8-hydroxycoumarin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

8-hydroxycoumarin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	122783
CHEMBL ID	389988
SCHEMBL ID	1366927
MeSH ID	M0141896

Synonyms (27)

Synonym
8-hydroxy-2h-chromen-2-one
8-hydroxycoumarin
8-hydroxy-2h-chromene-2-one
8CM ,
CHEMBL389988
2442-31-1
8-hydroxychromen-2-one
2h-1-benzopyran-2-one, 8-hydroxy-
unii-854p936b10
854p936b10 ,
AKOS022636326
SCHEMBL1366927
DPTUTXWBBUARQB-UHFFFAOYSA-N
8-hydroxy-2h-chromen-2-one #
8-hydroxy-2h-1-benzopyran-2-one
coumarin, 8-hydroxy-
8-hydroxy coumarin
CS-B1326
DTXSID50873761
F19924
mfcd18450722
CS-13458
Q27269592
A929390
CAA44231
HY-21509
PD157915

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID392744	Antioxidant activity assessed as DPPH radical scavenging activity at 0.01 mM after 20 mins	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID392745	Antioxidant activity assessed as DPPH radical scavenging activity at 0.01 mM after 60 mins	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID392748	Antiinflammatory activity in rat assessed as inhibition of carrageenan-induced paw edema at 0.01 mmol/kg, ip after 3.5 hrs	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID392746	Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 100 uM	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID392743	Antioxidant activity assessed as DPPH radical scavenging activity at 0.05 mM after 60 mins	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID392742	Antioxidant activity assessed as DPPH radical scavenging activity at 0.05 mM after 20 mins	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID392747	Inhibition of soybean lipoxygenase at 100 uM by UV absorbance based assay	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID392741	Antioxidant activity assessed as superoxide radical scavenging activity at 100 uM by nitroblue tetrazolium method	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (11.11)	18.7374
1990's	1 (11.11)	18.2507
2000's	4 (44.44)	29.6817
2010's	2 (22.22)	24.3611
2020's	1 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.80 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	5.10 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.80)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
coumarin 2H-chromen-2-one: coumarin derivative	2.41	2	coumarins	fluorescent dye; human metabolite; plant metabolite
oxyquinoline Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.	2.4	2	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator
cimetidine Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.. cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.	1.97	1	aliphatic sulfide; guanidines; imidazoles; nitrile	adjuvant; analgesic; anti-ulcer drug; H2-receptor antagonist; P450 inhibitor
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.05	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
masoprocol nordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata)	2.05	1	catechols; lignan; tetrol	antioxidant; ferroptosis inhibitor; geroprotector; plant metabolite
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	1.97	1	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
carbostyril Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.	2.05	1	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite
quinoline [no description available]	7.44	2	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinolines
oleanolic acid [no description available]	2.05	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
2-cyclohexen-1-one 2-cyclohexen-1-one: RN given refers to unlabeled cpd with specified locant for double bond. cyclohexenone : The parent compound of the cyclohexenones, composed of cyclohexanone having one double bond in the ring.. cyclohex-2-enone : A cyclohexenone having its C=C double bond at the 2-position.	2.05	1	cyclohexenone
7-methylcoumarin 7-methylcoumarin: structure in first source	2.05	1	coumarins
tiletamine hydrochloride Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.	2.05	1
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid [no description available]	2.05	1	chromanol; monocarboxylic acid; phenols	antioxidant; ferroptosis inhibitor; neuroprotective agent; radical scavenger; Wnt signalling inhibitor
2,8-dihydroxyquinoline [no description available]	2.4	2	dihydroxyquinoline; monohydroxyquinoline; quinolone
ribulose-1,5 diphosphate ribulose-1,5 diphosphate: RN given refers to cpd without isomeric designation. D-ribulose 1,5-bisphosphate : A ribulose phosphate that is D-ribulose attached to phosphate groups at positions 1 and 5. It is an intermediate in photosynthesis.	2.07	1	ribulose phosphate	Escherichia coli metabolite; plant metabolite
caffeic acid trans-caffeic acid : The trans-isomer of caffeic acid.	2.05	1	caffeic acid	geroprotector; mouse metabolite
nadp [no description available]	2.05	1
daphnetin [no description available]	2.07	1	hydroxycoumarin
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.41	2	hydroxycoumarin	fluorescent probe; food component; plant metabolite
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	2.05	1	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
chiniofon Hydroxyquinolines: The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.	2.4	2
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	3.53	8	benzenes; hydroxycoumarin; methyl ketone

Condition	Indicated	Relationship Strength	Studies	Trials
Anasarca [description not available]	0	2.05	1	0
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	0	2.05	1	0

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