Target type: cellularcomponent
A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules. [GOC:krc]
Storage vacuoles are membrane-bound organelles found in plant cells, often occupying a large portion of the cell's volume. They serve as a central hub for diverse cellular functions, including storage of water, ions, nutrients, pigments, and secondary metabolites. The vacuole membrane, known as the tonoplast, plays a crucial role in maintaining osmotic balance and regulating the flow of substances in and out of the vacuole. The storage vacuole's cellular components encompass the tonoplast and its enclosed lumen, which is a large, fluid-filled space. The lumen contains a complex mixture of solutes, including sugars, amino acids, organic acids, and inorganic ions. These solutes contribute to the vacuole's turgor pressure, which is essential for maintaining cell shape and structure. Additionally, the vacuole may contain insoluble materials like crystals, pigments, and protein aggregates. Storage vacuoles are dynamic organelles, constantly adjusting their contents and volume to meet the changing needs of the cell. They are involved in processes like seed germination, nutrient recycling, and defense against pathogens. Notably, the vacuole's pH can vary depending on the stored substances, ranging from acidic to neutral or alkaline. These variations in pH are important for enzymatic reactions and the regulation of cellular processes.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Cell division control protein 42 homolog | A cell division control protein 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P60953] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| fasudil | fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia. fasudil: intracellular calcium antagonist; structure in first source | isoquinolines; N-sulfonyldiazepane | antihypertensive agent; calcium channel blocker; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; geroprotector; neuroprotective agent; nootropic agent; vasodilator agent |
| ketorolac | 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively. ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure. Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed) | amino acid; aromatic ketone; monocarboxylic acid; pyrrolizines; racemate | analgesic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug |
| sanguinarine chloride | |||
| chelerythrine chloride | |||
| 2-[[benzamido(sulfanylidene)methyl]amino]-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid | CID1067700: a pan-GTPase inhibitor; structure in first source | thienopyran | |
| y 27632, dihydrochloride, (4(r)-trans)-isomer | |||
| secramine a | secramine A: inhibits VSVG transport from the Golgi to the plasma membrane; also inhibits Cdc42-dependent cell functions; structure in first source |