ilekudinol B: stimulates glucose uptake; from Weigela subsessilis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Weigela | genus | [no description available] | Caprifoliaceae | A plant family of the order Dipsacales, subclass Asteridae, class Magnoliopsida.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 10647480 |
| CHEMBL ID | 523827 |
| SCHEMBL ID | 15392167 |
| MeSH ID | M0543778 |
| Synonym |
|---|
| bdbm50250331 |
| 2alpha, 3beta-dihydroxy-24-nor-urs-4(23),12-dien-28-oic acid |
| ilekudinol b |
| CHEMBL523827 , |
| SCHEMBL15392167 |
| (1s,2r,4as,6ar,6as,6br,8ar,10r,11r,12ar,14bs)-10,11-dihydroxy-1,2,6a,6b,12a-pentamethyl-9-methylidene-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1h-picene-4a-carboxylic acid |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Sterol O-acyltransferase 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 44.0000 | 0.0058 | 0.6626 | 6.0000 | AID380812 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1435531 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2016 | Journal of natural products, 11-23, Volume: 79, Issue:11 | Bioactive Pentacyclic Triterpenoids from the Leaves of Cleistocalyx operculatus. |
| AID1436763 | Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway preincubated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometer | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Anticomplement triterpenoids from the roots of Ilex asprella. |
| AID1435530 | Cytotoxicity against human NCI-N87 cells after 72 hrs by MTT assay | 2016 | Journal of natural products, 11-23, Volume: 79, Issue:11 | Bioactive Pentacyclic Triterpenoids from the Leaves of Cleistocalyx operculatus. |
| AID1435529 | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | 2016 | Journal of natural products, 11-23, Volume: 79, Issue:11 | Bioactive Pentacyclic Triterpenoids from the Leaves of Cleistocalyx operculatus. |
| AID380812 | Inhibition of rat liver microsomal ACAT | 1999 | Journal of natural products, Jul, Volume: 62, Issue:7 | Activity-guided isolation of triterpenoid acyl CoA cholesteryl acyl transferase (ACAT) inhibitors from Ilex kudincha. |
| AID1436764 | Anticomplement activity in New Zealand White rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway preincubated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 min | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Anticomplement triterpenoids from the roots of Ilex asprella. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.87) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||