adrenomedullin receptor complex

Definition

Target type: cellularcomponent

A transmembrane, G protein-coupled signaling receptor complex which is capable of adrenomedullin receptor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22102369]

The adrenomedullin receptor complex is a multi-protein complex responsible for the signal transduction of adrenomedullin, a potent vasodilator peptide. The complex consists of three main components:

1. **Calcitonin receptor-like receptor (CLR)**: This is the primary receptor protein that binds adrenomedullin. It is a seven-transmembrane G protein-coupled receptor (GPCR) and belongs to the family of calcitonin receptors.

2. **Receptor activity-modifying protein 1 (RAMP1)**: RAMP1 is a single-transmembrane protein that associates with CLR and is essential for the formation of a functional adrenomedullin receptor complex. RAMP1 interacts with CLR through its extracellular domain and modulates the binding affinity and signaling properties of the complex.

3. **G protein:** Upon adrenomedullin binding, the CLR-RAMP1 complex activates a specific type of G protein, typically Gαs. This G protein is a heterotrimeric complex consisting of alpha, beta, and gamma subunits. The activated Gαs subunit then interacts with adenylate cyclase, leading to the production of cyclic AMP (cAMP), a second messenger molecule that mediates downstream signaling events.

The cellular component of the adrenomedullin receptor complex can be localized to the plasma membrane of various cell types, including vascular endothelial cells, smooth muscle cells, and neurons. It plays a crucial role in regulating blood pressure, vascular tone, and other physiological processes.'
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Proteins (3)

Compounds (8)