propyliodone profile

Propyliodone, also known as diatrizoic acid, is an organic compound used as a radiocontrast agent in medical imaging. It is an iodinated benzoic acid derivative. Propyliodone is administered intravenously or orally, and it works by increasing the density of tissues and organs, making them more visible on X-ray images. It is used for a variety of diagnostic procedures, including angiography, urography, and computed tomography (CT) scans. The compound is synthesized through a multi-step process involving iodination and esterification reactions. Its effects include temporary changes in iodine levels in the body, which are generally well-tolerated. The importance of propyliodone lies in its ability to enhance diagnostic imaging, leading to improved medical diagnoses and treatment plans. Research on propyliodone focuses on optimizing its safety and efficacy, exploring alternative formulations, and investigating its potential applications in other fields such as drug delivery and cancer therapy.'

Propyliodone: Radiopaque medium usually in oil; used in bronchography. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	4949
CHEMBL ID	1200821
CHEBI ID	32064
SCHEMBL ID	38586
MeSH ID	M0017783

Synonym
1(4h)-pyridineacetic acid, 3,5-diiodo-4-oxo-, propyl ester
propyl (3,5-diiodo-4-oxopyridin-1(4h)-yl)acetate
a.g. 33-107
propyl 3,5-diiodo-4-oxo-1(4h)-pyridineacetate
brn 0206829
nsc 97103
propiliodona [inn-spanish]
propyl 3,5-diiodo-4-oxo-1(4h) pyridineacetate
propyliodonum [inn-latin]
einecs 209-603-5
bronchodiagnostin
587-61-1
dionosil
propyliodone
brosombra
nsc97103
diostril
nsc-97103
propyl 3,5-diiodo-4-pyridone-n-acetate
1(4h)-pyridineacetic acid,5-diiodo-4-oxo-, propyl ester
a. g. 33-107
3,5-diiodo-4-pyridone-n-acetic acid propyl ester
propyl-3,5-diiodo-4-oxo-1(4h)pyridineacetate
propiodone
3,5-diiodo-4-oxo-1(4h)-pyridineacetic acid propyl ester
bronkhodiagnostin
wln: t6n dvj a1vo3 ci ei
propyliodon
D01755
propyliodone (jan/usp/inn)
propyliodonum
CHEMBL1200821
propyl 2-(3,5-diiodo-4-oxopyridin-1-yl)acetate
propiliodona
propyliodone [usp:inn:ban:jan]
unii-5npj6bpx36
5npj6bpx36 ,
dionosil aqueous
propyliodone [orange book]
propyliodone [jan]
propyliodone [who-dd]
propyliodone [vandf]
propyliodone [mart.]
propyliodone [inn]
propyliodone [mi]
propyliodonum [who-ip latin]
propyliodone [usp impurity]
propyliodone [who-ip]
SCHEMBL38586
ROSXARVHJNYYDO-UHFFFAOYSA-N
pyridine acetic acid, 3,5-diiodo-4-oxo-1(4h)-, propyl ester
3,5-diodo-1-propoxycarbonylmethylpyrid-4-one
propyl (3,5-diiodo-4-oxo-1(4h)-pyridinyl)acetate #
propyl-3,5-diiodo-4-oxo-1(4h)pyridine, acetate
DTXSID6023527 ,
AKOS030530659
propyl (3,5-diiodo-4-oxo-1(4h)-pyridinyl)acetate
CHEBI:32064
propyl 2-(3,5-diiodo-4-oxo-1,4-dihydropyridin-1-yl)acetate
DB09366
Q7250472
2-pyridin-4-yl-1-(4-trifluoromethylphenyl)ethanone
propyl 2-(3,5-diiodo-4-oxopyridin-1(4h)-yl)acetate
CS-0030876
HY-107925
propyliodone (usp impurity)
dtxcid703527
propyliodonum (inn-latin)
v08ad03
propyliodone (usp:inn:ban:jan)
propiliodona (inn-spanish)
propyliodone (mart.)
EN300-11754796

Class	Description
organic molecular entity	Any molecular entity that contains carbon.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	85 (96.59)	18.7374
1990's	3 (3.41)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	9 (9.09%)	4.05%
Observational	0 (0.00%)	0.25%
Other	90 (90.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.33	2	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
iodine Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..	8.04	5	diatomic iodine	nutrient
nitrous oxide Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.. dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.	1.95	1	gas molecular entity; nitrogen oxide	analgesic; bacterial metabolite; food packaging gas; food propellant; general anaesthetic; greenhouse gas; inhalation anaesthetic; NMDA receptor antagonist; raising agent; refrigerant; vasodilator agent
iohexol Iohexol: An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.. iohexol : A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.	1.99	1	benzenedicarboxamide; organoiodine compound	environmental contaminant; radioopaque medium; xenobiotic
ioxaglate Ioxaglic Acid: A low-osmolar, ionic contrast medium used in various radiographic procedures.. ioxaglic acid : A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an acetyl(methyl)amino group at the 5-position.	1.96	1	benzenedicarboxamide; benzoic acids; organoiodine compound	radioopaque medium
sulfanilamide [no description available]	1.93	1	substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; drug allergen; EC 4.2.1.1 (carbonic anhydrase) inhibitor
tetracaine Tetracaine: A potent local anesthetic of the ester type used for surface and spinal anesthesia.. tetracaine : A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.	1.94	1	benzoate ester; tertiary amino compound	local anaesthetic
thyroxine Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	1.96	1	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
triiodothyronine Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.. 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.	1.96	1	2-halophenol; amino acid zwitterion; iodophenol; iodothyronine	human metabolite; mouse metabolite; thyroid hormone
diatrizoate meglumine Diatrizoate Meglumine: A versatile contrast medium used for DIAGNOSTIC X-RAY RADIOLOGY.. meglumine amidotrizoate : The N-methylglucamine salt of amidotrizoic acid. Both the sodium and the meglumine salts of amidotrizoic acid have been widely used as water-soluble radioopaque media in diagnostic radiography. The use of a mixture of the two salts is often preferred, as adverse effects can be reduced.	2.37	2	monocarboxylic acid anion	radioopaque medium
perflubron perflubron: potential anti-obesity compound; reduces food adsorption; 8-carbon perfluorocarbon radiopaque compound; an oral contrast agent for use with MRI to enhance delineation of the bowel distinguishing it from adjacent organs. perflubron : A haloalkane that is perfluorooctane in which a fluorine attached to one of the terminal carbons has been replaced by a bromine.	1.99	1	haloalkane; organobromine compound; perfluorinated compound	blood substitute; radioopaque medium
4-hydroxypyridine 4-pyridone: structure in first source. 4-hydroxypyridine : A monohydroxypyridine that is pyridine in which the hydrogen at position 4 has been replaced by a hydroxy group.. 4-pyridone : The simplest member of the class of pyridin-4-ones, that is 1,4-dihydropyridine in which the hydrogens at position 4 have been replaced by an oxo group.	2.62	3	4-pyridones; monohydroxypyridine
iopydone iopydone: minor descriptor (75-80); on-line & Index Medicus search IODOPYRIDONES (68-80)	2.64	3
tantalum Tantalum: A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices.	1.95	1	vanadium group element atom
barium sulfate Barium Sulfate: A compound used as an x-ray contrast medium that occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield.. barium sulfate : A metal sulfate with formula BaO4S. Virtually insoluble in water at room temperature, it is mostly used as a component in oil well drilling fluid it occurs naturally as the mineral barite.	7.86	4	barium salt; inorganic barium salt; metal sulfate	radioopaque medium
iodine [no description available]	7.63	3	halide anion; monoatomic iodine	human metabolite
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.62	3	benzenes; phenyl acetates
fomesafen fomesafen: a protoporphyrinogen oxidase-inhibiting herbicide. fomesafen : An N-sulfonylcarboxamide that is N-(methylsulfonyl)benzamide in which the phenyl ring is substituted by a nitro group at position 2 and a 2-chloro-4-(trifluoromethyl)phenoxy group at position 5. A protoporphyrinogen oxidase inhibitor, it was specially developed for use (generally as the corresponding sodium salt, fomesafen-sodium) for post-emergence control of broad-leaf weeds in soya.	1.95	1	aromatic ether; C-nitro compound; monochlorobenzenes; N-sulfonylcarboxamide; organofluorine compound; phenols	agrochemical; EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor; herbicide
iopamidol Iopamidol: A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.. iopamidol : A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a (2S)-2-hydroxypropanamido group at the 5-position.	1.97	1	benzenedicarboxamide; organoiodine compound; pentol	environmental contaminant; radioopaque medium; xenobiotic
metrizamide Metrizamide: A solute for density gradient centrifugation offering higher maximum solution density without the problems of increased viscosity. It is also used as a resorbable, non-ionic contrast medium.	1.96	1	amino sugar
barium Barium: An element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.	2.34	2	alkaline earth metal atom; elemental barium
triiodothyronine, reverse Triiodothyronine, Reverse: A metabolite of THYROXINE, formed by the peripheral enzymatic monodeiodination of T4 at the 5 position of the inner ring of the iodothyronine nucleus.. 3,3',5'-triiodo-L-thyronine zwitterion : Zwitterionic form of 3,3',5'-triiodo-L-thyronine.	1.96	1	3,3',5'-triiodothyronine; amino acid zwitterion

Condition	Relationship Strength	Studies
Koch's Disease [description not available]	2.84	4
Pulmonary Consumption [description not available]	2.84	4
Tuberculosis Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.	2.84	4
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	2.84	4
Dermatitis Seborrheica [description not available]	3.03	5
Dermatitis, Seborrheic A chronic inflammatory disease of the skin with unknown etiology. It is characterized by moderate ERYTHEMA, dry, moist, or greasy (SEBACEOUS GLAND) scaling and yellow crusted patches on various areas, especially the scalp, that exfoliate as dandruff. Seborrheic dermatitis is common in children and adolescents with HIV INFECTIONS.	3.03	5
Anesthesia A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.	1.93	1
Bronchiectasis Persistent abnormal dilatation of the bronchi.	1.93	1
Granulomas [description not available]	1.93	1
Abscess, Pulmonary [description not available]	1.93	1
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	2.63	3
Granuloma A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.	6.93	1
Lung Abscess Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.	1.93	1
Pneumonia Infection of the lung often accompanied by inflammation.	7.63	3
Cancer of Stomach [description not available]	1.93	1
Stomach Neoplasms Tumors or cancer of the STOMACH.	1.93	1
Dysphagia [description not available]	1.94	1
Hoarseness An unnaturally deep or rough quality of voice.	1.94	1
Deglutition Disorders Difficulty in SWALLOWING which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the PHARYNX and UPPER ESOPHAGEAL SPHINCTER; and esophageal dysphagia due to malfunction of the ESOPHAGUS.	1.94	1
Pyrexia [description not available]	2.35	2
Fever An abnormal elevation of body temperature, usually as a result of a pathologic process.	2.35	2
Hyperthyroid [description not available]	1.96	1
Hyperthyroidism Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.	1.96	1
Disease, Pulmonary [description not available]	2.66	3
Lung Diseases Pathological processes involving any part of the LUNG.	2.66	3
Bladder Diseases [description not available]	1.95	1
Bladder Cancer [description not available]	1.95	1
Malignant Melanoma [description not available]	1.95	1
Adenoma, Prostatic [description not available]	1.95	1
Cancer of Rectum [description not available]	1.95	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	1.95	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	1.95	1
Prostatic Hyperplasia Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.	1.95	1
Rectal Neoplasms Tumors or cancer of the RECTUM.	1.95	1
Embolus [description not available]	1.95	1
Embolism Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.	1.95	1
Cystic Kidney Diseases [description not available]	1.95	1
Cancer of Kidney [description not available]	1.95	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	1.95	1
Kidney Diseases, Cystic A heterogeneous group of hereditary and acquired disorders in which the KIDNEY contains one or more CYSTS unilaterally or bilaterally (KIDNEY, CYSTIC).	1.95	1
Acquired Laryngeal Stenosis [description not available]	1.95	1
Tracheal Stenosis A pathological narrowing of the TRACHEA.	1.95	1
Focal Neurologic Deficits [description not available]	1.95	1
Absence Seizure [description not available]	1.95	1
Brain Embolism and Thrombosis [description not available]	1.95	1
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	1.95	1
Centriacinar Emphysema [description not available]	1.95	1
Gagging Contraction of the muscle of the PHARYNX caused by stimulation of sensory receptors on the SOFT PALATE, by psychic stimuli, or systemically by drugs.	1.95	1
Atelectasis [description not available]	1.95	1
Esophageal Fistula Abnormal passage communicating with the ESOPHAGUS. The most common type is TRACHEOESOPHAGEAL FISTULA between the esophagus and the TRACHEA.	1.95	1
Esophageal Perforation An opening or hole in the ESOPHAGUS that is caused by TRAUMA, injury, or pathological process.	1.95	1
Foreign-Body Reaction Chronic inflammation and granuloma formation around irritating foreign bodies.	1.97	1
Foreign-Body Granuloma [description not available]	1.97	1
Injuries, Spinal Cord [description not available]	1.97	1
Spinal Cord Injuries Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).	1.97	1
Asthma, Bronchial [description not available]	1.96	1
Eosinophilia, Pulmonary [description not available]	1.96	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	1.96	1
Pulmonary Eosinophilia A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.	1.96	1

propyliodone

Description

Cross-References

Synonyms (73)

Drug Classes (1)

Research

Studies (88)

Market Indicators

Research Demand Index: 24.33

Study Types