indolylacryloylglycine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

indolylacryloylglycine: chromogen found in urine; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	5370648
CHEBI ID	145761
SCHEMBL ID	4224306
MeSH ID	M0042159

Synonyms (30)

Synonym
indoleacrylic glycine
indole-3-acryloylglycine
I-1975
CHEBI:145761
2-[[(e)-3-(1h-indol-3-yl)prop-2-enoyl]amino]acetic acid
3475-68-1
indolylacryloylglycine
n-(3-(1h-indol-3-yl)-1-oxo-2-propenyl)glycine
SCHEMBL4224306
DUIFVCFSAWHIOD-AATRIKPKSA-N
([(2e)-3-(1h-indol-3-yl)-2-propenoyl]amino)acetic acid #
indole-3-acryloyl-glycine
2-[(2e)-3-(1h-indol-3-yl)prop-2-enamido]acetic acid
n-(3-(1-indol-3-yl)-1-oxo-2-propenyl)glycine
indolyl acryloylglycine
indolyl-3-acryloylglycine
2-(3-(1h-indol-3-yl)acrylamido)acetic acid
(e)-2-(3-(1h-indol-3-yl)acrylamido)acetic acid
Q15411025
2-(3-(1h-indol-3-yl)acrylamido)aceticacid
61994-17-0
2-(3-(1h-indol-3-yl)prop-2-enoylamino)ethanoic acid
ney8pp6vm8 ,
n-(3-indol-3-ylacryloyl)glycine
glycine, n-[3-(1h-indol-3-yl)-1-oxo-2-propenyl]-, (e)-
n-[(2e)-3-(1h-indol-3-yl)-1-oxo-2-propen-1-yl]glycine
glycine, n-[3-(1h-indol-3-yl)-1-oxo-2-propen-1-yl]-
n-[3-(1h-indol-3-yl)-1-oxo-2-propen-1-yl]glycine
glycine, n-[3-(1h-indol-3-yl)-1-oxo-2-propenyl]-
glycine, n-[(2e)-3-(1h-indol-3-yl)-1-oxo-2-propen-1-yl]-

Research Excerpts

Overview

Indolylacryloylglycine (IAcrGly) is a regular constituent of human urine.

Excerpt	Reference	Relevance
"Indolylacryloylglycine (IAcrGly) is a regular constituent of human urine. "	( Urinary excretion of indolylacryloylglycine, indolylacetic acid and 5-hydroxyindolylacetic acid in burn patients. Hais, IM; Klein, L; Marklová, E, 1993)	2.05

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
N-acyl-amino acid	A carboxamide resulting from the formal condensation of a carboxylic acid with the amino group of an amino acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

Pathway	Proteins	Compounds
Tryptophan metabolism	23	42

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (19.05)	18.7374
1990's	4 (19.05)	18.2507
2000's	6 (28.57)	29.6817
2010's	7 (33.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.42 (24.57)
Research Supply Index	3.18 (2.92)
Research Growth Index	4.59 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.42)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (9.52%)	5.53%
Reviews	2 (9.52%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (80.95%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
hippuric acid hippuric acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #4591. N-benzoylglycine : An N-acylglycine in which the acyl group is specified as benzoyl.	2.07	1	0	N-acylglycine	human blood serum metabolite; uremic toxin
creatine [no description available]	2.01	1	0	glycine derivative; guanidines; zwitterion	geroprotector; human metabolite; mouse metabolite; neuroprotective agent; nutraceutical
glycine [no description available]	10.07	22	3	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
indoleacetic acid indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841. auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").. indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.	1.98	1	0	indole-3-acetic acids; monocarboxylic acid	auxin; human metabolite; mouse metabolite; plant hormone; plant metabolite
porphobilinogen [no description available]	2.11	1	0	aralkylamino compound; dicarboxylic acid; pyrroles	Escherichia coli metabolite; metabolite; mouse metabolite
hydroxyindoleacetic acid (5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.	1.98	1	0	indole-3-acetic acids	drug metabolite; human metabolite; mouse metabolite
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	2.07	1	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.07	1	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	4	4	0	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
substance p [no description available]	2.01	1	0	peptide	neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent
lenticin lenticin: found in extracts of lentils. hypaphorine : An amino acid betaine obtaine by exhaustive methylation of the alpha-amino group of L-tryptophan with concomitant deprotonation of the carboxy group.	3.47	2	0	amino-acid betaine; indole alkaloid; L-tryptophan derivative	fungal metabolite; plant metabolite; xenobiotic
chlorogenic acid caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.	2.07	1	0	cinnamate ester; tannin	food component; plant metabolite
indoleacrylic acid indoleacrylic acid: Russian drug; natural auxin from lentil roots; RN given refers to parent cpd without isomeric designation	3.48	2	0
dermorphin dermorphin: opiate-like peptide present in amphibian skin	2.01	1	0	oligopeptide
caseins Caseins: A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.	6.77	3	3
neopterin [no description available]	3.16	1	0

Condition	Relationship Strength	Studies	Trials
Pervasive Child Development Disorders [description not available]	9.27	7	5
Hyperactivity, Motor [description not available]	8.07	5	5
Child Development Disorders, Pervasive Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.	9.27	7	5
Acute Porphyria [description not available]	2.11	1	0
Porphyria, Acute Intermittent An autosomal dominant porphyria that is due to a deficiency of HYDROXYMETHYLBILANE SYNTHASE in the LIVER, the third enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features are recurrent and life-threatening neurologic disturbances, ABDOMINAL PAIN, and elevated level of AMINOLEVULINIC ACID and PORPHOBILINOGEN in the urine.	2.11	1	0
Autism Spectrum Disorder Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)	2.55	2	0
Cholera Infantum [description not available]	2.49	2	0
Intestinal Diseases Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.	2.15	1	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	3.86	4	0
Autism [description not available]	3.13	5	0
Autistic Disorder A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)	3.13	5	0
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	7.65	5	4
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.07	1	0
Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome [description not available]	2.01	1	0
Rett Syndrome An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)	2.01	1	0
Child Development Deviations [description not available]	2.01	1	0
Developmental Disabilities Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)	2.01	1	0
Symptom Cluster [description not available]	2.02	1	0
Syndrome A characteristic symptom complex.	2.02	1	0
Burns Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.	2.39	2	0
Proteinuria The presence of proteins in the urine, an indicator of KIDNEY DISEASES.	1.99	1	0
Bladder Cancer [description not available]	2	1	0
Muscular Dystrophy [description not available]	2	1	0
Dermatoses [description not available]	2.37	2	0
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2	1	0
Muscular Dystrophies A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.	2	1	0
Skin Diseases Diseases involving the DERMIS or EPIDERMIS.	2.37	2	0
Scrofuloderma [description not available]	1.95	1	0

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