4-cyclopentene-1,3-dione: induces electrical excitability in crustacean muscle [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 70258 |
| CHEMBL ID | 224231 |
| MeSH ID | M0068924 |
| Synonym |
|---|
| 2-cyclopentene-1,4-dione |
| bdbm7811 |
| cyclopent-4-ene-1,3-dione |
| inchi=1/c5h4o2/c6-4-1-2-5(7)3-4/h1-2h,3h |
| nsc-155336 |
| 4-cyclopentene-1,3-dione |
| 930-60-9 |
| nsc155336 |
| 4-cyclopentene-1,3-dione, 95% |
| CHEMBL224231 |
| p054eq880i , |
| einecs 213-219-3 |
| nsc 155336 |
| unii-p054eq880i |
| AKOS015916278 |
| cyclopent-2-ene-1,4-dione |
| 2-cyclopenten-1,4-dione |
| 4-cyclopentene-1,3-dione # |
| 4-cyclopenten-1,3-dione |
| cyclopent-2-en-1,4-dione |
| FT-0699514 |
| DTXSID80239235 |
| AS-58342 |
| CS-0204257 |
| Q27285950 |
| A916287 |
| EN300-68153 |
| Z1083219844 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| [tau protein] kinase | Oryctolagus cuniculus (rabbit) | IC50 (µMol) | 12.0000 | 0.0020 | 1.6930 | 6.0000 | AID1796098 |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | IC50 (µMol) | 12.0000 | 0.0010 | 1.2249 | 9.1000 | AID282721 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 (µMol) | 12.0000 | 0.0006 | 0.8013 | 10.0000 | AID282721 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1796098 | Kinase Inhibition Assay from Article 10.1021/jm040895g: \\SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.\\ | 2005 | Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23 | SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors. |
| AID282721 | Inhibition of rabbit GSK3 | 2005 | Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23 | SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors. |
| AID1145206 | Toxicity in mouse ascites sarcoma 180 cells allografted ddN mouse at 3 mg/kg/day for 5 days administered 24 hrs after tumor inoculation measured 7th day after tumor inoculation | 1976 | Journal of medicinal chemistry, Mar, Volume: 19, Issue:3 | Structure and antitumor activity relationship of 2-arylidene-4-cyclopentene-1, 3-diones and 2-arylideneindan-1, 3-diones. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.97) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||