adrenomedullin receptor activity

Definition

Target type: molecularfunction

Combining with adrenomedullin to initiate a change in cell activity. [GOC:ai]

Adrenomedullin receptor activity is a molecular function associated with the transmembrane receptor that binds adrenomedullin, a potent vasodilator and hypotensive peptide. This receptor, also known as the calcitonin receptor-like receptor (CLR), belongs to the class B G protein-coupled receptors (GPCRs). Upon binding of adrenomedullin, the receptor activates downstream signaling pathways, primarily involving the G protein Gs, leading to the production of cAMP and the activation of protein kinase A (PKA). This signaling cascade results in a multitude of physiological effects, including:

* **Vasodilation:** Adrenomedullin receptor activation leads to relaxation of vascular smooth muscle, causing vasodilation and lowering blood pressure.
* **Cardioprotection:** Adrenomedullin plays a protective role in the heart, reducing myocardial damage and inflammation.
* **Anti-inflammatory effects:** Adrenomedullin receptor activation inhibits the production of pro-inflammatory cytokines, contributing to its overall anti-inflammatory properties.
* **Regulation of fluid balance:** Adrenomedullin receptor signaling affects renal function, influencing sodium and water excretion.
* **Regulation of cell growth and differentiation:** Adrenomedullin receptor activation influences cell proliferation and differentiation in various tissues.

The adrenomedullin receptor is expressed in a wide range of tissues and organs, including the cardiovascular system, kidneys, lungs, brain, and gastrointestinal tract. Its diverse functions highlight its significant role in maintaining physiological homeostasis and regulating various physiological processes.'
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Proteins (3)

Compounds (8)