superpathway of Allium flavor precursors	5	40
alliin metabolism	2	24
L-cysteine degradation III	4	7
L-cysteine degradation I	2	14
felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis	1	8
L-ornithine biosynthesis I	6	34
L-Nu03B4-acetylornithine biosynthesis	6	20
L-ornithine biosynthesis II	7	17
siroheme amide biosynthesis	1	11
superpathway of dTDP-glucose-derived antibiotic building blocks biosynthesis	31	39
superpathway of erythromycin biosynthesis	18	42
superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis	28	36
superpathway of megalomicin A biosynthesis	8	42
superpathway of L-tyrosine biosynthesis	15	57
superpathway of L-threonine biosynthesis	7	41
L-tryptophan degradation XIII (Stickland reaction)	3	12
superpathway of plastoquinol biosynthesis	1	19
putrescine degradation I	3	10
UDP-N-acetyl-D-galactosamine biosynthesis III	4	15
putrescine degradation II	4	15
L-arginine degradation VI (arginase 2 pathway)	3	12
L-arginine degradation (Stickland reaction)	12	54
superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation	12	42
UDP-yelosamine biosynthesis	2	14
superpathway of chorismate metabolism	56	186
L-arginine degradation I (arginase pathway)	8	31
L-arginine degradation XI	0	12
L-arginine degradation II (AST pathway)	8	22
superpathway of L-arginine and L-ornithine degradation	13	47
L-glutamate degradation X	2	9
L-glutamate degradation IV	6	20
L-glutamate degradation I	3	33
L-glutamate degradation VI (to pyruvate)	2	14
superpathway of pyrimidine ribonucleotides de novo biosynthesis	23	45
superpathway of taurine degradation	6	37
UDP-2,3-diacetamido-2,3-dideoxy-u03B1-D-mannuronate biosynthesis	5	16
UDP-N,N'-diacetylbacillosamine biosynthesis	6	12
L-proline biosynthesis II (from arginine)	0	18
L-proline biosynthesis I	5	17
L-proline biosynthesis III	2	16
L-proline biosynthesis IV	0	8
aspartate superpathway	25	122
UTP and CTP dephosphorylation II	6	14
UTP and CTP dephosphorylation I	3	14
hopanoid biosynthesis (bacteria)	8	30
pyridoxal 5'-phosphate biosynthesis I	7	26
superpathway of L-tryptophan biosynthesis	16	65
pyridoxal 5'-phosphate biosynthesis II	6	8
indole-3-acetate inactivation VIII	4	19
dimethylsulfoniopropanoate biosynthesis II (Spartina)	0	22
N-acetylglutaminylglutamine amide biosynthesis	2	8
superpathway of L-threonine metabolism	21	72
superpathway of indole-3-acetate conjugate biosynthesis	5	33
superpathway of anaerobic sucrose degradation	26	61
trans-4-hydroxy-L-proline degradation I	4	25
superpathway of pyridoxal 5'-phosphate biosynthesis and salvage	9	37
(S)-reticuline biosynthesis I	1	28
superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis	24	61
C4 photosynthetic carbon assimilation cycle, PEPCK type	2	23
(S)-reticuline biosynthesis II	1	17
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis	46	62
photorespiration	17	23
L-tryptophan degradation XI (mammalian, via kynurenine)	13	56
indole glucosinolate activation (intact plant cell)	4	23
ergothioneine biosynthesis I (bacteria)	5	22
sulfolactate degradation III	3	12
superpathway of sulfolactate degradation	6	17
tetrapyrrole biosynthesis I (from glutamate)	12	37
superpathway of L-methionine salvage and degradation	28	69
ethylene biosynthesis II (microbes)	1	19
hydrogen sulfide biosynthesis I	2	6
L-isoleucine biosynthesis IV	3	19
superpathway of L-isoleucine biosynthesis I	17	55
L-isoleucine biosynthesis V	0	12
4-hydroxyphenylpyruvate biosynthesis	3	8
L-isoleucine biosynthesis II	14	30
NAD salvage pathway I (PNC VI cycle)	4	20
L-isoleucine biosynthesis III	0	19
NAD salvage pathway II (PNC IV cycle)	3	14
L-isoleucine biosynthesis I (from threonine)	12	25
glutathione degradation (DUG pathway - yeast)	4	8
NAD de novo biosynthesis II (from tryptophan)	18	35
NAD de novo biosynthesis I (from aspartate)	7	34
superpathway of NAD biosynthesis in eukaryotes	11	35
NAD salvage pathway V (PNC V cycle)	4	21
taurine degradation III	1	8
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde	8	16
p-aminobenzoate biosynthesis	2	7
superpathway of serine and glycine biosynthesis I	6	13
superpathway of leucine, valine, and isoleucine biosynthesis	9	31
superpathway of phenylalanine, tyrosine and tryptophan biosynthesis	13	36
aspartate degradation II	5	9
leucine biosynthesis	5	16
L-glutamate degradation to 4-aminobutanoate	1	4
alanine degradation III	2	4
L-phenylalanine biosynthesis	2	9
de novo biosynthesis of pyrimidine ribonucleotides	10	24
histidine biosynthesis	7	22
glutamate biosynthesis from glutamine	1	6
arginine biosynthesis	9	26
glutamate biosynthesis from ammonia	2	7
superpathway of thiamin diphosphate biosynthesis III (eukaryotes)	25	41
alanine biosynthesis	2	4
serine biosynthesis from 3-phosphoglycerate	4	11
tyrosine biosynthesis	4	12
superpathway of glutathione metabolism (truncated u03B3-glutamyl cycle)	3	13
NAD salvage pathway	11	21
glutamine degradation I	2	5
tryptophan degradation VIII (to tryptophol)	12	13
phenylalanine degradation	11	12
isoleucine degradation II	13	12
leucine degradation III	9	12
UDP-N-acetylglucosamine biosynthesis	4	12
isoleucine biosynthesis	6	17
arginine degradation VI (arginase 2 pathway)	3	12
valine biosynthesis	6	12
glutathione degradation (DUG pathway)	4	8
tryptophan biosynthesis	5	17
citrulline biosynthesis	8	23
4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis	12	29
glutamate degradation to succinate	3	9
glutamate degradation to 2-oxoglutarate	1	7
superpathway of aspartate and asparagine biosynthesis	5	12
pyrimidine ribonucleotides interconversion	12	14
L-serine biosynthesis	6	11
tetrahydrofolate biosynthesis II	23	33
u03B3-glutamyl cycle (plant pathway)	3	14
folate polyglutamylation II	4	7
NAD biosynthesis I (from aspartate)	4	20
superpathway of proto- and siroheme biosynthesis	16	40
indole-3-acetyl-amide conjugate biosynthesis	12	19
ornithine-citrulline shuttle	5	13
lysine degradation II	2	21
glutamate-glutamine shuttle	4	8
superpathway of isoleucine and valine biosynthesis	8	22
superpathway of sterol biosynthesis	0	50
IAA biosynthesis I	0	25
folate polyglutamylation I	0	13
NAD biosynthesis II (from tryptophan)	0	24
pyrimidine nucleotide metabolism (phosphotransfer and nucleotide modification)	0	12
uridine-5'-phosphate biosynthesis	0	18
pyrimidine ribonucleotides de novo biosynthesis	0	22
purine nucleotide metabolism (phosphotransfer and nucleotide modification)	0	23
glutamate biosynthesis II	0	4
glutamine biosynthesis II	0	7
serine biosynthesis	0	11
alanine biosynthesis II	0	4
proline biosynthesis II	0	12
UDP-N-acetylglucosamine biosynthesis	0	12
tRNA charging pathway	0	23
tyrosine degradation II	0	9
tyrosine degradation I	0	13
leucine degradation I	0	20
aspartate degradation	0	4
valine degradation I	0	18
glutamate degradation	0	7
superpathway of 4-aminobutyrate degradation	0	11
4-aminobutyrate degradation I	0	9
4-aminobutyrate degradation II	0	9
glutamate degradation IX	0	7
glutamate degradation II	0	7
phenylalanine degradation II (anaerobic)	0	11
isoleucine degradation I	0	18
superpathway of threonine metabolism	0	34
superpathway of arginine and ornithine degradation	0	27
arginine degradation I (arginase pathway)	0	11
superpathway of arginine, putrescine, and 4-aminobutyrate degradation	0	26
arginine degradation VII	0	12
glutathione-mediated detoxification	0	8
superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine	0	12
arginine biosynthesis I	0	27
purine nucleotides de novo biosynthesis I	0	39
superpathway of histidine, purine, and pyrimidine biosynthesis	0	64
peptidoglycan and lipid A precursor biosynthesis	0	34
superpathway of lysine, threonine and methionine biosynthesis II	0	32
purine nucleotides de novo biosynthesis II	0	33
superpathway of alanine biosynthesis	0	8
isoleucine biosynthesis I	0	24
superpathway of lysine, threonine and methionine biosynthesis I	0	38
threonine biosynthesis	0	16
tetrahydrofolate biosynthesis I	0	28
formylTHF biosynthesis II	0	27
formylTHF biosynthesis I	0	26
pyridine nucleotide cycling	0	17
UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-DAP-containing)	0	20
alanine biosynthesis I	0	7
isoleucine biosynthesis I (from threonine)	0	15
lysine biosynthesis VI	0	19
lysine biosynthesis I	0	24
ornithine biosynthesis	0	17
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I	6	26
arginine biosynthesis II (acetyl cycle)	0	26
glutamine biosynthesis I	0	7
tyrosine degradation IV (to 4-methylphenol)	0	10
4-aminobutyrate degradation III	0	7
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-DAP-containing)	0	20
glutamate degradation IX (via 4-aminobutyrate)	0	10
glutamate biosynthesis III	0	7
glutamate biosynthesis I	0	6
glutamine degradation II	0	6
superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis	0	38
NAD salvage pathway I	0	18
superpathway of tryptophan biosynthesis	0	30
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II	0	29
tyrosine biosynthesis I	0	9
superpathway of tyrosine biosynthesis	0	24
superpathway of methionine biosynthesis (transsulfuration)	0	25
superpathway of phenylalanine biosynthesis	0	22
phenylalanine biosynthesis I	0	9
proline biosynthesis I	0	12
proline biosynthesis III	0	13
asparagine biosynthesis I	0	9
aspartate degradation I	0	4
superpathway of asparagine biosynthesis	0	10
arginine biosynthesis IV (archaebacteria)	0	20
arginine biosynthesis I (via L-ornithine)	0	27
superpathway of citrulline metabolism	2	27
phenylalanine degradation III	1	12
glutamate degradation V (via hydroxyglutarate)	1	16
glutamate biosynthesis IV	1	6
superpathway of phenylalanine and tyrosine biosynthesis	1	13
glutamate degradation I	1	7
arginine biosynthesis III	1	26
glutamate degradation VII (to butanoate)	1	25
glutamate biosynthesis V	1	3
4-aminobutyrate degradation V	2	17
glutamate degradation VI (to pyruvate)	0	9
phenylalanine biosynthesis II	1	9
superpathway of chorismate	5	76
tetrapyrrole biosynthesis I	4	14
superpathway of branched amino acid biosynthesis	9	31
superpathay of heme biosynthesis from glutamate	7	21
asparagine biosynthesis III (tRNA-dependent)	3	11
L-glutamine biosynthesis II (tRNA-dependent)	3	9
glutamate degradation X	1	5
isoleucine biosynthesis III	9	15
formylTHF biosynthesis	11	26
arginine degradation II (AST pathway)	6	16
superpathway of methionine biosynthesis (by sulfhydrylation)	6	30
histidine degradation I	4	8
tyrosine biosynthesis III	2	9
isoleucine biosynthesis IV	3	19
superpathway of purine nucleotides de novo biosynthesis II	26	38
superpathway of guanosine nucleotides de novo biosynthesis II	4	17
arginine, ornithine and proline interconversion	7	25
proline degradation III	3	7
proline biosynthesis II (from arginine)	5	13
4-hydroxyproline degradation I	4	13
histidine degradation III	6	12
Leucine Catabolism	12	21
glutamate degradation IV	4	13
glutamate degradation VII	4	16
proline degradation II	2	5
glutamate degradation III (via 4-aminobutyrate)	4	10
arginine biosynthesis IV	5	19
alanine degradation II (to D-lactate)	0	10
superpathway of glutamate biosynthesis	0	9
GDP-u03B1-D-perosamine biosynthesis	0	7
superpathway of leucine, valine, alanine, and isoleucine biosynthesis	0	33
aspartate biosynthesis II	0	10
pantothenate biosynthesis II	0	16
adenosylcobalamin biosynthesis II (aerobic)	0	60
aspartate threonine lysine biosynthesis superpathway	0	29
transulfuration	0	21
calcium-dependent antibiotic biosynthesis	0	22
tyrosine degradation III	12	12
valine degradation II	21	10
lysine biosynthesis IV	4	20
L-ornithine biosynthesis	5	17
adenosylcobalamin biosynthesis II (late cobalt incorporation)	26	55
histidine degradation IV	0	9
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (generic)	0	16
lysine biosynthesis II	0	23
phenylalanine degradation IV (mammalian, via side chain)	0	26
heme biosynthesis I	0	22
ornithine degradation II (Stickland reaction)	0	19
TCA cycle VI (obligate autotrophs)	0	27
glutamine biosynthesis III	0	24
L-Nu03B4-acetylornithine biosynthesis	0	15
archaeosine biosynthesis	0	5
glutamate and glutamine biosynthesis	0	12
asparagine degradation III (mammalian)	9	10
Pyrimidine metabolism and related diseases	18	44
Vitamin B6-dependent and responsive disorders	2	19
Cysteine and methionine catabolism	14	36
Arginine biosynthesis	5	26
Arginine biosynthesis II (acetyl cycle)	4	25
Arginine degradation	4	12
Asparagine biosynthesis	1	11
Asparagine biosynthesis III	0	9
Aspartate biosynthesis I	0	4
Citrulline biosynthesis	5	22
Glutamate biosynthesis IV	0	6
Glutamine biosynthesis I	1	6
Histidine biosynthesis I	7	21
Isoleucine biosynthesis from threonine	2	15
Leucine biosynthesis	0	15
Lysine biosynthesis I	2	24
Lysine biosynthesis II	2	26
Lysine biosynthesis VI	3	19
Ornithine biosynthesis	2	16
Phenylalanine biosynthesis I	0	8
Tryptophan biosynthesis	2	16
Proline biosynthesis I	2	14
Proline biosynthesis V (from arginine)	4	14
Valine biosynthesis	1	12
Asparagine degradation I	0	11
GABA shunt	1	10
Lysine degradation II	3	18
Ehrlich pathway	0	11
tyrosine degradation I	2	12
Proline degradation	1	8
Valine degradation	8	17
Cysteine degradation	6	19
Peptidoglycan biosynthesis I	1	21
Folate polyglutamylation I	1	12
Folate polyglutamylation II	1	4
Gamma-glutamyl cycle	1	11
Glutathione biosynthesis	0	8
NAD biosynthesis I (from aspartate)	4	19
Pantothenate biosynthesis I	1	17
Pantothenate biosynthesis II	1	17
Pyridoxal 5'-phosphate biosynthesis	0	20
Folate biosynthesis	0	29
Tetrahydrofolate biosynthesis II	1	28
Tetrapyrrole biosynthesis I	5	14
IAA biosynthesis I	0	21
UDP-N-acetylgalactosamine biosynthesis	1	12
Glutamate synthase cycle	3	10
Nitrate assimilation	0	12
Response to iron deficiency	10	17
Mugineic acid biosynthesis	2	14
Amino acid metabolism	3	16
Pyrimidine metabolism: de novo synthesis of UMP	2	21
De novo synthesis of UMP	2	21
Purine metabolism	9	38
De novo synthesis of IMP	5	26
De novo synthesis of GMP	1	12

Protein Targets (16)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Glutamate receptor, ionotropic kainate 1	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor, ionotropic kainate 1	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor, ionotropic kainate 1	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor 4	Rattus norvegicus (Norway rat)	Ki	0.1710	0.1710	0.1710	0.1710	AID977610
Chain A, Glutamate carboxypeptidase III	Homo sapiens (human)	Ki	270.0000	270.0000	270.0000	270.0000	AID977610
Chain A, Glutamate carboxypeptidase III	Homo sapiens (human)	Ki	270.0000	270.0000	270.0000	270.0000	AID977610
Chain A, Glutamate carboxypeptidase III	Homo sapiens (human)	Ki	270.0000	270.0000	270.0000	270.0000	AID977610
Chain A, Glutamate receptor, ionotropic kainate 1	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor, ionotropic kainate 1	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor, ionotropic kainate 1	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor, ionotropic kainate 1	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor, ionotropic kainate 1	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor, ionotropic kainate 1	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor ionotropic, kainate 2	Homo sapiens (human)	Ki	0.2900	0.2900	0.2900	0.2900	AID977610
Chain A, Glutamate receptor, ionotropic kainate 3	Rattus norvegicus (Norway rat)	Ki	7.4300	7.4300	7.4300	7.4300	AID977610
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Ionotropic glutamate receptor bacterial homologue	Nostoc punctiforme PCC 73102	Kd	25.0000	25.0000	25.0000	25.0000	AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2011	Journal of structural biology, Dec, Volume: 176, Issue:3	Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2008	FEBS letters, Dec-10, Volume: 582, Issue:29	Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2011	Journal of molecular biology, Oct-28, Volume: 413, Issue:3	Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2008	Journal of molecular biology, Feb-15, Volume: 376, Issue:2	Crystal structure of the GluR0 ligand-binding core from Nostoc punctiforme in complex with L-glutamate: structural dissection of the ligand interaction and subunit interface.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2009	The FEBS journal, Aug, Volume: 276, Issue:16	Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

glutamate

Description

Cross-References

Synonyms (21)

Roles (3)

Drug Classes (2)

Pathways (743)

Protein Targets (16)

Inhibition Measurements

Activation Measurements

Bioassays (5)

Research

Studies (5)

Study Types

glutamate

Description

Cross-References

Synonyms (21)

Roles (3)

Drug Classes (2)

Pathways (743)

Protein Targets (16)

Inhibition Measurements

Activation Measurements

Bioassays (5)

Research

Studies (5)

Study Types

Related Conditions (0)