lamellarin-d and Sarcoma

lamellarin-d has been researched along with Sarcoma* in 1 studies

Other Studies

1 other study(ies) available for lamellarin-d and Sarcoma

Article	Year
Synthesis and structure-activity relationship study of lamellarin derivatives. Journal of natural products, 2002, Volume: 65, Issue:4 Ten derivatives (3-12) of marine alkaloid lamellarin D (1) were synthesized and evaluated for cytotoxicity against a HeLa cell line in an effort to examine their structure-activity relationships. It appeared that the hydroxyl groups at positions C-8 and C-20 of 1 were important structural requirements for cytotoxic activity, while the hydroxyl group at C-14 and the two methoxy groups at C-13 and C-21 were not necessary for the activity. Topics: Alkaloids; Animals; Chlorocebus aethiops; Coumarins; Dogs; Drug Screening Assays, Antitumor; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Isoquinolines; Kidney; Mitomycin; Molecular Structure; Mollusca; Pyrroles; Rats; Sarcoma; Structure-Activity Relationship; Tumor Cells, Cultured; Uterine Cervical Neoplasms	2002

Article

Year

Synthesis and structure-activity relationship study of lamellarin derivatives.

Journal of natural products, 2002, Volume: 65, Issue:4

Ten derivatives (3-12) of marine alkaloid lamellarin D (1) were synthesized and evaluated for cytotoxicity against a HeLa cell line in an effort to examine their structure-activity relationships. It appeared that the hydroxyl groups at positions C-8 and C-20 of 1 were important structural requirements for cytotoxic activity, while the hydroxyl group at C-14 and the two methoxy groups at C-13 and C-21 were not necessary for the activity.

Topics: Alkaloids; Animals; Chlorocebus aethiops; Coumarins; Dogs; Drug Screening Assays, Antitumor; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Isoquinolines; Kidney; Mitomycin; Molecular Structure; Mollusca; Pyrroles; Rats; Sarcoma; Structure-Activity Relationship; Tumor Cells, Cultured; Uterine Cervical Neoplasms

2002