amylin receptor complex 1

Definition

Target type: cellularcomponent

A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM). [GOC:aruk, GOC:bc, PMID:22500019]

The amylin receptor complex 1 (AMYLR1) is a heteromeric complex composed of three proteins: the calcitonin receptor-like receptor (CLR), the receptor activity-modifying protein 1 (RAMP1), and the amyloid polypeptide (AMY). The CLR is a seven-transmembrane G protein-coupled receptor that binds to both calcitonin and amylin. RAMP1 is a single-transmembrane protein that associates with CLR to form the functional amylin receptor. AMY is a 37-amino acid peptide hormone that is produced by the pancreatic beta cells. When AMY binds to AMYLR1, it activates a signaling pathway that leads to the inhibition of insulin secretion. The cellular component of AMYLR1 is the plasma membrane. The CLR and RAMP1 proteins are expressed in the plasma membrane of many different cell types, including pancreatic beta cells, neurons, and bone cells. AMY is secreted from the pancreatic beta cells and circulates in the blood. When AMY binds to AMYLR1 in the plasma membrane of target cells, it initiates a signaling cascade that leads to the physiological effects of AMY. The AMYLR1 complex is thought to play an important role in regulating blood glucose levels and insulin secretion. It is also thought to be involved in the pathogenesis of type 2 diabetes.'
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Proteins (1)

Compounds (2)