Rhynchophylline and Alzheimer-Disease

Here, we report a microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition reaction to produce highly regioselective and stereoselective bis-spirooxindoles as potential inhibitors against amyloid-β fibrillation. Ease of synthesis, promising anti-amyloidogenic activity, low toxicity, and in vitro blood brain barrier permeability makes these compounds attractive therapeutic leads to treat Alzheimer's disease.

Topics: Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Cycloaddition Reaction; Humans