Compounds > pca 4230
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pca 4230

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Description

PCA 4230: platelet activating factor inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID124236
CHEMBL ID57193
SCHEMBL ID3846524
MeSH IDM0199071

Synonyms (16)

Synonym
trombodipine
pca-4230
3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, ethyl 2-(3-oxo-1,2-benzisothiazol-2(3h)-yl)ethyl ester, s,s-dioxide
brn 6547524
pca 4230
CHEMBL57193
3-o-ethyl 5-o-[2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)ethyl] 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
2-(1,1,3-trioxo-2,3-dihydro-1,2-benzisothiazol-2-yl)ethyl-2,6-dimethyl-5-(ethoxycarbonyl)-4-methyl-1,4-dihydropyridine carboxylate
113658-85-8
SCHEMBL3846524
3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, 3-[2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3h)-yl)ethyl] 5-ethyl ester
ethyl 2-(1,1,3-trioxo-1,3-dihydro-2h-1lambda~6~,2-benzothiazol-2-yl)ethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
DTXSID40921144
CS-0014761
HY-19052
AKOS040740458
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (120)

Assay IDTitleYearJournalArticle
AID75069Effect on guinea pig artia (beats/min), at the a dose of 10e-6 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75497Chronotropic activity on left and right guinea pig artia (beats/min), at 180 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49051Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 18 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50228Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 45 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49047Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 60 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID166476Effect on 35 mM K+-induced contraction on rabbit aorta at a dose of 10E-9 mol/L1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75059Chronotropic activity on left and right guinea pig artia (beats/min), at 120 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75380Chronotropic activity on left and right guinea pig artia (beats/min), at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50059Effect of intravenous infusion on diastolic pressure in Anesthetized cats at a dose of 0.15 mg/kg at 1 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49052Effect of intravenous infusion on respiration frequency in Anesthetized cats at a dose of 0.15 mg/kg at 1 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50227Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 30 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50058Effect of intravenous infusion on systolic pressure in Anesthetized cats at a dose of 1.50 mg/kg at 10 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50052Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 90 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50045Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50064Effect of intravenous infusion on diastolic pressure in Anesthetized cats at a dose of 2.25 mg/kg at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50065Effect of intravenous infusion on diastolic pressure in Anesthetized cats at a dose of 3.0 mg/kg at 20 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50049Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 45 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID48910Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 105 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID166482Effect on 35 mM K+-induced contraction on rabbit aorta at a dose of 3*10e-9 mol/L1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50062Effect of intravenous infusion on diastolic pressure in Anesthetized cats at a dose of 0 mg/kg at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID132053Dose required to protect 50% of tested mice against experimental antithrombosis.1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50225Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID48911Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 135 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50236Effect of intravenous infusion on cardiac frequency in Anesthetized cats at a dose of 0.75 mg/kg at 5 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75064Chronotropic activity on left and right guinea pig artia (beats/min), at 45 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75501Chronotropic activity on left and right guinea pig artia (beats/min), at 75 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75068Effect on guinea pig artia (beats/min), at the a dose of 0 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50221Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 105 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75382Chronotropic activity on left and right guinea pig artia (beats/min), at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49049Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 90 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75063Chronotropic activity on left and right guinea pig artia (beats/min), at 30 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50232Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 180 mins1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50044Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 150 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75499Chronotropic activity on left and right guinea pig artia (beats/min), at 45 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75070Effect on guinea pig artia (beats/min), at the a dose of 10e-7 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75071Effect on guinea pig artia (beats/min), at the a dose of 10e-9 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50050Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 60 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50053Effect of intravenous infusion of compound on diastolic pressure in Anesthetized cats at a dose of 3 mg/kg at 20 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50029Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 120 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75061Chronotropic activity on left and right guinea pig artia (beats/min), at 150 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID48915Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 30 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID48916Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 45 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50063Effect of intravenous infusion on diastolic pressure in Anesthetized cats at a dose of 1.50 mg/kg at 10 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50223Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 135 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50054Effect of intravenous infusion on systolic pressure in Anesthetized cats at a dose of 0.15 mg/kg at 1 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50035Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 30 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID166475Effect on 35 mM K+-induced contraction on rabbit aorta at a dose of 10E-8 mol/L1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75505Effect on guinea pig artia (beats/min), at the a dose of 0 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50038Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 75 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50034Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 180 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75383Chronotropic activity on left and right guinea pig artia (beats/min), at 150 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50030Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 135 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50235Effect of intravenous infusion on cardiac frequency in Anesthetized cats at a dose of 0.30 mg/kg at 2 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49058Effect on respiration frequency in Anesthetized cats at a dose of 2.25 mg/kg at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50224Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 150 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75498Chronotropic activity on left and right guinea pig artia (beats/min), at 30 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49048Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 75 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50226Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 165 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50231Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 90 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID166479Effect on 35 mM K+-induced contraction on rabbit aorta at a dose of 3*10e-7 mol/L1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50066Effect of intravenous infusion on systolic pressure in Anesthetized cats at a dose of 2.25 mg/kg at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50039Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 90 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75507Effect on guinea pig artia (beats/min), at the a dose of 10e-7 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50043Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 135 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID48912Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 150 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID166474Effect on 35 mM K+-induced contraction on rabbit aorta at a dose of 10E-7 mol/L1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID166481Effect on 35 mM K+-induced contraction on rabbit aorta at a dose of 3*10e-8 mol/L1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75066Chronotropic activity on left and right guinea pig artia (beats/min), at 75 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49054Effect of intravenous infusion on respiration frequency in Anesthetized cats at a dose of 0.75 mg/kg at 5 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75072Effect on guinea pig artia (beats/min), at the a dose of 10e-8 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50233Effect of intravenous infusion on cardiac frequency in Anesthetized cats at a dose of 0.00 mg/kg at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49057Effect of intravenous infusion on respiration frequency in Anesthetized cats at a dose of 3 mg/kg at 20 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75509Effect on guinea pig artia (beats/min), at the a dose of 10e-8 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75065Chronotropic activity on left and right guinea pig artia (beats/min), at 60 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49055Effect of intravenous infusion on respiration frequency in Anesthetized cats at a dose of 0 mg/kg at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49053Effect of intravenous infusion on respiration frequency in Anesthetized cats at a dose of 0.30 mg/kg at 2 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75502Chronotropic activity on left and right guinea pig artia (beats/min), at 90 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50048Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 30 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50220Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49908Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50060Effect of intravenous infusion on diastolic pressure in Anesthetized cats at a dose of 0.30 mg/kg at 2 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID48914Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 165 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75508Effect on guinea pig artia (beats/min), at the a dose of 10e-9 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50040Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50042Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 120 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50056Effect of intravenous infusion on systolic pressure in Anesthetized cats at a dose of 0.75 mg/kg at 5 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50033Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 165 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75381Chronotropic activity on left and right guinea pig artia (beats/min), at 120 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50237Effect of intravenous infusion on cardiac frequency in Anesthetized cats at a dose of 1.50 mg/kg at 10 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50041Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 105 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50061Effect of intravenous infusion on diastolic pressure in Anesthetized cats at a dose of 0.75 mg/kg at 5 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50239Effect on cardiac frequency in Anesthetized cats at a dose of 2.25 mg/kg at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50037Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 60 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID166472Effect on 35 mM K+-induced contraction on rabbit aorta at a dose of 10E-6 mol/L1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50047Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 180 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49056Effect of intravenous infusion on respiration frequency in Anesthetized cats at a dose of 1.50 mg/kg at 10 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75500Chronotropic activity on left and right guinea pig artia (beats/min), at 60 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50036Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 45 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID48909Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID89409Inhibition of 2 ug/mL collagen induced platelet aggregation in platelet-rich human plasma (PRP)1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50230Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 75 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50051Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 75 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75506Effect on guinea pig artia (beats/min), at the a dose of 10e-6 M1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID166477Effect on 35 mM K+-induced contraction on rabbit aorta at a dose of 3*10e-6 mol/L1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75058Chronotropic activity on left and right guinea pig artia (beats/min), at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50057Effect of intravenous infusion on systolic pressure in Anesthetized cats at a dose of 0 mg/kg at 0 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49050Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 120 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75067Chronotropic activity on left and right guinea pig artia (beats/min), at 90 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50234Effect of intravenous infusion on cardiac frequency in Anesthetized cats at a dose of 0.15 mg/kg at 1 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50222Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 120 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50032Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75060Chronotropic activity on left and right guinea pig artia (beats/min), at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50238Effect of intravenous infusion on cardiac frequency in Anesthetized cats at a dose of 3 mg/kg at 20 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID49909Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 105 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50031Effect of intraperitoneal infusion on diastolic pressure in Anesthetized cats at a dose of 200 mg/kg at 150 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50046Effect of intraperitoneal infusion on systolic pressure in Anesthetized cats at a dose of 200 mg/kg at 165 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID75062Chronotropic activity on left and right guinea pig artia (beats/min), at 180 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50055Effect of intravenous infusion on systolic pressure in Anesthetized cats at a dose of 0.30 mg/kg at 2 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID50229Effect of intraperitoneal infusion of compound on cardiac frequency in Anesthetized cats at a dose of 200 mg/kg at 60 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
AID48913Effect of intraperitoneal infusion on respiration frequency in Anesthetized cats at a dose of 200 mg/kg at 15 min1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's7 (77.78)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.75 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.06 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		1.9710benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
dipyridamole
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752). dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.		1.9710piperidines;
pyrimidopyrimidine;
tertiary amino compound;
tetrol		adenosine phosphodiesterase inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor;
platelet aggregation inhibitor;
vasodilator agent
1-methyl-3-isobutylxanthine
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES. 3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.		1.99103-isobutyl-1-methylxanthine
nifedipine
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.		1.9710C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
nitrendipine
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.. nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.		1.9710C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
ethyl ester;
methyl ester		antihypertensive agent;
calcium channel blocker;
geroprotector;
vasodilator agent
pca 4248
PCA 4248: structure given in first source; platelet activating factor antagonist		1.9810dihydropyridine
ticlopidine
Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.. ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.		2.3820monochlorobenzenes;
thienopyridine		anticoagulant;
fibrin modulating drug;
hematologic agent;
P2Y12 receptor antagonist;
platelet aggregation inhibitor
manganese
Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.		1.9810elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
colforsin
Colforsin: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.		1.9910acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol		adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
fura-2
Fura-2: A fluorescent calcium chelating agent which is used to study intracellular calcium in tissues.		1.9810
fibrinogen
Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.		1.9810iditolfungal metabolite
1,4-dihydropyridine
[no description available]		1.9810
indo-1
indo-1: structure given in first source		1.9810indolesfluorochrome
1-hexadecyl-2-acetyl-glycero-3-phosphocholine
Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.. 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine : A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.		2.67302-acetyl-1-alkyl-sn-glycero-3-phosphocholineantihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent
dihydropyridines
Dihydropyridines: Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.		3.4980
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		1.9810icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
thromboxane b2
Thromboxane B2: A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).. thromboxane B2 : A member of the class of thromboxanes B that is (5Z,13E)-thromboxa-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15.		1.9810thromboxanes Bhuman metabolite;
mouse metabolite
calcimycin
Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.		1.9810benzoxazole
cyclin d1
Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.		210
cyclic gmp
Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.		1.99103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Blood Clot
[description not available]		02.3820
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.		02.3820
Carcinoma, Epidermoid
[description not available]		01.9810
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)		01.9810