Page last updated: 2024-12-11
jorumycin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
jorumycin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 9849761 |
| CHEMBL ID | 539920 |
| MeSH ID | M0494262 |
Synonyms (3)
| Synonym |
|---|
| CHEMBL539920 |
| jorumycin |
| [(1r,2s,10r,12s,13s)-12-hydroxy-7,18-dimethoxy-6,17,21-trimethyl-5,8,16,19-tetraoxo-11,21-diazapentacyclo[11.7.1.02,11.04,9.015,20]henicosa-4(9),6,15(20),17-tetraen-10-yl]methyl acetate |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (12)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID265918 | Antiproliferative activity against human A549 cell line | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G. |
| AID1871296 | Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 4 days by Cell counting kit-8 assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| AID1871295 | Cytotoxicity against human HT-29 cells assessed as cell growth inhibition | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| AID1871294 | Cytotoxicity against human Melanoma cell line assessed as cell growth inhibition | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| AID1871292 | Cytotoxicity against mouse NIH3T3 cells assessed as cell growth inhibition at 50 ng/ml | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| AID1871289 | Cytotoxicity against mouse P388 cells assessed as cell growth inhibition | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| AID265919 | Antiproliferative activity against human HCT116 cell line | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G. |
| AID1871293 | Cytotoxicity against human A549 cells assessed as cell growth inhibition | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| AID1871297 | Cytotoxicity against human QG-56 cells assessed as cell growth inhibition incubated for 4 days by Cell counting kit-8 assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| AID427238 | Cytotoxicity against human HCT116 cells at 1.4 to 100 nM after 3 days by MTT assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Chemistry of renieramycins. Part 8: synthesis and cytotoxicity evaluation of renieramycin M-jorunnamycin A analogues. |
| AID427237 | Cytotoxicity against human QG56 cells at 1.4 to 100 nM after 3 days by MTT assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Chemistry of renieramycins. Part 8: synthesis and cytotoxicity evaluation of renieramycin M-jorunnamycin A analogues. |
| AID1871298 | Cytotoxicity against human DU-145 cells assessed as cell growth inhibition incubated for 4 days by Cell counting kit-8 assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 20.10
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.10) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (14.29%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (85.71%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||