Compounds > n-methylphenylethanolamine
Page last updated: 2024-11-04

n-methylphenylethanolamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-methylphenylethanolamine (NMPE) is a synthetic compound that has been investigated as a potential therapeutic agent for various conditions, including Parkinson's disease and depression. Its synthesis typically involves the methylation of phenylethanolamine, a naturally occurring compound found in the human body. NMPE is believed to exert its effects by modulating the activity of certain neurotransmitters, particularly dopamine and norepinephrine, in the brain. Its importance lies in its potential to offer alternative therapeutic strategies for conditions currently lacking effective treatments. However, further research is necessary to elucidate its exact mechanisms of action, optimize its therapeutic efficacy, and assess its safety and tolerability in humans. This compound is studied due to its structural similarity to other known psychoactive drugs and its potential to interact with neurotransmitter systems implicated in various neurological and psychiatric disorders.'

2-methylamino-1-phenylethanol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Halostachysgenus[no description available]AmaranthaceaeA family of flowering plants in the order Caryophyllales, with about 60 genera and more than 800 species of plants, with a few shrubs, trees, and vines. The leaves usually have nonindented edges.[MeSH]

Cross-References

ID SourceID
PubMed CID913
CHEMBL ID1241267
CHEBI ID16913
SCHEMBL ID210960
MeSH IDM0088467

Synonyms (65)

Synonym
6589-55-5
2-(methylamino)-1-phenylethan-1-ol
(+-)-halostachine
(+-)-alpha-((methylamino)methyl)benzenemethanol
2-(methylamino)-1-phenylethanol
CHEBI:16913 ,
benzyl alcohol, alpha-((methylamino)methyl)-, dl-
benzyl alcohol, alpha-((methylamino)methyl)-
ethanol, 2-(methylamino)-1-phenyl-
win 5529-2
alpha-((methylamino)methyl)benzyl alcohol
einecs 229-525-5
brn 1072841
dl-1-phenyl-1-oxy-2-(methylamino)-aethan [german]
benzenemethanol, alpha-((methylamino)methyl)-, (+-)-
C03711
N-METHYLPHENYLETHANOLAMINE ,
alpha-[(methylamino)methyl]-benzyl alcohol
68579-60-2
alpha-(methylaminomethyl)benzyl alcohol, 99%
alpha-(methylaminomethyl)benzyl alcohol
alpha-[(methylamino)methyl]benzyl alcohol
BMSE000396
2-methylamino-1-phenylethanol
CHEMBL1241267
AKOS005207037
dl-1-phenyl-1-oxy-2-(methylamino)-aethan
4-13-00-01802 (beilstein handbook reference)
unii-u7b63fx8ch
u7b63fx8ch ,
FT-0625424
FT-0625425
BRD-A79058669-001-01-1
SCHEMBL210960
2-methylamino-1-phenyl-ethanol
alpha-[(methylamino)methyl]benzenemethanol
(2-hydroxy-2-phenylethyl)methylamine
alpha-(methylaminomethyl)-benzyl alcohol
TS-02000
benzenemethanol, .alpha.-[(methylamino)methyl]-
.alpha.-((methylamino)methyl)benzyl alcohol
benzyl alcohol, .alpha.-((methylamino)methyl)-
.alpha.-(methylaminomethyl)benzyl alcohol
dl-halostachine
n-methyl-.beta.-hydroxylphenylethylamine
1-phenyl-2-(n-methylamino)ethanol
halostachine, (+/-)-
methyl(2-hydroxy-2-phenylethyl)amine
(+/-)-halostachine
benzenemethanol, .alpha.-((methylamino)methyl)-
dl-alpha-(methylaminomethyl)benzylalcohol
mfcd00004506
dl-alpha-(methylaminomethyl)benzyl alcohol
alpha-((methylamino)methyl)-dl-benzyl alcohol
BCP22653
CS-0204443
|a-(methylaminomethyl)benzyl alcohol
DTXSID90988242
Q27102132
SB38173
a-(methylaminomethyl)benzyl alcohol
A867016
EN300-1251177
alpha -(methylaminomethyl)benzyl alcohol
SY078893
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
phenylethanolaminesAn ethanolamine compound having a phenyl (substituted or unsubstituted) group on the carbon bearing the hydroxy substituent.
alkaloidAny of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID513146Binding affinity to human beta-2 adrenergic receptor delta 5-C271 mutant expressed in Spodoptera frugiperda Sf9 cells2006Nature chemical biology, Aug, Volume: 2, Issue:8
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.
AID513152Partial agonist activity at human biamane labelled beta-2 adrenergic receptor delta 5-C271/Trp135 mutant assessed as bimane response by fluorescence spectroscopy2006Nature chemical biology, Aug, Volume: 2, Issue:8
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.
AID513154Binding affinity to human beta-2 adrenergic receptor delta 5-C271/W135 mutant expressed in Spodoptera frugiperda Sf9 cells2006Nature chemical biology, Aug, Volume: 2, Issue:8
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (50.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.01 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.58 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2-hydroxyphenethylamine
2-amino-1-phenylethanol: structure in first source		2.0510phenylethanolamineshuman metabolite
phenethylamine
phenethylamine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7016. 2-phenylethylamine : A phenylethylamine having the phenyl substituent at the 2-position.		210alkaloid;
aralkylamine;
phenylethylamine		Escherichia coli metabolite;
human metabolite;
mouse metabolite
albuterol
Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.. albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).		2.0310phenols;
phenylethanolamines;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
environmental contaminant;
xenobiotic
alprenolol
Alprenolol: One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.. alprenolol : A secondary alcohol that is propan-2-ol substituted by a 2-allylphenoxy group at position 1 and an isopropylamino group at position 3. It is a beta-adrenergic antagonist used as a antihypertensive, anti-arrhythmia and a sympatholytic agent.		2.0310secondary alcohol;
secondary amino compound		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent
ici 118551
[no description available]		2.0310indanes
isoproterenol
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.		2.0310catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
clorgyline
Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.. clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.		2.3620aromatic ether;
dichlorobenzene;
terminal acetylenic compound;
tertiary amino compound		antidepressant;
EC 1.4.3.4 (monoamine oxidase) inhibitor
phenylethyl alcohol
Phenylethyl Alcohol: An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.. 2-phenylethanol : A primary alcohol that is ethanol substituted by a phenyl group at position 2.		2.0510benzenes;
primary alcohol		Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		210amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		210amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
methylamine
methyl group : An alkyl group that is the univalent group derived from methane by removal of a hydrogen atom.		1.9610methylamines;
one-carbon compound;
primary aliphatic amine		mouse metabolite
methamphetamine
Methamphetamine: A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.. methamphetamine : A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.		1.9510amphetamines;
secondary amine		central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic
n-methylphenethylamine
N-methylphenethylamine: substrate for type A & B monoamine oxidase; RN given refers to parent cpd		1.9510
selegiline
Selegiline: A selective, irreversible inhibitor of Type B monoamine oxidase that is used for the treatment of newly diagnosed patients with PARKINSON DISEASE, and for the treatment of depressive disorders. The compound without isomeric designation is Deprenyl.		2.3620selegiline;
terminal acetylenic compound		geroprotector
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0310