Page last updated: 2024-09-23

2,6-diaminopurine 2',3'-dideoxyriboside

Description

2,6-diaminopurine 2',3'-dideoxyriboside: selectively inhibits HIV virus replication in vitro; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID64976
CHEMBL ID49157
SCHEMBL ID3239663
MeSH IDM0149487

Synonyms (17)

Synonym
adenosine, 2-amino-2',3'-dideoxy-
[(2s,5r)-5-(2,6-diaminopurin-9-yl)tetrahydrofuran-2-yl]methanol
dddapr
dapddr
2,6-diamino-2',3'-dideoxypurine-9-ribofuranoside
2,6-diamino-ddp
dddap
107550-73-2
CHEMBL49157
[(2s,5r)-5-(2,6-diaminopurin-9-yl)oxolan-2-yl]methanol
2-amino-2',3'-dideoxyadenosine
2,6-diaminopurine 2',3'-dideoxyriboside
SCHEMBL3239663
DTXSID10148083
mfcd00871205
((2s,5r)-5-(2,6-diamino-9h-purin-9-yl)tetrahydrofuran-2-yl)methanol
[(2s,5r)-5-(2,6-diamino-9h-purin-9-yl)oxolan-2-yl]methanol

Bioassays (12)

Assay IDTitleYearJournalArticle
AID89116Effective dose required to inhibit HIV-induced cytopathogenicity in human MT-4 cells1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides.
AID141914Effective dose required to inhibit MSV-induced transformation in murine C3H cells1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides.
AID297672Antimycobacterial activity against Mycobacterium tuberculosis H37Ra at 100 uM by microplate alamar blue assay2007Journal of medicinal chemistry, Sep-20, Volume: 50, Issue:19
Inhibition of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium by novel dideoxy nucleosides.
AID297676Antimycobacterial activity against Mycobacterium bovis BCG at 100 uM by microplate alamar blue assay2007Journal of medicinal chemistry, Sep-20, Volume: 50, Issue:19
Inhibition of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium by novel dideoxy nucleosides.
AID28386Partition coefficient in 1-octanol and 10 mM aqueous potassium phosphate buffer at pH 7.41989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides.
AID297680Antimycobacterial activity against Mycobacterium avium ATCC 25291 at 100 uM by microplate alamar blue assay2007Journal of medicinal chemistry, Sep-20, Volume: 50, Issue:19
Inhibition of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium by novel dideoxy nucleosides.
AID232359Ratio of CD50 and ED50 values against inhibition of HIV in MT-4 cells1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides.
AID89115Cytotoxic dose required to inhibit HIV-induced cytopathogenicity in human MT-4 cells1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides.
AID141915Toxic dose required to cause an alteration of normal C3H cell morphology1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides.
AID31902In vitro cytotoxicity against uninfected ATH-8 (human T-cell) cell line.1992Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
Synthesis and anti-HIV activity of isonucleosides.
AID297677Antimycobacterial activity against Mycobacterium bovis BCG at 50 uM by microplate alamar blue assay2007Journal of medicinal chemistry, Sep-20, Volume: 50, Issue:19
Inhibition of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium by novel dideoxy nucleosides.
AID31903In vitro effective dose which provides 50% protection of ATH-8 cells against the cytopathic effect of HIV1992Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
Synthesis and anti-HIV activity of isonucleosides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (54.55)18.7374
1990's4 (36.36)18.2507
2000's1 (9.09)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]