amylin receptor signaling pathway

Definition

Target type: biologicalprocess

A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]

The amylin receptor signaling pathway is initiated when amylin, a peptide hormone produced by pancreatic beta cells, binds to its receptor, the calcitonin receptor-like receptor (CLR). This binding activates a G protein-coupled receptor (GPCR) signaling cascade, which involves the following steps: 1. **Ligand binding:** Amylin binds to CLR, a GPCR that is also the receptor for calcitonin and adrenomedullin. 2. **G protein activation:** Binding of amylin to CLR triggers the activation of a heterotrimeric G protein, specifically Gαs. 3. **Adenylate cyclase activation:** The activated Gαs subunit stimulates the enzyme adenylate cyclase, leading to the production of cyclic AMP (cAMP) from ATP. 4. **Protein kinase A (PKA) activation:** cAMP activates protein kinase A (PKA), which phosphorylates and activates downstream signaling proteins. 5. **Insulin secretion regulation:** PKA activation leads to the regulation of insulin secretion by pancreatic beta cells. 6. **Other cellular effects:** Amylin receptor signaling also influences various other cellular processes, including glucose metabolism, appetite regulation, and neuronal activity. Amylin signaling has been implicated in the regulation of glucose homeostasis, appetite regulation, and the pathogenesis of type 2 diabetes. Amylin receptor agonists are being investigated as potential therapeutic agents for diabetes and obesity.'
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Proteins (4)

Compounds (6)