Compounds > 2-hydroxyphenethylamine
Page last updated: 2024-12-04

2-hydroxyphenethylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-amino-1-phenylethanol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1000
CHEMBL ID19216
CHEBI ID16343
SCHEMBL ID2021
MeSH IDM0023191

Synonyms (158)

Synonym
benzyl alcohol, .alpha.-(aminomethyl)-
ethylamine, .beta.-hydroxy-.beta.-phenyl-
benzeneethanamine, .beta.-hydroxy-
phenethylamine, .beta.-hydroxy-
ethanol, 2-amino-1-phenyl-
benzenemethanol, .alpha.-(aminomethyl)- (va
.beta.-phenethanolamine
.beta.-phenylethanolamine
2-amino-1-phenyl-1-ethanol
2-phenyl-2-hydroxyethylamine
wln: z1yqr
.beta.-hydroxyphenylethylamine
.beta.-hydroxy-.beta.-phenylethylamine
bisnorephedrine
nsc5021
2-hydroxy-2-phenylethylamine
.alpha.-(aminomethyl)benzyl alcohol
phenethanolamine
nsc-5021
.beta.-hydroxyphenethylamine
beta-phenethanolamine
alpha-(aminomethyl)benzyl alcohol
CHEBI:16343 ,
beta-hydroxyphenethylamine
beta-hydroxy-beta-phenylethylamine
beta-phenylethanolamine
benzenemethanol, .alpha.-(aminomethyl)-
nsc46837
nsc-46837
brn 0971222
ethylamine, beta-hydroxy-beta-phenyl-
benzyl alcohol, alpha-(aminomethyl)- (van)
(+-)-alpha-phenylglycinol
(rs)-2-amino-1-phenylethanol
benzeneethanamine, beta-hydroxy-
einecs 231-469-1
benzyl alcohol, alpha-(aminomethyl)-, (+-)-
benzyl alcohol, alpha-(aminomethyl)-
(+-)-alpha-(aminomethyl)benzenemethanol
(+-)-phenylethanolamine
phenylethanolamin
phenethylamine, beta-hydroxy-
nsc 5021
dl-1-phenyl-1-oxy-2-amino-aethan [german]
benzenemethanol, alpha-(aminomethyl)- (van)
benzenemethanol, alpha-(aminomethyl)-
nsc 46837
OPREA1_790333
7568-93-6
2-amino-1-phenylethanol
C02735
phenylethanolamine ,
2-amino-1-phenylethanol, 98%
A-7000
STK399775
A1018
BMSE000307
benzenemethanol, .alpha.- (aminomethyl)-
benzyl alcohol, .alpha.- (aminomethyl)-
benzyl alcohol, alpha-(aminomethyl)- (van) (8ci)
dl-2-amino-1-phenylethanol
benzenemethanol, alpha-(aminomethyl)- (van) (9ci)
dl-beta-hydroxyphenethylamine
CHEMBL19216
AKOS003790979
A9620
(s)-(-)-2-phenylglycinol
2-amino-1-phenyl-ethanol
niosh/dn5520000
l-1-phenyl-1-oxy-2-amino-aethan [german]
benzyl alcohol, alpha-(aminomethyl)-, (-)-
(-)-alpha-(aminomethyl)benzyl alcohol
DN55200000
l-1-phenyl-1-oxy-2-amino-aethan
benzenemethanol, alpha-(aminomethyl)-, l-
4-13-00-01801 (beilstein handbook reference)
2p4y56479o ,
unii-2p4y56479o
dl-1-phenyl-1-oxy-2-amino-aethan
BP-10077
FT-0611013
FT-0602666
FT-0601946
benzenemethanol, alpha-(aminomethyl)-, d-
d-1-phenyl-1-oxy-2-amino-aethan
(+)-alpha-(aminomethyl)benzyl alcohol
benzyl alcohol, alpha-(aminomethyl)-, (+)-
d-1-phenyl-1-oxy-2-amino-aethan [german]
DN55300000
niosh/dn5530000
AM20060775
2-amino-1-phenylethan-1-ol
S3135
(+/-)-.alpha.-phenylglycinol
rac-2-amino-1-phenylethanol
(+/-)-2-amino-1-phenylethanol
(+/-)-.beta.-hydroxyphenethylamine
dl-phenylethanolamine
(+/-)-phenylethanolamine
dl-.beta.-hydroxy-.beta.-phenethylamine
1-phenyl-2-aminoethanol
apophedrin
1-phenyl-1-hydroxy-2-aminoethane
1-phenylethanolamine
(+/-)-1-phenylethanolamine
(rs)-2-amino-1-phenylethano
dl-.beta.-hydroxyphenylethylamine
phenylethanolamine [mi]
.alpha.-(aminomethyl)benzenemethanol
CS-B0721
bdbm13015
SCHEMBL2021
racemic alpha-(aminomethyl)benzenemethanol
2-amino-1-phenyl ethanol
2amino-1-phenylethanol
2-hydroxy-2-phenylethanamine
alpha-(aminomethyl)-benzyl alcohol
2-hydroxy-2-phenyl-ethylamine
(2-hydroxy-2-phenyl-ethyl)-amine
(1rs)-2-amino-1-phenylethanol
(1rs)-2-amino-1-phenyleihanol
alpha-(aminomethyl)benzenemethanol
beta-hydroxy-phenethyl-amine
2-hydroxy-2-phenyl ethanamine
(.+/-.)-phenylethanolamine
dl-.beta.-phenyl-.beta.-hydroxyethylamine
mfcd00008137
mfcd00239405
beta-hydroxy-phenethylamine
b-hydroxyphenethylamine
beta-hydroxy-beta-phenyl-ethylamine
2-amino-1-phenylethanol-1
dl-beta-phenyl-beta-hydroxyethylamine
(s)-2-amino-1-phenylethanol;(s)-(+)-2-amino-1-phenylethanol
HY-59132
BBL104344
s-(+)-2-amino-1-phenylethanol
F0001-1913
1936-63-6
DTXSID10864094
SY013940
SY042533
AS-38454
2-amino-1-phenylethanol hcl
Q7181429
4,5-dimethyl-9h-xanthene-9-carboxylic acid
h-dl-phg-ol
SY009089
rac-(1r*)-1-phenyl-2-aminoethanol
PB48015
PB48014
alpha-(aminomethyl)benzyl alcohol, dl-beta-hydroxyphenethylamine, phenylethanolamine
EN300-19918
a-(aminomethyl)benzyl alcohol
dl-a-phenyl-b-hydroxyethylamine
2-hydroxy-2-phenyl ethylamine
benzenemethanol,
Z104476088
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
phenylethanolaminesAn ethanolamine compound having a phenyl (substituted or unsubstituted) group on the carbon bearing the hydroxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))IC50 (µMol)870.00000.00000.503510.0000AID1496052
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1496052Inhibition of Influenza A H1N1 virus neuraminidase activity preincubated for 2 mins followed by MUNANA substrate addition measured after 30 mins by fluorescence enzyme immunoassay2018Bioorganic & medicinal chemistry letters, 06-15, Volume: 28, Issue:11
Discovery of (E)-1-amino-4-phenylbut-3-en-2-ol derivatives as novel neuraminidase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (30.00)29.6817
2010's7 (70.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.40 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		2.2110elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
n-methylphenylethanolamine
2-methylamino-1-phenylethanol: structure in first source		2.0510alkaloid;
phenylethanolamines		human metabolite;
plant metabolite
albuterol
Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.. albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).		2.1110phenols;
phenylethanolamines;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
environmental contaminant;
xenobiotic
octopamine
Octopamine: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.. octopamine : A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.		2.1310phenylethanolamines;
tyramines		neurotransmitter
sotalol
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.. sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.		2.1110ethanolamines;
secondary alcohol;
secondary amino compound;
sulfonamide		anti-arrhythmia drug;
beta-adrenergic antagonist;
environmental contaminant;
xenobiotic
phenylethyl alcohol
Phenylethyl Alcohol: An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.. 2-phenylethanol : A primary alcohol that is ethanol substituted by a phenyl group at position 2.		2.0510benzenes;
primary alcohol		Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite
1-phenylpropanol
1-phenylpropanol: structure in first source		2.0310organic molecular entity
acetophenone
acetophenone : A methyl ketone that is acetone in which one of the methyl groups has been replaced by a phenyl group.		2.0310acetophenonesanimal metabolite;
photosensitizing agent;
xenobiotic
phenacylamine
phenacylamine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #6990		2.4720aromatic ketone
rhodium
Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.		2.2110cobalt group element atom
alkenes
[no description available]		2.1310
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.1110cyclodextrin
nadp
[no description available]		2.1110
ConditionIndicatedRelationship StrengthStudiesTrials