A GMP synthase [glutamine-hydrolyzing] that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49915]
EC 6.3.5.2;
GMP synthetase;
Glutamine amidotransferase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| psicofuranine | Homo sapiens (human) | IC50 | 17.3000 | 1 | 1 |
| angustmycin a | Homo sapiens (human) | IC50 | 46.5000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| GMP synthase activity | molecular function | Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+. [RHEA:18301] |
| GMP synthase (glutamine-hydrolyzing) activity | molecular function | Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+. [RHEA:11680] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| GMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. [ISBN:0198506732] |
| glutamine metabolic process | biological process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. [GOC:ai] |
| purine nucleobase biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. [ISBN:0198506732] |
| purine ribonucleoside monophosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732] |