amylin receptor complex 3

Definition

Target type: cellularcomponent

A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 3. Amylin receptor complex 3 (AMY3) also serves as a receptor for the amyloid-beta complex. Ligand binding to AMY3 results in increased cytosolic calcium ion levels and in activation on multiple intracellular signaling pathways. [GOC:aruk, GOC:bc, PMID:22500019]

The amylin receptor complex 3 (AMYR3) is a heterotrimeric complex composed of three transmembrane proteins: the amylin receptor (AMY), the receptor activity-modifying protein 1 (RAMP1), and the calcitonin receptor-like receptor (CLR). AMYR3 is a G protein-coupled receptor (GPCR) that is responsible for mediating the cellular effects of amylin, a hormone produced by the pancreatic beta cells.

The AMYR3 complex is assembled in the endoplasmic reticulum (ER) and then trafficked to the plasma membrane. The AMYR3 complex is a complex structure with multiple transmembrane domains and extracellular loops.

The AMYR3 complex is activated by the binding of amylin to the extracellular domain of the AMYR. Amylin binding to the AMYR induces a conformational change in the receptor, which activates the G protein signaling pathway.

The G protein signaling pathway is a cascade of events that ultimately leads to the production of intracellular second messengers, such as cyclic adenosine monophosphate (cAMP).

The AMYR3 complex plays a role in regulating glucose homeostasis. It is involved in the inhibition of insulin secretion, the suppression of glucagon secretion, and the promotion of satiety.

The AMYR3 complex has been implicated in a number of physiological and pathological processes, including diabetes mellitus, obesity, and Alzheimer's disease.

The cellular component of the AMYR3 complex includes the following:

- The AMYR receptor is a type I transmembrane protein with a large extracellular domain, seven transmembrane domains, and a short intracellular domain.
- The RAMP1 is a type I transmembrane protein with a single transmembrane domain and a large extracellular domain.
- The CLR is a type II transmembrane protein with a large extracellular domain, seven transmembrane domains, and a short intracellular domain.

The AMYR3 complex is located in the plasma membrane of cells. It is expressed in a variety of tissues, including the pancreas, the brain, and the gastrointestinal tract.'
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Proteins (2)

Compounds (2)