Encephalomyelitis, Western Equine

A form of arboviral encephalitis (which primarily affects horses) endemic to western and central regions of NORTH AMERICA. The causative organism (ENCEPHALOMYELITIS VIRUS, WESTERN EQUINE) may be transferred to humans via the bite of mosquitoes (CULEX tarsalis and others). Clinical manifestations include headache and influenza-like symptoms followed by alterations in mentation, SEIZURES, and COMA. DEATH occurs in a minority of cases. Survivors may recover fully or be left with residual neurologic dysfunction, including PARKINSONISM, POSTENCEPHALITIC. (From Joynt, Clinical Neurology, 1996, Ch26, pp8-9)

Synonym
Western Equine Encephalitis
Encephalomyelitis, Western Equine

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	10 (90.91)	23.3326
1990's	0 (0.00)	12.5806
2000's	1 (9.09)	18.1394
2010's	0 (0.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
formaldehyde	low	1
ddt	low	2
ether	low	1
phenolsulfonphthalein	low	1
lysine	low	1
methionine	low	1
histidine	low	1
pyrazines	low	1
ethionine	low	1
metaperiodate	low	1
puromycin	low	2
favipiravir	low	1

Protein Targets (206)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Cruzipain	1	0	0	1
interleukin 8	1	0	0	1
pregnane X receptor	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
RAR-related orphan receptor gamma	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
TDP1 protein	1	0	0	1
GLI family zinc finger 3	1	0	0	1
AR protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
progesterone receptor	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
retinoid X nuclear receptor alpha	1	0	0	1
estrogen-related nuclear receptor alpha	3	0	0	3
farnesoid X nuclear receptor	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
estrogen nuclear receptor alpha	2	0	0	2
G	3	0	0	3
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
aryl hydrocarbon receptor	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
Histone H2A.x	2	0	0	2
Caspase-7	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	1	0	0	1
thyroid hormone receptor beta isoform 2	1	0	0	1
heat shock protein beta-1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	1	0	0	1
geminin	1	0	0	1
peripheral myelin protein 22	2	0	0	2
lethal factor (plasmid)	2	0	0	2
lamin isoform A-delta10	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	1	0	0	1
Androgen receptor	0	1	0	1
Glutamate receptor 2	2	0	0	2
Nuclear receptor ROR-gamma	1	0	0	1
Inositol hexakisphosphate kinase 1	3	0	0	3
cytochrome P450 2C9, partial	3	0	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
ATAD5 protein, partial	1	0	0	1
flap endonuclease 1	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Carbonic anhydrase 12	0	0	0	1
Carbonic anhydrase 1	0	2	0	4
Carbonic anhydrase 2	0	2	0	4
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
GABA theta subunit	1	0	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Cationic amino acid transporter 3	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Luciferase	1	0	0	1
USP1 protein, partial	1	0	0	1
GLS protein	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
Histamine H2 receptor	1	0	0	1
30S ribosomal protein S6	0	1	0	2
30S ribosomal protein S7	0	1	0	2
50S ribosomal protein L15	0	1	0	2
50S ribosomal protein L10	0	1	0	2
50S ribosomal protein L11	0	1	0	2
50S ribosomal protein L7/L12	0	1	0	2
50S ribosomal protein L19	0	1	0	2
50S ribosomal protein L1	0	1	0	2
50S ribosomal protein L20	0	1	0	2
50S ribosomal protein L27	0	1	0	2
50S ribosomal protein L28	0	1	0	2
50S ribosomal protein L29	0	1	0	2
50S ribosomal protein L31	0	1	0	2
50S ribosomal protein L31 type B	0	1	0	2
50S ribosomal protein L32	0	1	0	2
50S ribosomal protein L33	0	1	0	2
50S ribosomal protein L34	0	1	0	2
50S ribosomal protein L35	0	1	0	2
50S ribosomal protein L36	0	1	0	2
30S ribosomal protein S10	0	1	0	2
30S ribosomal protein S11	0	1	0	2
30S ribosomal protein S12	0	1	0	2
30S ribosomal protein S13	0	1	0	2
30S ribosomal protein S16	0	1	0	2
30S ribosomal protein S18	0	1	0	2
30S ribosomal protein S19	0	1	0	2
30S ribosomal protein S20	0	1	0	2
30S ribosomal protein S2	0	1	0	2
30S ribosomal protein S3	0	1	0	2
30S ribosomal protein S4	0	1	0	2
30S ribosomal protein S5	0	1	0	2
30S ribosomal protein S8	0	1	0	2
30S ribosomal protein S9	0	1	0	2
50S ribosomal protein L13	0	1	0	2
50S ribosomal protein L14	0	1	0	2
50S ribosomal protein L16	0	1	0	2
50S ribosomal protein L23	0	1	0	2
30S ribosomal protein S15	0	1	0	2
50S ribosomal protein L17	0	1	0	2
50S ribosomal protein L21	0	1	0	2
50S ribosomal protein L30	0	1	0	2
50S ribosomal protein L6	0	1	0	2
30S ribosomal protein S14	0	1	0	2
30S ribosomal protein S17	0	1	0	2
30S ribosomal protein S1	0	1	0	2
50S ribosomal protein L18	0	1	0	2
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Puromycin-sensitive aminopeptidase	0	1	0	1
50S ribosomal protein L2	0	1	0	2
50S ribosomal protein L3	0	1	0	2
50S ribosomal protein L24	0	1	0	2
50S ribosomal protein L4	0	1	0	2
50S ribosomal protein L22	0	1	0	2
50S ribosomal protein L5	0	1	0	2
30S ribosomal protein S21	0	1	0	2
50S ribosomal protein L25	0	1	0	2
50S ribosomal protein L36 2	0	1	0	2
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Encephalomyelitis, Western Equine

Synonyms(2)

Research

Studies (11)

Protein Targets (206)

Encephalomyelitis, Western Equine

Synonyms(2)

Research

Studies (11)

Drugs Studied (15)

Protein Targets (206)