mci 826 profile

ID Source	ID
PubMed CID	6439428
SCHEMBL ID	9094380
SCHEMBL ID	9094397
MeSH ID	M0207548

Synonym
2,2-diethyl-3'-(2-(2-(4-isopropyl)thiazolyl)ethenyl)succinanilic acid
140646-80-6
butanoic acid, 2,2-diethyl-4-((3-(2-(4-(1-methylethyl)-2-thiazolyl)ethenyl)phenyl)amino)-4-oxo-, (e)-
butanoic acid, 2,2-diethyl-4-(3-(2-(4-(1-methylethyl)-2-thiazolyl)ethenyl)amino)-4-oxo-, (e)-
mci-826
mci 826
SCHEMBL9094380
SCHEMBL9094397
2,2-diethyl-4-oxo-4-[3-[(e)-2-(4-propan-2-yl-1,3-thiazol-2-yl)ethenyl]anilino]butanoic acid
mci826
CS-7430
HY-U00247
AKOS040742109

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (77.78)	18.2507
2000's	2 (22.22)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's
aa 861	1	1,4-benzoquinones; acetylenic compound; primary alcohol	EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; ferroptosis inhibitor	1993	1993	31.0	low	1	0
albuterol	1	phenols; phenylethanolamines; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; environmental contaminant; xenobiotic	1992	1992	32.0	low	1	0
theophylline	1	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent	1992	1992	32.0	low	1	0
indomethacin	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic	1993	1993	31.0	low	1	0
ly 171883	1	acetophenones; aromatic ether; phenols; tetrazoles	anti-asthmatic drug; leukotriene antagonist	1992	1992	32.0	low	1	0
ono 1078	1	chromones		2002	2002	22.0	low	0	1
pyrilamine	2	aromatic ether; ethylenediamine derivative	H1-receptor antagonist	1994	2000	27.0	low	2	0
prednisolone	1	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; drug metabolite; environmental contaminant; immunosuppressive agent; xenobiotic	1992	1992	32.0	low	1	0
penicillin g	3	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope	1992	2000	28.7	low	3	0
thiazoles	9	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		1992	2002	29.7	high	8	1
cromolyn sodium	1	organic sodium salt	anti-asthmatic drug; drug allergen	1992	1992	32.0	low	1	0
substance p	1	peptide	neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent	2000	2000	24.0	low	1	0
cp 96345	1			2000	2000	24.0	low	1	0
sr 48968	1			2000	2000	24.0	low	1	0
fpl 55712	1	aromatic ketone		1992	1992	32.0	low	1	0
prostaglandin d2	1	prostaglandins D	human metabolite; mouse metabolite	1992	1992	32.0	low	1	0
ovalbumin	1			2002	2002	22.0	low	0	1
leukotriene c4	1	leukotriene	bronchoconstrictor agent; human metabolite; mouse metabolite	1994	1994	30.0	low	1	0
leukotriene d4	1	dipeptide; leukotriene; organic sulfide	bronchoconstrictor agent; human metabolite; mouse metabolite	1994	1994	30.0	low	1	0
cysteine	1	cysteinium	fundamental metabolite	2002	2002	22.0	low	0	1
piperidines	1			2000	2000	24.0	low	1	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's
Angiitis	1	1992	1992	32.0	low	1	0
Asthma	2	1992	2002	27.0	medium	1	1
Asthma, Bronchial	2	1992	2002	27.0	medium	1	1
Bright Disease	1	1992	1992	32.0	low	1	0
Disease Models, Animal	1	1992	1992	32.0	low	1	0
Eosinophilia	1	2002	2002	22.0	low	0	1
Eosinophilia, Pulmonary	1	2002	2002	22.0	low	0	1
Eosinophilia, Tropical	1	2002	2002	22.0	low	0	1
Glomerulonephritis	1	1992	1992	32.0	low	1	0
Muscle Contraction	4	1992	1994	31.5	high	4	0
Pulmonary Eosinophilia	1	2002	2002	22.0	low	0	1
Vasculitis	1	1992	1992	32.0	low	1	0

Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 32, Issue:4, 2002

Development of an animal model of late asthmatic response in guinea pigs and effects of anti-asthmatic drugs.
Prostaglandins, , Volume: 43, Issue:6, 1992

Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 32, Issue:4, 2002

Effect of a newly synthesized leukotriene antagonist, (E)-2,2-diethyl-3'-2-2-(4-isopropyl) thiazolyl ethenyl succinanilic acid (MCI-826), on immunological liver injury and nephritis in mice.
Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 47, Issue:1, 1992

Pharmacological profile of the novel, potent and selective peptide leukotriene antagonist (E)-2,2-diethyl-3'-[2-[2-(4-isopropyl)thiazolyl]ethenyl]succinanilic acid.
Arzneimittel-Forschung, , Volume: 44, Issue:6, 1994

MCI-826 is a potent and selective antagonist of peptide leukotrienes (p-LTs) and has characteristics distinctive from those of FPL 55712.
Japanese journal of pharmacology, , Volume: 60, Issue:1, 1992

Leukotriene receptors in the skin of rats differ from those of mouse skin or rat stomach strip.
European journal of pharmacology, , Oct-20, Volume: 221, Issue:2-3, 1992

Significant role of peptide leukotrienes (p-LTs) in the antigen-induced contractions of human and guinea pig lung parenchymas and bronchi or tracheas in vitro.
Japanese journal of pharmacology, , Volume: 60, Issue:3, 1992

Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 32, Issue:4, 2002

Effect of a newly synthesized leukotriene antagonist, (E)-2,2-diethyl-3'-2-2-(4-isopropyl) thiazolyl ethenyl succinanilic acid (MCI-826), on immunological liver injury and nephritis in mice.
Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 47, Issue:1, 1992

Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 32, Issue:4, 2002

Development of an animal model of late asthmatic response in guinea pigs and effects of anti-asthmatic drugs.
Prostaglandins, , Volume: 43, Issue:6, 1992

Development of an animal model of late asthmatic response in guinea pigs and effects of anti-asthmatic drugs.
Prostaglandins, , Volume: 43, Issue:6, 1992

Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 32, Issue:4, 2002

Effect of a newly synthesized leukotriene antagonist, (E)-2,2-diethyl-3'-2-2-(4-isopropyl) thiazolyl ethenyl succinanilic acid (MCI-826), on immunological liver injury and nephritis in mice.
Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 47, Issue:1, 1992

Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 32, Issue:4, 2002

Effect of a newly synthesized leukotriene antagonist, (E)-2,2-diethyl-3'-2-2-(4-isopropyl) thiazolyl ethenyl succinanilic acid (MCI-826), on immunological liver injury and nephritis in mice.
Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 47, Issue:1, 1992

mci 826

Description

Cross-References

Synonyms (13)

Research

Studies (9)

Study Types

mci 826

Description

Cross-References

Synonyms (13)

Research

Studies (9)

Study Types

Related Drugs (21)

Drugs Researched Together (21)

Related Conditions (12)