Compounds > lamellarin d
Page last updated: 2024-11-11

lamellarin d

Description

lamellarin D: a benzo-isoquinoline-coumarin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9892144
CHEMBL ID373114
SCHEMBL ID14106879
MeSH IDM0425729

Synonyms (17)

Synonym
CHEMBL373114
lamellarin d
lamellarin-d
97614-65-8
lamellarine d
unii-yef6xd93ve
yef6xd93ve ,
SCHEMBL14106879
3,11-dihydroxy-14-(4-hydroxy-3-methoxyphenyl)-2,12-dimethoxy-6h-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one
Q18344928
7,17-dihydroxy-12-(4-hydroxy-3-methoxyphenyl)-8,16-dimethoxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2(11),5,7,9,12,14,16,18,20-nonaen-3-one
7,17-dihydroxy-12-(4-hydroxy-3-methoxyphenyl)-8,16-dimethoxy-4-oxa-1-azapentacyclo[11.8.0.0{2,11}.0{5,10}.0{14,19}]henicosa-2(11),5(10),6,8,12,14,16,18,20-nonaen-3-one
6h-(1)benzopyrano(4',3':4,5)pyrrolo(2,1-a)isoquinolin-6-one, 3,11-dihydroxy-14-(4-hydroxy-3-methoxyphenyl)-2,12-dimethoxy-, (+/-)-
3,11-dihydroxy-14-(4-hydroxy-3-methoxyphenyl)-2,12-dimethoxy-6h-(1)benzopyrano(4',3':4,5)pyrrolo(2,1-a)isoquinolin-6-one
6h-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one, 3,11-dihydroxy-14-(4-hydroxy-3-methoxyphenyl)-2,12-dimethoxy-
DTXSID501031665
AKOS040752394

Research Excerpts

Overview

Lamellarin D (LamD) is a hexacyclic pyrole alkaloid isolated from marine invertebrates. Its biologic properties have been attributed to mitochondrial targeting. It is a marine alkaloids with a pronounced cytotoxicity against a large panel of cancer cell lines.

ExcerptReferenceRelevance
"Lamellarin D (LamD) is a marine alkaloid with broad spectrum antitumor activities. "( Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros production.
Ballot, C; Buche, S; Formstecher, P; Jendoubi, M; Kluza, J; Marchetti, P; Martoriati, A; Mortier, L, 2014)		2.11
"Lamellarin D (Lam-D) is a hexacyclic pyrole alkaloid isolated from marine invertebrates, whose biologic properties have been attributed to mitochondrial targeting. "( Poisoning of mitochondrial topoisomerase I by lamellarin D.
Agama, K; Agrawal, S; Dalla Rosa, I; Fesen, K; Khiati, S; Neuman, KC; Pommier, Y; Seol, Y; Zhang, H, 2014)		2.1
"Lamellarin D (LamD) is a marine alkaloid with a pronounced cytotoxicity against a large panel of cancer cells, affecting cell growth and inducing apoptosis. "( Inhibition effects of lamellarin D on human leukemia K562 cell proliferation and underlying mechanisms.
Lin, H; Wang, D; Wang, J; Zhang, N; Zhu, Y, 2014)		2.16
"Lamellarin D (LAM-D) is a marine alkaloid endowed with potent cytotoxic activities against various tumor cells, in particular human prostate cancer cells and leukemia cells. "( Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.
Bailly, C; Cuevas, C; Kluza, J; Lansiaux, A; Otero, G; Tardy, C; Vanhuyse, M, 2005)		3.21
"Lamellarin D is a marine alkaloid with a pronounced cytotoxicity against a large panel of cancer cell lines and is a potent inhibitor of topoisomerase I. "( Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.
Bailly, C; Beauvillain, JC; Cuevas, C; Gallego, MA; Kluza, J; Loyens, A; Marchetti, P; Sousa-Faro, JM, 2006)		2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (44)

Assay IDTitleYearJournalArticle
AID1515359Antiproliferative activity against human ACHN cells after 48 hrs by SRB assay2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID1162581Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay2014European journal of medicinal chemistry, Oct-06, Volume: 85Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents.
AID1515347Antiproliferative activity against human NCI-H522 cells after 48 hrs by SRB assay2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID1162580Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay2014European journal of medicinal chemistry, Oct-06, Volume: 85Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents.
AID1515334Antiproliferative activity against human U251 cells after 48 hrs by SRB assay2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID1732036Cytotoxicity against human HGC-27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Mar-15, Volume: 214Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D.
AID1162582Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay2014European journal of medicinal chemistry, Oct-06, Volume: 85Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents.
AID1515366Antiproliferative activity against human DU145 cells after 48 hrs by SRB assay2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID338960Cytotoxicity against human HeLa cells assessed as inhibition of colony formation after 5 to 8 days by colony assay2002Journal of natural products, Apr, Volume: 65, Issue:4
Synthesis and structure-activity relationship study of lamellarin derivatives.
AID1515352Antiproliferative activity against human LOXIMVI cells after 48 hrs by SRB assay2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID338962Cytotoxicity against african green monkey Vero cells assessed as inhibition of colony formation after 5 to 8 days by colony assay2002Journal of natural products, Apr, Volume: 65, Issue:4
Synthesis and structure-activity relationship study of lamellarin derivatives.
AID644575Inhibition of human topoisomerase 1-mediated relaxation of supercoiled plasmid pUC19 DNA at 100 uM by agarose gel electrophoresis2012European journal of medicinal chemistry, Mar, Volume: 49Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.
AID1732040Inhibition of topoisomerase 1 (unknown origin) assessed as reduction in relaxation of supercoiled plasmid pBR322 DNA at 10 uM incubated for 30 mins by agarose gel electrophoresis2021European journal of medicinal chemistry, Mar-15, Volume: 214Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D.
AID1732041Induction of cell cycle arrest in human MDA-MB-231 cells assessed as increase in accumulation of G2/M phase incubated for 24 hrs by PI staining based flow cytometry analysis2021European journal of medicinal chemistry, Mar-15, Volume: 214Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D.
AID265672Antiproliferative activity against human HT29 cell line after 72 hrs by SRB assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid Lamellarin D.
AID644574Inhibition of human topoisomerase 1-mediated relaxation of supercoiled plasmid pUC19 DNA at 20 uM by agarose gel electrophoresis2012European journal of medicinal chemistry, Mar, Volume: 49Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.
AID1732035Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Mar-15, Volume: 214Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D.
AID1732039Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Mar-15, Volume: 214Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D.
AID644576Cytotoxicity against human CEM cells2012European journal of medicinal chemistry, Mar, Volume: 49Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.
AID338963Cytotoxicity against MDCK cells assessed as inhibition of colony formation after 5 to 8 days by colony assay2002Journal of natural products, Apr, Volume: 65, Issue:4
Synthesis and structure-activity relationship study of lamellarin derivatives.
AID1859462Cytotoxicity against human CEM cells assessed as cell growth inhibition2022European journal of medicinal chemistry, Jun-05, Volume: 236Topoisomerase I inhibitors: Challenges, progress and the road ahead.
AID1732037Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Mar-15, Volume: 214Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D.
AID248114Inhibitory concentration against CEM/C2 cell growth after incubation in liquid medium for 72 h2005Journal of medicinal chemistry, Jun-02, Volume: 48, Issue:11
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
AID612419Stimulation of human recombinant DNA topoisomerase 1-mediated 751-bp BamHI-EcoRV fragment of SV40 DNA cleavage at 1 to 50 uM after 30 mins by polyacrylamide gel-electrophoresis2011Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16
Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.
AID1515357Antiproliferative activity against human SKOV3 cells after 48 hrs by SRB assay2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID1515328Inhibition of calf thymus DNA topoisomerase 1 assessed as reduction in enzyme-mediated relaxation of supercoiled pBR322 plasmid DNA at 10 uM after 30 mins by ethidium bromide staining-based agarose gel electrophoresis2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID612418Antiproliferative activity against human NCI-H460 cells after 72 hrs by coulter counter analysis2011Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16
Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.
AID1515332Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID1859461Cytotoxicity against mouse P388 cells assessed as cell growth inhibition2022European journal of medicinal chemistry, Jun-05, Volume: 236Topoisomerase I inhibitors: Challenges, progress and the road ahead.
AID1515327Inhibition of calf thymus DNA topoisomerase 1 assessed as reduction in enzyme-mediated relaxation of supercoiled pBR322 plasmid DNA at 10 uM after 30 mins by agarose gel electrophoresis2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID248046Inhibitory concentration against CEM cell growth after incubation in liquid medium for 72 h2005Journal of medicinal chemistry, Jun-02, Volume: 48, Issue:11
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
AID245764Ratio of IC50 against CPT-resistant cell line to that of CPT-sensitive cell line expressed as relative resistant index2005Journal of medicinal chemistry, Jun-02, Volume: 48, Issue:11
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
AID265674Antiproliferative activity against human MDA-MB-231 cell line after 72 hrs by SRB assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid Lamellarin D.
AID338964Cytotoxicity against MDCK cells at 1 mM by MTT assay2002Journal of natural products, Apr, Volume: 65, Issue:4
Synthesis and structure-activity relationship study of lamellarin derivatives.
AID1515363Antiproliferative activity against human MKN28 cells after 48 hrs by SRB assay2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID1732043Aqueous solubility of compound in deionized water by HPLC-HRMS analysis2021European journal of medicinal chemistry, Mar-15, Volume: 214Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D.
AID771148Inhibition of calf thymus DNA topoisomerase 1-mediated relaxation of supercoiled pBR322 plasmid DNA at 50 uM 30 mins by ethidium bromide staining2013Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18
Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.
AID265670Antiproliferative activity against human A549 cell line after 72 hrs by SRB assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid Lamellarin D.
AID612417Antiproliferative activity against human NCI-H460 cells after 1 hr by coulter counter analysis2011Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16
Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.
AID1162583Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay2014European journal of medicinal chemistry, Oct-06, Volume: 85Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents.
AID1515344Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay2019Bioorganic & medicinal chemistry, 01-15, Volume: 27, Issue:2
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
AID338961Cytotoxicity against rat XC cells assessed as inhibition of colony formation after 5 to 8 days by colony assay2002Journal of natural products, Apr, Volume: 65, Issue:4
Synthesis and structure-activity relationship study of lamellarin derivatives.
AID1162584Inhibition of calf thymus Topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA at 100 uM after 30 mins by gel electrophoresis2014European journal of medicinal chemistry, Oct-06, Volume: 85Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents.
AID1732038Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Mar-15, Volume: 214Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (40)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's16 (40.00)29.6817
2010's22 (55.00)24.3611
2020's2 (5.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.85 (24.57)
Research Supply Index3.71 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (7.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other37 (92.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
coumarin
2H-chromen-2-one: coumarin derivative		2.1510coumarinsfluorescent dye;
human metabolite;
plant metabolite
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.0210aromatic ether;
nitrile;
polyether;
tertiary amino compound
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		2.0210
vitamin k 3
Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.		2.04101,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		2.0110mitomycinalkylating agent;
antineoplastic agent
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		3.1750pyrrole;
secondary amine
isoquinoline
[no description available]		2.5420azaarene;
isoquinolines;
mancude organic heterobicyclic parent;
ortho-fused heteroarene
1-methylisoquinoline
1-methylisoquinoline : An isoquinoline substituted by a methyl group at position 1.		2.1310isoquinolines
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		2.1510iron group element atom;
platinum group metal atom
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		4.6980delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
1,4-dioxane
1,4-dioxane: dehydrating agent; polar solvent miscible both with water & most organic solvents. dioxane : Any member of the class of dioxanes that is a cyclohexane in which two carbon atoms are replaced by oxygen atoms.. 1,4-dioxane : A dioxane with oxygen atoms at positions 1 and 4.		2.0210dioxane;
volatile organic compound		carcinogenic agent;
metabolite;
NMR chemical shift reference compound;
non-polar solvent
etoposide
[no description available]		2.0210beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
topotecan
Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.. topotecan : A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.		2.0610pyranoindolizinoquinolineantineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor
irinotecan
[no description available]		3.7820carbamate ester;
delta-lactone;
N-acylpiperidine;
pyranoindolizinoquinoline;
ring assembly;
tertiary alcohol;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug
fluorexon
fluorexon: structure		2.0210xanthene dyefluorochrome
sn 38
SN-38 : A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.		2.5220delta-lactone;
phenols;
pyranoindolizinoquinoline;
tertiary alcohol		antineoplastic agent;
apoptosis inducer;
drug metabolite;
EC 5.99.1.2 (DNA topoisomerase) inhibitor
methoctramine
methoctramine: structure given in first source. methoctramine : A tetramine that is N,N'-bis(6-aminohexyl)octane-1,8-diamine where the primary amino groups both carry 2-methoxybenzyl substituents.. methoctramine tetrahydrochloride : A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid.		2.110hydrochloridemuscarinic antagonist
ecteinascidin 743
[no description available]		3.1910acetate ester;
azaspiro compound;
bridged compound;
hemiaminal;
isoquinoline alkaloid;
lactone;
organic heteropolycyclic compound;
organic sulfide;
oxaspiro compound;
polyphenol;
tertiary amino compound		alkylating agent;
angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
marine metabolite
evodiamine
[no description available]		3.5110beta-carbolines
lamellarin h
lamellarin H: a benzo-isoquinoline-coumarin		3.3460
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.0510stilbene
ytterbium(iii) triflate
[no description available]		2.1310
3-nitrocoumarin
[no description available]		2.1310
rhodamine 123
Rhodamine 123: A fluorescent probe with low toxicity which is a potent substrate for ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 in both normal and malignant cells. (Leukemia 1997;11(7):1124-30). rhodamine 123(1+) : A cationic fluorescent dye derived from 9-phenylxanthene.		2.0210organic cation;
xanthene dye		fluorochrome
fosbretabulin
fosbretabulin: a microtubule destabilizing agent isolated from Combretum caffrum; structure in first source		2.0510
luotonin a
luotonin A: structure in first source		3.5110quinazolines
ningalin b
ningalin B: structure in first source		2.0610
nsc 725776
NSC 725776: inhibits topoisomerase I; structure in first source		2.1110
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.0310
interleukin-8
Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.		2.110
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		6.62370benzenes;
hydroxycoumarin;
methyl ketone
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.110
chir-124
[no description available]		3.5110
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Cervix
[description not available]		02.0110
Sarcoma, Epithelioid
[description not available]		02.0110
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.0110
Sarcoma
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.		02.0110
Cancer of Colon
[description not available]		02.6120
Colonic Neoplasms
Tumors or cancer of the COLON.		02.6120
Benign Neoplasms
[description not available]		03.6930
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.6930
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.7130
Adenocarcinoma, Basal Cell
[description not available]		02.0310
Breast Cancer
[description not available]		02.0310
Cancer of Lung
[description not available]		02.4420
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.0310
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0310
Lung Neoplasms
Tumors or cancer of the LUNG.		02.4420
Carcinoma, Non-Small Cell Lung
[description not available]		02.0410
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.0410
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