migrastatin has been researched along with Adenocarcinoma* in 1 studies
1 other study(ies) available for migrastatin and Adenocarcinoma
| Article | Year |
|---|---|
Synthesis of migrastatin and its macroketone analogue and in vivo FRAP analysis of the macroketone on E-cadherin dynamics.
An efficient and scalable synthesis of a key acyclic intermediate used for the preparation of migrastatin and its macroketone analogue is described; Brown alkoxyallylation is the key step for this synthesis. The macroketone was prepared on 100 mg scale by this route. Treatment of invasive pancreatic cancer cells grown on a cell-derived matrix or as subcutaneous tumours in nude mice with the macroketone inhibited E-cadherin dynamics in a manner consistent with increased cell adhesion and reduced invasive potential. Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cadherins; Cell Adhesion; Cell Movement; Fluorescence Recovery After Photobleaching; Humans; Macrolides; Mice, Nude; Pancreatic Neoplasms; Piperidones; Tumor Cells, Cultured | 2014 |