triflic anhydride
Description
Triflic anhydride, also known as trifluoromethanesulfonic anhydride, is a powerful electrophilic reagent used in organic synthesis. It is a colorless, corrosive liquid with a pungent odor. It is synthesized by reacting triflic acid with a strong dehydrating agent, such as phosphorus pentoxide. Triflic anhydride is a versatile reagent that can be used to activate a wide range of functional groups, such as alcohols, amines, and carboxylic acids. It is also used in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and polymers. The strong electron-withdrawing nature of the trifluoromethyl group in triflic anhydride makes it an excellent leaving group, promoting various reactions. It is a powerful reagent for introducing triflate groups into organic molecules, which can be further functionalized. Triflic anhydride is also used in the synthesis of triflate salts, which are important catalysts in various organic reactions. Due to its high reactivity and potential hazards, the use of triflic anhydride requires proper safety precautions.'
triflic anhydride: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 67749 |
| CHEBI ID | 48509 |
| SCHEMBL ID | 160 |
| MeSH ID | M0450519 |
Synonyms (86)
| Synonym |
|---|
| trifluormethylsulfonyl trifluormethansulfonat |
| methanesulfonic acid, trifluoro-, anhydride |
| trifluoromethanesulfonic anhydride , |
| triflic anhydride |
| 1,1,1-trifluoromethanesulfonic acid 1,1'-anhydride |
| CHEBI:48509 |
| 358-23-6 |
| trifluoromethanesulfonic anhydride, >=99% |
| trifluoromethylsulfonyl trifluoromethanesulfonate |
| T1100 |
| AKOS007930319 |
| (trifluoromethane)sulfonyl trifluoromethanesulfonate |
| 8w034lhg1u , |
| methanesulfonic acid, 1,1,1-trifluoro-, 1,1'-anhydride |
| einecs 206-616-8 |
| unii-8w034lhg1u |
| trifluoromethanesulfonic acid anhydride |
| trifluoromethanesulphonic acid anhydride |
| trifluoromethanesulfonyl anhydride |
| trifluoromethane sulfonic anhydride |
| trifluoromethanesulphonic anhydride |
| A822989 |
| trifluoromethanesulfonic acid trifluoromethylsulfonyl ester |
| trifluoromethylsulfonyl tris(fluoranyl)methanesulfonate |
| trifluoromethane sulfonic acid anhydride |
| BP-20541 |
| FT-0632032 |
| tf2o |
| trifluoromethanesulfonyl trifluoromethanesulfonate |
| SCHEMBL160 |
| CS-B0874 |
| otf2 |
| trifluoromethansulfonic anhydride |
| trifluoromethane-sulfonic acid anhydride |
| trifluoromethane -sulfonic anhydride |
| triflouromethanesulfonic anhydride |
| trifluoro methane sulfonic acid anhydride |
| trifluoromethanesulfonic-acid anhydride |
| (cf3so2)2o |
| trifluoro-methanesulfonic acid anhydride |
| trifluorornethanesulfonic anhydride |
| trifluoromethyl sulfonic anhydride |
| trifluormethane sulfonic acid anhydride |
| trifluoromethane-sulphonic anhydride |
| trifluoro-methansulfonic acid anhydride |
| trifluromethane sulfonic anhydride |
| trifluoromethylsulfonic acid anhydride |
| trifluoromethylsulfonic anhydride |
| trifluorometansulfonic anhydrid |
| trifluro methanesulfonic anhydride |
| trifluoro-methanesulfonic anhydride |
| trifluormethanesulfonic anhydride |
| trifluoromethanesufonic anhydride |
| trifluoro methanesulfonic anhydride |
| trifluoromethylsulphonic anhydride |
| trifiuoromethanesulphonic anhydride |
| trifluormethanesulfonic acid anhydride |
| triflouromethane-sulfonic anhydride |
| trifluoromethansulphonic anhydride |
| trifluoromethane-sulfonic anhydride |
| triflic acid anhydride |
| trifloromethanesulfonic anhydride |
| trifluoromethane sulphonic anhydride |
| trifluormethane sulfonic anhydride |
| trifluoromethyl sulphonic anhydride |
| (tf)2o |
| trifluormethansulphonic anhydride |
| trifluoro-methanesulphonic anhydride |
| trifluoromethanesulfonic-anhydride |
| trifluoromethane-sulfonic-anhydride |
| Q-101271 |
| triflate anhydride |
| trifluoromethanesulfonic anhydride [mi] |
| mfcd00000408 |
| c2f6o5s2 |
| trifluoromethanesulfonic anhydride, purum, >=98.0% (t) |
| GS-3207 |
| BCP24336 |
| Q6128335 |
| STL558688 |
| DTXSID501014629 |
| BBL036267 |
| AMY3637 |
| EN300-50306 |
| trifluoromethanesulfonic?anhydride |
| triflic anhydride solution |
Drug Classes (1)
| Class | Description |
|---|---|
| organosulfonic anhydride | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Research
Studies (19)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 59.91
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (59.91) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 19 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||