lamellarin-d and 1-4-dioxane

lamellarin-d has been researched along with 1-4-dioxane* in 1 studies

Other Studies

1 other study(ies) available for lamellarin-d and 1-4-dioxane

Article	Year
Modular total synthesis of lamellarin D. The Journal of organic chemistry, 2005, Sep-30, Volume: 70, Issue:20 [Chemical reaction: see text] A modular total synthesis of lamellarin D, a marine alkaloid with potent cytotoxic as well as topoisomerase I inhibition properties, has been accomplished. A sequential and regioselective bromination/Suzuki cross-coupling procedure was applied for the introduction of aryl groups at positions 1 and 2 of scaffold 1. Microwave-assisted 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) oxidation to yield pyrroloisoquinoline 15, followed by phenol group deprotection and subsequent lactonization, gave lamellarin D (18% in eight steps from 1). Topics: Alkaloids; Coumarins; Dioxanes; Enzyme Inhibitors; Heterocyclic Compounds, 4 or More Rings; Indicators and Reagents; Isoquinolines; Models, Molecular; Topoisomerase I Inhibitors	2005

Article

Year

Modular total synthesis of lamellarin D.

The Journal of organic chemistry, 2005, Sep-30, Volume: 70, Issue:20

[Chemical reaction: see text] A modular total synthesis of lamellarin D, a marine alkaloid with potent cytotoxic as well as topoisomerase I inhibition properties, has been accomplished. A sequential and regioselective bromination/Suzuki cross-coupling procedure was applied for the introduction of aryl groups at positions 1 and 2 of scaffold 1. Microwave-assisted 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) oxidation to yield pyrroloisoquinoline 15, followed by phenol group deprotection and subsequent lactonization, gave lamellarin D (18% in eight steps from 1).

Topics: Alkaloids; Coumarins; Dioxanes; Enzyme Inhibitors; Heterocyclic Compounds, 4 or More Rings; Indicators and Reagents; Isoquinolines; Models, Molecular; Topoisomerase I Inhibitors

2005