Compounds > iopydone
Page last updated: 2024-11-05

iopydone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Iopydone is a contrast agent used in X-ray imaging, particularly in cholangiography. It is a derivative of iodized fatty acids, specifically a triiodinated derivative of poppyseed oil. Iopydone is administered intravenously or directly into the biliary tract. It works by increasing the density of the bile ducts and gallbladder, making them more visible on X-ray images. This allows for better visualization of these structures, helping in the diagnosis of various conditions such as gallstones, cholecystitis, and bile duct strictures. Research on iopydone primarily focuses on its efficacy, safety, and potential adverse effects. Studies have explored its use in various clinical settings, including the diagnosis of biliary tract diseases, evaluation of liver function, and assessment of pancreatic duct anatomy. The compound is also studied for its potential interactions with other drugs and its effects on different patient populations, including pregnant women and individuals with specific medical conditions.'

iopydone: minor descriptor (75-80); on-line & Index Medicus search IODOPYRIDONES (68-80) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID21752
CHEMBL ID2104367
SCHEMBL ID666661
MeSH IDM0086937

Synonyms (66)

Synonym
brn 1447538
iopidona [inn-spanish]
4(1h)-pyridone, 3,5-diiodo-
nsc 135284
hytrast (van)
4(1h)-pyridinone, 3,5-diiodo-
iopydone [usan:inn:ban:jan]
jopydonum
einecs 226-969-1
iopydonum [inn-latin]
4(1h)-pyridone,5-diiodo-
iopydone
wln: t6m dvj ci ei
DJP ,
3,5-diiodo-4-pyridone
5579-93-1
3,5-diiodo-4(1h)-pyridone
nsc-135284
component of hytrast
4(1h)-pyridinone,5-diiodo-
iopydon
hytrast
nsc135284
3,5-diiodo-4-pyridinol
AC-907/25014036
3,5-diiodopyridin-4(1h)-one
7153-08-4
nsc-60547
nsc60547
4-pyridinol,5-diiodo-
3,5-diiodo-1h-pyridin-4-one
D04587
iopydone (usan)
3,5-diiodo-4-hydroxypyridine
AKOS000631308
iopidona
unii-j6b56xb19t
iopydonum
j6b56xb19t ,
AKOS015899046
CHEMBL2104367
iopydone [mart.]
iopydone [inn]
iopydone [who-dd]
iopydone [mi]
iopydone [usan]
SCHEMBL666661
3,5-diiodopyridin-4-ol
DTXSID9063954
3,5-diiodo-4-hydrox-ypyridine
smr002530268
MLS006011639
4-pyridinol, 3,5-diiodo-
component of hytrast (salt/mix)
3,5-diiodo-4(1h)-pyridinone
mfcd00023554
W12571
W18704
CS-0036290
SY040052
FT-0762575
AS-20011
4-hydroxy-3,5-diiodopyridine
Q27281264
A917903
EN300-109702

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"The toxic effects of Hytrast were studied on the peritoneum of laboratory rats in order to define the lethal dose and possible causes of toxicity."( Intraperitoneal toxicity of Hytrast: an experimental study.
Ginai, AZ; Hoornstra, K; Ten Berg, RG; Ten Kate, FJ, 1986)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-199014 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies2 (13.33%)4.05%
Observational0 (0.00%)0.25%
Other13 (86.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
iodine
Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..		1.9410diatomic iodinenutrient
ioxaglate
Ioxaglic Acid: A low-osmolar, ionic contrast medium used in various radiographic procedures.. ioxaglic acid : A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an acetyl(methyl)amino group at the 5-position.		1.9610benzenedicarboxamide;
benzoic acids;
organoiodine compound		radioopaque medium
propyliodone
Propyliodone: Radiopaque medium usually in oil; used in bronchography.		2.6430organic molecular entity
tetracaine
Tetracaine: A potent local anesthetic of the ester type used for surface and spinal anesthesia.. tetracaine : A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.		1.9410benzoate ester;
tertiary amino compound		local anaesthetic
diatrizoate meglumine
Diatrizoate Meglumine: A versatile contrast medium used for DIAGNOSTIC X-RAY RADIOLOGY.. meglumine amidotrizoate : The N-methylglucamine salt of amidotrizoic acid. Both the sodium and the meglumine salts of amidotrizoic acid have been widely used as water-soluble radioopaque media in diagnostic radiography. The use of a mixture of the two salts is often preferred, as adverse effects can be reduced.		1.9610monocarboxylic acid anionradioopaque medium
barium sulfate
Barium Sulfate: A compound used as an x-ray contrast medium that occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield.. barium sulfate : A metal sulfate with formula BaO4S. Virtually insoluble in water at room temperature, it is mostly used as a component in oil well drilling fluid it occurs naturally as the mineral barite.		1.9610barium salt;
inorganic barium salt;
metal sulfate		radioopaque medium
iodine
[no description available]		1.9410halide anion;
monoatomic iodine		human metabolite
metrizamide
Metrizamide: A solute for density gradient centrifugation offering higher maximum solution density without the problems of increased viscosity. It is also used as a resorbable, non-ionic contrast medium.		1.9610amino sugar
ConditionIndicatedRelationship StrengthStudiesTrials
Bronchial Pneumonia
[description not available]		02.3520
Experimental Lung Inflammation
Inflammation of any part, segment or lobe, of the lung parenchyma.		02.6330
Pneumonia
Infection of the lung often accompanied by inflammation.		02.6330
Koch's Disease
[description not available]		01.9410
Pulmonary Consumption
[description not available]		01.9410
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		01.9410
Tuberculosis, Pulmonary
MYCOBACTERIUM infections of the lung.		01.9410
Pyrexia
[description not available]		01.9410
Fever
An abnormal elevation of body temperature, usually as a result of a pathologic process.		01.9410
Abscess, Pulmonary
[description not available]		01.9410
Disease, Pulmonary
[description not available]		02.3420
Bronchiectasis
Persistent abnormal dilatation of the bronchi.		02.3520
Bronchitis
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.		01.9410
Hemoptysis
Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.		01.9410
Lung Abscess
Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.		01.9410
Lung Diseases
Pathological processes involving any part of the LUNG.		02.3420
Bronchiolitis, Viral
An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.		01.9410
Bronchiolitis
Inflammation of the BRONCHIOLES.		01.9410
Extravasation of Contrast Media
[description not available]		01.9610