Compounds > 1-methylthymine
Page last updated: 2024-12-07

1-methylthymine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-methylthymine is a methylated derivative of thymine, a nucleobase found in DNA. It is an important component of DNA methylation, a critical epigenetic modification that influences gene expression and cellular processes. 1-methylthymine is formed by the methylation of the N1 position of thymine. This methylation is catalyzed by DNA methyltransferases (DNMTs). 1-methylthymine has been shown to play a role in various biological processes, including DNA replication, repair, and transcription. Studies have shown that 1-methylthymine can also be a biomarker for certain cancers and other diseases. The unique chemical structure and biological significance of 1-methylthymine make it a target for research and development in fields like cancer therapy, epigenetics, and diagnostics.'

1,5-dimethyluracil : A pyrimidone that is uracil with methyl group substituents at positions 1 and 5. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID95961
CHEMBL ID4586019
CHEBI ID74765
SCHEMBL ID12154069
SCHEMBL ID16248
MeSH IDM0096733

Synonyms (33)

Synonym
uracil, 1,5-dimethyl-
4160-72-9
1-methylthymine
1,5-dimethyluracil
nsc-44824
uracil,5-dimethyl-
nsc44824
2,3h)-pyrimidinedione, 1,5-dimethyl-
1,5-dimethylpyrimidine-2,4(1h,3h)-dione
1,5-dimethylpyrimidine-2,4-dione
AKOS004910261
SCHEMBL12154069
AKOS006238096
CHEBI:74765
unii-cn6a9brm5h
cn6a9brm5h ,
nsc 44824
2,4(1h,3h)-pyrimidinedione, 1,5-dimethyl-
1-methylh
FT-0635163
SCHEMBL16248
GKMIDMKPBOUSBQ-UHFFFAOYSA-N
W-202714
DTXSID30194426
Z821318488
Q27144889
4-hydroxy-1,5-dimethylpyrimidin-2(1h)-one
1,5-dimethyl-2,4(1h,3h)-pyrimidinedione
n1-methylthymine
AT19349
CHEMBL4586019
4-hydroxy-1,5-dimethyl-1,2-dihydropyrimidin-2-one
EN300-246064
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
methylthymineA pyrimidone that is thymine bearing a single methyl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (29)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (10.34)18.7374
1990's3 (10.34)18.2507
2000's11 (37.93)29.6817
2010's11 (37.93)24.3611
2020's1 (3.45)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.29 (24.57)
Research Supply Index3.47 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other31 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		3.891206-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ammonium hydroxide
azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.		2.0510azane;
gas molecular entity;
mononuclear parent hydride		EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant
formic acid
formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.		7.0510monocarboxylic acidantibacterial agent;
astringent;
metabolite;
protic solvent;
solvent
cytosine
[no description available]		8.2560aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		7.3720elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
thymine
[no description available]		4.72290pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		8.470pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
4-cresol
4-cresol: RN given refers to parent cpd. p-cresol : A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.		1.9910cresolEscherichia coli metabolite;
human metabolite;
uremic toxin
uridine
[no description available]		210uridinesdrug metabolite;
fundamental metabolite;
human metabolite
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		210aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
glycylglycine
[no description available]		210dipeptide zwitterion;
dipeptide		human metabolite
1-methyluracil
1-methyluracil: RN given refers to parent cpd; structure. 1-methyluracil : A pyrimidone that is uracil with a methyl group substituent at position 1.		3.150nucleobase analogue;
pyrimidone		metabolite
n-methylacrylamide
N-methylacrylamide: structure in first source		2.0510
mercury
Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.		2.110elemental mercury;
zinc group element atom		neurotoxin
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		210metal allergen;
nickel group element atom;
platinum group metal atom
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.0810copper group element atom;
elemental silver		Escherichia coli metabolite
argon
Argon: A noble gas with the atomic symbol Ar, atomic number 18, and atomic weight 39.948. It is used in fluorescent tubes and wherever an inert atmosphere is desired and nitrogen cannot be used.		2.0210monoatomic argon;
noble gas atom;
p-block element atom		food packaging gas;
neuroprotective agent
4-aminopyrimidine
[no description available]		2.0810aminopyrimidine
9-methyladenine
9-methyladenine : Adenine substituted with a methyl group at position N-9.		3.5180methyladeninemetabolite
1-methylguanine
[no description available]		2.0210methylguanine
3-methyluracil
3-methyluracil : A pyrimidone that is uracil with a methyl group at position 3.		2.0310nucleobase analogue;
pyrimidone		metabolite
1-methylcytosine
1-methylcytosine: RN given refers to parent cpd. 1-methylcytosine : A pyrimidone that is cytosine in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group.		7.9240aminopyrimidine;
methylcytosine;
pyrimidone		metabolite
n-acetylmethionine
N-acetylmethionine: RN given refers to L-isomer. N-acetylmethionine : A methionine derivative that is methionine in which one of the amine hydrogens is substituted by an acetyl group.		210L-methionine derivative;
N-acetyl-L-amino acid;
N-acetylmethionine		nutraceutical
n-glycylalanine
Gly-Ala : A dipeptide formed from glycine and L-alanine residues.		210dipeptidemetabolite
guanine
[no description available]		8.13502-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
1-methyladenine
1-methyladenine : Adenine substituted with a methyl group at position N-1.		2.0210
9-methylguanine
9-methylguanine: structure in first source		7.7130
9-ethylguanine
[no description available]		2.2510
pyrimidinones
Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials