adenosine triphosphate profile

ATP(4-) : A nucleoside triphosphate(4-) obtained by global deprotonation of the triphosphate OH groups of ATP; major species present at pH 7.3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Products

ID Source	ID
PubMed CID	5461108
CHEMBL ID	2364735
CHEBI ID	30616
MeSH ID	M0000395

Synonym
CHEBI:30616 ,
adenosine 5'-triphosphate(4-)
atp(4-)
adenylpyrophosphate
2J9L
2HMW
2P0X
2P09
2E5Y
2HMU
5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-ylmethoxy-hydroxy-phosphoryloxy-hydroxy-phosphoryl oxyphosphonic acid
bdbm50192459
adenosine 5''-triphosphate(4-)
cid_16654697
3B2Q ,
2VT3
3D2E
adenosinetriphosphate
[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
CHEMBL2364735 ,
bdbm50422407
4FUT
3EFS
3DNT
2YCH
2W5G
4FVR
3QX9
2VHQ
3LF0
2W5I
4FVQ
2KMX
3DGL
3NCQ
2PZE
3TA0
2XBP
3QXC
3DGO
AKOS026750622
Q27113900

Product Category	Products
Professional Supplements	1

Product	Brand	Category	Compounds Matched from Ingredients	Date Retrieved
Dr. Mercola Full Spectrum Enzymes -- 90 Capsules	Dr. Mercola	Professional Supplements	Adenosine Triphosphate	2024-11-29 10:47:42

Role	Description
human metabolite	Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
fundamental metabolite	Any metabolite produced by all living cells.
cofactor	An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
nucleoside 5'-triphoshate(4-)	A ribonucleoside triphosphate oxoanion arising from global deprotonation of the triphosphate groups of any nucleoside triphosphate; major species at pH 7.3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2,509)

Pathway	Proteins	Compounds
Glycolysis	61	32
Transport of small molecules	392	95
ABC-family proteins mediated transport	77	11
ABC transporters in lipid homeostasis	14	5
Mitochondrial ABC transporters	4	6
SLC-mediated transmembrane transport	135	67
Cellular hexose transport	12	3
Transport of vitamins, nucleosides, and related molecules	27	18
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	4
Aquaporin-mediated transport	18	11
Vasopressin regulates renal water homeostasis via Aquaporins	9	9
Iron uptake and transport	29	19
Transferrin endocytosis and recycling	10	7
Ion channel transport	45	16
Ion transport by P-type ATPases	13	12
Stimuli-sensing channels	29	10
Lipoprotein metabolism	53	9
Plasma lipoprotein assembly	16	8
HDL assembly	5	8
Plasma lipoprotein remodeling	25	6
HDL remodeling	9	6
Mitophagy	21	2
Receptor Mediated Mitophagy	7	2
Vesicle-mediated transport	333	16
Membrane Trafficking	308	14
ER to Golgi Anterograde Transport	63	6
COPII-mediated vesicle transport	33	6
COPI-mediated anterograde transport	31	5
Intra-Golgi and retrograde Golgi-to-ER traffic	77	10
Retrograde transport at the Trans-Golgi-Network	39	6
Intra-Golgi traffic	24	5
Golgi-to-ER retrograde transport	26	8
COPI-dependent Golgi-to-ER retrograde traffic	19	4
COPI-independent Golgi-to-ER retrograde traffic	7	7
trans-Golgi Network Vesicle Budding	37	5
Golgi Associated Vesicle Biogenesis	22	5
Lysosome Vesicle Biogenesis	19	5
Gap junction trafficking and regulation	9	2
Regulation of gap junction activity	4	2
Clathrin-mediated endocytosis	65	7
Cargo recognition for clathrin-mediated endocytosis	37	3
Endosomal Sorting Complex Required For Transport (ESCRT)	13	3
Translocation of SLC2A4 (GLUT4) to the plasma membrane	45	9
Rab regulation of trafficking	58	8
RAB GEFs exchange GTP for GDP on RABs	37	4
Organelle biogenesis and maintenance	232	16
Mitochondrial biogenesis	66	8
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	2	3
Transcriptional activation of mitochondrial biogenesis	35	7
Developmental Biology	727	30
Axon guidance	313	13
Semaphorin interactions	40	7
Sema4D in semaphorin signaling	10	7
Sema4D mediated inhibition of cell attachment and migration	8	7
Sema4D induced cell migration and growth-cone collapse	5	5
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	10	6
Sema3A PAK dependent Axon repulsion	7	3
CRMPs in Sema3A signaling	7	2
NCAM signaling for neurite out-growth	16	5
NCAM1 interactions	5	1
Netrin-1 signaling	26	7
DCC mediated attractive signaling	7	4
Netrin mediated repulsion signals	5	2
Role of second messengers in netrin-1 signaling	5	4
DSCAM interactions	6	4
Signaling by ROBO receptors	163	7
Regulation of commissural axon pathfinding by SLIT and ROBO	6	2
Role of ABL in ROBO-SLIT signaling	2	2
ROBO receptors bind AKAP5	6	2
L1CAM interactions	54	7
Recycling pathway of L1	12	5
Interaction between L1 and Ankyrins	3	2
Signal transduction by L1	19	4
Neurofascin interactions	7	2
EPH-Ephrin signaling	38	9
EPHA-mediated growth cone collapse	3	4
EPHB-mediated forward signaling	24	9
Ephrin signaling	6	4
EPH-ephrin mediated repulsion of cells	9	4
RET signaling	13	2
Reelin signalling pathway	5	2
Myogenesis	10	3
Regulation of beta-cell development	29	2
Regulation of gene expression in beta cells	17	2
AKT-mediated inactivation of FOXO1A	1	2
Signaling by NODAL	13	2
Cell-Cell communication	79	3
Signal regulatory protein family interactions	9	2
Nephrin family interactions	7	2
Hemostasis	239	44
Platelet homeostasis	18	27
Platelet calcium homeostasis	5	5
Elevation of cytosolic Ca2+ levels	3	3
Platelet sensitization by LDL	8	3
Platelet activation, signaling and aggregation	63	15
Signal amplification	8	6
ADP signalling through P2Y purinoceptor 1	4	5
GPVI-mediated activation cascade	17	5
Platelet Aggregation (Plug Formation)	21	7
Integrin signaling	15	7
p130Cas linkage to MAPK signaling for integrins	3	2
Effects of PIP2 hydrolysis	1	10
Response to elevated platelet cytosolic Ca2+	8	6
Disinhibition of SNARE formation	5	3
Platelet degranulation	3	5
Cell surface interactions at the vascular wall	80	7
Tie2 Signaling	11	4
PECAM1 interactions	7	2
Factors involved in megakaryocyte development and platelet production	50	15
Kinesins	15	2
Reproduction	86	8
Meiosis	59	4
Meiotic synapsis	34	2
Metabolism	1496	1108
Carbohydrate metabolism	173	120
Glycogen metabolism	20	16
Glycogen breakdown (glycogenolysis)	13	11
Glucose metabolism	76	42
Gluconeogenesis	30	31
Fructose metabolism	7	21
Fructose catabolism	5	15
Galactose catabolism	4	10
Pentose phosphate pathway	13	30
PRPP biosynthesis	3	8
Glycosaminoglycan metabolism	36	37
Transport and synthesis of PAPS	0	7
Formation of xylulose-5-phosphate	5	15
Inositol phosphate metabolism	32	35
Synthesis of IP3 and IP4 in the cytosol	20	11
Synthesis of IPs in the nucleus	2	14
Synthesis of pyrophosphates in the cytosol	6	15
Metabolism of lipids	500	463
Fatty acid metabolism	113	203
Fatty acyl-CoA biosynthesis	16	35
Synthesis of very long-chain fatty acyl-CoAs	3	23
Arachidonic acid metabolism	36	82
Synthesis of Leukotrienes (LT) and Eoxins (EX)	13	29
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	41
alpha-linolenic acid (ALA) metabolism	10	31
Linoleic acid (LA) metabolism	5	24
Carnitine metabolism	10	13
Mitochondrial Fatty Acid Beta-Oxidation	22	60
mitochondrial fatty acid beta-oxidation of saturated fatty acids	9	42
Beta oxidation of butanoyl-CoA to acetyl-CoA	3	14
Propionyl-CoA catabolism	3	9
Peroxisomal lipid metabolism	25	52
Alpha-oxidation of phytanate	6	25
Triglyceride metabolism	13	17
Triglyceride biosynthesis	3	10
Triglyceride catabolism	10	13
Phospholipid metabolism	122	42
Glycerophospholipid biosynthesis	74	39
Synthesis of PE	9	14
Synthesis of PC	20	17
PI Metabolism	49	11
Synthesis of PIPs at the ER membrane	3	4
Synthesis of PIPs at the Golgi membrane	8	5
Synthesis of PIPs at the plasma membrane	27	5
Synthesis of PIPs at the early endosome membrane	9	4
Synthesis of PIPs at the late endosome membrane	6	4
Synthesis of PIPs in the nucleus	4	4
Sphingolipid metabolism	55	50
Sphingolipid de novo biosynthesis	17	16
Glycosphingolipid metabolism	30	31
Metabolism of steroids	111	135
Cholesterol biosynthesis	22	49
Bile acid and bile salt metabolism	31	71
Synthesis of bile acids and bile salts	20	68
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	16	44
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	8	31
Recycling of bile acids and salts	18	10
Ketone body metabolism	10	19
Synthesis of Ketone Bodies	8	17
Integration of energy metabolism	49	27
Regulation of insulin secretion	30	19
Acetylcholine regulates insulin secretion	3	8
Free fatty acids regulate insulin secretion	2	11
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	9	7
Glucagon signaling in metabolic regulation	2	6
PKA activation in glucagon signalling	0	5
PKA-mediated phosphorylation of key metabolic factors	2	2
AMPK inhibits chREBP transcriptional activation activity	8	3
Metabolism of nitric oxide: NOS3 activation and regulation	14	26
eNOS activation	10	26
The citric acid (TCA) cycle and respiratory electron transport	147	56
Pyruvate metabolism and Citric Acid (TCA) cycle	41	46
Pyruvate metabolism	20	26
Regulation of pyruvate dehydrogenase (PDH) complex	9	14
Citric acid cycle (TCA cycle)	18	27
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	110	19
Formation of ATP by chemiosmotic coupling	18	5
Nucleotide metabolism	89	125
Nucleotide biosynthesis	12	46
Purine ribonucleoside monophosphate biosynthesis	9	36
Pyrimidine biosynthesis	3	21
Interconversion of nucleotide di- and triphosphates	22	30
Nucleotide salvage	21	28
Purine salvage	13	22
Pyrimidine salvage	9	13
Metabolism of vitamins and cofactors	146	155
Metabolism of water-soluble vitamins and cofactors	102	114
Vitamin B1 (thiamin) metabolism	3	9
Vitamin B2 (riboflavin) metabolism	4	11
Vitamin B5 (pantothenate) metabolism	16	20
Coenzyme A biosynthesis	5	14
Vitamin B6 activation to pyridoxal phosphate	3	18
Cobalamin (Cbl, vitamin B12) transport and metabolism	18	25
Biotin transport and metabolism	11	8
Nicotinate metabolism	22	43
Nicotinamide salvaging	10	30
Metabolism of folate and pterines	16	29
Molybdenum cofactor biosynthesis	8	17
Metabolism of cofactors	19	47
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	25
Amino acid and derivative metabolism	250	260
Serine biosynthesis	4	16
Branched-chain amino acid catabolism	20	31
Histidine catabolism	8	22
Creatine metabolism	6	15
Urea cycle	8	22
Sulfur amino acid metabolism	27	63
Selenoamino acid metabolism	24	50
Metabolism of ingested SeMet, Sec, MeSec into H2Se	4	23
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	2	18
Selenocysteine synthesis	6	14
Threonine catabolism	5	14
Porphyrin metabolism	23	44
Heme biosynthesis	15	30
Heme degradation	10	21
Biological oxidations	150	276
Phase I - Functionalization of compounds	69	175
Ethanol oxidation	12	16
Phase II - Conjugation of compounds	73	122
Cytosolic sulfonation of small molecules	17	47
Methylation	13	38
Glutathione conjugation	35	23
Glutathione synthesis and recycling	11	14
Amino Acid conjugation	0	15
Conjugation of carboxylic acids	0	15
Conjugation of benzoate with glycine	0	8
Conjugation of phenylacetate with glutamine	0	8
Conjugation of salicylate with glycine	0	8
Abacavir ADME	6	24
Abacavir transmembrane transport	2	5
Abacavir metabolism	4	23
Programmed Cell Death	170	12
Apoptosis	147	5
Caspase activation via extrinsic apoptotic signalling pathway	15	2
Ligand-independent caspase activation via DCC	7	2
Intrinsic Pathway for Apoptosis	46	4
Activation of BH3-only proteins	21	4
Activation of BAD and translocation to mitochondria	12	4
Activation of BIM and translocation to mitochondria	3	2
Activation of BMF and translocation to mitochondria	3	2
Apoptotic factor-mediated response	20	2
Cytochrome c-mediated apoptotic response	13	2
Formation of apoptosome	11	2
Activation of caspases through apoptosome-mediated cleavage	6	2
Apoptotic execution phase	44	2
Stimulation of the cell death response by PAK-2p34	2	2
Regulated Necrosis	38	9
RIPK1-mediated regulated necrosis	23	7
Regulation of necroptotic cell death	21	6
DNA Repair	255	47
DNA Damage Bypass	41	7
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	35	7
Translesion Synthesis by POLH	6	4
DNA Double-Strand Break Repair	103	13
DNA Double Strand Break Response	37	9
Sensing of DNA Double Strand Breaks	6	4
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	33	7
Homology Directed Repair	83	9
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	79	9
Processing of DNA double-strand break ends	51	8
HDR through Homologous Recombination (HRR)	48	5
Homologous DNA Pairing and Strand Exchange	31	2
Presynaptic phase of homologous DNA pairing and strand exchange	25	2
Resolution of D-Loop Structures	33	4
Resolution of D-loop Structures through Holliday Junction Intermediates	32	4
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	23	4
HDR through Single Strand Annealing (SSA)	31	2
Nonhomologous End-Joining (NHEJ)	33	4
Nucleotide Excision Repair	84	7
Global Genome Nucleotide Excision Repair (GG-NER)	58	7
Formation of Incision Complex in GG-NER	29	4
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	58	5
Dual incision in TC-NER	47	3
MMR	15	8
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	8
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	8
Fanconi Anemia Pathway	29	4
Signaling Pathways	1269	117
Signaling by Receptor Tyrosine Kinases	293	35
Signaling by EGFR	29	7
EGFR interacts with phospholipase C-gamma	2	2
SHC1 events in EGFR signaling	4	4
GAB1 signalosome	10	4
EGFR downregulation	15	5
Signaling by FGFR	47	7
Signaling by FGFR1	27	5
FGFR1 ligand binding and activation	7	2
FGFR1b ligand binding and activation	4	2
FGFR1c ligand binding and activation	5	2
FGFR1c and Klotho ligand binding and activation	2	2
Downstream signaling of activated FGFR1	10	4
FRS-mediated FGFR1 signaling	6	4
Phospholipase C-mediated cascade: FGFR1	2	2
SHC-mediated cascade:FGFR1	3	4
PI-3K cascade:FGFR1	6	2
Negative regulation of FGFR1 signaling	13	3
Spry regulation of FGF signaling	10	3
Signaling by FGFR2	31	5
FGFR2 ligand binding and activation	4	2
FGFR2b ligand binding and activation	2	2
FGFR2c ligand binding and activation	2	2
Downstream signaling of activated FGFR2	9	4
FRS-mediated FGFR2 signaling	5	4
Phospholipase C-mediated cascade; FGFR2	1	2
SHC-mediated cascade:FGFR2	2	4
PI-3K cascade:FGFR2	6	2
Negative regulation of FGFR2 signaling	11	3
Signaling by FGFR3	21	7
FGFR3 ligand binding and activation	4	4
FGFR3b ligand binding and activation	1	2
FGFR3c ligand binding and activation	3	4
Downstream signaling of activated FGFR3	11	4
FRS-mediated FGFR3 signaling	7	4
Phospholipase C-mediated cascade; FGFR3	3	2
SHC-mediated cascade:FGFR3	4	4
PI-3K cascade:FGFR3	6	2
Negative regulation of FGFR3 signaling	11	3
Signaling by FGFR4	20	5
FGFR4 ligand binding and activation	3	2
betaKlotho-mediated ligand binding	3	2
Downstream signaling of activated FGFR4	12	4
FRS-mediated FGFR4 signaling	8	4
Phospholipase C-mediated cascade; FGFR4	4	2
SHC-mediated cascade:FGFR4	5	4
PI-3K cascade:FGFR4	6	2
Negative regulation of FGFR4 signaling	11	3
Signaling by NTRKs	85	10
Signaling by NTRK1 (TRKA)	66	9
Activation of TRKA receptors	6	3
TRKA activation by NGF	3	2
NGF-independant TRKA activation	3	3
Signalling to ERKs	21	6
Signalling to RAS	8	5
p38MAPK events	4	5
Prolonged ERK activation events	15	5
Frs2-mediated activation	12	5
ARMS-mediated activation	7	5
PLC-gamma1 signalling	3	2
PI3K/AKT activation	3	2
Signalling to STAT3	3	2
Signalling to ERK5	2	2
Nuclear Events (kinase and transcription factor activation)	33	4
ERK/MAPK targets	8	4
CREB phosphorylation	4	2
Signaling by NTRK2 (TRKB)	20	4
BDNF activates NTRK2 (TRKB) signaling	2	2
NTF3 activates NTRK2 (TRKB) signaling	2	2
NTF4 activates NTRK2 (TRKB) signaling	2	2
Activated NTRK2 signals through RAS	3	4
Activated NTRK2 signals through PLCG1	2	2
Activated NTRK2 signals through PI3K	5	2
Activated NTRK2 signals through FRS2 and FRS3	6	4
Activated NTRK2 signals through FYN	5	4
Activated NTRK2 signals through CDK5	5	4
Signaling by NTRK3 (TRKC)	11	6
NTF3 activates NTRK3 signaling	2	2
Activated NTRK3 signals through PLCG1	3	2
Activated NTRK3 signals through RAS	4	4
Activated NTRK3 signals through PI3K	6	2
Signaling by Insulin receptor	16	9
Insulin receptor signalling cascade	10	8
IRS activation	3	2
IRS-mediated signalling	6	7
PI3K Cascade	4	5
Activation of PKB	2	2
PKB-mediated events	2	5
PDE3B signalling	2	5
Signal attenuation	6	3
Signaling by PDGF	17	6
Downstream signal transduction	10	4
Signaling by VEGF	62	25
VEGFA-VEGFR2 Pathway	52	25
VEGFR2 mediated vascular permeability	20	16
VEGFR2 mediated cell proliferation	9	8
Signaling by SCF-KIT	18	4
Regulation of KIT signaling	9	2
Signaling by ERBB2	30	7
SHC1 events in ERBB2 signaling	7	5
PI3K events in ERBB2 signaling	5	2
PLCG1 events in ERBB2 signaling	2	2
ERBB2 Activates PTK6 Signaling	1	2
Downregulation of ERBB2 signaling	12	4
Downregulation of ERBB2:ERBB3 signaling	4	2
Signaling by ERBB4	33	6
SHC1 events in ERBB4 signaling	3	4
PI3K events in ERBB4 signaling	2	2
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	9	7
IGF1R signaling cascade	8	7
SHC-related events triggered by IGF1R	3	4
IRS-related events triggered by IGF1R	8	7
Signaling by MET	32	6
MET Receptor Activation	5	3
MET activates RAS signaling	7	4
MET activates PI3K/AKT signaling	5	2
MET promotes cell motility	10	4
MET activates PTK2 signaling	3	2
MET activates STAT3	2	2
Negative regulation of MET activity	8	4
Signaling by MST1	3	3
Signaling by TGFB family members	84	7
Signaling by TGF-beta Receptor Complex	67	7
TGF-beta receptor signaling activates SMADs	35	4
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	12	3
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	32	6
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	23	2
Downregulation of SMAD2/3:SMAD4 transcriptional activity	17	6
Signaling by BMP	11	2
Signaling by Activin	15	2
Signaling by GPCR	249	55
GPCR ligand binding	193	39
Class A/1 (Rhodopsin-like receptors)	161	36
Nucleotide-like (purinergic) receptors	12	7
P2Y receptors	12	6
GPCR downstream signalling	172	52
G alpha (s) signalling events	10	11
Olfactory Signaling Pathway	80	28
G alpha (i) signalling events	87	41
Opioid Signalling	23	19
G-protein mediated events	16	15
PLC beta mediated events	15	14
Ca-dependent events	14	9
phospho-PLA2 pathway	2	5
CaM pathway	12	8
Calmodulin induced events	12	8
PKA-mediated phosphorylation of CREB	4	6
PKA activation	3	5
CaMK IV-mediated phosphorylation of CREB	6	3
Adenylate cyclase activating pathway	1	7
DARPP-32 events	7	11
Visual phototransduction	62	41
The canonical retinoid cycle in rods (twilight vision)	14	15
The phototransduction cascade	26	21
Inactivation, recovery and regulation of the phototransduction cascade	25	18
G alpha (z) signalling events	1	9
G alpha (q) signalling events	79	28
Gastrin-CREB signalling pathway via PKC and MAPK	12	4
G-protein beta:gamma signalling	7	4
G beta:gamma signalling through PI3Kgamma	3	2
Signaling by NOTCH	113	14
Pre-NOTCH Expression and Processing	24	13
Pre-NOTCH Transcription and Translation	17	4
Signaling by NOTCH1	26	3
NOTCH1 Intracellular Domain Regulates Transcription	15	2
Signaling by NOTCH3	29	3
NOTCH3 Activation and Transmission of Signal to the Nucleus	13	3
Signaling by NOTCH4	65	3
Negative regulation of NOTCH4 signaling	49	2
Signaling by WNT	148	20
Degradation of beta-catenin by the destruction complex	62	2
Beta-catenin phosphorylation cascade	6	2
TCF dependent signaling in response to WNT	104	9
WNT mediated activation of DVL	3	2
Disassembly of the destruction complex and recruitment of AXIN to the membrane	11	2
Deactivation of the beta-catenin transactivating complex	19	2
Beta-catenin independent WNT signaling	81	13
PCP/CE pathway	66	5
Asymmetric localization of PCP proteins	52	2
WNT5A-dependent internalization of FZD4	11	3
Ca2+ pathway	16	12
Signaling by Hippo	15	2
Signaling by Hedgehog	93	11
Hedgehog ligand biogenesis	56	7
Hedgehog 'off' state	67	6
GLI3 is processed to GLI3R by the proteasome	53	2
Degradation of GLI2 by the proteasome	53	2
Degradation of GLI1 by the proteasome	53	2
Hedgehog 'on' state	70	2
Activation of SMO	13	2
Signaling by Leptin	7	2
Signaling by Nuclear Receptors	152	46
Signaling by Retinoic Acid	24	31
ESR-mediated signaling	102	23
Estrogen-dependent gene expression	80	4
MAPK family signaling cascades	115	19
ERK1/ERK2 pathway	93	19
RAF/MAP kinase cascade	91	19
RAF activation	8	5
MAP2K and MAPK activation	9	3
Negative regulation of MAPK pathway	16	5
Negative feedback regulation of MAPK pathway	4	2
RAF-independent MAPK1/3 activation	7	4
MAPK3 (ERK1) activation	4	2
MAPK1 (ERK2) activation	3	2
MAPK6/MAPK4 signaling	68	5
Intracellular signaling by second messengers	126	14
PI3K/AKT Signaling	113	8
AKT phosphorylates targets in the cytosol	7	2
AKT phosphorylates targets in the nucleus	3	2
Negative regulation of the PI3K/AKT network	18	5
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	17	4
PTEN Regulation	77	6
Regulation of PTEN gene transcription	22	3
Regulation of PTEN stability and activity	52	5
DAG and IP3 signaling	14	10
Signaling by Rho GTPases	181	20
Rho GTPase cycle	4	6
RHO GTPase Effectors	166	20
RHO GTPases Activate ROCKs	6	5
RHO GTPases activate PAKs	15	6
RHO GTPases activate PKNs	21	10
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	6	7
RHO GTPases activate CIT	14	3
RHO GTPases Activate WASPs and WAVEs	17	3
RHO GTPases Activate Formins	83	7
RHO GTPases Activate NADPH Oxidases	18	12
Signaling by Non-Receptor Tyrosine Kinases	31	6
Signaling by PTK6	31	6
PTK6 Activates STAT3	4	2
PTK6 Regulates Cell Cycle	2	2
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	9	5
PTK6 Regulates Proteins Involved in RNA Processing	5	2
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	5	2
PTK6 promotes HIF1A stabilization	6	2
PTK6 Down-Regulation	3	4
MTOR signalling	30	8
Inhibition of TSC complex formation by PKB	3	2
mTORC1-mediated signalling	11	3
Energy dependent regulation of mTOR by LKB1-AMPK	5	7
Death Receptor Signaling	75	9
TNF signaling	37	3
Regulation of TNFR1 signaling	32	2
p75 NTR receptor-mediated signalling	32	9
Cell death signalling via NRAGE, NRIF and NADE	15	5
NRAGE signals death through JNK	8	5
NRIF signals cell death from the nucleus	8	2
p75NTR signals via NF-kB	13	2
p75NTR recruits signalling complexes	10	2
NF-kB is activated and signals survival	8	2
Signaling by Erythropoietin	18	6
Erythropoietin activates STAT5	5	2
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	2
Erythropoietin activates RAS	11	4
Erythropoietin activates Phospholipase C gamma (PLCG)	5	4
Cellular responses to stimuli	483	56
Macroautophagy	56	7
Cellular responses to stress	469	54
Detoxification of Reactive Oxygen Species	30	27
Cellular response to heat stress	70	9
HSF1-dependent transactivation	9	4
Regulation of HSF1-mediated heat shock response	57	7
Cellular Senescence	84	9
Oncogene Induced Senescence	14	2
Oxidative Stress Induced Senescence	25	7
DNA Damage/Telomere Stress Induced Senescence	25	4
Senescence-Associated Secretory Phenotype (SASP)	37	4
HSP90 chaperone cycle for SHRs	14	5
Muscle contraction	77	21
Striated Muscle Contraction	6	4
Smooth Muscle Contraction	20	15
Cardiac conduction	52	12
Ion homeostasis	18	10
Neuronal System	166	50
Transmission across Chemical Synapses	122	50
Neurotransmitter release cycle	31	33
Norepinephrine Neurotransmitter Release Cycle	12	12
Serotonin Neurotransmitter Release Cycle	11	5
Dopamine Neurotransmitter Release Cycle	13	5
Acetylcholine Neurotransmitter Release Cycle	13	9
Neurotransmitter uptake and metabolism In glial cells	2	6
Astrocytic Glutamate-Glutamine Uptake And Metabolism	2	6
Neurotransmitter receptors and postsynaptic signal transmission	78	20
Glutamate binding, activation of AMPA receptors and synaptic plasticity	17	6
Trafficking of AMPA receptors	17	4
Trafficking of GluR2-containing AMPA receptors	11	4
Activation of NMDA receptors and postsynaptic events	40	13
Post NMDA receptor activation events	22	8
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	8	6
RSK activation	3	2
CREB1 phosphorylation through the activation of Adenylate Cyclase	2	5
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	6	3
Potassium Channels	24	4
Inwardly rectifying K+ channels	9	3
ATP sensitive Potassium channels	2	2
Cell Cycle	538	31
Cell Cycle Checkpoints	173	2
G1/S DNA Damage Checkpoints	59	2
p53-Dependent G1/S DNA damage checkpoint	57	2
p53-Dependent G1 DNA Damage Response	57	2
Stabilization of p53	53	2
Autodegradation of the E3 ubiquitin ligase COP1	48	2
p53-Independent G1/S DNA damage checkpoint	48	2
p53-Independent DNA Damage Response	48	2
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	48	2
G2/M Checkpoints	84	2
G2/M DNA damage checkpoint	31	2
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	2
G2/M DNA replication checkpoint	4	2
Activation of ATR in response to replication stress	17	2
Cell Cycle, Mitotic	410	31
Mitotic G1 phase and G1/S transition	118	4
G0 and Early G1	21	2
G1 Phase	17	4
Cyclin D associated events in G1	17	4
G1/S Transition	100	4
Cyclin E associated events during G1/S transition	60	4
SCF(Skp2)-mediated degradation of p27/p21	49	2
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	2	2
Activation of the pre-replicative complex	22	3
S Phase	131	14
Cyclin A:Cdk2-associated events at S phase entry	59	4
Synthesis of DNA	113	10
Switching of origins to a post-replicative state	84	2
Orc1 removal from chromatin	59	2
CDK-mediated phosphorylation and removal of Cdc6	65	2
DNA strand elongation	25	6
Leading Strand Synthesis	10	2
Polymerase switching	10	2
Lagging Strand Synthesis	16	6
Ubiquitin-dependent degradation of Cyclin D	48	2
Mitotic G2-G2/M phases	173	8
G2 Phase	1	2
G2/M Transition	172	8
Cyclin A/B1/B2 associated events during G2/M transition	18	7
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	3	2
Regulation of PLK1 Activity at G2/M Transition	75	5
Polo-like kinase mediated events	16	2
Centrosome maturation	79	2
Loss of proteins required for interphase microtubule organization from the centrosome	69	2
Loss of Nlp from mitotic centrosomes	69	2
The role of GTSE1 in G2/M progression after G2 checkpoint	53	2
AURKA Activation by TPX2	64	2
Interaction between PHLDA1 and AURKA	2	2
M Phase	279	21
Mitotic Prophase	62	14
Golgi Cisternae Pericentriolar Stack Reorganization	12	3
Condensation of Prophase Chromosomes	13	10
MASTL Facilitates Mitotic Progression	6	2
Nuclear Envelope Breakdown	39	5
Activation of NIMA Kinases NEK9, NEK6, NEK7	5	2
Nuclear Pore Complex (NPC) Disassembly	32	2
Depolymerization of the Nuclear Lamina	7	5
Mitotic Prometaphase	142	6
Resolution of Sister Chromatid Cohesion	47	6
Condensation of Prometaphase Chromosomes	9	4
Mitotic Metaphase and Anaphase	158	12
FOXO-mediated transcription	60	7
Regulation of localization of FOXO transcription factors	8	2
Extra-nuclear estrogen signaling	27	20
Estrogen-stimulated signaling through PRKCZ	3	4
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	14	2
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	5	6
Intracellular metabolism of fatty acids regulates insulin secretion	1	6
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	7	3
Assembly and cell surface presentation of NMDA receptors	17	3
Long-term potentiation	6	4
Activation of RAC1 downstream of NMDARs	5	5
Activation of AMPK downstream of NMDARs	3	3
Regulation of the apoptosome activity	11	2
Mitotic Metaphase/Anaphase Transition	2	2
Mitotic Anaphase	157	12
Regulatory network of nutrient accumulation	10	11
Regulation of leaf development	17	22
Response to Drought	5	4
HSFA7/ HSFA6B-regulatory network-induced by drought and ABA.	3	4
Response to salinity	4	4
Nuclear Envelope (NE) Reassembly	51	10
Initiation of Nuclear Envelope (NE) Reformation	14	7
cell division	11	2
Regulation of mitotic cell cycle	79	4
APC/C-mediated degradation of cell cycle proteins	79	4
Regulation of APC/C activators between G1/S and early anaphase	75	2
Phosphorylation of Emi1	4	2
Chromosome Maintenance	92	13
Telomere Maintenance	65	13
Extension of Telomeres	46	13
Telomere Extension By Telomerase	19	9
Telomere C-strand (Lagging Strand) Synthesis	31	13
Polymerase switching on the C-strand of the telomere	24	4
Processive synthesis on the C-strand of the telomere	16	13
Metabolism of proteins	1058	144
Translation	267	33
tRNA Aminoacylation	42	26
Cytosolic tRNA aminoacylation	24	26
Mitochondrial tRNA aminoacylation	21	26
Eukaryotic Translation Initiation	103	5
Cap-dependent Translation Initiation	103	5
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	52	3
Ribosomal scanning and start codon recognition	9	3
L13a-mediated translational silencing of Ceruloplasmin expression	47	2
Protein folding	24	4
Chaperonin-mediated protein folding	18	4
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	14	4
Formation of tubulin folding intermediates by CCT/TriC	7	4
Folding of actin by CCT/TriC	8	3
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	10	3
Post-translational protein modification	666	112
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	46	26
Synthesis of diphthamide-EEF2	8	7
Asparagine N-linked glycosylation	164	78
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	50	68
Synthesis of substrates in N-glycan biosythesis	37	56
Synthesis of Dolichyl-phosphate	6	17
Synthesis of UDP-N-acetyl-glucosamine	6	17
Sialic acid metabolism	13	18
GDP-fucose biosynthesis	6	16
Transport to the Golgi and subsequent modification	85	18
O-linked glycosylation	19	19
SUMOylation	167	6
Processing and activation of SUMO	7	3
SUMO is conjugated to E1 (UBA2:SAE1)	5	3
Deubiquitination	150	4
Ovarian tumor domain proteases	17	3
Protein ubiquitination	41	4
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	6	3
Carboxyterminal post-translational modifications of tubulin	7	9
Neddylation	91	4
Post-translational protein phosphorylation	2	2
Regulation of IGF Activity by IGFBP	11	3
Unfolded Protein Response (UPR)	85	2
IRE1alpha activates chaperones	50	2
PERK regulates gene expression	24	2
Surfactant metabolism	16	11
Circadian Clock	45	3
Disease	1278	231
Diseases of signal transduction by growth factor receptors and second messengers	262	31
Signaling by EGFR in Cancer	12	4
Signaling by Ligand-Responsive EGFR Variants in Cancer	11	4
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	11	4
Signaling by EGFRvIII in Cancer	12	4
Constitutive Signaling by EGFRvIII	12	4
Signaling by FGFR in disease	33	5
Signaling by FGFR1 in disease	23	4
FGFR1 mutant receptor activation	19	2
Signaling by FGFR1 amplification mutants	2	2
Signaling by activated point mutants of FGFR1	1	2
Signaling by cytosolic FGFR1 fusion mutants	14	2
Signaling by plasma membrane FGFR1 fusions	3	2
Signaling by FGFR2 in disease	13	4
FGFR2 mutant receptor activation	6	2
Activated point mutants of FGFR2	3	2
Signaling by FGFR2 amplification mutants	2	2
Signaling by FGFR2 fusions	1	2
Signaling by FGFR3 in disease	10	4
Signaling by FGFR3 point mutants in cancer	10	4
FGFR3 mutant receptor activation	3	2
Signaling by activated point mutants of FGFR3	3	2
t(4;14) translocations of FGFR3	1	2
Signaling by FGFR3 fusions in cancer	1	2
Signaling by FGFR4 in disease	8	5
FGFR4 mutant receptor activation	1	3
PI3K/AKT Signaling in Cancer	18	3
Constitutive Signaling by Aberrant PI3K in Cancer	2	2
Constitutive Signaling by AKT1 E17K in Cancer	16	2
Signaling by NOTCH1 in Cancer	19	3
Signaling by NOTCH1 PEST Domain Mutants in Cancer	19	3
Constitutive Signaling by NOTCH1 PEST Domain Mutants	19	3
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	19	3
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	19	3
Signaling by TGF-beta Receptor Complex in Cancer	6	1
Loss of Function of SMAD2/3 in Cancer	5	1
SMAD2/3 Phosphorylation Motif Mutants in Cancer	4	1
Loss of Function of TGFBR2 in Cancer	2	1
TGFBR2 Kinase Domain Mutants in Cancer	1	1
Signaling by WNT in cancer	9	3
Signaling by CTNNB1 phospho-site mutants	5	1
CTNNB1 S45 mutants aren't phosphorylated	5	1
CTNNB1 T41 mutants aren't phosphorylated	5	1
CTNNB1 S37 mutants aren't phosphorylated	5	1
CTNNB1 S33 mutants aren't phosphorylated	5	1
Hh mutants abrogate ligand secretion	50	5
Hh mutants are degraded by ERAD	49	5
Diseases associated with visual transduction	7	10
Retinoid cycle disease events	7	10
Oncogenic MAPK signaling	36	5
Signaling by RAS mutants	11	3
Signaling by high-kinase activity BRAF mutants	4	2
Signaling by moderate kinase activity BRAF mutants	10	3
Paradoxical activation of RAF signaling by kinase inactive BRAF	10	3
Signaling by BRAF and RAF1 fusions	28	2
Disorders of transmembrane transporters	102	43
ABC transporter disorders	57	10
Defective CFTR causes cystic fibrosis	50	6
Defective ABCB4 causes PFIC3, ICP3 and GBD1	0	2
Defective ABCB6 causes MCOPCB7	0	3
Defective ABCB11 causes PFIC2 and BRIC2	0	2
Defective ABCA1 causes TGD	1	3
Defective ABCA12 causes ARCI4B	0	2
Defective ABCA3 causes SMDP3	0	2
Defective ABCC2 causes DJS	0	2
Defective ABCC6 causes PXE	1	2
Defective ABCC8 can cause hypo- and hyper-glycemias	1	2
Defective ABCD1 causes ALD	0	2
Defective ABCD4 causes MAHCJ	2	3
Defective ABCG5 causes sitosterolemia	1	2
Defective ABCG8 causes GBD4 and sitosterolemia	1	2
SLC transporter disorders	45	37
Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)	0	2
Defective HK1 causes hexokinase deficiency (HK deficiency)	0	2
Diseases of metabolism	69	121
Diseases of carbohydrate metabolism	12	29
Essential fructosuria	1	1
Defects in vitamin and cofactor metabolism	17	17
Defects in cobalamin (B12) metabolism	11	14
Defective MMAB causes MMA, cblB type	0	2
Defects in biotin (Btn) metabolism	6	4
Defective HLCS causes multiple carboxylase deficiency	6	3
Metabolic disorders of biological oxidation enzymes	6	47
Defective GCLC causes HAGGSD	1	3
Defective GSS causes GSS deficiency	0	4
Defective OPLAH causes OPLAHD	0	3
Defective MAT1A causes MATD	0	3
Diseases associated with surfactant metabolism	5	4
Diseases of glycosylation	22	43
Diseases associated with glycosaminoglycan metabolism	5	13
Defective PAPSS2 causes SEMD-PA	0	3
Diseases associated with glycosylation precursor biosynthesis	6	21
Defective GALK1 causes GALCT2	0	2
Defective GNE causes sialuria, NK and IBM2	0	4
Infectious disease	895	79
HIV Infection	201	12
HIV Life Cycle	130	10
Late Phase of HIV Life Cycle	119	9
Transcription of the HIV genome	63	4
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	10	2
HIV Transcription Elongation	40	2
Tat-mediated elongation of the HIV-1 transcript	28	2
Formation of HIV-1 elongation complex containing HIV-1 Tat	28	2
Formation of HIV elongation complex in the absence of HIV Tat	26	2
Uptake and actions of bacterial toxins	38	9
Uptake and function of anthrax toxins	12	6
Listeria monocytogenes entry into host cells	12	4
InlA-mediated entry of Listeria monocytogenes into host cells	6	4
InlB-mediated entry of Listeria monocytogenes into host cell	6	2
Diseases of Immune System	13	1
Defects in Toll-like Receptor Cascades	13	1
IkBA variant leads to EDA-ID	4	1
Neurodegenerative Diseases	20	4
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	20	4
Pervasive developmental disorders	2	1
Loss of function of MECP2 in Rett syndrome	2	1
Loss of phosphorylation of MECP2 at T308	0	1
DNA Replication	119	11
DNA Replication Pre-Initiation	95	3
Assembly of the pre-replicative complex	78	2
Assembly of the ORC complex at the origin of replication	8	2
Protein localization	59	4
Mitochondrial protein import	29	4
Peroxisomal protein import	20	3
Chromatin organization	120	16
Chromatin modifying enzymes	120	16
RMTs methylate histone arginines	18	4
Gene expression (Transcription)	902	49
RNA Polymerase I Transcription	41	4
RNA Polymerase I Promoter Clearance	40	4
RNA Polymerase I Promoter Opening	4	2
RNA Polymerase II Transcription	728	42
Generic Transcription Pathway	608	39
Transcriptional Regulation by TP53	219	31
TP53 Regulates Metabolic Genes	43	24
TP53 Regulates Transcription of Cell Death Genes	36	8
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	14	2
TP53 Regulates Transcription of Caspase Activators and Caspases	12	2
TP53 Regulates Transcription of Cell Cycle Genes	36	2
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	17	2
TP53 Regulates Transcription of DNA Repair Genes	24	2
Regulation of TP53 Activity	99	10
Regulation of TP53 Expression and Degradation	22	4
Regulation of TP53 Degradation	21	4
Regulation of TP53 Activity through Phosphorylation	49	3
Regulation of TP53 Activity through Association with Co-factors	9	2
Regulation of TP53 Activity through Methylation	15	4
Regulation of TP53 Activity through Acetylation	20	7
PI5P Regulates TP53 Acetylation	9	6
pseudouridine degradation	0	8
superpathway of L-asparagine biosynthesis	0	10
NADH repair	0	8
4-hydroxybenzoate biosynthesis I (eukaryotes)	0	18
inositol diphosphates biosynthesis	0	8
glucose and glucose-1-phosphate degradation	0	12
3-phosphoinositide biosynthesis	0	8
L-asparagine biosynthesis II	0	7
L-proline biosynthesis I	0	13
Transcriptional regulation by RUNX1	121	6
L-methionine biosynthesis II	0	17
L-proline biosynthesis I (from L-glutamate)	0	13
Regulation of RUNX1 Expression and Activity	7	4
trans-cinnamoyl-CoA biosynthesis	0	8
mevalonate pathway I (eukaryotes and bacteria)	0	17
S-adenosyl-L-methionine salvage II	0	11
L-lysine biosynthesis I	0	24
ethene biosynthesis I (plants)	0	15
NAD(P)/NADPH interconversion	0	11
adenosine deoxyribonucleotides de novo biosynthesis I	0	5
RUNX1 regulates transcription of genes involved in differentiation of HSCs	60	4
sedoheptulose bisphosphate bypass	0	7
4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I	0	11
fatty acid u03B2-oxidation II (plant peroxisome)	0	16
diphthamide biosynthesis II (eukaryotes)	0	13
NADH repair (eukaryotes)	0	8
acetyl-CoA biosynthesis from citrate	0	7
ceramide degradation (generic)	0	9
glycolysis IV	0	19
coenzyme A biosynthesis I (bacteria)	0	13
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	11	2
5-aminoimidazole ribonucleotide biosynthesis II	0	16
gluconeogenesis III	0	24
Transcriptional regulation by RUNX2	106	4
Regulation of RUNX2 expression and activity	68	2
RUNX2 regulates bone development	25	2
RUNX2 regulates osteoblast differentiation	18	2
acetate conversion to acetyl-CoA	4	6
RUNX2 regulates genes involved in cell migration	4	2
superpathway of proto- and siroheme biosynthesis	16	38
pyrimidine deoxyribonucleotides de novo biosynthesis III	6	21
superpathway of phosphatidylcholine biosynthesis	8	18
Transcriptional regulation by RUNX3	78	7
sorbitol biosynthesis II	0	10
[2Fe-2S] iron-sulfur cluster biosynthesis	0	6
thiamine salvage IV (yeast)	4	15
D-xylose degradation I	2	6
Regulation of RUNX3 expression and activity	49	2
thiamine salvage III	1	5
superpathway of aspartate and asparagine biosynthesis	4	12
simple coumarins biosynthesis	22	21
benzoate degradation II (aerobic and anaerobic)	3	6
Transcriptional Regulation by MECP2	38	2
Regulation of MECP2 expression and activity	10	2
thiamine formation from pyrithiamine and oxythiamine (yeast)	0	15
Transcriptional Regulation by E2F6	28	2
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)	0	10
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	5
RNA Polymerase II Promoter Escape	43	3
RNA Pol II CTD phosphorylation and interaction with CE	10	2
RNA Polymerase II Transcription Elongation	51	2
Formation of RNA Pol II elongation complex	39	2
RNA polymerase II transcribes snRNA genes	62	7
TCA cycle III (animals)	0	23
sucrose degradation V (sucrose u03B1-glucosidase)	0	11
NAD salvage pathway II (PNC IV cycle)	0	12
NAD phosphorylation and transhydrogenation	0	7
Immune System	914	82
Adaptive Immune System	264	24
TCR signaling	83	5
Phosphorylation of CD3 and TCR zeta chains	6	4
Translocation of ZAP-70 to Immunological synapse	5	4
Generation of second messenger molecules	12	4
Downstream TCR signaling	70	4
Costimulation by the CD28 family	33	7
CD28 co-stimulation	23	4
CD28 dependent PI3K/Akt signaling	12	2
CD28 dependent Vav1 pathway	9	4
CTLA4 inhibitory signaling	2	4
PD-1 signaling	4	3
B Cell Activation	90	9
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	24	5
Downstream signaling events of B Cell Receptor (BCR)	66	7
Activation of NF-kappaB in B cells	62	3
Activation of RAS in B cells	0	4
CD22 mediated BCR regulation	5	2
Class I MHC mediated antigen processing & presentation	76	15
Antigen processing: Ubiquitination & Proteasome degradation	46	4
4-deoxy-L-threo-hex-4-enopyranuronate degradation	0	12
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	14	7
L-rhamnose degradation I	0	8
Antigen processing-Cross presentation	67	9
ER-Phagosome pathway	61	4
MHC class II antigen presentation	24	7
Rap1 signalling	2	7
Innate Immune System	414	75
Toll-like Receptor Cascades	101	8
Trafficking and processing of endosomal TLR	7	3
Toll Like Receptor 10 (TLR10) Cascade	50	4
MyD88 cascade initiated on plasma membrane	49	4
IRAK1 recruits IKK complex	7	2
IRAK2 mediated activation of TAK1 complex	4	2
TAK1-dependent IKK and NF-kappa-B activation	20	3
MAP kinase activation	27	4
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	3	2
activated TAK1 mediates p38 MAPK activation	3	2
carnosine biosynthesis	0	7
ppGpp metabolism	0	11
MAP3K8 (TPL2)-dependent MAPK1/3 activation	10	2
lipoate salvage I	0	6
diphthamide biosynthesis I (archaea)	0	11
MAPK targets/ Nuclear events mediated by MAP kinases	14	4
UMP biosynthesis III	0	20
homocarnosine biosynthesis	0	7
Activation of the AP-1 family of transcription factors	5	2
Toll Like Receptor 3 (TLR3) Cascade	53	4
TICAM1-dependent activation of IRF3/IRF7	6	2
TICAM1,TRAF6-dependent induction of TAK1 complex	5	2
Toll Like Receptor 5 (TLR5) Cascade	49	4
Toll Like Receptor 7/8 (TLR7/8) Cascade	50	4
MyD88 dependent cascade initiated on endosome	48	4
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	46	4
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	7	2
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	4	2
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	5	2
Toll Like Receptor 9 (TLR9) Cascade	53	4
Toll Like Receptor 4 (TLR4) Cascade	76	4
thiamine salvage II	0	11
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	52	4
xylitol degradation	0	8
MyD88-independent TLR4 cascade	56	4
TRIF(TICAM1)-mediated TLR4 signaling	55	4
Activation of IRF3, IRF7 mediated by TBK1, IKBKE	8	2
TRAF6-mediated induction of TAK1 complex within TLR4 complex	7	2
Toll Like Receptor 2 (TLR2) Cascade	57	4
Toll Like Receptor TLR1:TLR2 Cascade	55	4
Toll Like Receptor TLR6:TLR2 Cascade	56	4
sucrose degradation IV (sucrose phosphorylase)	0	9
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	33	5
NOD1/2 Signaling Pathway	17	4
Inflammasomes	16	3
The NLRP3 inflammasome	13	2
The NLRP1 inflammasome	1	2
DDX58/IFIH1-mediated induction of interferon-alpha/beta	47	3
TRAF3-dependent IRF activation pathway	11	2
TRAF6 mediated IRF7 activation	5	2
TRAF6 mediated NF-kB activation	7	2
Negative regulators of RIG-I/MDA5 signaling	20	2
Cytosolic sensors of pathogen-associated DNA	47	12
ZBP1(DAI) mediated induction of type I IFNs	14	2
IRF3 mediated activation of type 1 IFN	5	2
RIP-mediated NFkB activation via ZBP1	10	2
STING mediated induction of host immune responses	16	6
IRF3-mediated induction of type I IFN	13	4
STAT6-mediated induction of chemokines	3	2
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	3	2
Fcgamma receptor (FCGR) dependent phagocytosis	32	11
FCGR activation	5	2
Regulation of actin dynamics for phagocytic cup formation	25	5
Role of phospholipids in phagocytosis	4	9
DAP12 interactions	28	4
DAP12 signaling	10	4
Fc epsilon receptor (FCERI) signaling	90	13
FCERI mediated MAPK activation	17	4
FCERI mediated Ca+2 mobilization	4	9
FCERI mediated NF-kB activation	63	5
Role of LAT2/NTAL/LAB on calcium mobilization	7	2
C-type lectin receptors (CLRs)	88	17
CLEC7A (Dectin-1) signaling	77	12
Dectin-1 mediated noncanonical NF-kB signaling	54	2
Dectin-2 family	9	3
CD209 (DC-SIGN) signaling	7	7
Antimicrobial peptides	38	18
Ion influx/efflux at host-pathogen interface	4	6
UMP biosynthesis II	0	20
Cytokine Signaling in Immune system	495	11
Interferon Signaling	141	7
Interferon alpha/beta signaling	38	4
Interferon gamma signaling	22	4
Antiviral mechanism by IFN-stimulated genes	90	6
ISG15 antiviral mechanism	40	3
OAS antiviral response	10	5
Signaling by Interleukins	294	4
Interleukin-1 family signaling	109	3
Interleukin-1 signaling	88	3
Interleukin-37 signaling	8	2
Interleukin-38 signaling	4	2
Interleukin-2 family signaling	27	2
Interleukin-2 signaling	9	2
Interleukin-9 signaling	7	2
Interleukin-15 signaling	10	2
Interleukin-21 signaling	5	2
Interleukin receptor SHC signaling	7	2
Interleukin-3, Interleukin-5 and GM-CSF signaling	24	2
Regulation of signaling by CBL	8	2
Interleukin-4 and Interleukin-13 signaling	21	2
Interleukin-6 family signaling	24	2
Interleukin-6 signaling	10	2
Interleukin-7 signaling	13	2
Interleukin-10 signaling	7	2
Interleukin-12 family signaling	56	2
Interleukin-12 signaling	45	2
Interleukin-23 signaling	9	2
Interleukin-27 signaling	9	2
Interleukin-35 Signalling	11	2
Interleukin-17 signaling	36	4
Interleukin-20 family signaling	17	2
Growth hormone receptor signaling	7	4
Prolactin receptor signaling	8	2
TNFR2 non-canonical NF-kB pathway	87	2
NIK-->noncanonical NF-kB signaling	53	2
Metabolism of RNA	637	40
Processing of Capped Intron-Containing Pre-mRNA	233	4
mRNA Splicing	165	4
pre-mRNA splicing	152	4
mRNA 3'-end processing	46	1
Regulation of mRNA stability by proteins that bind AU-rich elements	82	3
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	2
KSRP (KHSRP) binds and destabilizes mRNA	15	3
HuR (ELAVL1) binds and stabilizes mRNA	8	2
Nonsense-Mediated Decay (NMD)	20	3
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	20	3
rRNA processing	186	10
rRNA processing in the nucleus and cytosol	176	8
rRNA modification in the nucleus and cytosol	58	8
tRNA processing	107	29
tRNA processing in the nucleus	56	7
tRNA modification in the nucleus and cytosol	43	25
tRNA processing in the mitochondrion	5	3
Calvin-Benson-Bassham cycle	13	21
wax esters biosynthesis II	1	9
choline biosynthesis I	2	21
superpathway of lipid-dependent phytate biosynthesis	6	12
UMP biosynthesis I	3	19
urea degradation I	0	10
phosphatidylcholine biosynthesis I	0	10
glycolysis IV (plant cytosol)	13	47
C4 photosynthetic carbon assimilation cycle, NAD-ME type	3	21
superpathway of L-citrulline metabolism	6	29
phosphatidate metabolism, as a signaling molecule	11	14
TCA cycle II (plants and fungi)	14	19
superpathway of 1D-myo-inositol hexakisphosphate biosynthesis (plants)	6	10
1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)	6	8
acetate and ATP formation from acetyl-CoA II	0	6
UDP-u03B1-D-glucuronate biosynthesis (from myo-inositol)	4	15
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis	10	34
superpathway of adenosine nucleotides de novo biosynthesis I	6	14
indole-3-acetate inactivation VIII	6	14
isoprene biosynthesis II (engineered)	0	19
C4 photosynthetic carbon assimilation cycle, PEPCK type	1	19
naringenin biosynthesis (engineered)	3	14
trans-zeatin biosynthesis	7	18
L-proline biosynthesis III	1	15
UTP and CTP dephosphorylation I	1	13
adlupulone and adhumulone biosynthesis	4	16
UDP-u03B1-D-galacturonate biosynthesis II (from D-galacturonate)	2	9
flavonoid di-C-glucosylation	0	22
fructose 2,6-bisphosphate biosynthesis	0	7
superpathway of pyrimidine ribonucleotides de novo biosynthesis	6	22
1,4-dihydroxy-2-naphthoate biosynthesis II (plants)	5	20
phosphatidate metabolism, as a signaling molecule (Chlamydomonas)	0	9
glycerol degradation I	1	7
L-histidine biosynthesis	4	27
D-galactose degradation I (Leloir pathway)	3	11
u03B3-glutamyl cycle	6	14
phosphopantothenate biosynthesis II	0	11
D-sorbitol biosynthesis I	1	15
superpathway of thiamine diphosphate biosynthesis III (eukaryotes)	3	24
cutin biosynthesis	4	20
simplecoumarins biosynthesis	6	20
L-lysine biosynthesis VI	8	21
L-asparagine biosynthesis I	0	9
superpathway of choline biosynthesis	11	22
tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)	0	21
methyl ketone biosynthesis (engineered)	0	18
lipid IVA biosynthesis	1	14
superpathway of purine nucleotides de novo biosynthesis I	12	32
superpathway of tetrahydroxyxanthone biosynthesis	0	26
indole-3-acetate inactivation III	0	9
indole-3-acetate inactivation II	0	8
superpathway of seleno-compound metabolism	3	39
caffeoylglucarate biosynthesis	2	10
superpathway of pyrimidine deoxyribonucleoside salvage	6	19
glutathione biosynthesis	2	9
u03B2-alanine biosynthesis II	0	17
PRPP biosynthesis	4	5
ethanol degradation II	4	13
L-methionine degradation I (to L-homocysteine)	2	11
salicortin biosynthesis	0	17
L-arginine biosynthesis I (via L-ornithine)	2	27
superpathway of phylloquinol biosynthesis	17	31
ammonia assimilation cycle I	2	13
L-methionine salvage cycle II (plants)	8	29
phosphopantothenate biosynthesis I	3	15
superpathway of coenzyme A biosynthesis II (plants)	6	32
guanine and guanosine salvage III	0	10
lupulone and humulone biosynthesis	4	16
inosine-5'-phosphate biosynthesis II	1	15
purine deoxyribonucleosides salvage	4	11
L-selenocysteine biosynthesis II (archaea and eukaryotes)	0	10
superpathway of sucrose and starch metabolism I (non-photosynthetic tissue)	19	17
suberin monomers biosynthesis	10	36
pyrimidine ribonucleosides salvage I	2	9
L-arginine biosynthesis II (acetyl cycle)	2	26
L-methionine salvage cycle I (bacteria and plants)	2	32
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde	0	14
mannitol degradation II	1	13
trehalose degradation II (cytosolic)	6	8
curcuminoid biosynthesis	4	19
purine nucleosides salvage II (plant)	4	19
rosmarinic acid biosynthesis I	1	30
hyperxanthone E biosynthesis	1	24
folate transformations II	7	21
L-citrulline biosynthesis	6	21
cannabinoid biosynthesis	1	22
L-methionine biosynthesis II (plants)	3	17
C4 photosynthetic carbon assimilation cycle, NADP-ME type	0	14
folate polyglutamylation	5	9
acetyl-CoA biosynthesis III (from citrate)	0	7
1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)	0	8
adenosylcobalamin salvage from cobalamin	0	4
selenate reduction	1	15
D-myo-inositol (1,3,4)-trisphosphate biosynthesis	1	8
benzoate biosynthesis I (CoA-dependent, u03B2-oxidative)	1	19
acetate and ATP formation from acetyl-CoA I	2	7
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle	28	56
UDP-u03B2-L-arabinose biosynthesis II (from u03B2-L-arabinose)	3	11
L-asparagine biosynthesis III (tRNA-dependent)	1	11
stachyose degradation	5	14
guanosine ribonucleotides de novo biosynthesis	2	15
UTP and CTP dephosphorylation II	1	11
pyridoxal 5'-phosphate salvage II (plants)	3	19
mevalonate pathway I	8	17
ppGpp biosynthesis	0	11
S-adenosyl-L-methionine cycle II	4	27
alkane biosynthesis II	1	16
UDP-N-acetyl-D-glucosamine biosynthesis II	9	16
adenosine deoxyribonucleotides de novo biosynthesis	3	5
CMP phosphorylation	0	5
glycolysis I (from glucose 6-phosphate)	12	20
superpathway of acetyl-CoA biosynthesis	1	12
superpathway of bitter acids biosynthesis	5	25
GDP-glucose biosynthesis	0	9
superpathway of L-lysine, L-threonine and L-methionine biosynthesis II	11	33
L-leucine degradation I	7	20
copper transport II	4	6
ethanol degradation IV	0	13
glutathione-mediated detoxification II	8	16
1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)	7	11
pyrimidine deoxyribonucleosides salvage	6	15
pyrimidine ribonucleotides interconversion	4	16
L-arginine degradation V (arginine deiminase pathway)	0	12
thiamine diphosphate biosynthesis IV (eukaryotes)	2	11
superpathay of heme b biosynthesis from glutamate	11	28
flavin biosynthesis I (bacteria and plants)	5	21
2'-deoxymugineic acid phytosiderophore biosynthesis	11	15
adenosine nucleotides degradation I	3	27
D-galactose detoxification	6	17
chorismate biosynthesis from 3-dehydroquinate	0	14
5-aminoimidazole ribonucleotide biosynthesis I	4	16
L-glutamine biosynthesis I	2	7
L-homoserine biosynthesis	2	11
protein NEDDylation	0	4
phosphatidylcholine acyl editing	0	11
coenzyme A biosynthesis I (prokaryotic)	2	13
phosphatidylethanolamine biosynthesis II	5	15
formate assimilation into 5,10-methylenetetrahydrofolate	1	9
superpathway of indole-3-acetate conjugate biosynthesis	8	28
superpathway of pyrimidine ribonucleosides salvage	7	20
adenine and adenosine salvage VI	0	5
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)	0	27
biotin-carboxyl carrier protein assembly	1	10
jasmonoyl-amino acid conjugates biosynthesis II	0	10
sucrose degradation III (sucrose invertase)	9	10
calmodulin regulated calcium transport	1	6
GDP-L-fucose biosynthesis II (from L-fucose)	0	8
tetrahydroxyxanthone biosynthesis (from benzoate)	0	22
nitric oxide biosynthesis II (mammals)	0	14
lysine degradation III	2	22
saponin biosynthesis II	0	13
long-chain fatty acid activation	10	6
ornithine-citrulline shuttle	2	12
NAD biosynthesis III (from nicotinamide)	0	7
adenosine ribonucleotides de novo biosynthesis	3	11
superpathway of phospholipid biosynthesis II (plants)	17	31
coumarins biosynthesis (engineered)	6	28
TCA cycle variation V (plant)	14	22
L-threonine biosynthesis	0	8
xanthohumol biosynthesis	2	16
glutaminyl-tRNAgln biosynthesis via transamidation	1	10
indole-3-acetate inactivation V	6	7
starch biosynthesis	14	21
u03B3-glutamyl cycle (plant pathway)	3	12
tetrapyrrole biosynthesis I (from glutamate)	5	19
superpathway of purines degradation in plants	7	45
molybdenum cofactor biosynthesis	6	18
photorespiration	8	23
phenylpropanoid biosynthesis	16	28
4-hydroxybenzoate biosynthesis III (plants)	1	15
pyridoxal 5'-phosphate salvage I	1	14
S-adenosyl-L-methionine biosynthesis	1	6
superpathway of guanosine nucleotides de novo biosynthesis I	4	6
6-gingerol analog biosynthesis (engineered)	2	20
3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent)	12	21
sucrose biosynthesis II	15	18
pyruvate fermentation to (S)-lactate	0	13
superpathway of rosmarinic acid biosynthesis	1	40
UTP and CTP de novo biosynthesis	3	11
pyrimidine deoxyribonucleotides de novo biosynthesis II	0	17
NAD de novo biosynthesis I (from aspartate)	5	22
NAD de novo biosynthesis II (from tryptophan)	0	24
hydroxymethylpyrimidine salvage	1	6
superpathway of pyrimidine nucleobases salvage	5	14
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)	20	21
fatty acid biosynthesis (plant mitochondria)	2	8
sphingolipid biosynthesis (plants)	12	23
sucrose biosynthesis I (from photosynthesis)	11	24
indole-3-acetate inactivation VII	0	8
L-citrulline degradation	1	10
superpathway of jasmonoyl-amino acid conjugates biosynthesis	0	12
folate polyglutamylation II	2	6
cinnamoyl-CoA biosynthesis	0	8
homogalacturonan biosynthesis	0	15
superpathway of tetrahydrofolate biosynthesis	10	29
L-Nu03B4-acetylornithine biosynthesis	5	20
3-amino-3-phenylpropanoyl-CoA biosynthesis	1	7
urea cycle	2	17
D-myo-inositol (1,4,5)-trisphosphate biosynthesis	2	7
superpathway of pantothenate and coenzymeA biosynthesis	5	23
tetrahydrofolate biosynthesis	3	13
sulfate activation for sulfonation	3	7
2-carboxy-1,4-naphthoquinol biosynthesis	5	20
IAA biosynthesis VII	2	8
pyruvate fermentation to acetate IV	2	9
glycolysis II (from fructose 6-phosphate)	13	20
S-methyl-5'-thioadenosine degradation I	2	14
UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)	0	18
copper transport I	1	6
superpathway of L-isoleucine biosynthesis I	4	26
ceramide degradation	3	9
pyridine nucleotide cycling (plants)	3	22
L-ornithine biosynthesis I	1	17
cadmium transport I	1	6
pyrimidine deoxyribonucleotides de novo biosynthesis I	5	20
sporopollenin precursors biosynthesis	4	26
tetrahydrofolate biosynthesis II	12	32
D-myo-inositol-5-phosphate metabolism	3	6
chorismate biosynthesis I	4	18
gluconeogenesis I	0	24
jasmonoyl-amino acid conjugates biosynthesis I	1	11
superpathway of L-threonine biosynthesis	2	17
ethylene biosynthesis I (plants)	4	15
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I	4	17
indole-3-acetate inactivation IV	6	9
NAD/NADH phosphorylation and dephosphorylation	29	14
superpathway of glyoxylate cycle and fatty acid degradation	25	29
lipid-dependent phytate biosynthesis I (via Ins(1,4,5)P3)	2	8
phaselate biosynthesis	3	14
D-sorbitol degradation I	1	12
Rubisco shunt	6	32
purine nucleotides degradation I (plants)	3	34
superpathway of anaerobic sucrose degradation	33	60
flavonoid biosynthesis	8	19
guanosine deoxyribonucleotides de novo biosynthesis I	4	6
homoglutathione biosynthesis	2	9
starch degradation II	6	10
jasmonic acid biosynthesis	6	21
benzoate biosynthesis III (CoA-dependent, non-u03B2-oxidative)	0	16
fatty acid u03B2-oxidation II (peroxisome)	7	17
lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3)	6	9
colupulone and cohumulone biosynthesis	4	15
4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis	2	11
coenzyme A biosynthesis II (eukaryotic)	2	12
canavanine biosynthesis	0	14
pyrimidine deoxyribonucleotide phosphorylation	2	8
acridone alkaloid biosynthesis	4	17
umbelliferone biosynthesis	1	13
sucrose degradation II (sucrose synthase)	17	22
indole-3-acetate inactivation VI	0	7
tetrahydrofolate biosynthesis I	0	13
Stat5 Activation	1	2
Autophagy	61	7
Selective autophagy	36	4
Lipophagy	2	3
Response of EIF2AK4 (GCN2) to amino acid deficiency	13	2
Response of EIF2AK1 (HRI) to heme deficiency	14	3
Aspartate and asparagine metabolism	7	20
Glutamate and glutamine metabolism	11	27
ALPK1 signaling pathway	5	3
FLT3 Signaling	26	7
Signaling by ERBB2 in Cancer	16	10
Constitutive Signaling by Overexpressed ERBB2	8	4
Signaling by ERBB2 KD Mutants	13	4
Signaling downstream of RAS mutants	11	3
Diseases of programmed cell death	36	11
EML4 and NUDC in mitotic spindle formation	39	2
Sphingolipid metabolism (integrated pathway)	11	67
Major receptors targeted by epinephrine and norepinephrine	18	6
22q11.2 copy number variation syndrome	2	28
Sphingolipid metabolism overview	4	15
Sphingolipid metabolism: integrated pathway	1	63
Purine metabolism	13	36
nitrate reduction II (assimilatory)	2	15
superpathway of fermentation (Chlamydomonas reinhardtii)	7	17
Inorganic Nitrogen Assimilation	4	14
assimilatory sulfate reduction II	2	11
superpathway of ergosterol biosynthesis II	1	33
ammonia assimilation cycle II	3	8
superpathway of ammonia assimilation (plants)	3	13
taxadiene biosynthesis (engineered)	1	24
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP)	19	23
pyruvate fermentation to acetate VII	0	10
Organic Nitrogen Assimilation	4	36
L-ornithine biosynthesis II	2	15
oxalate degradation VI	2	14
L-glutamine biosynthesis III	7	25
ophthalmate biosynthesis	0	10
methylerythritol phosphate pathway I	0	20
glutamate-glutamine shuttle	2	8
methylerythritol phosphate pathway II	8	20
isoprene biosynthesis I	1	22
reductive TCA cycle I	0	25
oxygenic photosynthesis	0	22
NAD salvage pathway V (PNC V cycle)	0	17
thiamine diphosphate salvage IV (yeast)	0	15
3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)	0	23
Sealing of the nuclear envelope (NE) by ESCRT-III	13	7
Nervous system development	337	13
Signaling by ERBB2 ECD mutants	12	4
Signaling by ERBB2 TMD/JMD mutants	12	4
Signaling by PDGFR in disease	11	6
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	2	4
Signaling by PDGFRA extracellular domain mutants	3	4
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	3	2
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	5	2
Leishmania infection	66	26
Parasite infection	23	5
Leishmania phagocytosis	23	5
FCGR3A-mediated phagocytosis	23	5
Killing mechanisms	9	8
WNT5:FZD7-mediated leishmania damping	9	8
Cell recruitment (pro-inflammatory response)	18	7
Purinergic signaling in leishmaniasis infection	18	7
Leishmania parasite growth and survival	20	18
Anti-inflammatory response favouring Leishmania parasite infection	20	18
CD163 mediating an anti-inflammatory response	5	3
FCGR3A-mediated IL10 synthesis	7	9
ADORA2B mediated anti-inflammatory cytokines production	4	8
Diseases of the neuronal system	7	10
Disorders of Developmental Biology	2	1
NGF-stimulated transcription	24	2
HMOX1 pathway (COVID-19 Disease Map)	36	30
Signaling by RAF1 mutants	2	3
Signaling by MAP2K mutants	2	2
Signaling by KIT in disease	5	7
Signaling by kinase domain mutants of KIT	0	2
Signaling by juxtamembrane domain KIT mutants	1	2
Signaling by extracellular domain mutants of KIT	1	2
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	4	4
SARS-CoV Infections	282	29
SARS-CoV-1 Infection	114	22
SARS-CoV-1 Genome Replication and Transcription	6	8
Replication of the SARS-CoV-1 genome	5	8
Transcription of SARS-CoV-1 sgRNAs	2	7
Translation of Structural Proteins	11	14
Maturation of nucleoprotein	4	5
Potential therapeutics for SARS	59	2
RAS processing	13	18
SARS-CoV-1 Infection	60	19
SARS-CoV-2 Infection	77	20
Phosphoinositides metabolism	49	6
Negative regulation of FLT3	11	5
FLT3 signaling in disease	19	13
Signaling by FLT3 ITD and TKD mutants	10	9
STAT5 activation downstream of FLT3 ITD mutants	7	7
Signaling by FLT3 fusion proteins	14	9
SARS-CoV-2 Infection	195	27
SARS-CoV-2 Genome Replication and Transcription	7	10
Replication of the SARS-CoV-2 genome	5	9
Transcription of SARS-CoV-2 sgRNAs	3	8
Disorders of Nervous System Development	2	1
RHOBTB3 ATPase cycle	1	4
Cellular response to chemical stress	167	40
Cytoprotection by HMOX1	34	19
ROS sensing by NFE2L2	51	2
Regulation of BACH1 activity	7	2
Cellular response to starvation	35	8
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	185	20
RHO GTPase cycle	28	6
RHOU GTPase cycle	2	4
Sensory Perception	215	68
Sensory processing of sound	36	7
Sensory processing of sound by inner hair cells of the cochlea	30	6
Sensory processing of sound by outer hair cells of the cochlea	17	6
Signaling by CSF3 (G-CSF)	21	3
Kallmann syndrome	4	7
7q11.23 copy number variation syndrome	2	13
Complement system in neuronal development and plasticity	0	6
Signaling by ALK in cancer	71	4
Signaling by ALK fusions and activated point mutants	71	2
Nuclear events stimulated by ALK signaling in cancer	27	2
Signaling by ALK	19	7
Sensory perception of taste	40	12
Sensory perception of sweet, bitter, and umami (glutamate) taste	36	10
Sensory perception of salty taste	4	2
Defective Intrinsic Pathway for Apoptosis	21	4
GPR143 in melanocytes and retinal pigment epithelium cells	7	13
Pentose phosphate pathway in senescent cells	5	10
Drug ADME	63	87
Azathioprine ADME	16	26
Aspirin ADME	8	22
APAP ADME	17	30
GPER1 signaling	5	7
Biosynthesis and turnover of 1-deoxy-sphingoid bases	0	13
Creatine pathway	1	16
Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution	7	5
Early SARS-CoV-2 Infection Events	28	11
Late SARS-CoV-2 Infection Events	34	18
SARS-CoV-2-host interactions	155	9
SARS-CoV-2 activates/modulates innate and adaptive immune responses	85	8
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	3
KEAP1-NFE2L2 pathway	112	12
Nuclear events mediated by NFE2L2	89	12
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	47	2
Uptake of dietary cobalamins into enterocytes	6	4
Transport of RCbl within the body	8	4
Cobalamin (Cbl) metabolism	7	22
Hippocampal synaptogenesis and neurogenesis	1	6
Ribavirin ADME	9	16
Prednisone ADME	7	10
SARS-CoV-1 activates/modulates innate immune responses	41	4
Translation of Accessory Proteins	4	2
Transcriptional Regulation by NPAS4	24	4
NPAS4 regulates expression of target genes	19	2
NADP biosynthesis	0	5
NADPH repair (eukaryotes)	0	8
ATP biosynthesis	0	5
D-mannose degradation II	0	6
avenanthramide biosynthesis	0	21
N6-L-threonylcarbamoyladenosine37-modified tRNA biosynthesis	0	8
pyrimidine deoxyribonucleotides biosynthesis from CTP	0	16
propanoyl CoA degradation I	0	9
glycogen biosynthesis I (from ADP-D-Glucose)	0	9
superpathway of heme b biosynthesis from glutamate	0	22
glycolysis III (from glucose)	0	18
homolactic fermentation	0	19
NFE2L2 regulating anti-oxidant/detoxification enzymes	16	7
Ciprofloxacin ADME	5	13
Signaling by CSF1 (M-CSF) in myeloid cells	24	6
Carnosine metabolism of glial cells	0	9
Lactate shuttle in glial cells	18	18
Bacterial Infection Pathways	123	47
Viral Infection Pathways	727	39
Parasitic Infection Pathways	66	26
Cardiomyocyte signaling pathways converging on Titin	0	6
8p23.1 copy number variation syndrome	0	13
Disturbed pathways in Duchenne Muscular Dystrophy	2	11
G1 phase	2	2
G1/S transition	32	2
Assembly of pre-replication complex	13	2
S phase	34	10
Synthesis of DNA	34	10
DNA strand Elongation	13	2
Metabolic Epileptic Disorders	25	89
10q22q23 copy number variation	0	14
15q25 copy number variation	0	8
IFNG signaling activates MAPKs	4	2
PKR-mediated signaling	43	4
Glycosphingolipid biosynthesis	13	16
Mitochondrial RNA degradation	10	4
Maternal to zygotic transition (MZT)	60	17
Replacement of protamines by nucleosomes in the male pronucleus	10	6
Respiratory Syncytial Virus Infection Pathway	89	15
Respiratory syncytial virus (RSV) genome replication, transcription and translation	25	13
Respiratory syncytial virus genome transcription	3	8
Maturation of hRSV A proteins	22	8
RSV-host interactions	69	4
Mitochondrial protein degradation	12	5
Cellular response to mitochondrial stress	9	3
Mitochondrial Protein Import (yeast)	33	3
sucrose degradation	7	11
gluconeogenesis	24	25
5-aminoimidazole ribonucleotide biosynthesis	3	16
NAD salvage	4	7
NAD de novo biosynthesis	12	33
superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle	47	37
glutamine biosynthesis	1	8
L-glutamine tRNA biosynthesis	2	9
diphthamide biosynthesis	1	11
fructose 2,6-bisphosphate synthesis	5	7
acetyl-CoA biosynthesis from citrate	1	7
mevalonate pathway	10	25
glycerol degradation	4	6
selenocysteine biosynthesis	6	10
methionine salvage cycle III	10	28
stearate biosynthesis	13	17
sorbitol degradation I	1	9
2-oxobutanoate degradation	8	14
guanosine deoxyribonucleotides de novo biosynthesis	11	6
fatty acid activation	8	4
4-hydroxybenzoate biosynthesis	1	19
oxidative ethanol degradation III	7	15
leucine degradation	12	21
inosine-5'-phosphate biosynthesis	3	15
guanosine nucleotides de novo biosynthesis	15	18
purine nucleotides de novo biosynthesis	30	37
GDP-glucose biosynthesis II	7	11
flavin biosynthesis	2	7
coenzyme A biosynthesis	6	13
proline biosynthesis	3	12
BMP Signalling Pathway	5	2
lipoate salvage	1	6
thiamin salvage III	1	5
superpathway of tryptophan utilization	42	92
pyrimidine deoxyribonucleotides de novo biosynthesis	15	18
protein neddylation	6	4
ornithine de novo biosynthesis	3	14
glycolysis	25	19
arachidonate biosynthesis III (metazoa)	16	19
TCA cycle	17	24
propionyl-CoA degradation	4	9
inositol pyrophosphates biosynthesis	7	11
asparagine biosynthesis	1	9
trehalose degradation	5	9
cysteine biosynthesis	5	19
pyridoxal 5'-phosphate salvage	2	13
superpathway of methionine degradation	19	45
methionine degradation	4	10
icosapentaenoate biosynthesis II (metazoa)	13	17
fatty acid u03B1-oxidation	4	17
fatty acid u03B2-oxidation	16	9
fatty acid u03B2-oxidation (peroxisome)	15	12
UMP biosynthesis	3	20
phosphatidylcholine biosynthesis	6	11
u03B3-linolenate biosynthesis	14	10
NAD biosynthesis III (from nicotinamide)	3	10
sulfoquinovose degradation I	4	10
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)	5	13
NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)	5	26
superpathway NAD/NADP - NADH/NADPH interconversion (yeast)	10	31
pyridine nucleotide cycling (plants)	0	22
NAD/NADH phosphorylation and dephosphorylation	29	19
dissimilatory sulfate reduction I (to hydrogen sufide))	8	14
NAD phosphorylation and transhydrogenation	5	10
NAD phosphorylation and dephosphorylation	3	12
phytol degradation	2	15
(S)-propane-1,2-diol degradation	6	18
pyrimidine ribonucleosides degradation	5	13
superpathway of glycol metabolism and degradation	10	35
1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)	3	8
chitin biosynthesis	16	40
1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)	2	8
homogalacturonan biosynthesis	0	14
L-homoserine biosynthesis	6	27
superpathway of 1D-myo-inositol hexakisphosphate biosynthesis (plants)	3	10
superpathway of seleno-compound metabolism	7	44
superpathway of 5-aminoimidazole ribonucleotide biosynthesis	6	36
L-homomethionine biosynthesis	4	20
5-aminoimidazole ribonucleotide biosynthesis I	12	38
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)	15	15
5-aminoimidazole ribonucleotide biosynthesis II	6	32
PRPP biosynthesis	4	9
D-cycloserine biosynthesis	6	23
1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)	1	11
1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)	2	11
3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent)	19	24
UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)	9	26
allantoin degradation IV (anaerobic)	4	22
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)	17	38
superpathway of allantoin degradation in yeast	4	15
UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)	2	22
ammonia assimilation cycle I	4	14
ammonia assimilation cycle III	4	33
ammonia assimilation cycle II	6	8
cytidine-5'-diphosphate-glycerol biosynthesis	3	15
L-glutamine biosynthesis I	7	25
superpathway of ammonia assimilation (plants)	2	14
vancomycin resistance II	7	13
protein Pupylation and dePupylation	2	6
urea cycle	6	33
vancomycin resistance I	5	14
superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis	22	57
protein SAMPylation and SAMP-mediated thiolation	3	7
peptidoglycan biosynthesis V (u03B2-lactam resistance)	1	38
peptidoglycan biosynthesis IV (Enterococcus faecium)	3	36
pyruvate fermentation to propanoate II (acrylate pathway)	7	20
acetyl-CoA biosynthesis III (from citrate)	3	7
superpathway of acetyl-CoA biosynthesis	2	12
L-glutamate degradation VII (to butanoate)	10	36
N-acetylglucosamine degradation II	7	13
acetyl-CoA fermentation to butanoate II	5	18
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle	24	59
methyl ketone biosynthesis (engineered)	4	13
glyoxylate cycle	13	36
isopropanol biosynthesis (engineered)	5	28
nitrate reduction VI (assimilatory)	5	18
formaldehyde oxidation I	1	24
ethylmalonyl-CoA pathway	12	28
nitrate reduction II (assimilatory)	4	15
rosmarinic acid biosynthesis I	3	34
superpathway of glyoxylate cycle and fatty acid degradation	26	25
nitrate reduction V (assimilatory)	4	26
superpathway of thiosulfate metabolism (Desulfovibrio sulfodismutans)	0	10
NADH repair	3	10
ADP-L-glycero-u03B2-D-manno-heptose biosynthesis	4	16
N-acetylneuraminate and N-acetylmannosamine degradation II	2	4
superpathway of glycolysis and the Entner-Doudoroff pathway	23	58
N-acetylneuraminate and N-acetylmannosamine degradation I	4	16
Rubisco shunt	8	32
chitin degradation to ethanol	13	17
cis-alkene biosynthesis	4	10
anthranilate degradation II (aerobic)	3	11
1,5-anhydrofructose degradation	1	11
Kdo transfer to lipid IVA II	1	9
Calvin-Benson-Bassham cycle	13	24
hentriaconta-3,6,9,12,15,19,22,25,28-nonaene biosynthesis	4	14
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass	39	89
Kdo8N transfer to lipid IVA	1	8
long chain fatty acid ester synthesis (engineered)	2	12
superpathay of heme b biosynthesis from glutamate	20	47
methylaspartate cycle	10	35
sedoheptulose bisphosphate bypass	2	7
anthranilate degradation III (anaerobic)	2	8
phosphopantothenate biosynthesis I	13	29
pyruvate fermentation to acetate and lactate I	7	13
phosphopantothenate biosynthesis II	0	12
pyruvate fermentation to acetate VI	3	14
phosphopantothenate biosynthesis III (archaebacteria)	2	16
pyruvate fermentation to acetate III	2	9
anhydromuropeptides recycling II	8	19
anhydromuropeptides recycling I	13	48
pyruvate fermentation to acetate and alanine	3	12
L-lysine biosynthesis V	14	24
salicortin biosynthesis	0	20
peptidoglycan cross-bridge biosynthesis II (E. faecium)	2	11
L-lysine biosynthesis IV	3	23
pyruvate fermentation to acetate VII	2	10
L-lysine biosynthesis VI	8	23
L-lysine biosynthesis II	6	35
pyruvate fermentation to acetate IV	5	17
L-lysine biosynthesis III	4	20
L-lysine biosynthesis I	16	63
pyruvate fermentation to acetate and lactate II	6	25
(aminomethyl)phosphonate degradation	12	31
spermidine biosynthesis II	7	15
linoleate biosynthesis II (animals)	0	10
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)	7	38
pyruvate fermentation to acetate I	3	17
thiamine salvage IV (yeast)	4	17
plasmalogen biosynthesis	10	24
phosphatidate biosynthesis (yeast)	9	19
D-myo-inositol-5-phosphate metabolism	11	10
thiamine salvage III	2	5
pyruvate fermentation to acetate V	3	12
superpathway of inositol phosphate compounds	6	25
pyruvate fermentation to acetate II	6	11
phosphatidate metabolism, as a signaling molecule	11	17
3-phosphoinositide biosynthesis	29	19
thiamine salvage I	2	16
acetone degradation II (to acetoacetate)	3	16
sucrose biosynthesis II	9	18
sphingosine and sphingosine-1-phosphate metabolism	11	20
hydroxymethylpyrimidine salvage	6	7
sucrose biosynthesis III	1	15
ceramide degradation	3	5
3-amino-4,7-dihydroxy-coumarin biosynthesis	4	11
arachidonate biosynthesis III (6-desaturase, mammals)	5	19
glycerol degradation I	3	10
suberin monomers biosynthesis	13	42
umbelliferone biosynthesis	1	14
sporopollenin precursors biosynthesis	7	33
coumarins biosynthesis (engineered)	8	31
sphingolipid recycling and degradation (yeast)	8	20
cyanophycin metabolism	3	10
TCA cycle I (prokaryotic)	17	41
phenolphthiocerol biosynthesis	12	31
superpathway of choline biosynthesis	5	32
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)	7	17
superpathway of demethylmenaquinol-6 biosynthesis I	0	21
phosphatidylcholine acyl editing	1	6
8-amino-7-oxononanoate biosynthesis III	3	13
photosynthetic 3-hydroxybutanoate biosynthesis (engineered)	63	73
TCA cycle II (plants and fungi)	24	22
pyrimidine deoxyribonucleotides de novo biosynthesis II	10	30
pyrimidine deoxyribonucleotides de novo biosynthesis I	30	34
dimycocerosyl triglycosyl phenolphthiocerol biosynthesis	10	17
TCA cycle III (animals)	17	24
S-methyl-5'-thioadenosine degradation I	4	17
u03B2-D-mannosyl phosphomycoketide biosynthesis	1	12
superpathway of the 3-hydroxypropanoate cycle	16	34
3-hydroxypropanoate cycle	13	29
partial TCA cycle (obligate autotrophs)	0	26
Lipid A-core biosynthesis (E. coli K-12)	10	25
3-hydroxypropanoate/4-hydroxybutanate cycle	18	40
chitin derivatives degradation	3	21
L-arabinose degradation I	3	10
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria)	13	22
pyrimidine deoxyribonucleotides biosynthesis from CTP	14	17
biotin-carboxyl carrier protein assembly	6	15
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)	13	35
pyrimidine deoxyribonucleotide phosphorylation	15	15
CO2 fixation into oxaloacetate (anaplerotic)	4	15
dimycocerosyl phthiocerol biosynthesis	3	11
phthiocerol biosynthesis	13	20
cutin biosynthesis	6	25
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)	12	33
superpathway of L-phenylalanine biosynthesis	16	65
superpathway of dimethylsulfoniopropanoate degradation	6	16
formate assimilation into 5,10-methylenetetrahydrofolate	4	9
wax esters biosynthesis II	2	7
diphthamide biosynthesis II (eukaryotes)	6	13
pyrimidine deoxyribonucleotides de novo biosynthesis IV	2	16
superpathway of bitter acids biosynthesis	5	32
diphthamide biosynthesis I (archaea)	2	12
2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis	3	19
aerobic respiration III (alternative oxidase pathway)	39	15
aerobic respiration I (cytochrome c)	50	15
UMP biosynthesis II	7	24
pyrimidine deoxyribonucleotides de novo biosynthesis III	11	30
2-methylcitrate cycle II	3	15
UMP biosynthesis III	10	23
2-methylcitrate cycle I	12	19
methylthiolincosamide biosynthesis	5	19
propanoyl CoA degradation I	12	13
6-gingerol analog biosynthesis (engineered)	4	20
superpathway of rosmarinic acid biosynthesis	2	43
Entner-Doudoroff pathway II (non-phosphorylative)	4	25
phenylacetate degradation I (aerobic)	15	30
UMP biosynthesis I	12	34
phenylacetate degradation II (anaerobic)	0	15
D-galactarate degradation I	5	30
ethanol degradation II	4	16
superpathway of trimethylamine degradation	12	24
isopropylamine degradation	8	16
ethanol degradation III	4	15
superpathway of ornithine degradation	7	27
ethanol degradation IV	4	15
molybdenum cofactor biosynthesis	18	23
preQ0 biosynthesis	7	23
ethanolamine utilization	13	36
superpathway of L-lysine degradation	33	112
4-hydroxy-2(1H)-quinolone biosynthesis	5	15
superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation	9	24
superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation	18	55
dopamine degradation	4	31
pyruvate fermentation to acetone	5	29
L-lysine degradation V	1	33
superpathway of fermentation (Chlamydomonas reinhardtii)	9	17
benzoyl-CoA degradation III (anaerobic)	7	19
(-)-microperfuranone biosynthesis	0	7
3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)	9	34
3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)	8	23
benzoyl-CoA degradation II (anaerobic)	5	20
limonene degradation I (D-limonene)	3	26
superpathway of Clostridium acetobutylicum acidogenic fermentation	10	32
limonene degradation II (L-limonene)	3	25
2-amino-3-hydroxycyclopent-2-enone biosynthesis	2	14
assimilatory sulfate reduction I	10	24
superpathway of Clostridium acetobutylicum solventogenic fermentation	14	44
psilocybin biosynthesis	0	16
assimilatory sulfate reduction II	13	13
assimilatory sulfate reduction III	3	11
trans-caffeate degradation (aerobic)	3	11
pyruvate fermentation to butanoate	8	24
ferulate degradation	3	10
superpathway of sulfate assimilation and cysteine biosynthesis	12	41
grixazone biosynthesis	5	25
superpathway of quinolone and alkylquinolone biosynthesis	7	24
4-coumarate degradation (aerobic)	5	17
sulfoacetate degradation	2	11
shinorine biosynthesis	3	21
autoinducer AI-2 degradation	4	9
5-hydroxymethylfurfural degradation	8	21
3,3'-disulfanediyldipropannoate degradation	5	17
3-amino-5-hydroxybenzoate biosynthesis	3	24
tabtoxinine-u03B2-lactam biosynthesis	3	12
fructoselysine and psicoselysine degradation	3	13
gliotoxin biosynthesis	7	29
4-deoxy-L-threo-hex-4-enopyranuronate degradation	10	17
superpathway of microbial D-galacturonate and D-glucuronate degradation	35	92
L-glutamate and L-glutamine biosynthesis	14	42
adenosine nucleotides degradation I	2	27
pseudouridine degradation	2	9
2-oxobutanoate degradation I	10	28
purine nucleotides degradation I (plants)	2	34
purine nucleotides degradation II (aerobic)	22	46
adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II	2	12
inosine 5'-phosphate degradation	13	24
nucleoside and nucleotide degradation (archaea)	7	22
flavin biosynthesis IV (mammalian)	2	7
flavin biosynthesis I (bacteria and plants)	17	26
flavin biosynthesis II (archaea)	8	28
flavin biosynthesis III (fungi)	8	23
phosphatidylcholine biosynthesis I	8	16
furfural degradation	5	17
L-cysteine biosynthesis II (tRNA-dependent)	2	10
L-carnitine degradation III	7	24
tRNA charging	26	54
glutaminyl-tRNAgln biosynthesis via transamidation	9	10
L-carnitine degradation I	4	17
D-galactose detoxification	5	23
atromentin biosynthesis	3	8
glutathione-mediated detoxification II	15	17
superpathway of sulfur metabolism (Desulfocapsa sulfoexigens)	0	11
adenosine deoxyribonucleotides de novo biosynthesis	10	5
superpathway of adenosine nucleotides de novo biosynthesis I	24	24
trehalose degradation IV	0	23
superpathway of purine nucleotides de novo biosynthesis I	36	49
superpathway of guanosine nucleotides de novo biosynthesis I	24	36
trehalose degradation I (low osmolarity)	4	12
citronellol degradation	1	12
cis-genanyl-CoA degradation	4	21
trehalose degradation V	2	13
L-alanine degradation II (to D-lactate)	0	17
trehalose degradation II (cytosolic)	6	21
methylthiopropanoate degradation I (cleavage)	3	12
naphthalene degradation (anaerobic)	5	14
reductive TCA cycle I	3	27
UTP and CTP de novo biosynthesis	13	21
4-hydroxybenzoate biosynthesis III (plants)	1	16
incomplete reductive TCA cycle	6	18
4-chlorobenzoate degradation	4	16
acetate and ATP formation from acetyl-CoA I	12	23
L-alanine fermentation to propanoate and acetate	7	31
reductive TCA cycle II	10	24
u03B3-linolenate biosynthesis II (animals)	3	10
L-glutamate degradation V (via hydroxyglutarate)	7	26
acetate and ATP formation from acetyl-CoA II	2	6
L-lysine fermentation to acetate and butanoate	8	57
Bifidobacterium shunt	3	26
D-glucarate degradation I	5	31
hexitol fermentation to lactate, formate, ethanol and acetate	7	36
acetylene degradation	1	21
anaerobic energy metabolism (invertebrates, mitochondrial)	13	42
mixed acid fermentation	32	76
ferrichrome biosynthesis	1	17
ecdysteroid metabolism (arthropods)	8	14
long-chain fatty acid activation	8	4
alkane biosynthesis II	1	14
fumiquinazoline D biosynthesis	5	15
superpathway of anaerobic energy metabolism (invertebrates)	16	60
enterobactin biosynthesis	5	19
purine nucleobases degradation I (anaerobic)	2	40
sulfate activation for sulfonation	13	11
crotonate fermentation (to acetate and cyclohexane carboxylate)	3	27
purine nucleobases degradation II (anaerobic)	0	51
benzoate fermentation (to acetate and cyclohexane carboxylate)	3	30
pyoverdine I biosynthesis	7	23
anaerobic energy metabolism (invertebrates, cytosol)	3	29
acridone alkaloid biosynthesis	3	17
bisucaberin biosynthesis	3	15
6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)	4	14
6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)	1	10
5-N-acetylardeemin biosynthesis	0	14
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I	6	26
fumitremorgin C biosynthesis	5	18
4-oxopentanoate degradation	6	22
viridicatin biosynthesis	0	20
6-hydroxymethyl-dihydropterin diphosphate biosynthesis V (Pyrococcus)	1	13
desferrioxamine B biosynthesis	0	16
6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)	4	17
D-erythronate degradation I	1	10
phosphatidylethanolamine biosynthesis II	1	16
tetrahydrofolate biosynthesis	7	42
superpathway of acetate utilization and formation	4	15
superpathway of roquefortine, meleagrin and neoxaline biosynthesis	0	22
superpathway of tetrahydrofolate biosynthesis	19	65
roquefortine C biosynthesis	0	13
acinetoferrin biosynthesis	4	14
peramine biosynthesis	1	10
acetate conversion to acetyl-CoA	5	10
folate polyglutamylation	4	20
oleandomycin activation/inactivation	4	10
cyclohexane-1-carboxylate degradation (anaerobic)	2	9
superpathway of demethylmenaquinol-8 biosynthesis I	11	33
superpathway of tetrahydrofolate biosynthesis and salvage	13	70
asperlicin E biosynthesis	0	12
D-erythronate degradation II	4	11
N10-formyl-tetrahydrofolate biosynthesis	12	56
aniline degradation	5	16
D-gluconate degradation	2	5
ethylbenzene degradation (anaerobic)	11	24
4'-methoxyviridicatin biosynthesis	0	18
L-threonate degradation	4	11
peptidoglycan biosynthesis III (mycobacteria)	12	36
superpathway of N-acetylneuraminate degradation	39	79
rhizobactin 1021 biosynthesis	6	22
D-threonate degradation	1	10
superpathway of coenzyme A biosynthesis I (bacteria)	9	42
norspermidine biosynthesis	7	25
peptidoglycan biosynthesis I (meso-diaminopimelate containing)	11	42
creatine-phosphate biosynthesis	4	7
trypanothione biosynthesis	0	7
peptidoglycan biosynthesis II (staphylococci)	20	44
achromobactin biosynthesis	2	17
superpathway of polyamine biosynthesis III	7	28
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP)	26	39
glutathionylspermidine biosynthesis	1	9
ectoine biosynthesis	5	20
yersiniabactin biosynthesis	4	15
methanofuran biosynthesis	6	24
superpathway of arginine and polyamine biosynthesis	18	101
[2Fe-2S] iron-sulfur cluster biosynthesis	9	6
factor 430 biosynthesis	6	20
L-leucine degradation I	20	26
putrebactin biosynthesis	4	16
tetrahydromonapterin biosynthesis	3	22
superpathway of pyrimidine deoxyribonucleoside salvage	22	22
phenylpropanoid biosynthesis	12	29
taxadiene biosynthesis (engineered)	11	38
glycerol degradation to butanol	10	35
staphyloferrin A biosynthesis	3	9
malonate decarboxylase activation	2	6
superpathway of pyrimidine ribonucleosides salvage	22	37
pyruvate fermentation to butanol II (engineered)	6	15
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)	36	33
1,3-propanediol biosynthesis (engineered)	15	35
citrate lyase activation	4	12
phytol salvage pathway	1	9
1-butanol autotrophic biosynthesis (engineered)	49	38
pyrimidine ribonucleosides salvage I	6	13
tetrahydromethanopterin biosynthesis	9	38
pyruvate fermentation to butanol I	11	25
S-adenosyl-L-methionine biosynthesis	5	19
glucosylglycerol biosynthesis	4	14
polyacyltrehalose biosynthesis	3	14
vibriobactin biosynthesis	6	18
FeMo cofactor biosynthesis	6	14
inosine-5'-phosphate biosynthesis III	3	17
CMP phosphorylation	10	6
inosine-5'-phosphate biosynthesis I	5	18
pseudomonine biosynthesis	2	15
u03B3-glutamyl cycle	12	19
inosine-5'-phosphate biosynthesis II	8	18
coenzyme B biosynthesis	3	31
aurachin RE biosynthesis	6	18
guanosine ribonucleotides de novo biosynthesis	15	35
aurachin A, B, C and D biosynthesis	10	26
2'-deoxymugineic acid phytosiderophore biosynthesis	12	14
nickel cofactor biosynthesis	2	14
GDP-glucose biosynthesis	10	11
adenosine ribonucleotides de novo biosynthesis	6	17
actinomycin D biosynthesis	5	19
guanine and guanosine salvage III	1	15
blasticidin S biosynthesis	9	25
folate transformations II	5	21
superpathway of guanine and guanosine salvage	6	21
superpathway of purine nucleotide salvage	13	34
ferrichrome A biosynthesis	5	20
folate transformations I	22	41
GDP-L-fucose biosynthesis II (from L-fucose)	0	9
(5R)-carbapenem carboxylate biosynthesis	3	18
superpathway of pyrimidine nucleobases salvage	11	26
roseoflavin biosynthesis	1	19
prodigiosin biosynthesis	10	29
alginate degradation	2	14
aerobactin biosynthesis	4	17
GDP-D-glycero-u03B1-D-manno-heptose biosynthesis	4	12
pyrimidine deoxyribonucleosides salvage	15	17
L-phenylalanine degradation IV (mammalian, via side chain)	6	39
4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis (yeast)	7	29
L-threonine biosynthesis	4	17
cephamycin C biosynthesis	2	16
6-methylpretetramide biosynthesis	9	17
4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis	6	14
glycine degradation (Stickland reaction)	8	10
pyochelin biosynthesis	3	14
thiamine triphosphate metabolism	0	8
holomycin biosynthesis	8	19
superpathway of thiamine diphosphate biosynthesis III (eukaryotes)	12	25
alcaligin biosynthesis	4	16
superpathway of rifamycin B biosynthesis	13	54
thiamine formation from pyrithiamine and oxythiamine (yeast)	3	17
nocardicin A biosynthesis	6	19
ATP biosynthesis	40	15
staphyloferrin B biosynthesis	7	20
mycothiol biosynthesis	5	20
superpathway of L-methionine biosynthesis (transsulfuration)	9	59
thiocoraline biosynthesis	4	15
superpathway of polybrominated aromatic compound biosynthesis	8	31
desferrioxamine E biosynthesis	4	16
glutathione biosynthesis	6	17
pyoluteorin biosynthesis	4	17
L-methionine biosynthesis II (plants)	3	21
novobiocin biosynthesis	17	41
brominated pyrroles biosynthesis	4	14
superpathway of L-homoserine and L-methionine biosynthesis	6	49
validamycin biosynthesis	10	34
baumannoferrin biosynthesis	6	20
L-methionine biosynthesis IV (archaea)	4	16
fatty acid u03B2-oxidation II (peroxisome)	9	12
superpathway of candicidin biosynthesis	15	30
superpathway of L-methionine biosynthesis (by sulfhydrylation)	19	55
fatty acid u03B1-oxidation II	7	18
D-xylose degradation I	2	10
gentamicin biosynthesis	4	26
fatty acid u03B2-oxidation I	23	16
formaldehyde assimilation II (assimilatory RuMP Cycle)	0	23
formaldehyde assimilation III (dihydroxyacetone cycle)	4	22
fatty acid u03B2-oxidation (peroxisome, yeast)	4	13
formaldehyde assimilation I (serine pathway)	9	44
dapdiamides biosynthesis	8	31
starch degradation II	6	8
bacimethrin and bacimethrin pyrophosphate biosynthesis	4	14
fatty acid u03B1-oxidation III	3	12
mevalonate pathway III (archaea)	4	18
glycerol-3-phosphate shuttle	4	10
superpathway of penicillin, cephalosporin and cephamycin biosynthesis	11	69
mevalonate pathway I	24	31
mevalonate pathway II (archaea)	6	19
fatty acid u03B2-oxidation VI (peroxisome)	14	12
deacetylcephalosporin C biosynthesis	4	44
superpathway of tetracycline and oxytetracycline biosynthesis	15	30
L-pyrrolysine biosynthesis	3	13
streptomycin biosynthesis	4	52
erythritol degradation II	3	10
taurine biosynthesis II	2	19
phosalacine biosynthesis	20	49
erythritol degradation I	5	12
myo-, chiro- and scyllo-inositol degradation	9	21
gluconeogenesis III	24	25
D-sorbitol degradation I	5	12
gluconeogenesis I	28	62
superpathway of hexitol degradation (bacteria)	29	60
gluconeogenesis II (Methanobacterium thermoautotrophicum)	15	42
D-altritol and galactitol degradation	4	10
bacilysin biosynthesis	6	20
glycogen degradation II	12	15
myo-inositol degradation I	9	21
xylitol degradation	6	12
jadomycin biosynthesis	11	27
glycogen degradation I	8	50
ribitol degradation	1	14
D-arabitol degradation	0	8
D-threitol degradation	3	10
penicillin G and penicillin V biosynthesis	3	19
mannitol cycle	3	15
arginomycin biosynthesis	7	22
L-histidine biosynthesis	18	33
adenine and adenosine salvage VI	3	6
L-methionine salvage cycle I (bacteria and plants)	19	38
galactitol degradation	9	13
clavulanate biosynthesis	5	25
L-methionine salvage cycle III	10	29
L-threitol degradation	4	11
adenine and adenosine salvage V	4	17
L-methionine salvage cycle II (plants)	8	32
rhizocticin A and B biosynthesis	7	23
adenine and adenosine salvage II	4	15
UDP-N-acetyl-D-glucosamine biosynthesis II	23	33
lactose and galactose degradation I	5	21
phosphinothricin tripeptide biosynthesis	19	56
oxalate degradation VI	4	14
purine deoxyribonucleosides salvage	12	12
D-galactose degradation V (Leloir pathway)	8	13
D-galactose degradation I (Leloir pathway)	10	46
saframycin A biosynthesis	6	18
polymyxin A biosynthesis	3	10
rifamycin B biosynthesis	9	30
isopenicillin N biosynthesis	3	23
indolmycin biosynthesis	8	30
salicylate degradation IV	3	15
candicidin biosynthesis	10	21
puromycin biosynthesis	2	27
L-threonine degradation I	7	15
echinomycin and triostin A biosynthesis	6	18
L-arginine biosynthesis III (via N-acetyl-L-citrulline)	2	28
L-arginine biosynthesis I (via L-ornithine)	11	53
dehydrophos biosynthesis	10	25
L-arginine biosynthesis IV (archaebacteria)	6	20
L-arginine biosynthesis II (acetyl cycle)	1	37
nitric oxide biosynthesis II (mammals)	5	23
L-cysteine biosynthesis VI (from L-methionine)	5	18
L-cysteine biosynthesis V (mycobacteria)	2	10
superpathway of L-cysteine biosynthesis (mammalian)	9	28
glyphosate degradation III	7	18
jasmonic acid biosynthesis	7	34
superpathway of ergosterol biosynthesis II	1	35
superpathway of ergosterol biosynthesis I	21	56
Escherichia coli serotype O9a O-antigen biosynthesis	4	18
nitrogen fixation II (flavodoxin)	10	12
nitrogen fixation I (ferredoxin)	6	19
benzoate degradation II (aerobic and anaerobic)	4	7
superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)	10	43
guanosine deoxyribonucleotides de novo biosynthesis I	15	6
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I	19	94
superpathway of L-aspartate and L-asparagine biosynthesis	7	30
icosapentaenoate biosynthesis III (8-desaturase, mammals)	4	19
glycolate and glyoxylate degradation I	7	26
icosapentaenoate biosynthesis II (6-desaturase, mammals)	4	17
superpathway of cholesterol biosynthesis	21	78
superpathway of L-lysine, L-threonine and L-methionine biosynthesis II	8	35
superpathway of aromatic amino acid biosynthesis	21	84
L-asparagine biosynthesis III (tRNA-dependent)	4	10
L-asparagine biosynthesis II	2	9
tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)	0	23
Methanobacterium thermoautotrophicum biosynthetic metabolism	22	79
superpathway of L-asparagine biosynthesis	2	16
L-asparagine biosynthesis I	2	26
choline biosynthesis I	0	21
sulfite oxidation III	9	9
superpathway of u03B2-D-glucuronosides degradation	11	36
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)	14	44
superpathway of L-citrulline metabolism	18	52
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)	17	31
L-citrulline biosynthesis	7	36
superpathway of cholesterol degradation II (cholesterol dehydrogenase)	30	58
superpathway of cholesterol degradation I (cholesterol oxidase)	17	55
cholesterol degradation to androstenedione I (cholesterol oxidase)	19	31
cholesterol degradation to androstenedione II (cholesterol dehydrogenase)	13	34
colupulone and cohumulone biosynthesis	4	18
3-phenylpropanoate degradation	1	24
superpathway of phenylethylamine degradation	9	39
chorismate biosynthesis I	15	59
chorismate biosynthesis from 3-dehydroquinate	10	37
adlupulone and adhumulone biosynthesis	4	18
methylamine degradation II	9	17
chorismate biosynthesis II (archaea)	9	30
tRNA splicing I	7	12
cannabinoid biosynthesis	3	25
glyoxylate assimilation	11	31
tRNA-uridine 2-thiolation (thermophilic bacteria)	5	9
tRNA-uridine 2-thiolation (mammalian mitochondria)	5	12
lupulone and humulone biosynthesis	4	18
N-methylpyrrolidone degradation	4	15
N6-L-threonylcarbamoyladenosine37-modified tRNA biosynthesis	4	7
superpathway of CMP-sialic acids biosynthesis	14	60
glutathione-mediated detoxification I	10	18
CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis	4	19
tRNA-uridine 2-thiolation (yeast mitochondria)	4	11
sucrose degradation II (sucrose synthase)	13	20
homocarnosine biosynthesis	1	7
tRNA-uridine 2-thiolation (bacteria)	10	19
tRNA-uridine 2-thiolation (cytoplasmic)	9	10
sucrose degradation V (sucrose u03B1-glucosidase)	6	11
glycolysis II (from fructose 6-phosphate)	21	49
L-citrulline degradation	4	15
cell-surface glycoconjugate-linked phosphocholine biosynthesis	3	11
glycolysis I (from glucose 6-phosphate)	37	51
glycolysis V (Pyrococcus)	7	30
glycolysis IV (plant cytosol)	7	47
sucrose degradation IV (sucrose phosphorylase)	2	9
glycolysis III (from glucose)	37	25
L-ascorbate degradation II (bacterial, aerobic)	4	19
sucrose degradation VII (sucrose 3-dehydrogenase)	0	15
sucrose degradation III (sucrose invertase)	8	9
L-rhamnose degradation I	8	22
trans-zeatin biosynthesis	7	21
sucrose degradation I (sucrose phosphotransferase)	8	10
superpathway of bacteriochlorophyll a biosynthesis	22	70
L-ornithine biosynthesis I	6	34
pyruvate fermentation to lactate	4	20
L-Nu03B4-acetylornithine biosynthesis	6	20
bacteriochlorophyll b biosynthesis	6	20
L-ornithine biosynthesis II	7	17
bacteriochlorophyll a biosynthesis	11	24
siroheme amide biosynthesis	1	11
bile acids degradation	9	40
glycogen biosynthesis III (from u03B1-maltose 1-phosphate)	8	18
2-carboxy-1,4-naphthoquinol biosynthesis	21	29
glycogen biosynthesis I (from ADP-D-Glucose)	4	25
androstenedione degradation	34	39
sitosterol degradation to androstenedione	0	33
starch biosynthesis	12	20
superpathway of testosterone and androsterone degradation	11	36
superpathway of tetrahydroxyxanthone biosynthesis	0	28
superpathway of L-tyrosine biosynthesis	15	57
superpathway of menaquinol-11 biosynthesis	0	24
L-selenocysteine biosynthesis II (archaea and eukaryotes)	6	13
superpathway of L-threonine biosynthesis	7	41
superpathway of menaquinol-6 biosynthesis I	3	24
L-selenocysteine biosynthesis I (bacteria)	3	14
superpathway of menaquinol-8 biosynthesis I	10	36
superpathway of menaquinol-12 biosynthesis	0	24
stearate biosynthesis I (animals and fungi)	8	17
urea degradation I	1	11
toluene degradation VI (anaerobic)	18	38
superpathway of menaquinol-9 biosynthesis	1	24
superpathway of menaquinol-13 biosynthesis	0	24
superpathway of menaquinol-10 biosynthesis	0	24
UDP-N-acetyl-D-galactosamine biosynthesis II	7	24
thiamine salvage II	9	28
putrescine degradation II	4	15
superpathway of menaquinol-7 biosynthesis	9	25
L-arginine degradation V (arginine deiminase pathway)	6	19
methylphosphonate degradation I	7	17
methylphosphonate degradation II	1	16
L-arginine degradation (Stickland reaction)	12	54
superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation	12	42
UDP-yelosamine biosynthesis	2	14
superpathway of chorismate metabolism	56	186
sucrose biosynthesis I (from photosynthesis)	13	26
gallate degradation III (anaerobic)	1	30
superpathway of L-arginine and L-ornithine degradation	13	47
superpathway of D-glucarate and D-galactarate degradation	6	37
L-glutamate degradation IV	6	20
superpathway of pyrimidine ribonucleotides de novo biosynthesis	23	45
superpathway of sulfide oxidation (phototrophic sulfur bacteria)	16	9
superpathway of taurine degradation	6	37
Entner-Doudoroff pathway I	16	39
superpathway of fucose and rhamnose degradation	11	41
Entner-Doudoroff pathway III (semi-phosphorylative)	2	28
superpathway of coenzyme A biosynthesis II (plants)	5	32
coenzyme A biosynthesis I (prokaryotic)	3	15
coenzyme A biosynthesis II (eukaryotic)	10	12
superpathway of coenzyme A biosynthesis III (mammals)	6	13
jasmonoyl-amino acid conjugates biosynthesis I	0	9
jasmonoyl-amino acid conjugates biosynthesis II	1	8
methylerythritol phosphate pathway I	9	34
methylerythritol phosphate pathway II	10	27
isoprene biosynthesis II (engineered)	8	21
UDP-u03B1-D-galacturonate biosynthesis II (from D-galacturonate)	0	9
homolactic fermentation	34	23
heterolactic fermentation	7	37
L-proline biosynthesis I	5	17
lipoate salvage I	4	8
L-proline biosynthesis III	2	16
glycerol and glycerophosphodiester degradation	4	12
glycerol degradation II	3	18
lipoate biosynthesis and incorporation II	2	11
superpathway of glycerol degradation to 1,3-propanediol	8	26
lipoate salvage II	2	8
aspartate superpathway	25	122
superpathway of phylloquinol biosynthesis	16	36
thiamine diphosphate biosynthesis III (Staphylococcus)	0	12
pentose phosphate pathway	9	29
aminopropanol phosphate biosynthesis II	3	28
thiamine diphosphate biosynthesis IV (eukaryotes)	7	12
aminopropanol phosphate biosynthesis I	3	8
thiamine diphosphate biosynthesis II (Bacillus)	2	9
D-galacturonate degradation I	5	27
D-galacturonate degradation II	4	26
ketogluconate metabolism	7	12
thiamine diphosphate biosynthesis I (E. coli)	2	18
glucose degradation (oxidative)	7	18
pentose phosphate pathway (oxidative branch) I	8	11
D-fructuronate degradation	8	29
D-galactonate degradation	4	17
superpathway of S-adenosyl-L-methionine biosynthesis	9	61
L-idonate degradation	3	7
superpathway of hexuronide and hexuronate degradation	8	38
UTP and CTP dephosphorylation II	6	14
UDP-u03B1-D-glucuronate biosynthesis (from myo-inositol)	5	15
creatinine degradation II	3	27
UTP and CTP dephosphorylation I	3	14
(4S)-carveol and (4S)-dihydrocarveol degradation	2	31
(4R)-carveol and (4R)-dihydrocarveol degradation	2	31
superpathway of demethylmenaquinol-9 biosynthesis	4	21
pyridoxal 5'-phosphate salvage I	5	19
inositol diphosphates biosynthesis	7	11
D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis	2	9
D-myo-inositol (1,4,5)-trisphosphate biosynthesis	16	21
D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis	3	9
superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism	20	15
superpathway of L-tryptophan biosynthesis	16	65
D-myo-inositol (1,3,4)-trisphosphate biosynthesis	17	12
superpathway of jasmonoyl-amino acid conjugates biosynthesis	1	10
indole-3-acetate inactivation VIII	4	19
superpathway of purines degradation in plants	6	45
indole-3-acetate inactivation V	4	11
saponin biosynthesis II	0	17
indole-3-acetate inactivation III	0	12
superpathway of L-threonine metabolism	21	72
superpathway of indole-3-acetate conjugate biosynthesis	5	33
sphingolipid biosynthesis (plants)	12	26
indole-3-acetate inactivation VI	0	10
superpathway of phosphatidylcholine biosynthesis	0	19
indole-3-acetate inactivation IV	4	11
carnosine biosynthesis	1	7
fructose 2,6-bisphosphate biosynthesis	5	7
superpathway of fumitremorgin biosynthesis	9	25
indole-3-acetate inactivation VII	0	12
ppGpp biosynthesis	5	23
flavonoid biosynthesis	8	23
superpathway of anaerobic sucrose degradation	26	61
flavonoid di-C-glucosylation	0	29
indole-3-acetate inactivation II	0	10
naringenin biosynthesis (engineered)	4	15
D-arabinose degradation II	0	12
D-arabinose degradation I	4	19
fructose degradation	1	8
2-O-u03B1-mannosyl-D-glycerate degradation	3	8
L-lyxose degradation	4	11
superpathway of glyoxylate bypass and TCA	18	55
D-galactosamine and N-acetyl-D-galactosamine degradation	5	12
N-acetyl-D-galactosamine degradation	3	12
ribose phosphorylation	2	10
superpathway of pyridoxal 5'-phosphate biosynthesis and salvage	9	37
D-allose degradation	3	8
isoprene degradation	8	17
2-methylpropene degradation	0	18
C4 photosynthetic carbon assimilation cycle, PEPCK type	2	23
fucose degradation	4	14
methyl tert-butyl ether degradation	14	25
L-glucose degradation	0	17
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis	46	62
photorespiration	17	23
mannitol degradation II	1	15
C4 photosynthetic carbon assimilation cycle, NADP-ME type	0	19
3,6-anhydro-u03B1-L-galactopyranose degradation	5	15
glucose and glucose-1-phosphate degradation	4	34
superpathway of glucose and xylose degradation	0	29
oxygenic photosynthesis	71	28
superpathway of pentose and pentitol degradation	46	61
squid bioluminescence	0	12
firefly bioluminescence	1	25
ergothioneine biosynthesis I (bacteria)	5	22
5,6-dimethylbenzimidazole biosynthesis I (aerobic)	3	11
tetrapyrrole biosynthesis I (from glutamate)	12	37
sorbitol biosynthesis II	2	11
superpathway of L-methionine salvage and degradation	28	69
L-methionine degradation I (to L-homocysteine)	8	18
ethylene biosynthesis V (engineered)	78	42
ethylene biosynthesis I (plants)	8	15
methanogenesis from dimethylamine	2	6
L-isoleucine biosynthesis IV	3	19
methyl-coenzyme M reduction to methane	6	13
3-dehydroquinate biosynthesis II (archaea)	6	23
superpathway of L-isoleucine biosynthesis I	17	55
dissimilatory sulfate reduction II (to thiosulfate)	0	15
methanogenesis from acetate	5	26
L-isoleucine biosynthesis V	0	12
S-adenosyl-L-methionine cycle I	4	17
NAD salvage pathway I (PNC VI cycle)	4	20
trans-cinnamoyl-CoA biosynthesis	4	12
NAD salvage pathway II (PNC IV cycle)	3	14
NAD de novo biosynthesis II (from tryptophan)	18	35
terrequinone A biosynthesis	4	18
protein O-mannosylation III (mammals, core M3)	8	11
NAD de novo biosynthesis I (from aspartate)	7	34
NAD salvage pathway IV (from nicotinamide riboside)	8	8
superpathway of NAD biosynthesis in eukaryotes	11	35
acetylaszonalenin biosynthesis	3	15
NAD salvage pathway V (PNC V cycle)	4	21
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde	8	16
CreCB Two-Component Signal Transduction System	2	2
BasSR Two-Component Signal Transduction System	2	2
QseBC Two-Component Signal Transduction System, quorum sensing related	2	2
DpiBA Two-Component Signal Transduction System	2	2
KdpDE Two-Component Signal Transduction System, potassium-dependent	2	2
EvgSA Two-Component Signal Transduction System	2	2
CusSR Two-Component Signal Transduction System	2	2
PhoRB Two-Component Signal Transduction System, phosphate-dependent	2	2
PRPP biosynthesis II	2	8
ArcAB Two-Component Signal Transduction System, quinone dependent	2	2
AtoSC Two-Component Signal Transduction System	2	2
prenylated FMNH2 biosynthesis	4	11
PhoQP Two-Component Signal Transduction System, magnesium-dependent	2	2
HprSR Two-Component Signal Transduction System	2	2
RstBA Two-Component Signal Transduction System	2	2
galactose degradation I (Leloir pathway)	5	26
UhpBA Two Component Signal Transduction System	2	2
NarQ Two-Component Signal Transduction System, nitrate dependent	3	2
CpxAR Two-Component Signal Transduction System	2	2
BaeSR Two-Component Signal Transduction System	2	2
BarA UvrY Two-Component Signal Transduction System	2	2
DcuSR Two-Component Signal Transduction System, dicarboxylate-dependent	2	2
ZraSR Two-Component Signal Transduction System	2	2
YpdAB Two-Component Signal Transduction System	2	2
salvage pathways of pyrimidine ribonucleotides	9	36
RcsCDB Two-Component Signal Transduction System	4	2
salvage pathways of pyrimidine deoxyribonucleotides	4	32
NarX Two-Component Signal Transduction System, nitrate dependent	3	2
iron-sulfur cluster biosynthesis	6	7
glucose-6-phosphate biosynthesis	5	5
superpathway of phenylalanine, tyrosine and tryptophan biosynthesis	13	36
salvage pathways of adenine, hypoxanthine and their nucleosides	8	16
methionine degradation I (to homocysteine)	3	17
urea degradation	1	11
de novo biosynthesis of pyrimidine ribonucleotides	10	24
folate transformations	12	19
histidine biosynthesis	7	22
glycerol biosynthesis	4	12
sulfate reduction I (assimilatory)	5	18
arginine biosynthesis	9	26
superpathway of thiamin diphosphate biosynthesis III (eukaryotes)	25	41
chorismate biosynthesis	4	16
mannose degradation	3	6
superpathway of purine nucleosides salvage	9	20
4-methyl-5(u03B2-hydroxyethyl)thiazole salvage	1	10
superpathway NAD/NADP - NADH/NADPH interconversion	11	29
thiamin salvage IV	9	17
superpathway of ergosterol biosynthesis	22	56
adenosine nucleotides de novo biosynthesis	4	17
superpathway of glutathione metabolism (truncated u03B3-glutamyl cycle)	3	13
thiamin triphosphate metabolism	0	8
thiamin formation from pyrithiamine and oxythiamine	3	17
folate interconversions	13	17
tRNA splicing	8	12
phosphopantothenate biosynthesis	4	15
nicotinate riboside salvage pathway I	1	5
nicotinamide riboside salvage pathway I	3	7
NAD salvage pathway	11	21
NAD/NADP-NADH/NADPH cytosolic interconversion	6	26
NAD/NADP-NADH/NADPH mitochondrial interconversion	7	13
threonine biosynthesis from homoserine	2	8
sucrose degradation III	7	9
phospholipid biosynthesis II (Kennedy pathway)	2	9
pyridoxal 5'-phosphate salvage pathway	4	14
superpathway phosphatidate biosynthesis (yeast)	10	19
adenosine deoxyribonucleotides de novo biosynthesis I	4	5
citrulline biosynthesis	8	23
homoserine biosynthesis	3	10
fatty acid oxidation (non-cyclic)	9	13
4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis	12	29
thiamin diphosphate biosynthesis IV (eukaryotes)	7	12
phosphatidylinositol phosphate biosynthesis	14	10
inositol phosphate biosynthesis	5	13
sorbitol degradation	4	9
phospholipid biosynthesis (Kennedy pathway)	4	14
1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)	2	8
1,4-dihydroxy-2-naphthoate biosynthesis II (plants)	5	17
coenzyme A biosynthesis I	1	13
superpathway of aspartate and asparagine biosynthesis	5	12
cadmium transport I	3	6
indole-3-acetate degradation IV	12	11
pyrimidine ribonucleotides interconversion	12	14
1,4-dihydroxy-2-naphthoate biosynthesis	5	17
lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3)	8	9
L-methionine biosynthesis II	9	16
indole-3-acetate degradation V	12	11
lipid-dependent phytate biosynthesis I (via Ins(1,4,5)P3)	4	8
tetrahydrofolate biosynthesis II	23	33
u03B3-glutamyl cycle (plant pathway)	3	14
D-galactose degradation III	4	19
folate polyglutamylation II	4	7
UDP-L-arabinose biosynthesis II (from L-arabinose)	2	8
purine nucleosides salvage II (plant)	6	13
L-citrulline-nitric oxide cycle	5	14
TCA cycle variation V (plant)	23	25
UDP-D-galacturonate biosynthesis II (from D-galacturonate)	2	9
NAD biosynthesis I (from aspartate)	4	20
superpathway of proto- and siroheme biosynthesis	16	40
indole-3-acetyl-amide conjugate biosynthesis	12	19
sulfate reduction II (assimilatory)	1	11
trehalose degradation II (trehalase)	6	9
ornithine-citrulline shuttle	5	13
simple coumarins biosynthesis	28	23
glutamate-glutamine shuttle	4	8
xylose degradation I	2	6
PRPP biosynthesis I	5	5
superpathway of sucrose and starch metabolism I (non-photosynthetic tissue)	29	16
superpathway of lipid-dependent phytate biosynthesis	8	12
L-homoserine and L-methionine biosynthesis	10	26
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I	6	26
acetate formation from acetyl-CoA II	1	6
adenosylcobalamin salvage from cobinamide I	4	19
adenosylcobalamin salvage from cobalamin	1	4
superpathway of demethylmenaquinol-8 biosynthesis	8	21
arginine biosynthesis II (acetyl cycle)	0	26
glutamine biosynthesis I	0	7
1,4-dihydroxy-2-naphthoate biosynthesis I	0	17
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-DAP-containing)	0	20
thiamin diphosphate biosynthesis I (E. coli)	0	9
superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis	0	38
acetyl-CoA fermentation to butyrate II	0	16
NAD salvage pathway I	0	18
glycolysis I (from glucose-6P)	0	18
glycolysis II (from fructose-6P)	0	17
superpathway of u03B2-D-glucuronide and D-glucuronate degradation	0	14
Lipid A-core biosynthesis	0	18
superpathway of tryptophan biosynthesis	0	30
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II	0	29
superpathway of tyrosine biosynthesis	0	24
homoserine and methionine biosynthesis	0	22
superpathway of methionine biosynthesis (transsulfuration)	0	25
citrulline degradation	0	9
superpathway of phenylalanine biosynthesis	0	22
proline biosynthesis I	0	12
thiamin salvage I	0	6
proline biosynthesis III	0	13
thiamin salvage II	0	11
asparagine biosynthesis I	0	9
superpathway of asparagine biosynthesis	0	10
biotin biosynthesis from 8-amino-7-oxononanoate I	0	13
pantothenate and coenzyme A biosynthesis I	0	24
arginine biosynthesis IV (archaebacteria)	0	20
anhydromuropeptides recycling	0	26
arginine biosynthesis I (via L-ornithine)	0	27
propionyl CoA degradation	7	9
superpathay of heme biosynthesis from glutamate	7	21
asparagine biosynthesis III (tRNA-dependent)	3	11
L-glutamine biosynthesis II (tRNA-dependent)	3	9
glucose and xylose degradation	23	28
citrulline-nitric oxide cycle	5	23
carnitine degradation I	2	10
NAD phosphorylation and dephosphorylation I	2	8
formylTHF biosynthesis	11	26
formate reduction to 5,10-methylenetetrahydrofolate	1	11
5-dehydro-4-deoxy-D-glucuronate degradation	4	11
arginine degradation V (arginine deiminase pathway)	4	10
superpathway of methionine biosynthesis (by sulfhydrylation)	6	30
pantothenate and coenzyme A biosynthesis II	4	34
sulfate reduction III (assimilatory)	1	11
biotin biosynthesis from 8-amino-7-oxononanoate	2	12
isoleucine biosynthesis IV	3	19
myo-, chiro- and scillo-inositol degradation	6	17
adenosine deoxyribonucleotides de novo biosynthesis II	2	5
superpathway of purine nucleotides de novo biosynthesis II	26	38
superpathway of guanosine nucleotides de novo biosynthesis II	4	17
superpathway of adenosine nucleotides de novo biosynthesis II	14	14
guanosine deoxyribonucleotides de novo biosynthesis II	2	7
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)	5	19
arginine, ornithine and proline interconversion	7	25
gluconate degradation	0	7
salvage pathways of purine and pyrimidine nucleotides	0	30
coelichelin biosynthesis	0	7
biotin biosynthesis III	0	15
aspartate biosynthesis II	0	10
superpathway of glycolysis and TCA variant VIII	0	33
ethylmalonyl pathway	0	21
pantothenate biosynthesis II	0	16
fatty acid oxidation pathway I	0	11
streptorubin B biosynthesis	0	20
adenosylcobalamin biosynthesis II (aerobic)	0	60
acetyl-CoA dissimilation	0	7
aspartate threonine lysine biosynthesis superpathway	0	29
leucine degradation IV	0	23
transulfuration	0	21
calcium-dependent antibiotic biosynthesis	0	22
PhoPR two-component signal transduction pathway	2	2
YdfHI two-component signal transduction system	2	2
DegSU two-component signal transduction system	2	2
WalKR two-component signal transduction system	2	2
ComPA two-component signal transduction system	2	2
DctSR two-component signal transduction system	2	1
DesKR two-component signal transduction system	2	2
LytST two-component signal transduction system	2	2
BceSR two-component signal transduction system	2	2
CssSR two-component signal transduction system	2	2
GlnKL two-component signal transduction system	2	2
LiaSR two-component signal transduction system	2	2
NatKR two-component signal transduction system	2	2
CitST two-component signal transduction system	2	2
YxdKJ two-component signal transduction system	2	2
ResED two-component signal transduction system	2	2
calcium transport I	0	6
chlorophyllide a biosynthesis I (aerobic, light-dependent)	11	24
chlorophyllide a biosynthesis III (aerobic, light independent)	13	24
L-ornithine biosynthesis	5	17
SphS sensory histidine kinase	2	2
NblS sensory histidine kinase	2	2
circadian clock oscillator KaiABC	1	2
SasA sensory histidine kinase	2	2
adenosylcobalamin biosynthesis II (late cobalt incorporation)	26	55
sulfoglycolysis	4	10
galactosamine degradation	8	11
N-acetyl-galactosamine degradation	9	12
adenosylcobalamin salvage from cobinamide II	0	21
molybdenum cofactor biosynthesis I	0	13
7-keto-8-aminopelargonate biosynthesis II	0	10
biotin biosynthesis from 7-keto-8-aminopelargonate	0	12
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (generic)	0	16
lysine biosynthesis II	0	23
sucrose degradation IV	0	9
L-1,2-propanediol degradation	0	13
glycolysis III (glucokinase)	0	17
acidification and chitin degradation (in carnivorous plants)	0	5
3-hydroxypropionate/4-hydroxybutyrate cycle	0	29
suberin biosynthesis	0	29
galactose degradation IV	0	13
phenylalanine degradation IV (mammalian, via side chain)	0	26
stearate biosynthesis I (animals)	0	17
heme biosynthesis I	0	22
TCA cycle VI (obligate autotrophs)	0	27
4-hydroxybenzoate biosynthesis V	0	15
chlorophyllide a biosynthesis II	0	23
thiamin diphosphate biosynthesis III (Staphylococcus)	0	10
UDP-D-glucuronate biosynthesis (from myo-inositol)	0	11
3-hydroxypropionate cycle	0	24
glutamine biosynthesis III	0	24
L-Nu03B4-acetylornithine biosynthesis	0	15
thiamin diphosphate biosynthesis II (Bacillus)	0	8
2'-(5'-phosphoribosyl)-3'-dephospho-CoA biosynthesis I (citrate lyase)	0	6
nitrogen fixation	0	7
chlorophyllide a biosynthesis III	0	23
glutamate and glutamine biosynthesis	0	12
lysine biosynthesis III	8	18
glycolysis VI (metazoan)	18	18
4-methyl-5(u03B2-hydroxyethyl)thiazole salvage (yeast)	2	8
4-coumarate degradation	4	14
aminomethylphosphonate degradation	4	19
sulfate reduction V (dissimilatory, to thiosulfate)	4	10
sulfate reduction IV (dissimilatory, to hydrogen sufide))	5	9
6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (archaea)	0	15
diphthamide biosynthesis (archaea)	1	11
Poly(glycerol phosphate) wall teichoic acid biosynthesis	0	12
Glycolysis and Gluconeogenesis	0	8
Cori cycle	1	21
Purine metabolism and related disorders	23	53
Cysteine and methionine catabolism	14	36
Effect of L-carnitine on metabolism	0	9
Responses to stimuli: abiotic stimuli and stresses	95	26
TCA cycle (plant)	7	21
Citrulline-nitric oxide cycle	2	14
Yang cycle	2	17
SAM cycle	1	11
Beta-alanine biosynthesis II	1	18
Arginine biosynthesis	5	26
Arginine biosynthesis II (acetyl cycle)	4	25
Asparagine biosynthesis	1	11
Asparagine biosynthesis III	0	9
Canavanine biosynthesis	1	10
Citrulline biosynthesis	5	22
Glutamine biosynthesis I	1	6
Histidine biosynthesis I	7	21
Homoserine biosynthesis	0	10
Lysine biosynthesis I	2	24
Lysine biosynthesis II	2	26
Lysine biosynthesis VI	3	19
Methionine biosynthesis II	0	17
Ornithine biosynthesis	2	16
Proline biosynthesis I	2	14
Threonine biosynthesis from homoserine	0	7
shikimate pathway	3	15
Allantoin degradation	6	16
glycolysis IV	1	19
glycolysis I	4	18
Calvin cycle	3	19
Starch biosynthesis	0	9
GDP-mannose metabolism	1	9
Peptidoglycan biosynthesis I	1	21
UDP-D-GlcA biosynthesis	3	9
UDP-L-arabinose biosynthesis and transport	6	16
Galactose degradation II	0	15
Mannose catabolism	0	4
Trehalose degradation II	1	7
Xylose catabolism	1	6
Biotin biosynthesis II	1	13
Flavin biosynthesis	2	21
Folate polyglutamylation I	1	12
Folate polyglutamylation II	1	4
Gamma-glutamyl cycle	1	11
Glutathione biosynthesis	0	8
DXP pathway	5	20
NAD biosynthesis I (from aspartate)	4	19
Pantothenate and coenzyme A biosynthesis III	1	19
Pantothenate biosynthesis I	1	17
Pantothenate biosynthesis II	1	17
vitamin K1	2	18
Pyridoxal 5'-phosphate salvage pathway	1	12
Pyridoxamine anabolism	1	7
Folate biosynthesis	0	29
Tetrahydrofolate biosynthesis II	1	28
Tetrapyrrole biosynthesis I	5	14
Thiamin biosynthesis	1	17
Reactive oxygen species (ROS) homeostasis	1	11
Generation of superoxide radicals	1	9
Trans-zeatin biosynthesis	0	22
Jasmonic acid signaling	1	6
ABA biosynthesis and mediated signaling	3	15
Abscisic acid (ABA) mediated signaling	2	4
Ethylene biosynthesis and signaling	11	16
Ethene biosynthesis from methionine	1	14
Ethylene mediated signaling	10	4
Auxin transport	1	6
Polar auxin transport	1	6
Flavonoid biosynthesis	1	19
Lipid-independent phytate biosynthesis	5	12
MVA pathway	1	16
Lignin biosynthesis	2	21
Suberin biosynthesis	0	22
Fatty acid activation	0	4
Lipid-A-precursor biosynthesis	3	13
Choline biosynthesis I	0	14
Sphingolipid metabolism	4	15
Glutamate synthase cycle	3	10
Nitrate assimilation	0	12
Sulfation pathway	0	6
Response to iron deficiency	10	17
Mugineic acid biosynthesis	2	14
PRPP biosynthesis I	0	4
PCO cycle	8	24
Circadian rhythm	17	2
Drosophila signaling pathways	192	8
Circadian Clock pathway	63	4
Phosphorylation of PER and TIM	21	3
Transcription repression by PER and activation by PDP1	7	2
Hedgehog pathway	71	4
N-HH ligand not bound to PTC receptor complex	60	2
Assembly of the CI containing complexes	20	2
Phosphorylation of CI	19	2
N-HH ligand bound to PTC receptor complex	63	2
Phosphorylation of SMO	20	2
Activation of CI	5	2
Hippo/Warts pathway	18	2
DS ligand bound to FT receptor	15	2
Subcellular localisation of D	4	2
Formation of the Hippo kinase cassette	4	2
Phosphorylation-dependent inhibition of YKI	7	2
Imd pathway	24	4
Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY	8	2
Catalytic processing of the nuclear factor, REL	6	2
Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'	6	2
Formation of the cytosolic BSK 'scaffolding complex'	4	3
Formation of the nuclear AP-1 transcription factor 'scaffolding complex'	4	2
Insulin receptor mediated signaling	16	5
Insulin signaling pathway	8	3
TOR signaling pathway	10	5
JAK/STAT pathway	7	3
Formation of the activated receptor complex	2	2
Formation of the activated STAT92E dimer and transport to the nucleus	3	2
Planar Cell Polarity pathway	34	5
Activation of Downstream Effectors	31	5
RHO1 signalling	23	5
Activation of non-muscle Myosin II	13	3
Activation of RAC1:GTP by FZ:DSH complex	9	3
JNK signalling	6	3
Toll pathway	47	2
Degradation of NF-kappa-B inhibitor, CACT	42	2
Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'	5	2
DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'	6	2
Wingless pathway	55	3
WG ligand not bound to FZ receptors	49	2
Assembly of the 'destruction complex'	8	2
Phosphorylation of AXN and APC	7	2
Phosphorylation of ARM	8	2
WG ligand bound to FZ receptors	16	3
Assembly of receptor complex	4	2
Phosphorylation of ARR	4	2
DNA replication and repair	53	15
DNA repair	46	10
Chk1-controlled and DNA-damage induced centrosome duplication	8	2
Double strand break repair	22	2
Homologous recombination repair	19	2
Homologous recombination repair of replication-dependent DSB	7	2
Homologous recombination repair of replication-independent double-strand breaks	16	2
ATM mediated response to DNA double-strand break	10	2
ATM mediated phosphorylation of repair proteins	8	2
Homologous DNA pairing and strand exchange	5	2
Non-homologous end joining (NHEJ)	3	2
Fanconi Anemia Pathway in DNA repair	6	2
Glucose transport	0	6
Lipid metabolism	3	21
The tricarboxylic acid cycle	4	22
Amino acid metabolism	3	16
Arginine metabolism	1	12
Pyrimidine metabolism: de novo synthesis of UMP	2	21
Purine metabolism	9	38
De novo synthesis of IMP	5	26
De novo synthesis of GMP	1	12
Toll-like receptors (TLR) cascades	30	3
TLR2 subfamily cascade	17	3
MyD88:TIRAP-dependent cascade initiated on plasma membrane	14	3
NFkB and MAPK activation mediated by TRAF6	12	2
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	6	2
MAPK activation in TLR cascade	4	2
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation	2	2
Activated TAK1 mediates p38 MAP kinase phosphorylation	1	2
ERK activation	2	2
TLR3 cascade	16	2
IKK related kinases bound to dsRNA:TLR3:TICAM1 activate IRF3	3	2
Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1	3	2
Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK	3	2
NFkB activation mediated by RIP1 complexed with activated TLR3	9	2
TRAF6 mediated induction of proinflammatory cytokines	14	2
TLR4 cascade	17	3
TLR5 cascade	14	2
TLR7 cascade	14	2
MyD88-dependent cascade initiated on endosome membrane	13	2
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation	13	2
TLR15 cascade	14	2
TLR21 cascade	14	2
RLR (RIG-like receptor) mediated induction of IFN alpha/beta	16	2
TRAF mediated activation of IRF	6	2

Protein Targets (45)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, RIBONUCLEASE PANCREATIC	Bos taurus (cattle)	Ki	14.9300	0.8600	14.9300	29.0000	AID977610
Chain A, RIBONUCLEASE PANCREATIC	Bos taurus (cattle)	Ki	14.9300	0.8600	14.9300	29.0000	AID977610
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, ATP synthase epsilon chain	Bacillus sp. PS3	Kd	1.4000	1.4000	1.4000	1.4000	AID977611
Chain B, ATP synthase epsilon chain	Bacillus sp. PS3	Kd	1.4000	1.4000	1.4000	1.4000	AID977611
Chain A, YuaA protein	Bacillus subtilis	Kd	0.0200	0.0200	0.0200	0.0200	AID977611
Chain B, YuaA protein	Bacillus subtilis	Kd	0.0200	0.0200	0.0200	0.0200	AID977611
Chain A, YuaA protein	Bacillus subtilis	Kd	0.0200	0.0200	0.0200	0.0200	AID977611
Chain A, YuaA protein	Bacillus subtilis	Kd	0.0200	0.0200	0.0200	0.0200	AID977611
Chain B, YuaA protein	Bacillus subtilis	Kd	0.0200	0.0200	0.0200	0.0200	AID977611
Chain A, Chloride Channel Protein 5	Homo sapiens (human)	Kd	100.0000	100.0000	100.0000	100.0000	AID977611
Chain A, Chloride Channel Protein 5	Homo sapiens (human)	Kd	100.0000	100.0000	100.0000	100.0000	AID977611
Chain A, Copper-transporting ATPase 1	Homo sapiens (human)	Kd	83.3000	83.3000	83.3000	83.3000	AID977611
Chain A, a non-biological ATP binding protein with two mutations N32D and D65V	unidentified	Kd	0.4500	0.4500	0.4500	0.4500	AID977611
Chain A, abiotic ATP-binding, folding optimized protein	unidentified	Kd	0.4940	0.4940	0.4940	0.4940	AID977611
Chain A, Ntpase P4	Pseudomonas phage phi12	Kd	140.0000	125.0000	132.5000	140.0000	AID977611
Chain C, Ntpase P4	Pseudomonas phage phi12	Kd	140.0000	125.0000	132.5000	140.0000	AID977611
Chain A, Ntpase P4	Pseudomonas phage phi12	Kd	140.0000	125.0000	132.5000	140.0000	AID977611
Chain C, Ntpase P4	Pseudomonas phage phi12	Kd	140.0000	125.0000	132.5000	140.0000	AID977611
Chain A, REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX	Bacillus subtilis	Kd	70.0000	70.0000	70.0000	70.0000	AID977611
Chain B, REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX	Bacillus subtilis	Kd	70.0000	70.0000	70.0000	70.0000	AID977611
Chain A, NITROGEN REGULATORY PROTEIN P-II	Synechococcus elongatus PCC 7942 = FACHB-805	Kd	9.6000	9.6000	9.6000	9.6000	AID977611
Chain A, Competence Protein Pilm	Thermus thermophilus HB27	Kd	1,000.0000	1,000.0000	1,000.0000	1,000.0000	AID977611
Chain A, V-type ATP synthase beta chain	Methanosarcina mazei	Kd	28.0000	28.0000	28.0000	28.0000	AID977611
Chain B, V-type ATP synthase beta chain	Methanosarcina mazei	Kd	28.0000	28.0000	28.0000	28.0000	AID977611
Chain A, ATP Binding Protein-DX	unidentified	Kd	0.2150	0.1800	0.3500	0.6200	AID977611
Chain A, ATP Binding Protein-DX	unidentified	Kd	0.2150	0.1800	0.3500	0.6200	AID977611
Chain A, ATP Binding Protein-DX	unidentified	Kd	0.2150	0.1800	0.3500	0.6200	AID977611
Chain A, Protein hipA	Escherichia coli	Kd	18.0000	18.0000	18.0000	18.0000	AID977611
Chain A, Biotin [acetyl-CoA-carboxylase] ligase	Aquifex aeolicus	Kd	4.6000	4.6000	6.4500	8.3000	AID977611
Chain A, Biotin [acetyl-CoA-carboxylase] ligase	Aquifex aeolicus	Kd	4.6000	4.6000	6.4500	8.3000	AID977611
Chain A, Protein hipA	Escherichia coli	Kd	18.0000	18.0000	18.0000	18.0000	AID977611
Chain A, Nitrogen regulatory protein P-II	Mycobacterium tuberculosis	Kd	1.9300	1.9300	1.9300	1.9300	AID977611
Chain B, Nitrogen regulatory protein P-II	Mycobacterium tuberculosis	Kd	1.9300	1.9300	1.9300	1.9300	AID977611
Chain A, Dethiobiotin synthetase	Helicobacter pylori 26695	Kd	1.7000	1.7000	4.4333	5.8000	AID977611
Chain A, Nitrogen regulatory protein P-II (GlnB-2)	Archaeoglobus fulgidus	Kd	4.4000	4.4000	40.9500	77.5000	AID977611
Chain B, Nitrogen regulatory protein P-II (GlnB-2)	Archaeoglobus fulgidus	Kd	4.4000	4.4000	40.9500	77.5000	AID977611
Chain A, Nitrogen regulatory protein P-II (GlnB-2)	Archaeoglobus fulgidus	Kd	4.4000	4.4000	40.9500	77.5000	AID977611
Chain B, Nitrogen regulatory protein P-II (GlnB-2)	Archaeoglobus fulgidus	Kd	4.4000	4.4000	40.9500	77.5000	AID977611
Chain A, Protein argonaute-2	Homo sapiens (human)	Kd	90.0000	90.0000	90.0000	90.0000	AID977611
Chain A, Protein argonaute-2	Homo sapiens (human)	Kd	90.0000	90.0000	90.0000	90.0000	AID977611
Chain A, Dethiobiotin synthetase	Helicobacter pylori 26695	Kd	1.7000	1.7000	4.4333	5.8000	AID977611
Chain A, Dethiobiotin synthetase	Helicobacter pylori 26695	Kd	1.7000	1.7000	4.4333	5.8000	AID977611
Chain A, Malonyl CoA synthetase	Rhodopseudomonas palustris CGA009	Kd	0.3100	0.3100	0.3100	0.3100	AID977611
Chain A, Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	1.0000	1.0000	1.0000	1.0000	AID977611
Chain A, Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	1.0000	1.0000	1.0000	1.0000	AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (25)

Assay ID	Title	Year	Journal	Article
AID1811	Experimentally measured binding affinity data derived from PDB	2006	Cell, Sep-22, Volume: 126, Issue:6	The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2006	Cell, Sep-22, Volume: 126, Issue:6	The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2012	Nature structural & molecular biology, Aug, Volume: 19, Issue:8	Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2008	The Journal of biological chemistry, Feb-08, Volume: 283, Issue:6	Structural basis of mechanochemical coupling in a hexameric molecular motor.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2009	Proteins, Jun, Volume: 75, Issue:4	Spectroscopic and crystallographic studies of the mutant R416W give insight into the nucleotide binding traits of subunit B of the A1Ao ATP synthase.
AID1811	Experimentally measured binding affinity data derived from PDB	2007	PloS one, May-23, Volume: 2, Issue:5	Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2007	PloS one, May-23, Volume: 2, Issue:5	Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2012	The FEBS journal, Mar, Volume: 279, Issue:6	Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2009	Biopolymers, Dec, Volume: 91, Issue:12	Influence of naturally-occurring 5'-pyrophosphate-linked substituents on the binding of adenylic inhibitors to ribonuclease a: an X-ray crystallographic study.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2009	Journal of molecular biology, Mar-20, Volume: 387, Issue:1	Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2007	Proceedings of the National Academy of Sciences of the United States of America, Jul-03, Volume: 104, Issue:27	Structures of the thermophilic F1-ATPase epsilon subunit suggesting ATP-regulated arm motion of its C-terminal domain in F1.
AID1811	Experimentally measured binding affinity data derived from PDB	2007	Proceedings of the National Academy of Sciences of the United States of America, Jul-03, Volume: 104, Issue:27	Structures of the thermophilic F1-ATPase epsilon subunit suggesting ATP-regulated arm motion of its C-terminal domain in F1.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2011	EMBO reports, May, Volume: 12, Issue:5	Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2009	Science (New York, N.Y.), Jan-16, Volume: 323, Issue:5912	Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
AID1811	Experimentally measured binding affinity data derived from PDB	2007	Nature structural & molecular biology, Jan, Volume: 14, Issue:1	Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2007	Nature structural & molecular biology, Jan, Volume: 14, Issue:1	Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2009	ACS chemical biology, Aug-21, Volume: 4, Issue:8	A synthetic protein selected for ligand binding affinity mediates ATP hydrolysis.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2010	Journal of molecular biology, Jun-11, Volume: 399, Issue:3	A novel signal transduction protein P(II) variant from Synechococcus elongatus PCC 7942 indicates a two-step process for NAGK-P(II) complex formation.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2007	Journal of molecular biology, Aug-10, Volume: 371, Issue:2	Structure and evolutionary analysis of a non-biological ATP-binding protein.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2010	Journal of molecular biology, Sep-10, Volume: 402, Issue:1	Cooperative binding of MgATP and MgADP in the trimeric P(II) protein GlnK2 from Archaeoglobus fulgidus.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2010	Protein science : a publication of the Protein Society, Aug, Volume: 19, Issue:8	Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2012	Applied and environmental microbiology, Sep, Volume: 78, Issue:18	Structure-guided expansion of the substrate range of methylmalonyl coenzyme A synthetase (MatB) of Rhodopseudomonas palustris.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2008	Molecular microbiology, Jul, Volume: 69, Issue:2	Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2011	The Journal of biological chemistry, Jul-08, Volume: 286, Issue:27	Structure of the PilM-PilN inner membrane type IV pilus biogenesis complex from Thermus thermophilus.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2010	The Journal of biological chemistry, Jan-22, Volume: 285, Issue:4	The binding mode of ATP revealed by the solution structure of the N-domain of human ATP7A.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	12 (57.14)	29.6817
2010's	9 (42.86)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
biotinate biotinate : Conjugate base of biotin arising from deprotonation of the carboxy group.	2.05	1	0	monocarboxylic acid anion; vitamin B7	cofactor; human metabolite; Saccharomyces cerevisiae metabolite
adenosine diphosphate ADP(3-) : A nucleoside 5'-diphosphate(3-) arising from deprotonation of all three diphosphate OH groups of adenosine 5'-diphosphate (ADP); major species present at pH 7.3.	3.3	6	0	nucleoside 5'-diphosphate(3-)	fundamental metabolite; human metabolite

adenosine triphosphate

Description

Cross-References

Synonyms (42)

Occurs in Manufacturing (1 Product(s))

Product Categories

Products

Roles (3)

Drug Classes (1)

Pathways (2,509)

Protein Targets (45)

Inhibition Measurements

Activation Measurements

Bioassays (25)

Research

Studies (21)

Study Types

adenosine triphosphate

Description

Cross-References

Synonyms (42)

Occurs in Manufacturing (1 Product(s))

Product Categories

Products

Roles (3)

Drug Classes (1)

Pathways (2,509)

Protein Targets (45)

Inhibition Measurements

Activation Measurements

Bioassays (25)

Research

Studies (21)

Study Types

Related Drugs (2)

Related Conditions (1)