Page last updated: 2024-12-05

4-aminodiphenyl ether

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID8764
CHEMBL ID249550
SCHEMBL ID159084
MeSH IDM0246896

Synonyms (75)

Synonym
HMS1473P08
BIDD:GT0348
AC-14414
ccris 3561
brn 0777708
4-aminodifenylether [czech]
nsc 4629
4-aminodiphenylether
4-phenoxybenzenamine
einecs 205-367-2
4-aminobiphenyl ether
BB 0221228
bdbm50334276
aniline, p-phenoxy-
wln: zr dor
p-aminophenyl phenyl ether
nsc4629
ether, 4-aminophenyl phenyl
4-phenoxyaniline
benzenamine, 4-phenoxy-
4-aminophenyl phenyl ether
nsc-4629
4-aminodiphenyl ether
p-phenoxyaniline
4-aminodifenylether
139-59-3
4-amino-1-phenoxybenzene
nsc-57084
nsc61131
nsc57084
nsc-61131
OPREA1_328270
CHEMDIV3_000338
4-phenoxyaniline, 97%
IDI1_019656
NCGC00175907-01
STK041542
CHEMBL249550 ,
AKOS000103555
BRD-K85539327-001-01-4
P0981
A807567
44p7paw368 ,
unii-44p7paw368
CCG-103474
FT-0602155
4-phenoxyphenylamine
CL8445
SCHEMBL159084
4-phenoxy-phenyl amine
4-phenoxy-aniline
4-(phenoxy)aniline
p-phenoxy aniline
4-phenyloxyaniline
4-phenoxy aniline
4-phenoxy-phenylamine
para-phenoxyaniline
DTXSID8059687
W-108213
Z57124586
CS-W020611
4-(phenyloxy)aniline
4-phenoxaniline
F0020-1798
SR-01000393015-1
sr-01000393015
mfcd00007862
(4-phenoxyphenyl)amine
4-amino diphenyl ether
AS-15655
aniline, 4-phenoxy-
benzenamine, p-phenoxy-
EN300-17937
4-phenoxyaniline(chunks or pellets or flake)
4-phenoxyaniline(chunks or pellets)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Amine oxidase [flavin-containing] AHomo sapiens (human)IC50 (µMol)91.40000.00002.37899.7700AID551122
Amine oxidase [flavin-containing] AHomo sapiens (human)Ki24.10000.00192.379710.0000AID551122
Amine oxidase [flavin-containing] BHomo sapiens (human)IC50 (µMol)303.00000.00001.89149.5700AID551123
Amine oxidase [flavin-containing] BHomo sapiens (human)Ki131.00000.00061.777110.0000AID551123
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (15)

Processvia Protein(s)Taxonomy
biogenic amine metabolic processAmine oxidase [flavin-containing] AHomo sapiens (human)
positive regulation of signal transductionAmine oxidase [flavin-containing] AHomo sapiens (human)
dopamine catabolic processAmine oxidase [flavin-containing] AHomo sapiens (human)
response to xenobiotic stimulusAmine oxidase [flavin-containing] BHomo sapiens (human)
response to toxic substanceAmine oxidase [flavin-containing] BHomo sapiens (human)
response to aluminum ionAmine oxidase [flavin-containing] BHomo sapiens (human)
response to selenium ionAmine oxidase [flavin-containing] BHomo sapiens (human)
negative regulation of serotonin secretionAmine oxidase [flavin-containing] BHomo sapiens (human)
phenylethylamine catabolic processAmine oxidase [flavin-containing] BHomo sapiens (human)
substantia nigra developmentAmine oxidase [flavin-containing] BHomo sapiens (human)
response to lipopolysaccharideAmine oxidase [flavin-containing] BHomo sapiens (human)
dopamine catabolic processAmine oxidase [flavin-containing] BHomo sapiens (human)
response to ethanolAmine oxidase [flavin-containing] BHomo sapiens (human)
positive regulation of dopamine metabolic processAmine oxidase [flavin-containing] BHomo sapiens (human)
hydrogen peroxide biosynthetic processAmine oxidase [flavin-containing] BHomo sapiens (human)
response to corticosteroneAmine oxidase [flavin-containing] BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
protein bindingAmine oxidase [flavin-containing] AHomo sapiens (human)
primary amine oxidase activityAmine oxidase [flavin-containing] AHomo sapiens (human)
aliphatic amine oxidase activityAmine oxidase [flavin-containing] AHomo sapiens (human)
monoamine oxidase activityAmine oxidase [flavin-containing] AHomo sapiens (human)
flavin adenine dinucleotide bindingAmine oxidase [flavin-containing] AHomo sapiens (human)
protein bindingAmine oxidase [flavin-containing] BHomo sapiens (human)
primary amine oxidase activityAmine oxidase [flavin-containing] BHomo sapiens (human)
electron transfer activityAmine oxidase [flavin-containing] BHomo sapiens (human)
identical protein bindingAmine oxidase [flavin-containing] BHomo sapiens (human)
aliphatic amine oxidase activityAmine oxidase [flavin-containing] BHomo sapiens (human)
monoamine oxidase activityAmine oxidase [flavin-containing] BHomo sapiens (human)
flavin adenine dinucleotide bindingAmine oxidase [flavin-containing] BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
mitochondrionAmine oxidase [flavin-containing] AHomo sapiens (human)
mitochondrial outer membraneAmine oxidase [flavin-containing] AHomo sapiens (human)
cytosolAmine oxidase [flavin-containing] AHomo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] AHomo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrial envelopeAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrial outer membraneAmine oxidase [flavin-containing] BHomo sapiens (human)
dendriteAmine oxidase [flavin-containing] BHomo sapiens (human)
neuronal cell bodyAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID307626Solubility in water
AID307625Partition coefficient, log P of the compound
AID551124Selectivity ratio of Ki for human recombinant MAOA to Ki for human recombinant MAOB2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.
AID1413263Inhibition of full length Escherichia coli DNA gyrase ATPase activity at 1 mM measured for 20 mins by lactate dehydrogenase assay relative to control2018MedChemComm, Oct-01, Volume: 9, Issue:10
Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes.
AID551123Inhibition of human recombinant MAOB expressed in insect cells by fluorescence assay2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.
AID551122Inhibition of human recombinant MAOA expressed in insect cells by fluorescence assay2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.00 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]