amylin receptor signaling pathway
Definition
Target type: biologicalprocess
A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
The amylin receptor signaling pathway is initiated when amylin, a peptide hormone produced by pancreatic beta cells, binds to its receptor, the calcitonin receptor-like receptor (CLR). This binding activates a G protein-coupled receptor (GPCR) signaling cascade, which involves the following steps: 1. **Ligand binding:** Amylin binds to CLR, a GPCR that is also the receptor for calcitonin and adrenomedullin. 2. **G protein activation:** Binding of amylin to CLR triggers the activation of a heterotrimeric G protein, specifically Gαs. 3. **Adenylate cyclase activation:** The activated Gαs subunit stimulates the enzyme adenylate cyclase, leading to the production of cyclic AMP (cAMP) from ATP. 4. **Protein kinase A (PKA) activation:** cAMP activates protein kinase A (PKA), which phosphorylates and activates downstream signaling proteins. 5. **Insulin secretion regulation:** PKA activation leads to the regulation of insulin secretion by pancreatic beta cells. 6. **Other cellular effects:** Amylin receptor signaling also influences various other cellular processes, including glucose metabolism, appetite regulation, and neuronal activity. Amylin signaling has been implicated in the regulation of glucose homeostasis, appetite regulation, and the pathogenesis of type 2 diabetes. Amylin receptor agonists are being investigated as potential therapeutic agents for diabetes and obesity.'
"
Proteins (4)
| Protein | Definition | Taxonomy |
|---|---|---|
| Calcitonin receptor | A calcitonin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30988] | Homo sapiens (human) |
| Islet amyloid polypeptide | An islet amyloid polypeptide that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10997] | Homo sapiens (human) |
| Receptor activity-modifying protein 3 | A receptor activity-modifying protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60896] | Homo sapiens (human) |
| Receptor activity-modifying protein 1 | A receptor activity-modifying protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60894] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| morin | morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5. morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria) | 7-hydroxyflavonol; pentahydroxyflavone | angiogenesis modulating agent; anti-inflammatory agent; antibacterial agent; antihypertensive agent; antineoplastic agent; antioxidant; EC 5.99.1.2 (DNA topoisomerase) inhibitor; hepatoprotective agent; metabolite; neuroprotective agent |
| telcagepant | telcagepant: structure in first source | ||
| mk 3207 | |||
| bms 694153 | |||
| mk-8825 | |||
| atogepant | atogepant : A secondary carboxamide resulting from the formal condensation of the carboxy group of (3'S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid with the amino group of (3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one. It is a selective oral, small-molecule antagonist of calcitonin gene-related peptide (CGRP) receptor that has been approved for the treatment of migraine. | azaspiro compound; organic heterotetracyclic compound; piperidones; secondary carboxamide; trifluorobenzene | calcitonin gene-related peptide receptor antagonist |