Assay ID | Title | Year | Journal | Article |
AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1180675 | Selectivity for human CGRP receptor over AM2 receptor (unknown origin) | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID1180703 | Inhibition of capsaicin-induced dermal vasodilation in human by laser Doppler imaging method | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID665602 | Displacement of [125I]CGRP from CGRP receptor in dog brain membrane after 3 hrs | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID772345 | Lipophilicity, log D of the compound at pH 7.0 by HPLC analysis | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| [(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor. |
AID1180673 | Binding affinity to rhesus monkey CGRP receptor | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID772349 | Efflux ratio of human MDR1-mediated drug transport from basolateral to apical side over apical to basolateral side in pig LLC cells expressing human MDR1 at 5 uM | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| [(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor. |
AID1180749 | Antimigraine activity in migraine patient assessed as pain relief incidence at 10 mg after 2 hrs (Rvb = 36.1%) | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID665603 | Antimigraine activity in iv dosed rat assessed as inhibition of capsaicin-induced dermal vasodilation administered 10 mins post capsaicin-challenge measured after 20 mins by laser doppler scanning | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID665606 | Fraction unbound in monkey plasma | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID772351 | Ratio of Bmax to Ki for human CGRP receptor expressed in HEK293 cells | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| [(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor. |
AID665647 | Ratio of Ki for rat CGRP receptor to Ki for rhesus monkey CGRP receptor | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID665646 | Antimigraine activity in iv dosed rhesus monkey assessed as inhibition of capsaicin-induced dermal vasodilation administered 5 mins post capsaicin-challenge measured after 20 mins by laser doppler scanning | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID1180682 | Inhibition of capsaicin-induced dermal vasodilation in rhesus monkey model by laser Doppler imaging method | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID772347 | Apparent passive permeability across pig LLC-PK1 cells | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| [(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor. |
AID1180747 | Antimigraine activity in migraine patient assessed as pain freedom incidence at 10 mg after 2 hrs (Rvb = 9.8%) | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID1180694 | Selectivity for human CGRP receptor over AMY1 receptor (unknown origin) | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID625500 | Displacement of [125I]adrenomedullin form CGRP receptor in human SK-N-MC cell membrane by competitive binding assay | 2011 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
| Identification of a novel RAMP-independent CGRP receptor antagonist. |
AID625501 | Inhibition of human CGRP receptor expressed in huamn HEK293 cells coexpressing CLR/RAMP1 assessed as inhibition of CGRP-stimulated cAMP production after 1 hr | 2011 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
| Identification of a novel RAMP-independent CGRP receptor antagonist. |
AID1180670 | Binding affinity to rat CGRP receptor | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID1180750 | Antimigraine activity in migraine patient assessed as pain relief incidence at 200 mg after 2 hrs (Rvb = 36.1%) | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID772350 | Displacement of [125I]-hCGRP from human CGRP receptor expressed in HEK293 cells | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| [(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor. |
AID1180674 | Selectivity for human CGRP receptor over AM1 receptor (unknown origin) | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID754796 | Antagonist activity at human CGRP receptor | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11
| Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migr |
AID665605 | Fraction unbound in dog plasma | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID665600 | Displacement of [125I]CGRP from CGRP receptor in rat brain membrane after 3 hrs | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID665608 | Aqueous solubility of the compound in phosphate buffer at pH 7 | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID772337 | Binding affinity to rhesus monkey cerebellum CGRP receptor | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| [(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor. |
AID665604 | Fraction unbound in human plasma | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID1180693 | Selectivity for human CGRP receptor over AM3 receptor (unknown origin) | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID665612 | Displacement of [125I]CGRP from CGRP receptor in rhesus monkey cerebellum after 3 hrs | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID665599 | Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrs | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID772348 | Fraction unbound in monkey plasma by equillibrium dialysis method | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| [(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor. |
AID1180681 | Binding affinity to human CGRP receptor using [3H]-labeled compound assessed as receptor binding half life | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID1180748 | Antimigraine activity in migraine patient assessed as pain freedom incidence at 200 mg after 2 hrs (Rvb = 9.8%) | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. |
AID665601 | Fraction unbound in rat plasma | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID772346 | Ratio of AUC in rhesus monkey CSF to AUC in rhesus monkey plasma | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| [(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor. |
AID665650 | Selectivity ratio of Ki for rat CGRP receptor to Ki for human CGRP receptor | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. |
AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |