GTP-dependent protein binding

Definition

Target type: molecularfunction

Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state. [GOC:go_curators, GOC:krc]

GTP-dependent protein binding is a molecular function that involves the specific interaction of a protein with a guanosine triphosphate (GTP) molecule. GTP is a nucleotide that plays a crucial role in many cellular processes, including signal transduction, protein synthesis, and cytoskeletal dynamics. When GTP binds to a protein, it often induces conformational changes that can activate or inactivate the protein, altering its activity and function. This interaction is highly specific, with proteins possessing distinct GTP-binding domains that recognize and bind to GTP with high affinity. These domains typically consist of conserved amino acid sequences that form a pocket-like structure to accommodate the GTP molecule. The binding of GTP is often regulated by other factors, such as the presence of other proteins or small molecules, ensuring that the interaction occurs only when and where it is required. This dynamic interplay between GTP and proteins is essential for maintaining cellular homeostasis and responding to environmental cues. For instance, GTP-dependent protein binding is crucial for regulating the activity of signaling proteins, such as G-proteins, which are involved in transmitting signals from cell surface receptors to intracellular pathways. Additionally, GTP-binding proteins play vital roles in protein synthesis by facilitating the interaction between ribosomes and messenger RNA. Overall, GTP-dependent protein binding is a fundamental molecular mechanism that governs a wide range of cellular processes, underscoring its importance in maintaining cellular function and responding to environmental stimuli.'
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Proteins (1)

Compounds (7)