ecteinascidin 770 profile

ecteinascidin 770: fom the Thai tunicate Ecteinascidia thurstoni; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10952807
CHEMBL ID	448144
SCHEMBL ID	9765335
MeSH ID	M0438296

Synonyms (14)

Synonym
ecteinascidin 770
CHEMBL448144
BGFXHQYUWCGGLL-QWIBJBKUSA-N
SCHEMBL9765335
114899-80-8
CS-6236
HY-101191
et-770
ecteinascidine 770
F85510
MS-31394
[(1r,2r,3r,11s,12r,14r,26r)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2h-isoquinoline]-22-
ecteinascidin770
AKOS040733065

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID335534	Cytotoxicity against breast cancer cells	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Ecteinascidins 770 and 786 from the Thai tunicate Ecteinascidia thurstoni.
AID356602	Cytotoxicity against human NCI-H460 cells after 4 days	2003	Journal of natural products, Nov, Volume: 66, Issue:11	Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
AID356603	Cytotoxicity against human DLD1 cells after 4 days	2003	Journal of natural products, Nov, Volume: 66, Issue:11	Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
AID609863	Cytotoxicity against human DU145 cells after 4 days by MTT assay	2011	Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15	Chemistry of ecteinascidins. Part 3: preparation of 2'-N-acyl derivatives of ecteinascidin 770 and evaluation of cytotoxicity.
AID609862	Cytotoxicity against human QG56 cells after 4 days by MTT assay	2011	Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15	Chemistry of ecteinascidins. Part 3: preparation of 2'-N-acyl derivatives of ecteinascidin 770 and evaluation of cytotoxicity.
AID609861	Cytotoxicity against human HCT116 cells after 4 days by MTT assay	2011	Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15	Chemistry of ecteinascidins. Part 3: preparation of 2'-N-acyl derivatives of ecteinascidin 770 and evaluation of cytotoxicity.
AID356601	Cytotoxicity against human QG56 cells after 4 days	2003	Journal of natural products, Nov, Volume: 66, Issue:11	Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
AID335536	Antitubercular activity against Mycobacterium tuberculosis H37Ra	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Ecteinascidins 770 and 786 from the Thai tunicate Ecteinascidia thurstoni.
AID356600	Cytotoxicity against human HCT116 cells after 4 days	2003	Journal of natural products, Nov, Volume: 66, Issue:11	Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
AID335535	Cytotoxicity against human KB cells	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Ecteinascidins 770 and 786 from the Thai tunicate Ecteinascidia thurstoni.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (50.00)	29.6817
2010's	4 (50.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.31 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.31)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
benzene [no description available]	2.01	1	aromatic annulene; benzenes; volatile organic compound	carcinogenic agent; environmental contaminant; non-polar solvent
potassium cyanide [no description available]	2.01	1	cyanide salt; one-carbon compound; potassium salt	EC 1.15.1.1 (superoxide dismutase) inhibitor; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; neurotoxin
saframycin a saframycin A: structure given in first source	2.01	1
renieramycin m renieramycin M: from the Thai sponge Xestospongia sp.; structure in first source	2.01	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.06	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.06	1
Carcinoma, Non-Small Cell Lung [description not available]	2.08	1
Cancer of Lung [description not available]	2.08	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.08	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.08	1

ecteinascidin 770

Description