## 1,4-Diphenylbutadiene: A Versatile Building Block for Research
1,4-Diphenylbutadiene is a chemical compound with the formula C16H14. It's a white, crystalline solid that exhibits interesting properties, making it valuable for various research endeavors. Here's a breakdown of its importance:
**Structure and Properties:**
* **Extended π-system:** The molecule contains a conjugated system of double bonds along its carbon chain. This allows for delocalization of electrons, resulting in unique optical and electronic properties.
* **Fluorescence:** 1,4-Diphenylbutadiene is known for its strong fluorescence, emitting light when exposed to UV radiation. This property makes it useful in applications like:
* **Fluorescent probes:** Detecting specific molecules or environments within cells or materials.
* **Optical sensors:** Sensing changes in the surrounding environment, such as pH or temperature.
* **Photochemistry:** It undergoes photochemical reactions under UV irradiation, leading to the formation of various products. This makes it a valuable reagent in organic synthesis and photochemistry research.
**Research Applications:**
* **Materials science:**
* **Organic semiconductors:** Its π-system makes it suitable for use in organic semiconductors, particularly for applications like solar cells and organic light-emitting diodes (OLEDs).
* **Nonlinear optics:** Its strong optical properties are relevant for nonlinear optical materials, which can manipulate light in unique ways.
* **Biochemistry and cell biology:**
* **Fluorescent probes:** Its fluorescence makes it a useful tool for studying biological processes, cell imaging, and tracking molecules within cells.
* **Drug delivery:** Its potential to interact with biological systems opens possibilities for developing novel drug delivery systems.
* **Organic synthesis:**
* **Precursor for other compounds:** It can be used as a starting material for synthesizing other complex organic molecules.
* **Photochemical reactions:** Its photochemical reactivity allows for the development of novel synthetic strategies.
**Current Research:**
* **Developing new fluorescent probes:** Researchers are working on modifying 1,4-diphenylbutadiene's structure to create probes specific for different targets, improving sensitivity and specificity.
* **Improving organic semiconductor efficiency:** Optimizing the molecular structure and properties of 1,4-diphenylbutadiene-based materials to increase their efficiency in applications like solar cells.
* **Exploring its potential in biological systems:** Researchers are investigating its potential as a fluorescent probe for studying biological processes and its ability to interact with biological systems for drug delivery applications.
**Overall, 1,4-diphenylbutadiene is a versatile compound with interesting properties that make it a valuable tool in various research fields. Its importance lies in its potential to develop novel materials, probes, and technologies with exciting applications in various fields.**
| ID Source | ID |
|---|---|
| PubMed CID | 641683 |
| CHEMBL ID | 198810 |
| CHEBI ID | 51583 |
| CHEBI ID | 35100 |
| MeSH ID | M0060312 |
| Synonym |
|---|
| BIDD:ER0657 |
| ctq3u893lx , |
| unii-ctq3u893lx |
| 1,1'-buta-1,3-diene-1,4-diyldibenzene |
| CHEBI:51583 |
| AKOS002162253 |
| 886-65-7 |
| 1,4-diphenylerythrene |
| 1,4-diphenylbutadiene |
| distyryl |
| bistyryl |
| 1,3-butadiene, 1,4-diphenyl-, (e,e)- |
| trans,trans-1,4-diphenyl-1,3-butadiene |
| 1,4-diphenyl-1,3-butadiene |
| [(1e,3e)-4-phenylbuta-1,3-dienyl]benzene |
| AB-016/30004035 |
| (4-phenyl-1,3-butadienyl)benzene |
| [(1e,3e)-4-phenyl-1,3-butadienyl]benzene |
| 1,1'-(1e,3e)-buta-1,3-diene-1,4-diyldibenzene |
| benzene, 1,1'-[(1e,3e)-1,3-butadiene-1,4-diyl]bis- |
| inchi=1/c16h14/c1-3-9-15(10-4-1)13-7-8-14-16-11-5-2-6-12-16/h1-14h/b13-7+,14-8 |
| nsc316 |
| 1, 1,4-diphenyl-, (e,e)- |
| benzene,1'-(1,3-butadiene-1,4-diyl)bis-, (e,e)- |
| 1,trans-3-butadiene |
| trans,4-diphenyl-1,3-butadiene |
| nsc-316 |
| 1, 1,4-diphenyl-, trans,trans- |
| 1,3-butadiene, trans,trans- |
| 538-81-8 |
| (e,4-diphenyl-1,3-butadiene |
| trans,4-diphenylbutadiene |
| trans,trans-1,4-diphenyl-1,3-butadiene, 98% |
| 1,3-butadiene, 1,4-diphenyl- |
| einecs 212-952-6 |
| nsc 122702 |
| 1,4-diphenylbuta-1,3-diene |
| SR-01000633137-1 |
| STK384953 |
| D0879 |
| chebi:35100 , |
| CHEMBL198810 , |
| bdbm50172755 |
| 1,4-diphenyl-(1e,3e)-1,3-butadiene |
| trans,trans-1,4-diphenylbuta-1,3-diene |
| [(1e,3e)-4-phenyl-buta-1,3-dienyl]-benzene |
| CCG-43199 |
| unii-r7p15v6543 |
| 1,4-diphenyl-1,3-butadiene, (1e,3e)- |
| r7p15v6543 , |
| nsc 316 |
| all-trans-diphenylbutadiene |
| 4-phenyl-1,3-butadienyl)benzene, ((1e,3e)- |
| ((1e,3e)-4-phenyl-1,3-butadienyl)benzene |
| benzene, 1,1'-(1e,3e)-1,3-butadiene-1,4-diylbis- |
| 1,4-diphenyl-1,3-butadiene (e,e)-form [mi] |
| 1,3-butadiene, 1,4-diphenyl-, trans-trans- |
| t,t-1,4-diphenyl-1,3-butadiene |
| (e)-1,4-diphenylbuta-1,3-diene |
| a,a-bistyryl |
| [(1e,3e)-4-phenylbuta-1,3-dien-1-yl]benzene |
| STR04475 |
| (1e,3e)-1,4-diphenyl-1,3-butadiene |
| DTXSID3022459 |
| Z57214903 |
| mfcd00004791 |
| trans,trans-1,4-diphenyl-1,3-butadiene, purum, >=98.0% (gc) |
| (1e,3e)-1,4-diphenylbuta-1,3-diene |
| CS-W015307 |
| Q27116416 |
| D77776 |
| A870618 |
| beta,beta'-bistyryl |
| PD179202 |
| Class | Description |
|---|---|
| styrenes | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 0.3003 | 0.0006 | 1.7771 | 10.0000 | AID1239659; AID254307 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 0.0002 | 1.4940 | 10.0000 | AID1239659 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| protein binding | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| primary amine oxidase activity | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| electron transfer activity | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| identical protein binding | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| aliphatic amine oxidase activity | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| monoamine oxidase activity | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| flavin adenine dinucleotide binding | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| G protein-coupled adenosine receptor activity | Adenosine receptor A2a | Rattus norvegicus (Norway rat) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| mitochondrion | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| mitochondrial envelope | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| mitochondrial outer membrane | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| dendrite | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| neuronal cell body | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| mitochondrion | Amine oxidase [flavin-containing] B | Homo sapiens (human) |
| Golgi membrane | Adenosine receptor A2a | Rattus norvegicus (Norway rat) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1239659 | Inhibition of human MAOB | 2015 | Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 | New Frontiers in Selective Human MAO-B Inhibitors. |
| AID254307 | Inhibition constant against human recombinant Monoamine oxidase-B | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||