| Assay ID | Title | Year | Journal | Article |
|---|
| AID398154 | Intrinsic clearance in mouse liver microsomes measured per gram of liver | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398143 | AUC/dose in rat at 3 mg/kg, po | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398157 | Lipophilicity, log D at pH 7.4 | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398155 | Intrinsic clearance in rat liver microsomes measured per gram of liver | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398168 | AUC/dose in rat at 10 mg/kg, po | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID314042 | Inhibition of BACE1 assessed as amyloid beta40 production in human SHSY5Y-APP-swe cells | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID398150 | Inhibition of CYP2C19 | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398146 | Inhibition of BACE in human SHSY5Y cells expressing wild-type APP assessed as inhibition of intracellular amyloid beta-40 | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID314045 | Decrease in amyloid beta42 in TASTPM mouse brain at 250 mg/kg, po after 5 days | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID398167 | Half life in rat at 10 mg/kg, po | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID314036 | Inhibition of BACE1 expressed in CHO cells by FRET assay | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID314046 | Decrease in amyloid beta40 in TASTPM mouse brain at 250 mg/kg, po after 5 days in presence of Pgp inhibitor | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID398153 | Inhibition of CYP3A4 using 7-benzyloxyquinoline as substrate | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398156 | Intrinsic clearance in human liver microsomes measured per gram of liver | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID314043 | Inhibition of BACE1 assessed as amyloid beta42 production in human SHSY5Y-APP-swe cells | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID398152 | Inhibition of CYP3A4 using diethoxyfluorescein as substrate | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398145 | Inhibition of BACE | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398160 | Volume of distribution at steady state in iv dosed rat | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID314047 | Decrease in amyloid beta42 in TASTPM mouse brain at 250 mg/kg, po after 5 days in presence of Pgp inhibitor | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID398162 | Bioavailability in ipv dosed rat | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398149 | Inhibition of CYP2C9 | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID314044 | Decrease in amyloid beta40 in TASTPM mouse brain at 250 mg/kg, po after 5 days | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID398161 | Half life in iv dosed rat | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398165 | Half life in rat at 3 mg/kg, po | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398151 | Inhibition of CYP2D6 | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398147 | Inhibition of BACE in human SHSY5Y cells expressing swedish-mutant APP assessed as inhibition of intracellular amyloid beta-40 | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398159 | Blood clearance in iv dosed rat administered as saline containing kleptose | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID314040 | Inhibition of BACE1 assessed as amyloid beta40 production in human SHSY5Y-APP-wt cells | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID314041 | Inhibition of BACE1 assessed as amyloid beta42 production in human SHSY5Y-APP-wt cells | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID398164 | Oral bioavailability in rat at 3 mg/kg | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID398148 | Inhibition of CYP1A2 | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID314037 | Inhibition of BACE2 expressed in CHO cells by FRET assay | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID398166 | Oral bioavailability in rat at 10 mg/kg administered as tween solution containing aqueous methylcellulose | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| AID314038 | Inhibition of Cathepsin D expressed in CHO cells by FRET assay | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID1798729 | Enzyme Inhibition Assay from Article 10.1016/j.bmcl.2007.12.020: \\BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.\\ | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. |
| AID1799029 | Enzyme Inhibition Assay from Article 10.1016/j.bmcl.2009.03.165: \\Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.\\ | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |