3-methyluracil profile

3-Methyluracil (3-MU) is a naturally occurring pyrimidine base. It can be found in DNA and RNA as a result of methylation of uracil, and plays a role in the regulation of gene expression. 3-MU has also been found to have anti-tumor and anti-inflammatory effects. Its synthesis can be achieved through various methods, including the methylation of uracil using methyl iodide in the presence of a base, or by enzymatic methylation. 3-MU is studied for its potential therapeutic applications, such as its use in the treatment of cancer and inflammatory diseases. The compound has also been investigated for its ability to inhibit the growth of viruses and bacteria.'

3-methyluracil : A pyrimidone that is uracil with a methyl group at position 3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	79066
CHEBI ID	74732
SCHEMBL ID	40761
SCHEMBL ID	13242249
MeSH ID	M0157295

Synonym
3-methyl-2,4(1h,3h)-pyrimidinedione
nsc 45626
2,4-dihydroxy-3-methylpyrimidine
nsc-45626
608-34-4
2,3h)-pyrimidinedione, 3-methyl-
nsc45626
AC-907/25014072
3-methyluracil
3-methyl-1h-pyrimidine-2,4-dione
3-methylpyrimidine-2,4(1h,3h)-dione
inchi=1/c5h6n2o2/c1-7-4(8)2-3-6-5(7)9/h2-3h,1h3,(h,6,9
2,4(1h,3h)-pyrimidinedione, 3-methyl-
uracil, methyl-
methyl-2,4(1h,3h)-pyrimidinedione
2,4(1h,3h)-pyrimidinedione, methyl-
AKOS003348643
FT-0692244
AKOS002304012
27942-00-3
CHEBI:74732
3-meu
SCHEMBL40761
3-methylpyrimidine-2,4(1h, 3h)-dione
VPLZGVOSFFCKFC-UHFFFAOYSA-N
SCHEMBL13242249
W-203272
Z2588063529
mfcd00038014
A868880
2-hydroxy-3-methylpyrimidin-4(3h)-one
2-hydroxy-3-methyl-4-oxo-3,4-dihydropyrimidine
AS-47233
Q15632765
DTXSID30878779
SB57470
SY046017
F12763
CS-0199452
EN300-297986
3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
pyrimidone	A pyrimidine carrying one or more oxo substituents.
nucleobase analogue	A molecule that can substitute for a normal nucleobase in nucleic acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (18.18)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (45.45)	29.6817
2010's	3 (27.27)	24.3611
2020's	1 (9.09)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.05	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.03	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
thymine [no description available]	8.13	5	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	3.81	11	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
uric acid Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.. uric acid : An oxopurine that is the final oxidation product of purine metabolism.. 6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.. 7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.	2.04	1	uric acid	Escherichia coli metabolite; human metabolite; mouse metabolite
theophylline [no description available]	2.04	1	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent
caffeine [no description available]	2.43	2	purine alkaloid; trimethylxanthine	adenosine A2A receptor antagonist; adenosine receptor antagonist; adjuvant; central nervous system stimulant; diuretic; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; environmental contaminant; food additive; fungal metabolite; geroprotector; human blood serum metabolite; mouse metabolite; mutagen; plant metabolite; psychotropic drug; ryanodine receptor agonist; xenobiotic
thymidine [no description available]	2.05	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
melamine melamine: RN given refers to parent cpd; structure. melamine : A trimer of cyanamide, with a 1,3,5-triazine skeleton.	2.11	1	triamino-1,3,5-triazine	xenobiotic metabolite
pyrimidine pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.	1.93	1	diazine; pyrimidines	Daphnia magna metabolite
1-methyluracil 1-methyluracil: RN given refers to parent cpd; structure. 1-methyluracil : A pyrimidone that is uracil with a methyl group substituent at position 1.	1.97	1	nucleobase analogue; pyrimidone	metabolite
6-methyluracil 6-methyluracil: RN given refers to unlabeled cpd; structure. 6-methyluracil : A pyrimidone that is uracil with a methyl group at position 6.	2.35	2	pyrimidone	metabolite
2'-deoxyadenosine 2'-deoxyformycin A: RN not in Chemline 9/85; RN and structure given in first source	2.21	1	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
2,4,6-triaminopyrimidine 2,4,6-triaminopyrimidine: see also 2,4,6-triaminopyridinium (cation). 2,4,6-triaminopyrimidine : An aminopyrimidine in which a pyrimidine core carries amino substituents at positions 2, 4 and 6.	2.11	1	aminopyrimidine
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	2.21	1	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
methylthymidine methylthymidine: RN given refers to N-3-methylthymidine	2.05	1
1,3-dimethyluracil 1,3-dimethyluracil : A pyrimidone that is uracil with methyl group substituents at positions 1 and 3.	2.05	1	pyrimidone	metabolite
6-chlorouracil 6-chlorouracil: radiolabelled with 36Cl	7.11	1
1,3,7-trimethylurate 1,3,7-trimethylurate : An organic anion obtained by deprotonation of 1,3,7-trimethyluric acid.. 1,3,7-trimethyluric acid : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8, and the nitrogens at positions 1, 3, and 7 are substituted by methyl groups. It is a metabolite of caffeine.	2.04	1	oxopurine	human blood serum metabolite; human urinary metabolite; human xenobiotic metabolite; mouse metabolite
1-methylxanthine 1-methylxanthine: urinary metabolite of caffeine. 1-methylxanthine : A monomethylxanthine having the methyl group located at the 1-position. It is a metabolite of caffeine in humans.. 1-methyl-7H-xanthine : A 1-methylxanthine tautomer where the imidazole proton is located at the 7-position.	2.04	1	1-methylxanthine	mouse metabolite
3,7-dimethyluric acid 3,7-dimethyluric acid: structure given in first source. 3,7-dimethyluric acid : An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by methyl groups at N-3 and N-7.	2.04	1	oxopurine	metabolite; mouse metabolite
1-methylthymine 1,5-dimethyluracil : A pyrimidone that is uracil with methyl group substituents at positions 1 and 5.	2.03	1	methylthymine	metabolite
5-acetylamino-6-formylamino-3-methyluracil 5-acetylamino-6-formylamino-3-methyluracil: metabolite of caffeine	2.43	2	formamidopyrimidine	mouse metabolite
3-methylthymine 3,5-dimethyluracil : A pyrimidone that is uracil with methyl group substituents at positions 3 and 5.	7.77	3	methylthymine; pyrimidone	metabolite

3-methyluracil

Description

Cross-References

Synonyms (41)

Roles (1)

Drug Classes (2)

Research

Studies (11)

Market Indicators

Research Demand Index: 30.17

Study Types