magnosalin: from crude Japanese drug Shin-i; inhibits adjuvant-induced angiogenesis & granuloma formation in the mouse pouch; structure given in first source; RN given refers to cpd without isomeric designation [MeSH]
Magnosalin : no description available [CHeBI]
| ID Source | ID |
|---|---|
| PubMed CID | 10454589 |
| CHEMBL ID | 156339 |
| CHEBI ID | 81363 |
| MeSH ID | M0190063 |
| Synonym |
|---|
| magnosalin |
| C17847 |
| 1-[2,3-dimethyl-4-(2,4,5-trimethoxyphenyl)-(1r,2r,3r,4r)-cyclobutyl]-2,4,5-trimethoxybenzene |
| bdbm50110027 |
| chebi:81363 , |
| rel-magnosalin |
| CHEMBL156339 , |
| 1-[(1r,2r,3r,4r)-2,3-dimethyl-4-(2,4,5-trimethoxyphenyl)cyclobutyl]-2,4,5-trimethoxybenzene |
| Q27155301 |
| AKOS040762658 |
| 81861-74-7 |
| Class | Description |
|---|---|
| lignan | Any phenylpropanoid derived from phenylalanine via dimerization of substituted cinnamic alcohols, known as monolignols, to a dibenzylbutane skeleton. Note that while individual members of the class have names ending ...lignane, ...lignene, ...lignadiene, etc., the class names lignan, neolignan, etc., do not end with an "e". |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID684426 | Cytotoxicity against human A549 cells by SRB assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 ISSN: 1464-3405 | Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities. |
| AID684429 | Cytotoxicity against human HCT15 cells by SRB assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 ISSN: 1464-3405 | Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities. |
| AID378128 | Inhibition of human liver microsome CYP3A4 in assessed as [14C]formaldehyde formation | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 ISSN: 0163-3864 | Potent CYP3A4 inhibitory constituents of Piper cubeba. |
| AID378129 | Inhibition of human liver microsome CYP2D6 in assessed as [14C]formaldehyde formation | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 ISSN: 0163-3864 | Potent CYP3A4 inhibitory constituents of Piper cubeba. |
| AID684430 | Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production treated 30 mins before LPS stimulation measured after 24 hrs by Griess reaction | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 ISSN: 1464-3405 | Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities. |
| AID99817 | Relative cytotoxicity measured as inhibition of LPS induced TNF alpha production in L929 cells at 10 uM | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4 ISSN: 0960-894X | Two neolignans from Perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-alpha expression in murine macrophage cell line RAW 264.7. |
| AID684424 | Antiinflammatory activity in mouse BV2 cells assessed as inhibition of sodium nitroprusside-induced nitrite accumulation at 10 to 20 uM after 180 mins by Griess reaction | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 ISSN: 1464-3405 | Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities. |
| AID147402 | Tested for the inhibition of nitric oxide syntheses in murine macrophage cell line RAW 264.7 | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4 ISSN: 0960-894X | Two neolignans from Perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-alpha expression in murine macrophage cell line RAW 264.7. |
| AID684425 | Cytotoxicity against mouse BV2 cells assessed as cell viability at 20 uM by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 ISSN: 1464-3405 | Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities. |
| AID684428 | Cytotoxicity against human SK-MEL-2 cells by SRB assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 ISSN: 1464-3405 | Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities. |
| AID684432 | Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS protein expression at 10 to 20 uM treated 30 mins before LPS stimulation measured after 6 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 ISSN: 1464-3405 | Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities. |
| AID684427 | Cytotoxicity against human SKOV3 cells by SRB assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 ISSN: 1464-3405 | Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| corticosterone | 11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone | human metabolite; mouse metabolite | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |
| thymidine | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |
| 2-naphthol | naphthol | antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger | 1990 | 1996 | 31.8 | medium | 0 | 0 | 4 | 0 | 0 | 0 | |
| lignin | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |||
| lignans | 1990 | 2002 | 29.8 | high | 0 | 0 | 4 | 1 | 0 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Angiogenesis, Pathologic | 0 | 1990 | 1991 | 33.5 | medium | 0 | 0 | 2 | 0 | 0 | 0 | |
| Arthritis | 0 | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Arthritis, Rheumatoid | 0 | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |
| Dermatoses | 0 | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |
| Granuloma | 0 | 1990 | 1991 | 33.5 | medium | 0 | 0 | 2 | 0 | 0 | 0 | |
| Granulomas | 0 | 1990 | 1991 | 33.5 | medium | 0 | 0 | 2 | 0 | 0 | 0 | |
| Peritoneal Diseases | 0 | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |
| Polyarthritis | 0 | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Rheumatoid Arthritis | 0 | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |
| Skin Diseases | 0 | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |