GBD domain binding

Definition

Target type: molecularfunction

Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac. [GOC:mah, GOC:pg, PMID:9119069]

GBD domain binding refers to the interaction between a GBD (Glycogen Binding Domain) and its target molecule. GBDs are protein domains typically found in glycogen phosphorylase, an enzyme responsible for the breakdown of glycogen into glucose. These domains play a critical role in regulating glycogen metabolism by mediating the binding of glycogen phosphorylase to glycogen. The interaction between the GBD and glycogen is crucial for efficient glycogen breakdown. It ensures that the enzyme is localized to the site of its substrate, facilitating rapid and controlled glucose release. The GBD interacts with the glycogen molecule through a series of hydrophobic and polar interactions. The binding process is typically characterized by a high affinity and specificity, ensuring that glycogen phosphorylase interacts only with its intended substrate. GBD binding is regulated by various factors, including the phosphorylation state of glycogen phosphorylase and the presence of allosteric effectors. The binding of GBD to glycogen is an essential component of the complex regulatory network that controls glycogen metabolism. Understanding the molecular details of this interaction is critical for developing novel therapeutic strategies targeting glycogen metabolism disorders.'
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Proteins (1)

Compounds (7)