Page last updated: 2024-11-13
ortho evra
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
Ortho Evra: a combination transdermal contraceptive patch with a contact surface area of 20 cm2. It contains 6 mg norelgestromin and 0.75 mg ethinyl estradiol; was indexed to norelgestromin (2002-2006) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 53461729 |
| MeSH ID | M0492373 |
Synonyms (2)
| Synonym |
|---|
| ortho evra |
| FT-0665916 |
Research Excerpts
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| "Treatment-emergent adverse events of 2% or greater in the LNG/EE contraceptive patch were nasopharyngitis (5." | ( Safety and tolerability of a new low-dose contraceptive patch in obese and nonobese women. Archer, DF; Foegh, M; Kaunitz, AM; Mishell, DR, 2015) | 0.42 |
| "The LNG/EE contraceptive patch and combination oral contraceptives were well tolerated and associated with similar treatment-emergent adverse event incidences in obese and nonobese women." | ( Safety and tolerability of a new low-dose contraceptive patch in obese and nonobese women. Archer, DF; Foegh, M; Kaunitz, AM; Mishell, DR, 2015) | 0.42 |
Pharmacokinetics
| Excerpt | Reference | Relevance |
|---|---|---|
| " The method has been successfully applied to a pharmacokinetic study of the ORTHO EVRA patch in rabbits." | ( Determination of norelgestromin in rabbit plasma by LC-MS/MS and its application to the pharmacokinetic study of ORTHO EVRA. Ding, C; Ge, Q; Liu, X; Zhi, X; Zhou, Z, 2009) | 0.35 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| "Film forming polymeric solutions may present an alternative to the common transdermal dosage forms such as patches or gels." | ( Delivery of ethinylestradiol from film forming polymeric solutions across human epidermis in vitro and in vivo in pigs. Franke, P; Lehr, CM; Schaefer, UF; Zurdo Schroeder, I, 2007) | 0.34 |
| " This might be an effect of the convenience of the weekly dosing schedule." | ( Evaluation of the contraceptive efficacy, compliance, and satisfaction with the transdermal contraceptive patch system Evra: a comparison between adolescent and adult users. Bodner, K; Bodner-Adler, B; Grünberger, W, 2011) | 0.37 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (36)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (33.33) | 29.6817 |
| 2010's | 20 (55.56) | 24.3611 |
| 2020's | 4 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 9 (23.68%) | 5.53% |
| Reviews | 3 (7.89%) | 6.00% |
| Case Studies | 2 (5.26%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 24 (63.16%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Clinical Trials (8)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Bioequivalence Study to Evaluate the Effect of an Adhesive Overlay on the Delivery of Contraceptive Hormones From ORTHO EVRA® in Healthy Women [NCT01535820] | Phase 1 | 54 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| The Effects of Oral Contraceptive Pills vs Hormonal Patch on Coagulation Parameters [NCT00554632] | 24 participants (Actual) | Interventional | 2003-04-30 | Completed | |||
| An Open-Label, Randomized, Multicenter Trial to Evaluate Continuation Rates, Side Effects and Acceptability of NuvaRing Versus OrthoEvra [NCT00269620] | Phase 4 | 500 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| Comparison of Oral and Patch Forms of Hormonal Contraception on Plasma Lipoproteins, Glycemia, Clotting Factors, Indices of Inflammation and Vascular Reactivity [NCT00439972] | Phase 2 | 36 participants (Anticipated) | Interventional | 2007-02-28 | Active, not recruiting | ||
| A Phase II Pharmacokinetic Study of the Transdermal Contraceptive System and Oral Contraceptive in HIV-1 Infected Women on Lopinavir/Ritonavir [NCT00125983] | Phase 2 | 32 participants (Actual) | Interventional | Completed | |||
| Postmarketing Study of ORTHO EVRA in Relation to Venous Thromboembolism, Ischemic Stroke, and Myocardial Infarction [NCT00331071] | 334 participants (Actual) | Observational | 2002-04-30 | Completed | |||
| Patient Experiences Using Evra for Management of Menstrual Related Symptoms. [NCT00357981] | 0 participants (Actual) | Interventional | Withdrawn(stopped due to Both sponsor and UCSF decided this study was not clinical relevant at this time) | ||||
| The Pharmacokinetics of 12 Week Continuous Patch Use [NCT02585999] | 30 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||