amylin receptor complex 2

Definition

Target type: cellularcomponent

A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM). [GOC:aruk, GOC:bc, PMID:22500019]

Amylin receptor complex 2 is a multi-protein complex that is responsible for the cellular response to amylin, a peptide hormone secreted by pancreatic beta cells. The complex consists of at least two components: the amylin receptor (also known as the calcitonin receptor-like receptor, CRLR) and the receptor activity-modifying protein 1 (RAMP1). The CRLR is a member of the G protein-coupled receptor (GPCR) superfamily, and it has seven transmembrane domains. RAMP1 is a single-pass transmembrane protein that interacts with CRLR to form the amylin receptor complex. The CRLR and RAMP1 proteins assemble in the endoplasmic reticulum and then traffic to the plasma membrane where they are able to bind amylin. Amylin binding to the complex activates downstream signaling pathways, leading to a variety of physiological effects. These effects include: * Inhibition of insulin secretion * Inhibition of glucagon secretion * Inhibition of gastric emptying * Stimulation of satiety The amylin receptor complex is expressed in a variety of tissues, including the pancreas, brain, heart, and gastrointestinal tract. The cellular component of amylin receptor complex 2 is thus a multi-protein complex located on the plasma membrane of various cells. This complex is vital for the proper functioning of amylin, a hormone involved in glucose regulation and appetite control. '
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Proteins (1)

Compounds (2)